产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
PMEL单克隆抗体(HMB45)
目录 :
MA5-13232
规格 :
500微升
价格 :
美国439
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
HMB45
反应物种 :
人类, 小鼠,
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
文章摘录数: 60
出版应用/物种/样本/稀释参考文献
  • 免疫细胞化学; 人类; 1:40; 图 2a
Samuel W, Jaworski C, Postnikova O, Kutty R, Duncan T, Tan L, et al. Appropriately differentiated ARPE-19 cells regain phenotype and gene expression profiles similar to those of native RPE cells. Mol Vis. 2017;23:60-89 pubmed
  • 免疫组化-冰冻切片; 人类; 1:150; 图 1d
Osterburg A, Nelson R, Yaniv B, Foot R, Donica W, Nashu M, et al. NK cell activating receptor ligand expression in lymphangioleiomyomatosis is associated with lung function decline. JCI Insight. 2016;1:e87270 pubmed 出版商
  • 免疫细胞化学; 小鼠; 图 3o
Dennis M, Delevoye C, Acosta Ruiz A, Hurbain I, Romao M, Hesketh G, et al. BLOC-1 and BLOC-3 regulate VAMP7 cycling to and from melanosomes via distinct tubular transport carriers. J Cell Biol. 2016;214:293-308 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 图 1c
Kemper K, Krijgsman O, Kong X, Cornelissen Steijger P, Shahrabi A, Weeber F, et al. BRAF(V600E) Kinase Domain Duplication Identified in Therapy-Refractory Melanoma Patient-Derived Xenografts. Cell Rep. 2016;16:263-277 pubmed 出版商
  • 免疫组化; 人类; 1:80; 图 10
Costache M, Dumitru A, Pătraşcu O, Popa Cherecheanu D, Bădilă P, Miu J, et al. A challenging case of ocular melanoma. Rom J Morphol Embryol. 2015;56:817-22 pubmed
  • 流式细胞仪; 小鼠; 图 s1
Dennis M, Mantegazza A, Snir O, Tenza D, Acosta Ruiz A, Delevoye C, et al. BLOC-2 targets recycling endosomal tubules to melanosomes for cargo delivery. J Cell Biol. 2015;209:563-77 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:80
Costache M, Pătraşcu O, Dumitru A, Costache D, Voinea L, Simionescu O, et al. Histopathological findings concerning ocular melanomas. Rom J Morphol Embryol. 2014;55:649-53 pubmed
  • 免疫印迹; 人类
Abad S, Wieërs G, Colau D, Wildmann C, Delair E, Dhote R, et al. Absence of recognition of common melanocytic antigens by T cells isolated from the cerebrospinal fluid of a Vogt-Koyanagi-Harada patient. Mol Vis. 2014;20:956-69 pubmed
  • 免疫组化; 人类
Jabbour M, Seoud M, Al Ahmadie H, Abdul Karim F, Zaatari G. ASPL-TFE3 translocation in vulvovaginal alveolar soft part sarcoma. Int J Gynecol Pathol. 2014;33:263-7 pubmed 出版商
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
Theos A, WATT B, Harper D, Janczura K, Theos S, Herman K, et al. The PKD domain distinguishes the trafficking and amyloidogenic properties of the pigment cell protein PMEL and its homologue GPNMB. Pigment Cell Melanoma Res. 2013;26:470-86 pubmed 出版商
  • 免疫细胞化学; 人类; 1:50
  • 免疫印迹; 人类
Leonhardt R, Vigneron N, Hee J, Graham M, Cresswell P. Critical residues in the PMEL/Pmel17 N-terminus direct the hierarchical assembly of melanosomal fibrils. Mol Biol Cell. 2013;24:964-81 pubmed 出版商
  • 免疫组化; 人类; 1:100
Kim B, Bae Y, Kim S, Jeong H, Hong S, Yoon S. Usefulness of Ki-67 (MIB-1) immunostaining in the diagnosis of pulmonary sclerosing hemangiomas. APMIS. 2013;121:105-10 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:40
Niu H, Wang F, Zhang P, Bing Z. Cardiac Epithelioid PEComa: Report of Two Cases and Review of the Literature. Case Rep Med. 2012;2012:521678 pubmed 出版商
  • 免疫组化; 人类; 1:40
Wang Z, Gong Q, Fan Q. Expression of E-cadherin in angiomyolipoma. Hum Pathol. 2012;43:2348-53 pubmed 出版商
  • 免疫组化; 人类
Zhou Z, Yu M, Yang S, Zhou J, Sun R, Yang G. Dural angioleiomyoma of the middle cranial fossa: a case report and review of the literature. Brain Tumor Pathol. 2013;30:117-21 pubmed 出版商
  • 免疫组化; 人类; 1:40
Clayton E, Furth E, Ziober A, Xu T, Yao Y, Hwang P, et al. A case of primary clear cell hepatocellular carcinoma in a non-cirrhotic liver: an immunohistochemical and ultrastructural study. Rare Tumors. 2012;4:e29 pubmed 出版商
  • 免疫组化; 小鼠; 1:1000
Hooijkaas A, Gadiot J, van der Valk M, Mooi W, Blank C. Targeting BRAFV600E in an inducible murine model of melanoma. Am J Pathol. 2012;181:785-94 pubmed 出版商
  • 免疫细胞化学; 小鼠
Sitaram A, Dennis M, Chaudhuri R, De Jesus Rojas W, Tenza D, Setty S, et al. Differential recognition of a dileucine-based sorting signal by AP-1 and AP-3 reveals a requirement for both BLOC-1 and AP-3 in delivery of OCA2 to melanosomes. Mol Biol Cell. 2012;23:3178-92 pubmed
  • 免疫组化; 人类; 1:200
Duong T, Proulx S, Luciani P, Leroux J, Detmar M, Koopman P, et al. Genetic ablation of SOX18 function suppresses tumor lymphangiogenesis and metastasis of melanoma in mice. Cancer Res. 2012;72:3105-14 pubmed 出版商
  • 免疫组化; 人类; 1:50
Yin W, Li J, Chan J. Sporadic haemangioblastoma of the kidney with rhabdoid features and focal CD10 expression: report of a case and literature review. Diagn Pathol. 2012;7:39 pubmed 出版商
  • 免疫组化; 人类
Anbar T, El Sawy A, Attia S, Barakat M, Moftah N, El Ammawy T, et al. Effect of PUVA therapy on melanocytes and keratinocytes in non-segmental vitiligo: histopathological, immuno-histochemical and ultrastructural study. Photodermatol Photoimmunol Photomed. 2012;28:17-25 pubmed 出版商
  • 免疫印迹; 小鼠
WATT B, Tenza D, Lemmon M, Kerje S, Raposo G, Andersson L, et al. Mutations in or near the transmembrane domain alter PMEL amyloid formation from functional to pathogenic. PLoS Genet. 2011;7:e1002286 pubmed 出版商
  • 免疫细胞化学; 小鼠
  • 免疫印迹; 小鼠
Hellström A, WATT B, Fard S, Tenza D, Mannstrom P, Narfstrom K, et al. Inactivation of Pmel alters melanosome shape but has only a subtle effect on visible pigmentation. PLoS Genet. 2011;7:e1002285 pubmed 出版商
  • 免疫细胞化学; 人类; 1:300
Westbroek W, Klar A, Cullinane A, Ziegler S, Hurvitz H, Ganem A, et al. Cellular and clinical report of new Griscelli syndrome type III cases. Pigment Cell Melanoma Res. 2012;25:47-56 pubmed 出版商
  • 免疫组化; 人类; 1:100
Jabbour M, Fedda F, Tawil A, Shabb N, Boulos F. Follicular dendritic cell sarcoma of the head and neck expressing thyroid transcription factor-1: a case report with clinicopathologic and immunohistochemical literature review. Appl Immunohistochem Mol Morphol. 2014;22:705-12 pubmed 出版商
  • 免疫印迹; 小鼠
  • 免疫细胞化学; 人类; 1:100
Beaumont K, Hamilton N, Moores M, Brown D, Ohbayashi N, Cairncross O, et al. The recycling endosome protein Rab17 regulates melanocytic filopodia formation and melanosome trafficking. Traffic. 2011;12:627-43 pubmed 出版商
  • 免疫细胞化学; 人类; 图 3
  • 免疫印迹; 人类; 图 1
Leonhardt R, Vigneron N, Rahner C, Cresswell P. Proprotein convertases process Pmel17 during secretion. J Biol Chem. 2011;286:9321-37 pubmed 出版商
  • 免疫组化; 人类; 1:150
Clay M, Gibson P, Lowell J, Cooper K. Microscopic uterine lymphangioleiomyomatosis perivascular epithelioid cell neoplasm: a case report with the earliest manifestation of this enigmatic neoplasm. Int J Gynecol Pathol. 2011;30:71-5 pubmed 出版商
  • 免疫组化; 人类; 1:100
Yu G, Qu G, Kong L, Pan X, Wang W, Lv J. Primary myoepithelial carcinoma of the larynx: case report and review of the literature. Pathol Res Pract. 2011;207:127-30 pubmed 出版商
  • 免疫细胞化学; 人类; 1:800
Bean S, Baker A, Eloubeidi M, Eltoum I, Jhala N, Crowe R, et al. Endoscopic ultrasound-guided fine-needle aspiration of intrathoracic and intra-abdominal spindle cell and mesenchymal lesions. Cancer Cytopathol. 2011;119:37-48 pubmed 出版商
  • 免疫细胞化学; 人类; 1:200
Huizing M, Pederson B, Hess R, Griffin A, Helip Wooley A, Westbroek W, et al. Clinical and cellular characterisation of Hermansky-Pudlak syndrome type 6. J Med Genet. 2009;46:803-10 pubmed 出版商
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
WATT B, van Niel G, Fowler D, Hurbain I, Luk K, Stayrook S, et al. N-terminal domains elicit formation of functional Pmel17 amyloid fibrils. J Biol Chem. 2009;284:35543-55 pubmed 出版商
  • 免疫细胞化学; 小鼠
Truschel S, Simoes S, Setty S, Harper D, Tenza D, Thomas P, et al. ESCRT-I function is required for Tyrp1 transport from early endosomes to the melanosome limiting membrane. Traffic. 2009;10:1318-36 pubmed 出版商
  • 免疫组化; 人类
Zurac S, Andrei R, Petsakos G, Nichita L, Bastian A, Micu G, et al. Cutaneous metastases of malignant melanoma--how difficult can it be?. Rom J Intern Med. 2008;46:375-8 pubmed
  • 免疫组化; 人类
Anbar T, El Sawy A, Attia S, Moftah N, El Tonsy M. Patterns of repigmentation in two cases of hypopigmented type of vitiligo. Photodermatol Photoimmunol Photomed. 2009;25:156-8 pubmed 出版商
  • 免疫组化; 人类
Mukhopadhyay S, El Zammar O, Katzenstein A. Pulmonary meningothelial-like nodules: new insights into a common but poorly understood entity. Am J Surg Pathol. 2009;33:487-95 pubmed 出版商
  • 免疫组化; 人类
Fadare O, Liang S. Epithelioid smooth muscle tumors of the uterus do not express CD1a: a potential immunohistochemical adjunct in their distinction from uterine perivascular epithelioid cell tumors. Ann Diagn Pathol. 2008;12:401-5 pubmed 出版商
  • 免疫印迹; 小鼠
Setty S, Tenza D, Sviderskaya E, Bennett D, Raposo G, Marks M. Cell-specific ATP7A transport sustains copper-dependent tyrosinase activity in melanosomes. Nature. 2008;454:1142-6 pubmed 出版商
  • 免疫组化; 小鼠
Tabata H, Kawamura N, Sun Wada G, Wada Y. Vacuolar-type H(+)-ATPase with the a3 isoform is the proton pump on premature melanosomes. Cell Tissue Res. 2008;332:447-60 pubmed 出版商
  • 免疫细胞化学; 人类; 1:100
Westbroek W, Tuchman M, Tinloy B, De Wever O, Vilboux T, Hertz J, et al. A novel missense mutation (G43S) in the switch I region of Rab27A causing Griscelli syndrome. Mol Genet Metab. 2008;94:248-54 pubmed 出版商
  • 免疫细胞化学; 小鼠
  • 免疫印迹; 小鼠
Groux Degroote S, van Dijk S, Wolthoorn J, Neumann S, Theos A, De Mazière A, et al. Glycolipid-dependent sorting of melanosomal from lysosomal membrane proteins by lumenal determinants. Traffic. 2008;9:951-63 pubmed 出版商
  • 免疫印迹; 人类; 1:500
Roberts D, Newton R, Leonard J, Sturm R. Melanocytes expressing MC1R polymorphisms associated with red hair color have altered MSH-ligand activated pigmentary responses in coculture with keratinocytes. J Cell Physiol. 2008;215:344-55 pubmed
  • 免疫组化; 牛
Oruc E. Melanosis in a Holstein heifer. J Vet Med A Physiol Pathol Clin Med. 2007;54:501-3 pubmed
  • 免疫印迹; 人类
Kawakami A, Sakane F, Imai S, Yasuda S, Kai M, Kanoh H, et al. Rab7 regulates maturation of melanosomal matrix protein gp100/Pmel17/Silv. J Invest Dermatol. 2008;128:143-50 pubmed
  • 免疫组化; 人类
Westbroek W, Adams D, Huizing M, Koshoffer A, Dorward H, Tinloy B, et al. Cellular defects in Chediak-Higashi syndrome correlate with the molecular genotype and clinical phenotype. J Invest Dermatol. 2007;127:2674-7 pubmed
  • 免疫细胞化学; 人类; 1:200
Helip Wooley A, Westbroek W, Dorward H, Koshoffer A, Huizing M, Boissy R, et al. Improper trafficking of melanocyte-specific proteins in Hermansky-Pudlak syndrome type-5. J Invest Dermatol. 2007;127:1471-8 pubmed
  • 免疫组化; 人类
Pecciarini L, Cangi M, Lo Cunsolo C, Macri E, Dal Cin E, Martignoni G, et al. Characterization of t(6;11)(p21;q12) in a renal-cell carcinoma of an adult patient. Genes Chromosomes Cancer. 2007;46:419-26 pubmed
  • 流式细胞仪; 人类
Zhang J, Eguchi J, Kruse C, Gomez G, Fakhrai H, Schroter S, et al. Antigenic profiling of glioma cells to generate allogeneic vaccines or dendritic cell-based therapeutics. Clin Cancer Res. 2007;13:566-575 pubmed 出版商
  • 免疫细胞化学; 小鼠
  • 流式细胞仪; 人类
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
Setty S, Tenza D, Truschel S, Chou E, Sviderskaya E, Theos A, et al. BLOC-1 is required for cargo-specific sorting from vacuolar early endosomes toward lysosome-related organelles. Mol Biol Cell. 2007;18:768-80 pubmed
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
Theos A, Berson J, Theos S, Herman K, Harper D, Tenza D, et al. Dual loss of ER export and endocytic signals with altered melanosome morphology in the silver mutation of Pmel17. Mol Biol Cell. 2006;17:3598-612 pubmed
  • 免疫组化; 人类
Wankowicz Kalinska A, Mailliard R, Olson K, Graham F, Edington H, Kirkwood J, et al. Accumulation of low-avidity anti-melanocortin receptor 1 (anti-MC1R) CD8+ T cells in the lesional skin of a patient with melanoma-related depigmentation. Melanoma Res. 2006;16:165-74 pubmed
Matafora V, Farris F, Restuccia U, Tamburri S, Martano G, Bernardelli C, et al. Amyloid aggregates accumulate in melanoma metastasis modulating YAP activity. EMBO Rep. 2020;21:e50446 pubmed 出版商
Zhang Z, Gong J, Sviderskaya E, Wei A, Li W. Mitochondrial NCKX5 regulates melanosomal biogenesis and pigment production. J Cell Sci. 2019;: pubmed 出版商
Li Z, Wang C, Deng H, Wu J, Huang H, Sun R, et al. Robust Photodynamic Therapy Using 5-ALA-Incorporated Nanocomplexes Cures Metastatic Melanoma through Priming of CD4+CD8+ Double Positive T Cells. Adv Sci (Weinh). 2019;6:1802057 pubmed 出版商
Ozaki Y, Shindoh J, Miura Y, Nakajima H, Oki R, Uchiyama M, et al. Serial pseudoprogression of metastatic malignant melanoma in a patient treated with nivolumab: a case report. BMC Cancer. 2017;17:778 pubmed 出版商
Ling Y, Gong Q, Xiong X, Sun L, Zhao W, Zhu W, et al. Protective effect of madecassoside on H2O2-induced oxidative stress and autophagy activation in human melanocytes. Oncotarget. 2017;8:51066-51075 pubmed 出版商
Yu W, Wang Y, Jiang Y, Zhang W, Li Y. Distinct immunophenotypes and prognostic factors in renal cell carcinoma with sarcomatoid differentiation: a systematic study of 19 immunohistochemical markers in 42 cases. BMC Cancer. 2017;17:293 pubmed 出版商
Liu G, Ying H, Zeng G, Wheeler C, Black K, Yu J. HER-2, gp100, and MAGE-1 are expressed in human glioblastoma and recognized by cytotoxic T cells. Cancer Res. 2004;64:4980-6 pubmed
Ramakrishna V, Treml J, Vitale L, Connolly J, O Neill T, Smith P, et al. Mannose receptor targeting of tumor antigen pmel17 to human dendritic cells directs anti-melanoma T cell responses via multiple HLA molecules. J Immunol. 2004;172:2845-52 pubmed
Berson J, Theos A, Harper D, Tenza D, Raposo G, Marks M. Proprotein convertase cleavage liberates a fibrillogenic fragment of a resident glycoprotein to initiate melanosome biogenesis. J Cell Biol. 2003;161:521-33 pubmed
图像
图像 1 :
赛默飞世尔 MA5-13232 图像 1
Formalin-fixed, paraffin-embedded human melanoma stained with Melanoma antibody using peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of tumor cells.
图像 2 :
赛默飞世尔 MA5-13232 图像 2
产品信息
产品类型 :
抗体
产品名称 :
PMEL单克隆抗体(HMB45)
目录# :
MA5-13232
规格 :
500微升
价格 :
美国439
克隆性 :
单克隆
宿主 :
小鼠
反应物种 :
人类
应用 :
Immunohistochemistry (Paraffin): 1:40-1:80, Western Blot: 1:50
物种 :
人类
克隆 :
HMB45
抗体亚型 :
IgG1, kappa
储存 :
4° C
描述 :
Melanoma is a malignant tumor of melanocytes which are found predominantly in skin but also in the bowel and the eye (see uveal melanoma). It is one of the rarer types of skin cancer but causes the majority of skin cancer related deaths.
免疫原 :
Extract of pigmented melanoma metastases from lymph nodes
格式 :
液体
应用w/稀释 :
Immunohistochemistry (Paraffin): 1:40-1:80, Western Blot: 1:50
别名 :
95 kDa melanocyte-specific secreted glycoprotein; 95kDa melanocyte-specific secreted glycoprotein; D10H12S53E; D12S53E; D12S53Eh; gp100; gp87; M-alpha; M-beta; ME20; ME20M; ME20-M; ME20-S; Melanocyte lineage specific antigen GP100; melanocyte protein mel 17; melanocyte protein PMEL; Melanocyte protein Pmel 17; melanocytes lineage-specific antigen GP100; Melanoma-associated ME20 antigen; melanosomal matrix protein17; P1; P100; P26; PMEL; Pmel 17; PMEL17; premelanosome protein; Secreted melanoma-associated ME20 antigen; SI; SIL; SILV; silver homolog; silver locus protein; silver locus protein homolog; silver, mouse, homolog of
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国