产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
雌激素受体α单克隆抗体(1D5)
目录 :
MA5-13191
规格 :
500微升
价格 :
美国616
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
1D5
反应物种 :
African green monkey, 人类, 小鼠, 大鼠, 鸡, 猫, domestic rabbit, 猕猴
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, EMSA, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 82
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| Cardoso R, Burns A, Moeller J, Skinner D, Padmanabhan V. Developmental Programming: Insulin Sensitizer Prevents the GnRH-Stimulated LH Hypersecretion in a Sheep Model of PCOS. Endocrinology. 2016;157:4641-4653 pubmed
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| Einbond L, Soffritti M, Degli Esposti D, Tibaldi E, Lauriola M, Bua L, et al. Chemopreventive potential of black cohosh on breast cancer in Sprague-Dawley rats. Anticancer Res. 2012;32:21-30 pubmed
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| Habib F, Zaki M, El Aal A, Safwat M, Domiaty M. Immunohistochemical expression of oestrogen and progesterone receptors during experimental acute and chronic murine Schistosomiasis mansoni. Rev Soc Bras Med Trop. 2010;43:531-5 pubmed
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| Ceausu M, Terzea D, Georgescu A, Dobrea C, Mihai M, Iosif C, et al. Transitional cell tumors of the ovary: a compact group with a heterogeneous histological and immunophenotypical pattern. Rom J Morphol Embryol. 2008;49:513-6 pubmed
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| Onal B, Levin R, Kogan B, Whitbeck C, Chichester P, Walebowa O, et al. The effect of maturation and age on oestrogen-induced functional hypertrophy of the female rabbit bladder. BJU Int. 2007;99:674-9 pubmed
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| Singer C, Fink Retter A, Gschwantler Kaulich D, Thalhammer T, Hudelist G, Mueller R, et al. Selective spatial upregulation of intratumoral stromal aromatase in breast cancer patients: evidence for imbalance of local estrogen metabolism. Endocr Relat Cancer. 2006;13:1101-7 pubmed
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| Schmidt M, Tollenaar R, de Kemp S, Broeks A, Cornelisse C, Smit V, et al. Breast cancer survival and tumor characteristics in premenopausal women carrying the CHEK2*1100delC germline mutation. J Clin Oncol. 2007;25:64-9 pubmed
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| Hannemann J, Kristel P, VAN Tinteren H, Bontenbal M, van Hoesel Q, Smit W, et al. Molecular subtypes of breast cancer and amplification of topoisomerase II alpha: predictive role in dose intensive adjuvant chemotherapy. Br J Cancer. 2006;95:1334-41 pubmed
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| Wang M, Pan J, Song G, Chen H, An L, Qu S. Altered expression of estrogen receptor alpha and beta in advanced gastric adenocarcinoma: correlation with prothymosin alpha and clinicopathological parameters. Eur J Surg Oncol. 2007;33:195-201 pubmed
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| Amant F, Woestenborghs H, Vandenbroucke V, Berteloot P, Neven P, Moerman P, et al. Transition of endometrial stromal sarcoma into high-grade sarcoma. Gynecol Oncol. 2006;103:1137-40 pubmed
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| Rao K, Alper O, Opheim K, Bonnet G, Wolfe K, Bryant E, et al. Cytogenetic characterization and H-ras associated transformation of immortalized human mammary epithelial cells. Cancer Cell Int. 2006;6:15 pubmed
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| Turbyville T, Wijeratne E, Liu M, Burns A, Seliga C, Luevano L, et al. Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert. J Nat Prod. 2006;69:178-84 pubmed
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| Tse G, Tan P, Putti T, Lui P, Chaiwun B, Law B. Metaplastic carcinoma of the breast: a clinicopathological review. J Clin Pathol. 2006;59:1079-83 pubmed
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| Wang R, Zhang H, Balasenthil S, Medina D, Kumar R. PAK1 hyperactivation is sufficient for mammary gland tumor formation. Oncogene. 2006;25:2931-6 pubmed
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| Lipfert L, Fisher J, Wei N, Scafonas A, Su Q, Yudkovitz J, et al. Antagonist-induced, activation function-2-independent estrogen receptor alpha phosphorylation. Mol Endocrinol. 2006;20:516-33 pubmed
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| Saylam G, Yücel O, Sungur A, Onerci M. Proliferation, angiogenesis and hormonal markers in juvenile nasopharyngeal angiofibroma. Int J Pediatr Otorhinolaryngol. 2006;70:227-34 pubmed
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| Saglam E, Usubutun A, Kart C, Ayhan A, Kucukali T. Reactive nodular fibrous pseudotumor involving the pelvic and abdominal cavity: a case report and review of literature. Virchows Arch. 2005;447:879-82 pubmed
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| Akhan S, Yavuz E, Tecer A, Iyibozkurt C, Topuz S, Tuzlali S, et al. The expression of Ki-67, p53, estrogen and progesterone receptors affecting survival in uterine leiomyosarcomas. A clinicopathologic study. Gynecol Oncol. 2005;99:36-42 pubmed
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| Wittmann B, Fujinaga K, Deng H, Ogba N, Montano M. The breast cell growth inhibitor, estrogen down regulated gene 1, modulates a novel functional interaction between estrogen receptor alpha and transcriptional elongation factor cyclin T1. Oncogene. 2005;24:5576-88 pubmed
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| Dinulescu D, Ince T, Quade B, Shafer S, Crowley D, Jacks T. Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer. Nat Med. 2005;11:63-70 pubmed
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Flötotto T, Niederacher D, Hohmann D, Heimerzheim T, Dall P, Djahansouzi S, et al. Molecular mechanism of estrogen receptor (ER)alpha-specific, estradiol-dependent expression of the progesterone receptor (PR) B-isoform. J Steroid Biochem Mol Biol. 2004;88:131-42 pubmed
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Guler G, Uner A, Guler N, Han S, Iliopoulos D, Hauck W, et al. The fragile genes FHIT and WWOX are inactivated coordinately in invasive breast carcinoma. Cancer. 2004;100:1605-14 pubmed
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Kapucuoglu N, Coban T, Raunio H, Pelkonen O, Edwards R, Boobis A, et al. Expression of CYP3A4 in human breast tumour and non-tumour tissues. Cancer Lett. 2003;202:17-23 pubmed
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Beliakoff J, Bagatell R, Paine Murrieta G, Taylor C, Lykkesfeldt A, Whitesell L. Hormone-refractory breast cancer remains sensitive to the antitumor activity of heat shock protein 90 inhibitors. Clin Cancer Res. 2003;9:4961-71 pubmed
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Wittmann B, Wang N, Montano M. Identification of a novel inhibitor of breast cell growth that is down-regulated by estrogens and decreased in breast tumors. Cancer Res. 2003;63:5151-8 pubmed
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Wang H, Mahadevappa M, Yamamoto K, Wen Y, Chen B, Warrington J, et al. Distinctive proliferative phase differences in gene expression in human myometrium and leiomyomata. Fertil Steril. 2003;80:266-76 pubmed
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Bethea C, Lu N, Reddy A, Shlaes T, Streicher J, Whittemore S. Characterization of reproductive steroid receptors and response to estrogen in a rat serotonergic cell line. J Neurosci Methods. 2003;127:31-41 pubmed
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Hudelist G, Czerwenka K, Kubista E, Marton E, Pischinger K, Singer C. Expression of sex steroid receptors and their co-factors in normal and malignant breast tissue: AIB1 is a carcinoma-specific co-activator. Breast Cancer Res Treat. 2003;78:193-204 pubmed
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Seth P, Porter D, Lahti Domenici J, Geng Y, Richardson A, Polyak K. Cellular and molecular targets of estrogen in normal human breast tissue. Cancer Res. 2002;62:4540-4 pubmed
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Suzuki T, Darnel A, Akahira J, Ariga N, Ogawa S, Kaneko C, et al. 5alpha-reductases in human breast carcinoma: possible modulator of in situ androgenic actions. J Clin Endocrinol Metab. 2001;86:2250-7 pubmed
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El Khissiin A, Journe F, Laios I, Seo H, Leclercq G. Evidence of an estrogen receptor form devoid of estrogen binding ability in MCF-7 cells. Steroids. 2000;65:903-13 pubmed
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Lu N, Shlaes T, Gundlah C, Dziennis S, Lyle R, Bethea C. Ovarian steroid action on tryptophan hydroxylase protein and serotonin compared to localization of ovarian steroid receptors in midbrain of guinea pigs. Endocrine. 1999;11:257-67 pubmed
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图像
图像 1 :
Formalin-fixed, paraffin-embedded human breast carcinoma stained with Estrogen Receptor antibody1 using peroxidase-conjugate and DAB chromogen. Note intense nuclear staining of tumor cells.
图像 2 :
产品信息
产品类型 :
抗体
产品名称 :
雌激素受体α单克隆抗体(1D5)
目录# :
MA5-13191
规格 :
500微升
价格 :
美国616
克隆性 :
单克隆
纯度 :
蛋白质G
宿主 :
小鼠
反应物种 :
人类
应用 :
Immunocytochemistry: 1:500-1:1,000, Immunohistochemistry (Paraffin): 1:250-1:500, Western Blot: 0.5-1.0 µg/mL
物种 :
人类
克隆 :
1D5
抗体亚型 :
IgG1, kappa
储存 :
4° C
描述 :
Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins. There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively). Due to alternative RNA splicing, at least 4 estrogen receptor-alpha isoforms are known to exist (Isoform 1 (66 kDa), Isoform 2 (53 kDa), Isoform 3 (47 kDa), Isoform 4 (35 kDa)). Estrogen receptors are widely expressed in different tissue types and are essential for sexual development and reproductive function. They also play a role in other tissues such as bone. Estrogen receptors are involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis.
免疫原 :
重组人类雌激素受体蛋白
格式 :
液体
应用w/稀释 :
Immunocytochemistry: 1:500-1:1,000, Immunohistochemistry (Paraffin): 1:250-1:500, Western Blot: 0.5-1.0 µg/mL
别名 :
DKFZp686N23123; ER; Er alpha; ER36; ERa; ERalpha; ER-alpha; ERalpha protein; ESR; esr 1; Esr1; esr-1; ESRA; Estr; Estra; Estradiol receptor; estrogen nuclear receptor alpha; Estrogen receptor; estrogen receptor 1; estrogen receptor 1 (alpha); estrogen receptor alpha; estrogen receptor alpha c-terminus splice variant 1-2; estrogen receptor alpha E1-E2-1-2; estrogen receptor alpha E1-N2-E2-1-2; estrogen receptor alpha splice variant, CTERP-1; estrogen receptor alpha splice variant, ERalphaDup5; estrogen receptor alpha splice variant, ERalphai45a; estrogen receptor alpha splice variant, ERalphai45bL; estrogen receptor alpha splice variant, ERalphai45bS; estrogen receptor alpha splice variant, ERalphai45c; estrogen receptor alpha splice variant, ERalphai56; estrogen receptor alpha splice variant, ERalphai67; estrogen receptor alpha variant delta 4; estrogen receptor protein; estrogen receptor, alpha; ESTRR; hER-alpha36; I79_001166; Nr3a1; nuclear receptor; nuclear receptor subfamily 3 group A member 1; RNESTROR; RP1-130E4.1; unnamed protein product
更多信息或购买 :
公司信息
赛默飞世尔