产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
表皮生长因子受体单克隆抗体(111.6), 生物素
目录 :
MA5-13266
规格 :
500微升
价格 :
美国446.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
生物素
克隆名称 :
111.6
反应物种 :
人类, 小鼠, 犬, 家羊
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片, 抑制或激活实验
更多信息或购买 :
文章摘录数: 48
出版应用/物种/样本/稀释 | 参考文献 |
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| Keren S, Shoude Z, Lu Z, Beibei Y. Role of EGFR as a prognostic factor for survival in head and neck cancer: a meta-analysis. Tumour Biol. 2014;35:2285-95 pubmed
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| Munirah M, Siti Aishah M, Reena M, Sharifah N, Rohaizak M, Norlia A, et al. Identification of different subtypes of breast cancer using tissue microarray. Rom J Morphol Embryol. 2011;52:669-77 pubmed
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| Yoshida A, Kanno H, Watabe D, Akasaka T, Sawai T. The role of heparin-binding EGF-like growth factor and amphiregulin in the epidermal proliferation of psoriasis in cooperation with TNFalpha. Arch Dermatol Res. 2008;300:37-45 pubmed
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| Kreike B, van Kouwenhove M, Horlings H, Weigelt B, Peterse H, Bartelink H, et al. Gene expression profiling and histopathological characterization of triple-negative/basal-like breast carcinomas. Breast Cancer Res. 2007;9:R65 pubmed
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| Carlson A, Coghlan L, Gillenwater A, Richards Kortum R. Dual-mode reflectance and fluorescence near-video-rate confocal microscope for architectural, morphological and molecular imaging of tissue. J Microsc. 2007;228:11-24 pubmed
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| Hatiboglu M, Cosar M, Iplikcioglu A, Ozcan D. Sex steroid and epidermal growth factor profile of giant meningiomas associated with pregnancy. Surg Neurol. 2008;69:356-62; discussion 362-3 pubmed
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| Marci V, Volante M, Cappia S, Righi L, Novello C, Scagliotti G, et al. Basaloid adenocarcinoma. A new variant of pulmonary adenocarcinoma. Virchows Arch. 2007;451:729-36 pubmed
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| Zhou P, Liu D, Cang M, Ma Y, Yang D, Li H, et al. TGFalpha and EGFR in ovine preimplantation embryos and effects on development. Anim Reprod Sci. 2008;104:370-81 pubmed
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| Tampellini M, Longo M, Cappia S, Bacillo E, Alabiso I, Volante M, et al. Co-expression of EGF receptor, TGFalpha and S6 kinase is significantly associated with colorectal carcinomas with distant metastases at diagnosis. Virchows Arch. 2007;450:321-8 pubmed
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| Miettinen P, Ustinov J, Ormio P, Gao R, Palgi J, Hakonen E, et al. Downregulation of EGF receptor signaling in pancreatic islets causes diabetes due to impaired postnatal beta-cell growth. Diabetes. 2006;55:3299-308 pubmed
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| Hannemann J, Kristel P, VAN Tinteren H, Bontenbal M, van Hoesel Q, Smit W, et al. Molecular subtypes of breast cancer and amplification of topoisomerase II alpha: predictive role in dose intensive adjuvant chemotherapy. Br J Cancer. 2006;95:1334-41 pubmed
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| Doger F, Meteoglu I, Tuncyurek P, Okyay P, Cevikel H. Does the EGFR and VEGF expression predict the prognosis in colon cancer?. Eur Surg Res. 2006;38:540-4 pubmed
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| Hsu E, Gillenwater A, Hasan M, Williams M, El Naggar A, Richards Kortum R. Real-time detection of epidermal growth factor receptor expression in fresh oral cavity biopsies using a molecular-specific contrast agent. Int J Cancer. 2006;118:3062-71 pubmed
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| Watwe V, Javle M, Lawrence D, Groth J, Iyer R, El Hajjar D, et al. Cyclooxygenase-2 (COX-2) levels before and after chemotherapy: a study in rectal cancer. Am J Clin Oncol. 2005;28:560-4 pubmed
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| Nida D, Rahman M, Carlson K, Richards Kortum R, Follen M. Fluorescent nanocrystals for use in early cervical cancer detection. Gynecol Oncol. 2005;99:S89-94 pubmed
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| Akayama Y, Takekida S, Ohara N, Tateiwa H, Chen W, Nakabayashi K, et al. Gene expression and immunolocalization of heparin-binding epidermal growth factor-like growth factor and human epidermal growth factor receptors in human corpus luteum. Hum Reprod. 2005;20:2708-14 pubmed
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| Jang C, Tingey M, Korpi N, Wiepz G, Schiller J, Bertics P, et al. Using liquid crystals to report membrane proteins captured by affinity microcontact printing from cell lysates and membrane extracts. J Am Chem Soc. 2005;127:8912-3 pubmed
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| Haas Kogan D, Prados M, Tihan T, Eberhard D, Jelluma N, Arvold N, et al. Epidermal growth factor receptor, protein kinase B/Akt, and glioma response to erlotinib. J Natl Cancer Inst. 2005;97:880-7 pubmed
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Hsu E, Anslyn E, Dharmawardhane S, Alizadeh Naderi R, Aaron J, Sokolov K, et al. A far-red fluorescent contrast agent to image epidermal growth factor receptor expression. Photochem Photobiol. 2004;79:272-9 pubmed
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Cochran J, Kim Y, Olsen M, Bhandari R, Wittrup K. Domain-level antibody epitope mapping through yeast surface display of epidermal growth factor receptor fragments. J Immunol Methods. 2004;287:147-58 pubmed
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Gossett D, Alo P, Bristow R, Galati M, Kyshtoobayeva A, Fruehauf J, et al. Inability of immunohistochemistry to predict clinical outcomes of endometrial cancer patients. Int J Gynecol Cancer. 2004;14:145-51 pubmed
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Santoro A, Cavina R, Latteri F, Zucali P, Ginanni V, Campagnoli E, et al. Activity of a specific inhibitor, gefitinib (Iressa, ZD1839), of epidermal growth factor receptor in refractory non-small-cell lung cancer. Ann Oncol. 2004;15:33-7 pubmed
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Barzilay E, Ben Califa N, Supino Rosin L, Kashman Y, Hirschberg K, Elazar Z, et al. Geldanamycin-associated inhibition of intracellular trafficking is attributed to a co-purified activity. J Biol Chem. 2004;279:6847-52 pubmed
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Sokolov K, Aaron J, Hsu B, Nida D, Gillenwater A, Follen M, et al. Optical systems for in vivo molecular imaging of cancer. Technol Cancer Res Treat. 2003;2:491-504 pubmed
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Chen B, van den Brekel M, Buschers W, Balm A, van Velthuysen M. Validation of tissue array technology in head and neck squamous cell carcinoma. Head Neck. 2003;25:922-30 pubmed
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Nielsen U, Cardone M, Sinskey A, MacBeath G, Sorger P. Profiling receptor tyrosine kinase activation by using Ab microarrays. Proc Natl Acad Sci U S A. 2003;100:9330-5 pubmed
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Daneshmand M, Parolin D, Hirte H, Major P, Goss G, Stewart D, et al. A pharmacodynamic study of the epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 in metastatic colorectal cancer patients. Clin Cancer Res. 2003;9:2457-64 pubmed
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Piepkorn M, Predd H, Underwood R, Cook P. Proliferation-differentiation relationships in the expression of heparin-binding epidermal growth factor-related factors and erbB receptors by normal and psoriatic human keratinocytes. Arch Dermatol Res. 2003;295:93-101 pubmed
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Planque S, Taguchi H, Burr G, Bhatia G, Karle S, Zhou Y, et al. Broadly distributed chemical reactivity of natural antibodies expressed in coordination with specific antigen binding activity. J Biol Chem. 2003;278:20436-43 pubmed
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Praetorius L, Krogh J, Horn T. Retroperitoneal cystic papillary carcinoma of probable nephrogenic origin. Scand J Urol Nephrol. 2001;35:147-9 pubmed
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Baron A, Lafky J, Connolly D, Peoples J, O Kane D, Suman V, et al. A sandwich type acridinium-linked immunosorbent assay (ALISA) detects soluble ErbB1 (sErbB1) in normal human sera. J Immunol Methods. 1998;219:23-43 pubmed
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图像
图像 1 :
图像 2 :
图像 3 :
Formalin-fixed, paraffin-embedded human lung squamous cell carcinoma stained with Epidermal Growth Factor Receptor antibody0 using peroxidase-conjugate and AEC chromogen. Note membrane staining of tumor cells.
产品信息
产品类型 :
抗体
产品名称 :
表皮生长因子受体单克隆抗体(111.6), 生物素
目录# :
MA5-13266
规格 :
500微升
价格 :
美国446.00
克隆性 :
单克隆
纯度 :
蛋白质G
宿主 :
小鼠
反应物种 :
人类
应用 :
Immunohistochemistry (Paraffin): 2-4 µg/mL, Immunoprecipitation: 2 µg/mL, Western Blot: 2-4 µg/mL
物种 :
人类
克隆 :
111.6
抗体亚型 :
IgG1
储存 :
4° C
描述 :
EGFR (Epidermal growth factor receptor, HER1, ErbB1) is encoded by the EGFR gene located on chromosome 7 in humans. EGFR belongs to the HER/ERbB family of proteins that includes three other receptor tyrosine kinases, ERbB2, ERbB3, ERbB4. EGFR is a transmembrane receptor and binding of its cognate ligands such as EGF (Epidermal Growth Factor) and TGF alpha (Transforming Growth Factor alpha) to the extracellular domain leads to EGFR dimerization followed by autophosphorylation of the tyrosine residues in the cytoplasmic domain. Phosphorylation of EGFR at certain residues is also mediated by Src-non-receptor kinase. EGFR activation signals multiple downstream signaling cascades such as the Ras - ERK, PI3-K - Akt, Jak - STAT and PKC pathways that help in growth and proliferation of cells. Phosphorylation of EGFR at Y1086 specifically allows binding of the adaptor protein GRB2, leading to activation of the MAPK pathway. Upon receptor activation and signaling, EGFR is endocytosed and targeted for degradation or recycling. Mutations in the EGFR gene are associated with lung cancer and multiple alternatively spliced transcript variants encode different protein isoforms of EGFR have been found. Increased production or activation of EGFR has been associated with poor prognosis in a variety of tumors. Moreover, EGFR overexpression is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma.
免疫原 :
细胞外区域人的重组表皮生长因子受体蛋白
格式 :
液体
应用w/稀释 :
Immunohistochemistry (Paraffin): 2-4 µg/mL, Immunoprecipitation: 2 µg/mL, Western Blot: 2-4 µg/mL
别名 :
2.7.10.1; 9030024J15Rik; AI552599; avian erythroblastic leukemia viral (v-erbB) oncogene homolog; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; EC 2.7.10.1; egf receptor; Egfr; EGFR-related peptide; epidermal growth factor receptor; epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); epidermal growth factor receptor, formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); ERBB; ERBB1; ErbB-1; erb-b2 receptor tyrosine kinase 1; Errb1; Errp; HER1; kinase EGFR; mENA; NISBD2; Oncogene ERBB; PIG61; Proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1; Urogastrone; wa2; wa-2; Wa5; waved 2
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