表皮生长因子受体单克隆抗体(111.6) | 赛默飞世尔 MA5-13269 产品信息

产品简要

公司名称 :

赛默飞世尔

其他品牌 :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

产品类型 :

抗体

产品名称 :

表皮生长因子受体单克隆抗体(111.6)

MA5-13269

规格 :

500微升

价格 :

美国496

克隆性 :

单克隆

宿主 :

小鼠

共轭标签 :

未共轭

克隆名称 :

111.6

反应物种 :

人类, 小鼠, 犬, 家羊

应用 :

免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片, 抑制或激活实验

更多信息或购买 :

赛默飞世尔产品网页

文章摘录数: 69

出版应用/物种/样本/稀释	参考文献
免疫组化; 犬; 图 2f	Levi M, Muscatello L, Brunetti B, Benazzi C, Parenti F, Gobbo F, et al. High Intrinsic Expression of P-glycoprotein and Breast Cancer Resistance Protein in Canine Mammary Carcinomas Regardless of Immunophenotype and Outcome. Animals (Basel). 2021;11: pubmed 出版商
免疫细胞化学; 人类; 图 7a	Haag A, Walser M, Henggeler A, Hajnal A. The CHORD protein CHP-1 regulates EGF receptor trafficking and signaling in C. elegans and in human cells. elife. 2020;9: pubmed 出版商
免疫组化; 人类; 图 3a	Kang S, Wang Y, Reder N, Liu J. Multiplexed Molecular Imaging of Biomarker-Targeted SERS Nanoparticles on Fresh Tissue Specimens with Channel-Compressed Spectrometry. PLoS ONE. 2016;11:e0163473 pubmed 出版商
流式细胞仪; 人类; 图 5	Wang Y, Kang S, Khan A, Ruttner G, Leigh S, Murray M, et al. Quantitative molecular phenotyping with topically applied SERS nanoparticles for intraoperative guidance of breast cancer lumpectomy. Sci Rep. 2016;6:21242 pubmed 出版商
免疫组化-石蜡切片; 人类; 1:400; 图 1	Panvichian R, Tantiwetrueangdet A, Sornmayura P, Leelaudomlipi S. Missense Mutations in Exons 18-24 of EGFR in Hepatocellular Carcinoma Tissues. Biomed Res Int. 2015;2015:171845 pubmed 出版商
酶联免疫吸附测定; 人类; 图 2	Sinha L, Wang Y, Yang C, Khan A, Brankov J, Liu J, et al. Quantification of the binding potential of cell-surface receptors in fresh excised specimens via dual-probe modeling of SERS nanoparticles. Sci Rep. 2015;5:8582 pubmed 出版商
免疫印迹; 人类	Yun H, Kim H, Ga I, Oh H, Ho D, Kim J, et al. An early endosome regulator, Rab5b, is an LRRK2 kinase substrate. J Biochem. 2015;157:485-95 pubmed 出版商
免疫细胞化学; 人类免疫组化; 人类	Fichter C, Timme S, Braun J, Gudernatsch V, Schöpflin A, Bogatyreva L, et al. EGFR, HER2 and HER3 dimerization patterns guide targeted inhibition in two histotypes of esophageal cancer. Int J Cancer. 2014;135:1517-30 pubmed 出版商
免疫组化; 人类	Terragni R, Casadei Gardini A, Sabattini S, Bettini G, Amadori D, Talamonti C, et al. EGFR, HER-2 and KRAS in canine gastric epithelial tumors: a potential human model?. PLoS ONE. 2014;9:e85388 pubmed 出版商
免疫组化; 犬; 1:100	Danne C, Dubrac S, Trieu Cuot P, Dramsi S. Single cell stochastic regulation of pilus phase variation by an attenuation-like mechanism. PLoS Pathog. 2014;10:e1003860 pubmed 出版商
免疫组化; 人类; 1:100	Böger C, Kalthoff H, Goodman S, Behrens H, Rocken C. Integrins and their ligands are expressed in non-small cell lung cancer but not correlated with parameters of disease progression. Virchows Arch. 2014;464:69-78 pubmed 出版商
免疫组化; 人类	Keren S, Shoude Z, Lu Z, Beibei Y. Role of EGFR as a prognostic factor for survival in head and neck cancer: a meta-analysis. Tumour Biol. 2014;35:2285-95 pubmed
免疫组化; 人类	Foda A. No-cost manual method for preparation of tissue microarrays having high quality comparable to semiautomated methods. Appl Immunohistochem Mol Morphol. 2013;21:271-4 pubmed 出版商
抑制或激活实验; 人类; 1,000 ug/ml	Pötz O, Schneiderhan Marra N, Henzler T, Herget T, Joos T. Receptor tyrosine kinase inhibitor profiling using bead-based multiplex sandwich immunoassays. Methods Mol Biol. 2012;795:191-202 pubmed 出版商
免疫组化; 人类; 1:50	Munirah M, Siti Aishah M, Reena M, Sharifah N, Rohaizak M, Norlia A, et al. Identification of different subtypes of breast cancer using tissue microarray. Rom J Morphol Embryol. 2011;52:669-77 pubmed
免疫组化; 人类	Soonthornthum T, Arias Pulido H, Joste N, Lomo L, Muller C, Rutledge T, et al. Epidermal growth factor receptor as a biomarker for cervical cancer. Ann Oncol. 2011;22:2166-78 pubmed 出版商
免疫组化; 人类	Soda Y, Marumoto T, Friedmann Morvinski D, Soda M, Liu F, Michiue H, et al. Transdifferentiation of glioblastoma cells into vascular endothelial cells. Proc Natl Acad Sci U S A. 2011;108:4274-80 pubmed 出版商
免疫组化; 人类; 1:200	Vollebergh M, Lips E, Nederlof P, Wessels L, Schmidt M, van Beers E, et al. An aCGH classifier derived from BRCA1-mutated breast cancer and benefit of high-dose platinum-based chemotherapy in HER2-negative breast cancer patients. Ann Oncol. 2011;22:1561-70 pubmed 出版商
免疫组化; 人类; 1:100	Brunner A, Grimm C, Polterauer S, Hefler L, Stani J, Dudek G, et al. Expression of epidermal growth factor receptor and vascular endothelial growth factor in vaginal squamous cell cancer. Am J Obstet Gynecol. 2011;204:171.e1-6 pubmed 出版商
流式细胞仪; 人类	Tarcic G, Yarden Y. MAP Kinase activation by receptor tyrosine kinases: in control of cell migration. Methods Mol Biol. 2010;661:125-35 pubmed 出版商
免疫组化; 人类; 1:25	Mathieu A, Weynand B, Verbeken E, da Silva S, Decaestecker C, Salmon I, et al. Comparison of four antibodies for immunohistochemical evaluation of epidermal growth factor receptor expression in non-small cell lung cancer. Lung Cancer. 2010;69:46-50 pubmed 出版商
免疫印迹; 人类	Farin K, Di Segni A, Mor A, Pinkas Kramarski R. Structure-function analysis of nucleolin and ErbB receptors interactions. PLoS ONE. 2009;4:e6128 pubmed 出版商
免疫细胞化学; 人类; 4 ug/ml	Gruber H, Hoelscher G, Loeffler B, Chow Y, Ingram J, Halligan W, et al. Prostaglandin E1 and misoprostol increase epidermal growth factor production in 3D-cultured human annulus cells. Spine J. 2009;9:760-6 pubmed 出版商
免疫细胞化学; 人类	Xu Y, Shao Y, Zhou J, Voorhees J, Fisher G. Ultraviolet irradiation-induces epidermal growth factor receptor (EGFR) nuclear translocation in human keratinocytes. J Cell Biochem. 2009;107:873-80 pubmed 出版商
免疫组化; 人类	Dogu G, Ozkan M, Ozturk F, Dikilitas M, Er O, Ozturk A. Triple-negative breast cancer: immunohistochemical correlation with basaloid markers and prognostic value of survivin. Med Oncol. 2010;27:34-9 pubmed 出版商
免疫印迹; 人类; 1:500	Klessner J, Desai B, Amargo E, Getsios S, Green K. EGFR and ADAMs cooperate to regulate shedding and endocytic trafficking of the desmosomal cadherin desmoglein 2. Mol Biol Cell. 2009;20:328-37 pubmed 出版商
免疫沉淀; 人类	Lowe A, Ozer B, Wiepz G, Bertics P, Abbott N. Engineering of PDMS surfaces for use in microsystems for capture and isolation of complex and biomedically important proteins: epidermal growth factor receptor as a model system. Lab Chip. 2008;8:1357-64 pubmed 出版商
免疫组化; 人类	Yoshida A, Kanno H, Watabe D, Akasaka T, Sawai T. The role of heparin-binding EGF-like growth factor and amphiregulin in the epidermal proliferation of psoriasis in cooperation with TNFalpha. Arch Dermatol Res. 2008;300:37-45 pubmed
免疫组化; 人类; 1:100	Kreike B, van Kouwenhove M, Horlings H, Weigelt B, Peterse H, Bartelink H, et al. Gene expression profiling and histopathological characterization of triple-negative/basal-like breast carcinomas. Breast Cancer Res. 2007;9:R65 pubmed
免疫细胞化学; 人类	Carlson A, Coghlan L, Gillenwater A, Richards Kortum R. Dual-mode reflectance and fluorescence near-video-rate confocal microscope for architectural, morphological and molecular imaging of tissue. J Microsc. 2007;228:11-24 pubmed
免疫组化; 人类	Hatiboglu M, Cosar M, Iplikcioglu A, Ozcan D. Sex steroid and epidermal growth factor profile of giant meningiomas associated with pregnancy. Surg Neurol. 2008;69:356-62; discussion 362-3 pubmed
免疫组化; 人类; 1:60	Volante M, Saviozzi S, Rapa I, Ceppi P, Cappia S, Calogero R, et al. Epidermal growth factor ligand/receptor loop and downstream signaling activation pattern in completely resected nonsmall cell lung cancer. Cancer. 2007;110:1321-8 pubmed
免疫组化; 人类; 1:50	Marci V, Volante M, Cappia S, Righi L, Novello C, Scagliotti G, et al. Basaloid adenocarcinoma. A new variant of pulmonary adenocarcinoma. Virchows Arch. 2007;451:729-36 pubmed
免疫组化; 家羊	Zhou P, Liu D, Cang M, Ma Y, Yang D, Li H, et al. TGFalpha and EGFR in ovine preimplantation embryos and effects on development. Anim Reprod Sci. 2008;104:370-81 pubmed
免疫组化; 人类; 1:50	Tampellini M, Longo M, Cappia S, Bacillo E, Alabiso I, Volante M, et al. Co-expression of EGF receptor, TGFalpha and S6 kinase is significantly associated with colorectal carcinomas with distant metastases at diagnosis. Virchows Arch. 2007;450:321-8 pubmed
免疫组化; 小鼠免疫印迹; 小鼠	Miettinen P, Ustinov J, Ormio P, Gao R, Palgi J, Hakonen E, et al. Downregulation of EGF receptor signaling in pancreatic islets causes diabetes due to impaired postnatal beta-cell growth. Diabetes. 2006;55:3299-308 pubmed
免疫组化; 人类; 1:100	Hannemann J, Kristel P, VAN Tinteren H, Bontenbal M, van Hoesel Q, Smit W, et al. Molecular subtypes of breast cancer and amplification of topoisomerase II alpha: predictive role in dose intensive adjuvant chemotherapy. Br J Cancer. 2006;95:1334-41 pubmed
免疫组化; 人类	Doger F, Meteoglu I, Tuncyurek P, Okyay P, Cevikel H. Does the EGFR and VEGF expression predict the prognosis in colon cancer?. Eur Surg Res. 2006;38:540-4 pubmed
免疫组化; 人类; 1:10	Hsu E, Gillenwater A, Hasan M, Williams M, El Naggar A, Richards Kortum R. Real-time detection of epidermal growth factor receptor expression in fresh oral cavity biopsies using a molecular-specific contrast agent. Int J Cancer. 2006;118:3062-71 pubmed
免疫组化; 人类; 1 ug/ml	Watwe V, Javle M, Lawrence D, Groth J, Iyer R, El Hajjar D, et al. Cyclooxygenase-2 (COX-2) levels before and after chemotherapy: a study in rectal cancer. Am J Clin Oncol. 2005;28:560-4 pubmed
免疫细胞化学; 人类	Nida D, Rahman M, Carlson K, Richards Kortum R, Follen M. Fluorescent nanocrystals for use in early cervical cancer detection. Gynecol Oncol. 2005;99:S89-94 pubmed
免疫印迹; 人类	Pangburn H, Kraus H, Ahnen D, Rice P. Sulindac metabolites inhibit epidermal growth factor receptor activation and expression. J Carcinog. 2005;4:16 pubmed
免疫组化; 人类; 1:100	Akayama Y, Takekida S, Ohara N, Tateiwa H, Chen W, Nakabayashi K, et al. Gene expression and immunolocalization of heparin-binding epidermal growth factor-like growth factor and human epidermal growth factor receptors in human corpus luteum. Hum Reprod. 2005;20:2708-14 pubmed
免疫沉淀; 人类	Jang C, Tingey M, Korpi N, Wiepz G, Schiller J, Bertics P, et al. Using liquid crystals to report membrane proteins captured by affinity microcontact printing from cell lysates and membrane extracts. J Am Chem Soc. 2005;127:8912-3 pubmed
免疫组化; 人类; 1:500	Haas Kogan D, Prados M, Tihan T, Eberhard D, Jelluma N, Arvold N, et al. Epidermal growth factor receptor, protein kinase B/Akt, and glioma response to erlotinib. J Natl Cancer Inst. 2005;97:880-7 pubmed
	Chandler K, Alamoud K, Stahl V, Nguyen B, Kartha V, Bais M, et al. β-Catenin/CBP inhibition alters epidermal growth factor receptor fucosylation status in oral squamous cell carcinoma. Mol Omics. 2020;16:195-209 pubmed 出版商
	Galenkamp K, Sosicka P, Jung M, Recouvreux M, Zhang Y, Moldenhauer M, et al. Golgi Acidification by NHE7 Regulates Cytosolic pH Homeostasis in Pancreatic Cancer Cells. Cancer Discov. 2020;10:822-835 pubmed 出版商
	Sueangoen N, Tantiwetrueangdet A, Panvichian R. HCC-derived EGFR mutants are functioning, EGF-dependent, and erlotinib-resistant. Cell Biosci. 2020;10:41 pubmed 出版商
	Lee S, Oh H, Kim M, Lee B. Exosomes derived from oviduct cells mediate the EGFR/MAPK signaling pathway in cumulus cells. J Cell Physiol. 2020;235:1386-1404 pubmed 出版商
	Galle J, Fechtner T, Eierhoff T, Römer W, Hegemann J. A Chlamydia pneumoniae adhesin induces phosphatidylserine exposure on host cells. Nat Commun. 2019;10:4644 pubmed 出版商
	Quintanal Villalonga Á, Molina Pinelo S, Cirauqui C, Ojeda Márquez L, Marrugal A, Suarez R, et al. FGFR1 Cooperates with EGFR in Lung Cancer Oncogenesis, and Their Combined Inhibition Shows Improved Efficacy. J Thorac Oncol. 2019;14:641-655 pubmed 出版商
	Lee S, Oh H, Kim M, Setyawan E, Lee B. Interaction of the EGFR signaling pathway with porcine cumulus oocyte complexes and oviduct cells in a coculture system. J Cell Physiol. 2019;234:4030-4043 pubmed 出版商
	Klaus C, Raghunathan K, Dibenedetto E, Kenworthy A. Analysis of diffusion in curved surfaces and its application to tubular membranes. Mol Biol Cell. 2016;27:3937-3946 pubmed
	Shuch B, Mikhail M, Satagopan J, Lee P, Yee H, Chang C, et al. Racial disparity of epidermal growth factor receptor expression in prostate cancer. J Clin Oncol. 2004;22:4725-9 pubmed
	Hsu E, Anslyn E, Dharmawardhane S, Alizadeh Naderi R, Aaron J, Sokolov K, et al. A far-red fluorescent contrast agent to image epidermal growth factor receptor expression. Photochem Photobiol. 2004;79:272-9 pubmed
	Cochran J, Kim Y, Olsen M, Bhandari R, Wittrup K. Domain-level antibody epitope mapping through yeast surface display of epidermal growth factor receptor fragments. J Immunol Methods. 2004;287:147-58 pubmed
	Gossett D, Alo P, Bristow R, Galati M, Kyshtoobayeva A, Fruehauf J, et al. Inability of immunohistochemistry to predict clinical outcomes of endometrial cancer patients. Int J Gynecol Cancer. 2004;14:145-51 pubmed
	Cloven N, Kyshtoobayeva A, Burger R, Yu I, Fruehauf J. In vitro chemoresistance and biomarker profiles are unique for histologic subtypes of epithelial ovarian cancer. Gynecol Oncol. 2004;92:160-6 pubmed
	Santoro A, Cavina R, Latteri F, Zucali P, Ginanni V, Campagnoli E, et al. Activity of a specific inhibitor, gefitinib (Iressa, ZD1839), of epidermal growth factor receptor in refractory non-small-cell lung cancer. Ann Oncol. 2004;15:33-7 pubmed
	Harper M, Goddard L, Smith C, Nicholson R. Characterization of a transplantable hormone-responsive human prostatic cancer xenograft TEN12 and its androgen-resistant sublines. Prostate. 2004;58:13-22 pubmed
	Barzilay E, Ben Califa N, Supino Rosin L, Kashman Y, Hirschberg K, Elazar Z, et al. Geldanamycin-associated inhibition of intracellular trafficking is attributed to a co-purified activity. J Biol Chem. 2004;279:6847-52 pubmed
	Sokolov K, Aaron J, Hsu B, Nida D, Gillenwater A, Follen M, et al. Optical systems for in vivo molecular imaging of cancer. Technol Cancer Res Treat. 2003;2:491-504 pubmed
	Chen B, van den Brekel M, Buschers W, Balm A, van Velthuysen M. Validation of tissue array technology in head and neck squamous cell carcinoma. Head Neck. 2003;25:922-30 pubmed
	Nielsen U, Cardone M, Sinskey A, MacBeath G, Sorger P. Profiling receptor tyrosine kinase activation by using Ab microarrays. Proc Natl Acad Sci U S A. 2003;100:9330-5 pubmed
	Daneshmand M, Parolin D, Hirte H, Major P, Goss G, Stewart D, et al. A pharmacodynamic study of the epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 in metastatic colorectal cancer patients. Clin Cancer Res. 2003;9:2457-64 pubmed
	Piepkorn M, Predd H, Underwood R, Cook P. Proliferation-differentiation relationships in the expression of heparin-binding epidermal growth factor-related factors and erbB receptors by normal and psoriatic human keratinocytes. Arch Dermatol Res. 2003;295:93-101 pubmed
	Planque S, Taguchi H, Burr G, Bhatia G, Karle S, Zhou Y, et al. Broadly distributed chemical reactivity of natural antibodies expressed in coordination with specific antigen binding activity. J Biol Chem. 2003;278:20436-43 pubmed
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	Baron A, Lafky J, Connolly D, Peoples J, O Kane D, Suman V, et al. A sandwich type acridinium-linked immunosorbent assay (ALISA) detects soluble ErbB1 (sErbB1) in normal human sera. J Immunol Methods. 1998;219:23-43 pubmed

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产品信息

产品类型 :

抗体

产品名称 :

表皮生长因子受体单克隆抗体(111.6)

目录# :

MA5-13269

规格 :

500微升

价格 :

美国496

克隆性 :

单克隆

纯度 :

蛋白质G

宿主 :

小鼠

反应物种 :

人类, 小鼠

应用 :

Immunocytochemistry: 5 µg/mL, Immunofluorescence: 5 µg/mL, Immunohistochemistry (Paraffin): 2-4 µg/mL, Immunoprecipitation: 2 µg/mL, Western Blot: 2-4 µg/mL

物种 :

人类, 小鼠

克隆 :

111.6

抗体亚型 :

IgG1

储存 :

4° C

描述 :

EGFR (Epidermal growth factor receptor, HER1, ErbB1) is encoded by the EGFR gene located on chromosome 7 in humans. EGFR belongs to the HER/ERbB family of proteins that includes three other receptor tyrosine kinases, ERbB2, ERbB3, ERbB4. EGFR is a transmembrane receptor and binding of its cognate ligands such as EGF (Epidermal Growth Factor) and TGF alpha (Transforming Growth Factor alpha) to the extracellular domain leads to EGFR dimerization followed by autophosphorylation of the tyrosine residues in the cytoplasmic domain. Phosphorylation of EGFR at certain residues is also mediated by Src-non-receptor kinase. EGFR activation signals multiple downstream signaling cascades such as the Ras - ERK, PI3-K - Akt, Jak - STAT and PKC pathways that help in growth and proliferation of cells. Phosphorylation of EGFR at Y1086 specifically allows binding of the adaptor protein GRB2, leading to activation of the MAPK pathway. Upon receptor activation and signaling, EGFR is endocytosed and targeted for degradation or recycling. Mutations in the EGFR gene are associated with lung cancer and multiple alternatively spliced transcript variants encode different protein isoforms of EGFR have been found. Increased production or activation of EGFR has been associated with poor prognosis in a variety of tumors. Moreover, EGFR overexpression is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma.

免疫原 :

细胞外区域人的重组表皮生长因子受体蛋白

格式 :

液体

应用w/稀释 :

Immunocytochemistry: 5 µg/mL, Immunofluorescence: 5 µg/mL, Immunohistochemistry (Paraffin): 2-4 µg/mL, Immunoprecipitation: 2 µg/mL, Western Blot: 2-4 µg/mL

别名 :

2.7.10.1; 9030024J15Rik; AI552599; avian erythroblastic leukemia viral (v-erbB) oncogene homolog; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; EC 2.7.10.1; egf receptor; Egfr; EGFR-related peptide; epidermal growth factor receptor; epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); epidermal growth factor receptor, formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); ERBB; ERBB1; ErbB-1; erb-b2 receptor tyrosine kinase 1; Errb1; Errp; HER1; kinase EGFR; mENA; NISBD2; Oncogene ERBB; PIG61; Proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1; Urogastrone; wa2; wa-2; Wa5; waved 2

更多信息或购买 :

赛默飞世尔产品网页

公司信息

赛默飞世尔

上海浦东新金桥路27号7号楼

analyze.cn@thermofisher.com

http://www.thermo.com.cn

1084193588

公司总部: 美国