产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
雌激素受体α单克隆抗体(6F11)
目录 :
MA5-13304
规格 :
500µL
价格 :
美国425.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
nonconjugated
克隆名称 :
6F11
反应物种 :
African green monkey, 人类, 大鼠, , , ,
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, EMSA, 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
文章摘录数: 57
出版应用/物种/样品/稀释参考文献
  • 免疫组化-石蜡切片; 猫; 1:125; 表 4
Soares M, Ribeiro R, Najmudin S, Gameiro A, Rodrigues R, Cardoso F, et al. Serum HER2 levels are increased in cats with mammary carcinomas and predict tissue HER2 status. Oncotarget. 2016;7:17314-26 pubmed 出版商
  • 免疫组化; 猫; 1:100; 图 1a
Soares M, Correia J, Peleteiro M, Ferreira F. St Gallen molecular subtypes in feline mammary carcinoma and paired metastases-disease progression and clinical implications from a 3-year follow-up study. Tumour Biol. 2016;37:4053-64 pubmed 出版商
  • 免疫组化; 猪; 图 s5
Rowson Hodel A, Manjarin R, Trott J, Cardiff R, Borowsky A, Hovey R. Neoplastic transformation of porcine mammary epithelial cells in vitro and tumor formation in vivo. BMC Cancer. 2015;15:562 pubmed 出版商
  • 免疫细胞化学; 大鼠
Tkalia I, Vorobyova L, Grabovoy A, Svintsitsky V, Tarasova T. The antitumor efficacy of cisplatin in combination with triptorelin and exemestane therapy for an ovarian cancer ascites model in Wistar rats. Exp Oncol. 2015;37:30-5 pubmed
  • 免疫组化; 人类
  • 免疫组化; 大鼠
Tkalia I, Vorobyova L, Grabovoy A, Svintsitsky V, Tarasova T, Lukyanova N, et al. Increase of antitumor activity of cisplatin using agonist of gonadotropin-realising hormone and inhibitor of aromatase on the model of ascites ovarian tumor. Exp Oncol. 2014;36:184-90 pubmed
  • 免疫组化; 人类; 1:200
Khandakar B, Mathur S, Kumar L, Kumar S, Datta Gupta S, Iyer V, et al. Tissue biomarkers in prognostication of serous ovarian cancer following neoadjuvant chemotherapy. Biomed Res Int. 2014;2014:401245 pubmed 出版商
  • 免疫印迹; 人类
Lee J, Tiwari A, Shum V, Mills G, Mancini M, Igoshin O, et al. Unraveling the regulatory connections between two controllers of breast cancer cell fate. Nucleic Acids Res. 2014;42:6839-49 pubmed 出版商
  • 免疫组化; 人类; 1:100
Bredow L, Stützel L, Böhringer D, Gundlach E, Reinhard T, Auw Haedrich C. Progesterone and estrogen receptors in conjunctival melanoma and nevi. Graefes Arch Clin Exp Ophthalmol. 2014;252:359-65 pubmed 出版商
  • EMSA; 人类
Kruer T, Cummins T, Powell D, Wittliff J. Characterization of estrogen response element binding proteins as biomarkers of breast cancer behavior. Clin Biochem. 2013;46:1739-46 pubmed 出版商
  • 免疫组化; 人类; 1:50
Grosso S, Katayama M, Roela R, Nonogaki S, Soares F, Brentani H, et al. Breast cancer tissue slices as a model for evaluation of response to rapamycin. Cell Tissue Res. 2013;352:671-84 pubmed 出版商
  • 免疫印迹; 人类
Endoh T, Kawasaki Y, Sugimoto N. Stability of RNA quadruplex in open reading frame determines proteolysis of human estrogen receptor ?. Nucleic Acids Res. 2013;41:6222-31 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:100; 图 1
Corrêa N, Kuasne H, Faria J, Seixas C, Santos I, Abreu F, et al. Genomic and phenotypic profiles of two Brazilian breast cancer cell lines derived from primary human tumors. Oncol Rep. 2013;29:1299-307 pubmed 出版商
  • 免疫组化; 人类
  • 免疫印迹; 人类
Li Y, Meeran S, Patel S, Chen H, Hardy T, Tollefsbol T. Epigenetic reactivation of estrogen receptor-α (ERα) by genistein enhances hormonal therapy sensitivity in ERα-negative breast cancer. Mol Cancer. 2013;12:9 pubmed 出版商
  • 免疫细胞化学; 人类; 1:35
Marinšek Z, Nolde N, Kardum Skelin I, Nizzoli R, Onal B, Rezanko T, et al. Multinational study of oestrogen and progesterone receptor immunocytochemistry on breast carcinoma fine needle aspirates. Cytopathology. 2013;24:7-20 pubmed 出版商
  • 免疫组化; 人类; 1:100
Marian C, Boilă A, Soanca D, Malau M, Podeanu D, Resetkova E, et al. Malignant transformation of adenomyoepithelioma of the breast by a monophasic population: a report of two cases and review of literature. APMIS. 2013;121:272-9 pubmed 出版商
  • 免疫组化; 人类
Gill M, Paish E, Ronan J, Green A, Ellis I, Lee A. Comparison of the PharmDx immunohistochemical system with standard methods for assessing estrogen and progesterone receptors in invasive carcinoma of the breast. Appl Immunohistochem Mol Morphol. 2013;21:90-3 pubmed 出版商
  • 免疫组化; 鸡; 1:200
Machado S, Bahr J, Hales D, Braundmeier A, Quade B, Nowak R. Validation of the aging hen (Gallus gallus domesticus) as an animal model for uterine leiomyomas. Biol Reprod. 2012;87:86 pubmed 出版商
  • 免疫组化; 人类; 1:50
Martins F, De S, Almendro V, Gonen M, Park S, Blum J, et al. Evolutionary pathways in BRCA1-associated breast tumors. Cancer Discov. 2012;2:503-11 pubmed 出版商
  • 免疫组化; 人类; 1:100
Hovanessian Larsen L, Taylor D, Hawes D, Spicer D, Press M, Wu A, et al. Lowering oral contraceptive norethindrone dose increases estrogen and progesterone receptor levels with no reduction in proliferation of breast epithelium: a randomized trial. Contraception. 2012;86:238-43 pubmed 出版商
  • 免疫组化; 人类
Maae E, Olsen D, Steffensen K, Jakobsen E, Brandslund I, Sørensen F, et al. Prognostic impact of placenta growth factor and vascular endothelial growth factor A in patients with breast cancer. Breast Cancer Res Treat. 2012;133:257-65 pubmed 出版商
  • 免疫组化; 人类; 1:100
Chung K, Hovanessian Larsen L, Hawes D, Taylor D, Downey S, Spicer D, et al. Breast epithelial cell proliferation is markedly increased with short-term high levels of endogenous estrogen secondary to controlled ovarian hyperstimulation. Breast Cancer Res Treat. 2012;132:653-60 pubmed 出版商
  • 免疫组化; 人类; 1:50
Logullo A, Stiepcich M, Osório C, Nonogaki S, Pasini F, Rocha R, et al. Role of Fos-related antigen 1 in the progression and prognosis of ductal breast carcinoma. Histopathology. 2011;58:617-25 pubmed 出版商
  • 免疫组化; 人类; 1:50
Joosse S, Brandwijk K, Mulder L, Wesseling J, Hannemann J, Nederlof P. Genomic signature of BRCA1 deficiency in sporadic basal-like breast tumors. Genes Chromosomes Cancer. 2011;50:71-81 pubmed 出版商
  • 免疫组化; 人类; 1:50
Holstege H, van Beers E, Velds A, Liu X, Joosse S, Klarenbeek S, et al. Cross-species comparison of aCGH data from mouse and human BRCA1- and BRCA2-mutated breast cancers. BMC Cancer. 2010;10:455 pubmed 出版商
  • 免疫组化; 人类; 1:50
Joosse S, Brandwijk K, Devilee P, Wesseling J, Hogervorst F, Verhoef S, et al. Prediction of BRCA2-association in hereditary breast carcinomas using array-CGH. Breast Cancer Res Treat. 2012;132:379-89 pubmed 出版商
  • 免疫组化; 人类; 1:50
Roepman P, Horlings H, Krijgsman O, Kok M, Bueno de Mesquita J, Bender R, et al. Microarray-based determination of estrogen receptor, progesterone receptor, and HER2 receptor status in breast cancer. Clin Cancer Res. 2009;15:7003-11 pubmed 出版商
  • 免疫组化; 人类; 1:200
Bueno de Mesquita J, Nuyten D, Wesseling J, VAN Tinteren H, Linn S, van de Vijver M. The impact of inter-observer variation in pathological assessment of node-negative breast cancer on clinical risk assessment and patient selection for adjuvant systemic treatment. Ann Oncol. 2010;21:40-7 pubmed 出版商
  • 免疫组化; 猫
Misirlioglu D, Nak D, Ozyigit M, Nak Y, Akkoc A. HER-2/neu (c-erbB-2) oncoprotein in hyperplastic endometrial polyps detected in two cats. J Feline Med Surg. 2009;11:885-8 pubmed 出版商
  • 免疫组化; 人类; 1:50
Pietersen A, Horlings H, Hauptmann M, Langerød A, Ajouaou A, Cornelissen Steijger P, et al. EZH2 and BMI1 inversely correlate with prognosis and TP53 mutation in breast cancer. Breast Cancer Res. 2008;10:R109 pubmed 出版商
  • 免疫组化; 人类; 1:100
Chakravarty D, Srinivasan R, Ghosh S, Rajwanshi A, Gopalan S. Estrogen receptor beta (ERbeta) in endometrial simple hyperplasia and endometrioid carcinoma. Appl Immunohistochem Mol Morphol. 2008;16:535-42 pubmed 出版商
  • 免疫组化; 人类; 1:50
Horlings H, van Laar R, Kerst J, Helgason H, Wesseling J, van Der Hoeven J, et al. Gene expression profiling to identify the histogenetic origin of metastatic adenocarcinomas of unknown primary. J Clin Oncol. 2008;26:4435-41 pubmed 出版商
  • 免疫组化; 人类; 1:50
Joosse S, van Beers E, Tielen I, Horlings H, Peterse J, Hoogerbrugge N, et al. Prediction of BRCA1-association in hereditary non-BRCA1/2 breast carcinomas with array-CGH. Breast Cancer Res Treat. 2009;116:479-89 pubmed 出版商
  • 免疫组化-冰冻切片; 人类; 1:100
  • 免疫组化; 人类; 1:100
Shi S, Liu C, Pootrakul L, Tang L, Young A, Chen R, et al. Evaluation of the value of frozen tissue section used as "gold standard" for immunohistochemistry. Am J Clin Pathol. 2008;129:358-66 pubmed 出版商
  • 免疫组化; 人类
Barbareschi M, Buttitta F, Felicioni L, Cotrupi S, Barassi F, Del Grammastro M, et al. Different prognostic roles of mutations in the helical and kinase domains of the PIK3CA gene in breast carcinomas. Clin Cancer Res. 2007;13:6064-9 pubmed
  • 免疫组化; 兔; 1:50
Onal B, Levin R, Kogan B, Whitbeck C, Chichester P, Walebowa O, et al. The effect of maturation and age on oestrogen-induced functional hypertrophy of the female rabbit bladder. BJU Int. 2007;99:674-9 pubmed
  • 免疫组化; 人类
Schmidt M, Tollenaar R, de Kemp S, Broeks A, Cornelisse C, Smit V, et al. Breast cancer survival and tumor characteristics in premenopausal women carrying the CHEK2*1100delC germline mutation. J Clin Oncol. 2007;25:64-9 pubmed
  • 免疫组化; 人类; 1:50
Hannemann J, Kristel P, VAN Tinteren H, Bontenbal M, van Hoesel Q, Smit W, et al. Molecular subtypes of breast cancer and amplification of topoisomerase II alpha: predictive role in dose intensive adjuvant chemotherapy. Br J Cancer. 2006;95:1334-41 pubmed
  • 免疫组化; 人类
Wang M, Pan J, Song G, Chen H, An L, Qu S. Altered expression of estrogen receptor alpha and beta in advanced gastric adenocarcinoma: correlation with prothymosin alpha and clinicopathological parameters. Eur J Surg Oncol. 2007;33:195-201 pubmed
  • 免疫组化; 兔
Lin A, Levin R, Kogan B, Whitbeck C, Chichester P, Sokol R, et al. Estrogen induced functional hypertrophy and increased force generation of the female rabbit bladder. Neurourol Urodyn. 2006;25:473-9 pubmed
  • 免疫印迹; 人类; 1:100
Turbyville T, Wijeratne E, Liu M, Burns A, Seliga C, Luevano L, et al. Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert. J Nat Prod. 2006;69:178-84 pubmed
  • 免疫组化; 大鼠
  • 免疫印迹; 大鼠
Weroha S, Li S, Tawfik O, Li J. Overexpression of cyclins D1 and D3 during estrogen-induced breast oncogenesis in female ACI rats. Carcinogenesis. 2006;27:491-8 pubmed
  • 免疫细胞化学; African green monkey; 1:200
  • 免疫印迹; 人类; 1:750
Lipfert L, Fisher J, Wei N, Scafonas A, Su Q, Yudkovitz J, et al. Antagonist-induced, activation function-2-independent estrogen receptor alpha phosphorylation. Mol Endocrinol. 2006;20:516-33 pubmed
  • 免疫组化; 人类; 1:100
Akhan S, Yavuz E, Tecer A, Iyibozkurt C, Topuz S, Tuzlali S, et al. The expression of Ki-67, p53, estrogen and progesterone receptors affecting survival in uterine leiomyosarcomas. A clinicopathologic study. Gynecol Oncol. 2005;99:36-42 pubmed
  • 免疫组化-石蜡切片; 人类; 1:80; 图 6
Kuo K, Chen M, Lin M. Epithelioid trophoblastic tumor of the broad ligament: a case report and review of the literature. Am J Surg Pathol. 2004;28:405-9 pubmed
  • 免疫组化-石蜡切片; 大鼠; 表 1
Goyal H, Braden T, Williams C, Dalvi P, Mansour M, Mansour M, et al. Abnormal morphology of the penis in male rats exposed neonatally to diethylstilbestrol is associated with altered profile of estrogen receptor-alpha protein, but not of androgen receptor protein: a developmental and immunocytochemical study. Biol Reprod. 2004;70:1504-17 pubmed
  • 免疫组化-石蜡切片; 人类; 表 2
Halperin R, Zehavi S, Hadas E, Habler L, Bukovsky I, Schneider D. Simultaneous carcinoma of the endometrium and ovary vs endometrial carcinoma with ovarian metastases: a clinical and immunohistochemical determination. Int J Gynecol Cancer. 2003;13:32-7 pubmed
  • 免疫组化-石蜡切片; 人类; 表 1
Herbert M, Sandbank J, Liokumovich P, Yanai O, Pappo I, Karni T, et al. Breast hamartomas: clinicopathological and immunohistochemical studies of 24 cases. Histopathology. 2002;41:30-4 pubmed
  • 免疫组化-石蜡切片; 人类; 图 1
Halperin R, Zehavi S, Hadas E, Habler L, Bukovsky I, Schneider D. Immunohistochemical comparison of primary peritoneal and primary ovarian serous papillary carcinoma. Int J Gynecol Pathol. 2001;20:341-5 pubmed
Flötotto T, Niederacher D, Hohmann D, Heimerzheim T, Dall P, Djahansouzi S, et al. Molecular mechanism of estrogen receptor (ER)alpha-specific, estradiol-dependent expression of the progesterone receptor (PR) B-isoform. J Steroid Biochem Mol Biol. 2004;88:131-42 pubmed
Guler G, Uner A, Guler N, Han S, Iliopoulos D, Hauck W, et al. The fragile genes FHIT and WWOX are inactivated coordinately in invasive breast carcinoma. Cancer. 2004;100:1605-14 pubmed
Kapucuoglu N, Coban T, Raunio H, Pelkonen O, Edwards R, Boobis A, et al. Expression of CYP3A4 in human breast tumour and non-tumour tissues. Cancer Lett. 2003;202:17-23 pubmed
Beliakoff J, Bagatell R, Paine Murrieta G, Taylor C, Lykkesfeldt A, Whitesell L. Hormone-refractory breast cancer remains sensitive to the antitumor activity of heat shock protein 90 inhibitors. Clin Cancer Res. 2003;9:4961-71 pubmed
Zinser G, McEleney K, Welsh J. Characterization of mammary tumor cell lines from wild type and vitamin D3 receptor knockout mice. Mol Cell Endocrinol. 2003;200:67-80 pubmed
Querzoli P, Albonico G, di Iasio M, Ferretti S, Rinaldi R, Cariello A, et al. Biophenotypes and survival of BRCA1 and TP53 deleted breast cancer in young women. Breast Cancer Res Treat. 2001;66:135-42 pubmed
Suzuki T, Darnel A, Akahira J, Ariga N, Ogawa S, Kaneko C, et al. 5alpha-reductases in human breast carcinoma: possible modulator of in situ androgenic actions. J Clin Endocrinol Metab. 2001;86:2250-7 pubmed
Zunarelli E, Nicoll J, Migaldi M, Trentini G. Apolipoprotein E polymorphism and breast carcinoma: correlation with cell proliferation indices and clinical outcome. Breast Cancer Res Treat. 2000;63:193-8 pubmed
El Khissiin A, Journe F, Laios I, Seo H, Leclercq G. Evidence of an estrogen receptor form devoid of estrogen binding ability in MCF-7 cells. Steroids. 2000;65:903-13 pubmed
图像
图像 1 :
赛默飞世尔 MA5-13304 图像 1
图像 2 :
赛默飞世尔 MA5-13304 图像 2
图像 3 :
赛默飞世尔 MA5-13304 图像 3
Formalin-fixed, paraffin-embedded human breast carcinoma stained with Estrogen Receptor antibody2 using peroxidase-conjugate and DAB chromogen. Note intense nuclear staining of tumor cells.
产品信息
产品类型 :
抗体
产品名称 :
雌激素受体α单克隆抗体(6F11)
目录# :
MA5-13304
规格 :
500µL
价格 :
美国425.00
克隆性 :
单克隆
宿主 :
小鼠
反应物种 :
人类, 大鼠
应用 :
Immunocytochemistry: 1:50-1:200, Immunofluorescence: 1:50-1:200, Immunohistochemistry (Frozen): 1:40-1:80, Immunohistochemistry (Paraffin): 1:40-1:80, Immunoprecipitation: 10 µL/mg lysate, Western Blot: 1:100-1:1000
物种 :
人类, 大鼠
克隆 :
6F11
抗体亚型 :
IgG1
储存 :
4° C
描述 :
Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins. There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively). Due to alternative RNA splicing, at least 4 estrogen receptor-alpha isoforms are known to exist (Isoform 1 (66 kDa), Isoform 2 (53 kDa), Isoform 3 (47 kDa), Isoform 4 (35 kDa)). Estrogen receptors are widely expressed in different tissue types and are essential for sexual development and reproductive function. They also play a role in other tissues such as bone. Estrogen receptors are involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis.
免疫原 :
重组雌激素受体蛋白(甲形式)
格式 :
Liquid
应用w/稀释 :
Immunocytochemistry: 1:50-1:200, Immunofluorescence: 1:50-1:200, Immunohistochemistry (Frozen): 1:40-1:80, Immunohistochemistry (Paraffin): 1:40-1:80, Immunoprecipitation: 10 µL/mg lysate, Western Blot: 1:100-1:1000
别名 :
estrogen receptor beta, estrogen receptor beta 4, nuclear receptor subfamily 3 group A member 2
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
www.thermo.com.cn
1084193588
公司总部: 美国