产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
凝血酶敏感素1单克隆抗体(A6.1)
目录 :
MA5-13398
规格 :
200微升
价格 :
美国425.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
A6.1
反应物种 :
人类, 小鼠, 大鼠, , , pigs , 家羊, 国内马
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片, 抑制或激活实验
更多信息或购买 :
文章摘录数: 149
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 大鼠; 图 9a
Dunford E, Leclair E, Aiken J, Mandel E, Haas T, Birot O, et al. The effects of voluntary exercise and prazosin on capillary rarefaction and metabolism in streptozotocin-induced diabetic male rats. J Appl Physiol (1985). 2017;122:492-502 pubmed 出版商
  • 免疫印迹; 大鼠; 图 3f
Mandel E, Dunford E, Trifonova A, Abdifarkosh G, Teich T, Riddell M, et al. Prazosin Can Prevent Glucocorticoid Mediated Capillary Rarefaction. PLoS ONE. 2016;11:e0166899 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:50; 图 4
Kim S, Hayashi H, Ishikawa T, Shibata K, Shigetomi E, Shinozaki Y, et al. Cortical astrocytes rewire somatosensory cortical circuits for peripheral neuropathic pain. J Clin Invest. 2016;126:1983-97 pubmed 出版商
  • 免疫印迹; 人类; 图 5
Posner M, Upadhyay A, Abubaker A, Fortunato T, Vara D, Canobbio I, et al. Extracellular Fibrinogen-binding Protein (Efb) from Staphylococcus aureus Inhibits the Formation of Platelet-Leukocyte Complexes. J Biol Chem. 2016;291:2764-76 pubmed 出版商
  • 免疫细胞化学; 小鼠; 图 2
  • 免疫印迹; 小鼠; 图 1
Labrousse Arias D, Castillo González R, Rogers N, Torres Capelli M, Barreira B, Aragonés J, et al. HIF-2α-mediated induction of pulmonary thrombospondin-1 contributes to hypoxia-driven vascular remodelling and vasoconstriction. Cardiovasc Res. 2016;109:115-30 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:100; 图 2
Kuroki H, Hayashi H, Nakagawa S, Sakamoto K, Higashi T, Nitta H, et al. Effect of LSKL peptide on thrombospondin 1-mediated transforming growth factor β signal activation and liver regeneration after hepatectomy in an experimental model. Br J Surg. 2015;102:813-25 pubmed 出版商
  • 免疫印迹; 人类; 图 3
de la Rica L, García Gómez A, Comet N, Rodríguez Ubreva J, Ciudad L, Vento Tormo R, et al. NF-κB-direct activation of microRNAs with repressive effects on monocyte-specific genes is critical for osteoclast differentiation. Genome Biol. 2015;16:2 pubmed 出版商
  • 免疫印迹; 小鼠
Fei P, Zaitoun I, Farnoodian M, Fisk D, Wang S, Sorenson C, et al. Expression of thrombospondin-1 modulates the angioinflammatory phenotype of choroidal endothelial cells. PLoS ONE. 2014;9:e116423 pubmed 出版商
  • 免疫印迹; 小鼠
Shin E, Huang Q, Gurel Z, Sorenson C, Sheibani N. High glucose alters retinal astrocytes phenotype through increased production of inflammatory cytokines and oxidative stress. PLoS ONE. 2014;9:e103148 pubmed 出版商
  • 免疫印迹; 人类
Talme T, Bergdahl E, Sundqvist K. Regulation of T-lymphocyte motility, adhesion and de-adhesion by a cell surface mechanism directed by low density lipoprotein receptor-related protein 1 and endogenous thrombospondin-1. Immunology. 2014;142:176-92 pubmed 出版商
  • 免疫组化; 大鼠
Daniel C, Vogelbacher R, Stief A, Grigo C, Hugo C. Long-term gene therapy with thrombospondin 2 inhibits TGF-? activation, inflammation and angiogenesis in chronic allograft nephropathy. PLoS ONE. 2013;8:e83846 pubmed 出版商
  • 免疫印迹; 小鼠
Shin E, Sorenson C, Sheibani N. PEDF expression regulates the proangiogenic and proinflammatory phenotype of the lung endothelium. Am J Physiol Lung Cell Mol Physiol. 2014;306:L620-34 pubmed 出版商
  • 免疫印迹; 小鼠
Morrison M, Palenski T, Jamali N, Sheibani N, Sorenson C. Modulation of vascular cell function by bim expression. Int J Cell Biol. 2013;2013:297537 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1,000
Zhao Y, Wang S, Sorenson C, Teixeira L, Dubielzig R, Peters D, et al. Cyp1b1 mediates periostin regulation of trabecular meshwork development by suppression of oxidative stress. Mol Cell Biol. 2013;33:4225-40 pubmed 出版商
  • 免疫印迹; 人类
Bergström S, Bergdahl E, Sundqvist K. A cytokine-controlled mechanism for integrated regulation of T-lymphocyte motility, adhesion and activation. Immunology. 2013;140:441-55 pubmed 出版商
  • 免疫印迹; 小鼠
Palenski T, Sorenson C, Sheibani N. Inflammatory cytokine-specific alterations in retinal endothelial cell function. Microvasc Res. 2013;89:57-69 pubmed 出版商
  • 免疫印迹; 小鼠
Park S, Dimaio T, Liu W, Wang S, Sorenson C, Sheibani N. Endoglin regulates the activation and quiescence of endothelium by participating in canonical and non-canonical TGF-? signaling pathways. J Cell Sci. 2013;126:1392-405 pubmed 出版商
  • 免疫组化; 人类; 1:50
Bhattacharyya S, Sul K, Krukovets I, Nestor C, Li J, Adognravi O. Novel tissue-specific mechanism of regulation of angiogenesis and cancer growth in response to hyperglycemia. J Am Heart Assoc. 2012;1:e005967 pubmed 出版商
  • 酶联免疫吸附测定; 人类; 1:500
Martin Manso G, Navarathna D, Galli S, Soto Pantoja D, Kuznetsova S, Tsokos M, et al. Endogenous thrombospondin-1 regulates leukocyte recruitment and activation and accelerates death from systemic candidiasis. PLoS ONE. 2012;7:e48775 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4
Grutzmacher C, Park S, Zhao Y, Morrison M, Sheibani N, Sorenson C. Aberrant production of extracellular matrix proteins and dysfunction in kidney endothelial cells with a short duration of diabetes. Am J Physiol Renal Physiol. 2013;304:F19-30 pubmed 出版商
  • 免疫组化; 人类; 1:100
Alkim C, Sakiz D, Alkim H, Livaoglu A, Kendir T, Demirsoy H, et al. Thrombospondin-1 and VEGF in inflammatory bowel disease. Libyan J Med. 2012;7: pubmed 出版商
  • 免疫印迹; 大鼠
Kessler Icekson G, Hochhauser E, Sinai T, Kremer A, Dick J, Tarasenko N, et al. A histone deacetylase inhibitory prodrug - butyroyloxymethyl diethyl phosphate - protects the heart and cardiomyocytes against ischemia injury. Eur J Pharm Sci. 2012;45:592-9 pubmed 出版商
  • 免疫印迹; 小鼠
Sheibani N, Morrison M, Gurel Z, Park S, Sorenson C. BIM deficiency differentially impacts the function of kidney endothelial and epithelial cells through modulation of their local microenvironment. Am J Physiol Renal Physiol. 2012;302:F809-19 pubmed 出版商
  • 免疫组化; 大鼠
Matsuba M, Hutcheon A, Zieske J. Localization of thrombospondin-1 and myofibroblasts during corneal wound repair. Exp Eye Res. 2011;93:534-40 pubmed 出版商
  • 免疫印迹; 人类; 1:400
El Btaouri H, Morjani H, Greffe Y, Charpentier E, Martiny L. Role of JNK/ATF-2 pathway in inhibition of thrombospondin-1 (TSP-1) expression and apoptosis mediated by doxorubicin and camptothecin in FTC-133 cells. Biochim Biophys Acta. 2011;1813:695-703 pubmed 出版商
  • 免疫印迹; 人类; 1:500
Patten S, Adamcic U, Lacombe K, Minhas K, Skowronski K, Coomber B. VEGFR2 heterogeneity and response to anti-angiogenic low dose metronomic cyclophosphamide treatment. BMC Cancer. 2010;10:683 pubmed 出版商
  • 免疫印迹; 人类
Dews M, Fox J, Hultine S, Sundaram P, Wang W, Liu Y, et al. The myc-miR-17~92 axis blunts TGF{beta} signaling and production of multiple TGF{beta}-dependent antiangiogenic factors. Cancer Res. 2010;70:8233-46 pubmed 出版商
  • 免疫印迹; 大鼠
Ikeda H, Miyatake M, Koshikawa N, Ochiai K, Yamada K, Kiss A, et al. Morphine modulation of thrombospondin levels in astrocytes and its implications for neurite outgrowth and synapse formation. J Biol Chem. 2010;285:38415-27 pubmed 出版商
  • 免疫组化; 小鼠
Wang Y, Cheng W, Ke Y, Cai Z, Chen L, Xi Y, et al. Effect of Qingre Quyu Granule (??????) on stabilizing plaques in the brachiocephalic artery of apolipoprotein E deficient mice. Chin J Integr Med. 2010;16:442-7 pubmed 出版商
  • 免疫印迹; 大鼠
Tarasenko N, Kessler Icekson G, Boer P, Inbal A, Schlesinger H, Phillips D, et al. The histone deacetylase inhibitor butyroyloxymethyl diethylphosphate (AN-7) protects normal cells against toxicity of anticancer agents while augmenting their anticancer activity. Invest New Drugs. 2012;30:130-43 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Park S, Dimaio T, Scheef E, Sorenson C, Sheibani N. PECAM-1 regulates proangiogenic properties of endothelial cells through modulation of cell-cell and cell-matrix interactions. Am J Physiol Cell Physiol. 2010;299:C1468-84 pubmed 出版商
  • 免疫组化; 人类; 1:50
Guerrero D, Guarch R, Ojer A, Casas J, Méndez Meca C, Esteller M, et al. Differential hypermethylation of genes in vulvar cancer and lichen sclerosus coexisting or not with vulvar cancer. Int J Cancer. 2011;128:2853-64 pubmed 出版商
  • 免疫印迹; 人类; 1:250
Hohberg M, Knöchel J, Hoffmann C, Chlench S, Wunderlich W, Alter A, et al. Expression of ADAMTS1 in endothelial cells is induced by shear stress and suppressed in sprouting capillaries. J Cell Physiol. 2011;226:350-61 pubmed 出版商
  • 免疫印迹; 小鼠
Grutzmacher C, Park S, Elmergreen T, Tang Y, Scheef E, Sheibani N, et al. Opposing effects of bim and bcl-2 on lung endothelial cell migration. Am J Physiol Lung Cell Mol Physiol. 2010;299:L607-20 pubmed 出版商
  • 免疫组化; 小鼠
Lanz T, Ding Z, Ho P, Luo J, Agrawal A, Srinagesh H, et al. Angiotensin II sustains brain inflammation in mice via TGF-beta. J Clin Invest. 2010;120:2782-94 pubmed 出版商
  • 免疫印迹; 人类
Tan K, Lessieur E, Cutler A, Nerone P, Vasanji A, Asosingh K, et al. Impaired function of circulating CD34(+) CD45(-) cells in patients with proliferative diabetic retinopathy. Exp Eye Res. 2010;91:229-37 pubmed 出版商
  • 免疫印迹; 人类
Olsson A, Björk A, Vallon Christersson J, Isaacs J, Leanderson T. Tasquinimod (ABR-215050), a quinoline-3-carboxamide anti-angiogenic agent, modulates the expression of thrombospondin-1 in human prostate tumors. Mol Cancer. 2010;9:107 pubmed 出版商
  • 免疫组化; 人类
  • 免疫印迹; 人类
Haldar S, Lu Y, Jeyaraj D, Kawanami D, Cui Y, Eapen S, et al. Klf15 deficiency is a molecular link between heart failure and aortic aneurysm formation. Sci Transl Med. 2010;2:26ra26 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:70
  • 免疫组化; 小鼠; 1:70
  • 免疫印迹; 小鼠; 1:200
Yonezawa T, Hattori S, Inagaki J, Kurosaki M, Takigawa T, Hirohata S, et al. Type IV collagen induces expression of thrombospondin-1 that is mediated by integrin alpha1beta1 in astrocytes. Glia. 2010;58:755-67 pubmed 出版商
  • 免疫组化; 人类; 1:500
Zaslavsky A, Baek K, Lynch R, Short S, Grillo J, Folkman J, et al. Platelet-derived thrombospondin-1 is a critical negative regulator and potential biomarker of angiogenesis. Blood. 2010;115:4605-13 pubmed 出版商
  • 免疫沉淀; 小鼠; 2 ug/time
  • 免疫组化; 小鼠; 1:50
  • 免疫印迹; 小鼠
Fouladkou F, Lu C, Jiang C, Zhou L, She Y, Walls J, et al. The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1. J Biol Chem. 2010;285:6770-80 pubmed 出版商
  • 免疫组化; 大鼠
Daniel C, Wagner A, Hohenstein B, Hugo C. Thrombospondin-2 therapy ameliorates experimental glomerulonephritis via inhibition of cell proliferation, inflammation, and TGF-beta activation. Am J Physiol Renal Physiol. 2009;297:F1299-309 pubmed 出版商
  • 免疫组化; 小鼠; 1:100
Park C, Kim H, Lim J, Yoo K, Chung S, Shin S, et al. Vascular endothelial growth factor inhibition by dRK6 causes endothelial apoptosis, fibrosis, and inflammation in the heart via the Akt/eNOS axis in db/db mice. Diabetes. 2009;58:2666-76 pubmed 出版商
  • 免疫沉淀; 人类
  • 免疫印迹; 人类
Rex S, Beaulieu L, Perlman D, Vitseva O, Blair P, McComb M, et al. Immune versus thrombotic stimulation of platelets differentially regulates signalling pathways, intracellular protein-protein interactions, and alpha-granule release. Thromb Haemost. 2009;102:97-110 pubmed 出版商
  • 免疫组化; 大鼠
Szasz T, Eddy S, Paulauskis J, Burnett R, Ellekilde M, Iovanna J, et al. Differential expression of pancreatitis-associated protein and thrombospondins in arterial versus venous tissues. J Vasc Res. 2009;46:551-60 pubmed 出版商
  • 免疫印迹; 人类; 1:200
Hyder S, Liang Y, Wu J, Welbern V. Regulation of thrombospondin-1 by natural and synthetic progestins in human breast cancer cells. Endocr Relat Cancer. 2009;16:809-17 pubmed 出版商
  • 抑制或激活实验; 小鼠
Isenberg J, Shiva S, Gladwin M. Thrombospondin-1-CD47 blockade and exogenous nitrite enhance ischemic tissue survival, blood flow and angiogenesis via coupled NO-cGMP pathway activation. Nitric Oxide. 2009;21:52-62 pubmed 出版商
  • 免疫印迹; 人类; 1:200
Hyder S, Liang Y, Wu J. Estrogen regulation of thrombospondin-1 in human breast cancer cells. Int J Cancer. 2009;125:1045-53 pubmed 出版商
  • 免疫印迹; 人类; 1:400
Scheef E, Sorenson C, Sheibani N. Attenuation of proliferation and migration of retinal pericytes in the absence of thrombospondin-1. Am J Physiol Cell Physiol. 2009;296:C724-34 pubmed 出版商
  • 免疫组化; 小鼠; 1:100
Isenberg J, Maxhimer J, Powers P, Tsokos M, Frazier W, Roberts D. Treatment of liver ischemia-reperfusion injury by limiting thrombospondin-1/CD47 signaling. Surgery. 2008;144:752-61 pubmed 出版商
  • 免疫印迹; 小鼠
Huang Q, Sheibani N. High glucose promotes retinal endothelial cell migration through activation of Src, PI3K/Akt1/eNOS, and ERKs. Am J Physiol Cell Physiol. 2008;295:C1647-57 pubmed 出版商
  • 抑制或激活实验; 人类
Gayen Betal S, Setty B. Phosphatidylserine-positive erythrocytes bind to immobilized and soluble thrombospondin-1 via its heparin-binding domain. Transl Res. 2008;152:165-77 pubmed 出版商
  • 抑制或激活实验; 大鼠; 20 ug/ml
Anderson C, Hastings N, Blackman B, Price R. Capillary sprout endothelial cells exhibit a CD36 low phenotype: regulation by shear stress and vascular endothelial growth factor-induced mechanism for attenuating anti-proliferative thrombospondin-1 signaling. Am J Pathol. 2008;173:1220-8 pubmed 出版商
  • 免疫组化; 小鼠; 8 ug/ml
Gruber H, Bornstein P, Sage E, Ingram J, Zinchenko N, Norton H, et al. Disruption of the thrombospondin-2 gene alters the lamellar morphology but does not permit vascularization of the adult mouse lumbar disc. Arthritis Res Ther. 2008;10:R96 pubmed 出版商
  • 免疫印迹; 人类
Mazan Mamczarz K, Hagner P, Corl S, Srikantan S, Wood W, Becker K, et al. Post-transcriptional gene regulation by HuR promotes a more tumorigenic phenotype. Oncogene. 2008;27:6151-63 pubmed 出版商
  • 免疫组化; 人类
Ide M, Ishii H, Mukae H, Iwata A, Sakamoto N, Kadota J, et al. High serum levels of thrombospondin-1 in patients with idiopathic interstitial pneumonia. Respir Med. 2008;102:1625-30 pubmed 出版商
  • 免疫组化; 小鼠; 1:400
Johnson A, O Connell M, Miyamoto H, Huang J, Yao J, Messing E, et al. Androgenic dependence of exophytic tumor growth in a transgenic mouse model of bladder cancer: a role for thrombospondin-1. BMC Urol. 2008;8:7 pubmed 出版商
  • 免疫组化; 人类; 1:2000
  • 免疫印迹; 人类
Rojas A, Meherem S, Kim Y, Washington M, Willis J, Markowitz S, et al. The aberrant methylation of TSP1 suppresses TGF-beta1 activation in colorectal cancer. Int J Cancer. 2008;123:14-21 pubmed 出版商
  • 免疫印迹; 小鼠
Olerud J, Johansson M, Lawler J, Welsh N, Carlsson P. Improved vascular engraftment and graft function after inhibition of the angiostatic factor thrombospondin-1 in mouse pancreatic islets. Diabetes. 2008;57:1870-7 pubmed 出版商
  • 免疫印迹; 小鼠
Kondo S, Tang Y, Scheef E, Sheibani N, Sorenson C. Attenuation of retinal endothelial cell migration and capillary morphogenesis in the absence of bcl-2. Am J Physiol Cell Physiol. 2008;294:C1521-30 pubmed 出版商
  • 免疫组化; 人类; 1:50
Guerrero D, Guarch R, Ojer A, Casas J, Ropero S, Mancha A, et al. Hypermethylation of the thrombospondin-1 gene is associated with poor prognosis in penile squamous cell carcinoma. BJU Int. 2008;102:747-55 pubmed 出版商
  • 免疫沉淀; 人类
Bhattacharyya S, Marinic T, Krukovets I, Hoppe G, Stenina O. Cell type-specific post-transcriptional regulation of production of the potent antiangiogenic and proatherogenic protein thrombospondin-1 by high glucose. J Biol Chem. 2008;283:5699-707 pubmed
  • 免疫组化; 人类
  • 免疫印迹; 人类
Park J, Lee H, Ko K, Park S, Kim J, Choe G, et al. Meteorin regulates angiogenesis at the gliovascular interface. Glia. 2008;56:247-58 pubmed
  • 免疫印迹; 小鼠
Scheef E, Huang Q, Wang S, Sorenson C, Sheibani N. Isolation and characterization of corneal endothelial cells from wild type and thrombospondin-1 deficient mice. Mol Vis. 2007;13:1483-95 pubmed
  • 抑制或激活实验; 人类
Derks R, Jankowska Gan E, Xu Q, Burlingham W. Dendritic cell type determines the mechanism of bystander suppression by adaptive T regulatory cells specific for the minor antigen HA-1. J Immunol. 2007;179:3443-51 pubmed
  • 抑制或激活实验; 人类; 1:1000
  • 免疫印迹; 人类
Hong S, Chang S, Yeom D, Kang J, Hong K. Differential regulation of thrombospondin-1 expression and antiangiogenesis of ECV304 cells by trichostatin A and helixor A. Anticancer Drugs. 2007;18:1005-14 pubmed
  • 免疫组化; 家羊; 1:50
Sozo F, Hooper S, Wallace M. Thrombospondin-1 expression and localization in the developing ovine lung. J Physiol. 2007;584:625-35 pubmed
  • 酶联免疫吸附测定; 人类
Annis D, Gunderson K, Mosher D. Immunochemical analysis of the structure of the signature domains of thrombospondin-1 and thrombospondin-2 in low calcium concentrations. J Biol Chem. 2007;282:27067-75 pubmed
  • 免疫组化; 人类
Pohlers D, Beyer A, Koczan D, Wilhelm T, Thiesen H, Kinne R. Constitutive upregulation of the transforming growth factor-beta pathway in rheumatoid arthritis synovial fibroblasts. Arthritis Res Ther. 2007;9:R59 pubmed
  • 免疫印迹; 小鼠; 1:3000
Kondo S, Scheef E, Sheibani N, Sorenson C. PECAM-1 isoform-specific regulation of kidney endothelial cell migration and capillary morphogenesis. Am J Physiol Cell Physiol. 2007;292:C2070-83 pubmed
  • 免疫组化; 大鼠
de Nigris F, Balestrieri M, Williams Ignarro S, D Armiento F, Fiorito C, Ignarro L, et al. The influence of pomegranate fruit extract in comparison to regular pomegranate juice and seed oil on nitric oxide and arterial function in obese Zucker rats. Nitric Oxide. 2007;17:50-4 pubmed
  • 免疫组化; 小鼠
Kaipainen A, Kieran M, Huang S, Butterfield C, Bielenberg D, Mostoslavsky G, et al. PPARalpha deficiency in inflammatory cells suppresses tumor growth. PLoS ONE. 2007;2:e260 pubmed
  • 免疫组化; 小鼠
Isenberg J, Romeo M, Abu Asab M, Tsokos M, Oldenborg A, Pappan L, et al. Increasing survival of ischemic tissue by targeting CD47. Circ Res. 2007;100:712-20 pubmed
  • 免疫细胞化学; 人类; 2 ug/ml
Raman P, Krukovets I, Marinic T, Bornstein P, Stenina O. Glycosylation mediates up-regulation of a potent antiangiogenic and proatherogenic protein, thrombospondin-1, by glucose in vascular smooth muscle cells. J Biol Chem. 2007;282:5704-14 pubmed
  • 免疫组化; 人类
Kopp H, Hooper A, Broekman M, Avecilla S, Petit I, Luo M, et al. Thrombospondins deployed by thrombopoietic cells determine angiogenic switch and extent of revascularization. J Clin Invest. 2006;116:3277-91 pubmed
  • 免疫印迹; 小鼠; 1:4000
Sheibani N, Scheef E, Dimaio T, Wang Y, Kondo S, Sorenson C. Bcl-2 expression modulates cell adhesion and migration promoting branching of ureteric bud cells. J Cell Physiol. 2007;210:616-25 pubmed
  • 免疫组化; 小鼠; 1:25
Isenberg J, Hyodo F, Matsumoto K, Romeo M, Abu Asab M, Tsokos M, et al. Thrombospondin-1 limits ischemic tissue survival by inhibiting nitric oxide-mediated vascular smooth muscle relaxation. Blood. 2007;109:1945-52 pubmed
  • 免疫组化; 小鼠; 1:50
Giuriato S, Ryeom S, Fan A, Bachireddy P, Lynch R, Rioth M, et al. Sustained regression of tumors upon MYC inactivation requires p53 or thrombospondin-1 to reverse the angiogenic switch. Proc Natl Acad Sci U S A. 2006;103:16266-71 pubmed
  • 免疫细胞化学; 人类
Kuznetsova S, Issa P, Perruccio E, Zeng B, Sipes J, Ward Y, et al. Versican-thrombospondin-1 binding in vitro and colocalization in microfibrils induced by inflammation on vascular smooth muscle cells. J Cell Sci. 2006;119:4499-509 pubmed
  • 免疫组化; 人类; 1:500
Duvic M, Talpur R, Ni X, Zhang C, Hazarika P, Kelly C, et al. Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL). Blood. 2007;109:31-9 pubmed
  • 免疫组化; 小鼠; 1:50
Shoji T, Koyama H, Morioka T, Tanaka S, Kizu A, Motoyama K, et al. Receptor for advanced glycation end products is involved in impaired angiogenic response in diabetes. Diabetes. 2006;55:2245-55 pubmed
  • 免疫组化; 人类; 4 ug/ml
Wen X, Yang G, Mao W, Thornton A, Liu J, Bast R, et al. HER2 signaling modulates the equilibrium between pro- and antiangiogenic factors via distinct pathways: implications for HER2-targeted antibody therapy. Oncogene. 2006;25:6986-96 pubmed
  • 免疫印迹; 小鼠
Wang Y, Wang S, Sheibani N. Enhanced proangiogenic signaling in thrombospondin-1-deficient retinal endothelial cells. Microvasc Res. 2006;71:143-51 pubmed
  • 免疫组化; 人类; 1:50
Bodner Adler B, Nather A, Bodner K, Czerwenka K, Kimberger O, Leodolter S, et al. Expression of thrombospondin 1 (TSP 1) in patients with uterine smooth muscle tumors: an immunohistochemical study. Gynecol Oncol. 2006;103:186-9 pubmed
  • 免疫组化; 大鼠
Johansson M, Mattsson G, Andersson A, Jansson L, Carlsson P. Islet endothelial cells and pancreatic beta-cell proliferation: studies in vitro and during pregnancy in adult rats. Endocrinology. 2006;147:2315-24 pubmed
  • 免疫组化; 人类; 1,000 ug/ml
  • 免疫印迹; 人类; 1:200
Jo W, Mizukami Y, Duerr E, Zukerberg L, Chung D. Wnt signaling can repress thrombospondin-1 expression in colonic tumorigenesis. Cancer Biol Ther. 2005;4:1361-6 pubmed
  • 免疫组化; 人类; 1:50
Sutton C, O Byrne K, Goddard J, Marshall L, Jones L, Garcea G, et al. Expression of thrombospondin-1 in resected colorectal liver metastases predicts poor prognosis. Clin Cancer Res. 2005;11:6567-73 pubmed
  • 免疫印迹; 大鼠
Li Y, Spataro B, Yang J, Dai C, Liu Y. 1,25-dihydroxyvitamin D inhibits renal interstitial myofibroblast activation by inducing hepatocyte growth factor expression. Kidney Int. 2005;68:1500-10 pubmed
  • 免疫印迹; 小鼠
Scheef E, Wang S, Sorenson C, Sheibani N. Isolation and characterization of murine retinal astrocytes. Mol Vis. 2005;11:613-24 pubmed
  • 免疫组化; 大鼠
Vallbo C, Damber J. Thrombospondins, metallo proteases and thrombospondin receptors messenger RNA and protein expression in different tumour sublines of the Dunning prostate cancer model. Acta Oncol. 2005;44:293-8 pubmed
  • 免疫组化; 大鼠
Suzuki K, Wang R, Kubota H, Shibuya H, Saegusa J, Sato T. Kinetics of biglycan, decorin and thrombospondin-1 in mercuric chloride-induced renal tubulointerstitial fibrosis. Exp Mol Pathol. 2005;79:68-73 pubmed
  • 免疫印迹; 人类
Cambier S, Gline S, Mu D, Collins R, Araya J, Dolganov G, et al. Integrin alpha(v)beta8-mediated activation of transforming growth factor-beta by perivascular astrocytes: an angiogenic control switch. Am J Pathol. 2005;166:1883-94 pubmed
  • 酶联免疫吸附测定; 人类; 1:500
Isenberg J, Calzada M, Zhou L, Guo N, Lawler J, Wang X, et al. Endogenous thrombospondin-1 is not necessary for proliferation but is permissive for vascular smooth muscle cell responses to platelet-derived growth factor. Matrix Biol. 2005;24:110-23 pubmed
  • 免疫组化; 小鼠
Uno K, Hayashi H, Uchida H, Kuroki M, Oshima K. Impairment of thrombospondin-1 expression during epithelial wound healing in corneas of vitamin A-deficient mice. Histol Histopathol. 2005;20:493-9 pubmed 出版商
  • 免疫组化; 小鼠
Olson L, Zhang J, Taylor H, Rose D, Rosenfeld M. Barx2 functions through distinct corepressor classes to regulate hair follicle remodeling. Proc Natl Acad Sci U S A. 2005;102:3708-13 pubmed
  • 免疫印迹; 大鼠
Bouvet C, Gilbert L, Girardot D, Deblois D, Moreau P. Different involvement of extracellular matrix components in small and large arteries during chronic NO synthase inhibition. Hypertension. 2005;45:432-7 pubmed
  • 免疫沉淀; 大鼠
  • 免疫组化; 大鼠
  • 免疫印迹; 大鼠
Ihara Y, Manabe S, Kanda M, Kawano H, Nakayama T, Sekine I, et al. Increased expression of protein C-mannosylation in the aortic vessels of diabetic Zucker rats. Glycobiology. 2005;15:383-92 pubmed
Lemieux P, Roudier E, Birot O. Angiostatic freeze or angiogenic move? Acute cold stress prevents angiokine secretion from murine myotubes but primes primary endothelial cells for greater migratory capacity. Front Physiol. 2022;13:975652 pubmed 出版商
Guo B, Friedland S, Alexander W, Myers J, Wang W, O Dell M, et al. Arid1a mutation suppresses TGF-β signaling and induces cholangiocarcinoma. Cell Rep. 2022;40:111253 pubmed 出版商
Feng Q, Gu J, Chen J, Zheng W, Pan H, Xu X, et al. TSP1 promotes fibroblast proliferation and extracellular matrix deposition via the IL6/JAK2/STAT3 signalling pathway in keloids. Exp Dermatol. 2022;31:1533-1542 pubmed 出版商
Wang B, Li X, Yu N, Yang L, Nan C, Guo L, et al. Intracerebral hemorrhage alters α2δ1 and thrombospondin expression in rats. Exp Ther Med. 2022;23:327 pubmed 出版商
Yeung V, Zhang T, Yuan L, Parekh M, Cortinas J, Delavogia E, et al. Extracellular Vesicles Secreted by Corneal Myofibroblasts Promote Corneal Epithelial Cell Migration. Int J Mol Sci. 2022;23: pubmed 出版商
Shiau A, Fang S, Hsu C, Chiu M, Lam C, Wu C, et al. Prothymosin α Gene Transfer Modulates Myocardial Remodeling after Ischemia-Reperfusion Injury. Acta Cardiol Sin. 2022;38:187-200 pubmed 出版商
Sterken B, Ackermann T, M xfc ller C, Zuidhof H, Kortman G, Hernandez Segura A, et al. C/EBPβ isoform-specific regulation of migration and invasion in triple-negative breast cancer cells. NPJ Breast Cancer. 2022;8:11 pubmed 出版商
Wallis S, Wolska N, Englert H, Posner M, Upadhyay A, Renn xe9 T, et al. A peptide from the staphylococcal protein Efb binds P-selectin and inhibits the interaction of platelets with leukocytes. J Thromb Haemost. 2022;20:729-741 pubmed 出版商
Delaunay K, Sellam A, Dinet V, Moulin A, Zhao M, Gélizé E, et al. Meteorin Is a Novel Therapeutic Target for Wet Age-Related Macular Degeneration. J Clin Med. 2021;10: pubmed 出版商
Chung J, Jeong D, Kim G, Go S, Song J, Moon E, et al. Super-resolution imaging of platelet-activation process and its quantitative analysis. Sci Rep. 2021;11:10511 pubmed 出版商
Lam B, Nwadozi E, Haas T, Birot O, Roudier E. High Glucose Treatment Limits Drosha Protein Expression and Alters AngiomiR Maturation in Microvascular Primary Endothelial Cells via an Mdm2-dependent Mechanism. Cells. 2021;10: pubmed 出版商
Ferrara M, Chialli G, Ferreira L, Ruggieri E, Careccia G, Preti A, et al. Oxidation of HMGB1 Is a Dynamically Regulated Process in Physiological and Pathological Conditions. Front Immunol. 2020;11:1122 pubmed 出版商
Federico A, Steinfass T, Larribere L, Novak D, Morís F, Núñez L, et al. Mithramycin A and Mithralog EC-8042 Inhibit SETDB1 Expression and Its Oncogenic Activity in Malignant Melanoma. Mol Ther Oncolytics. 2020;18:83-99 pubmed 出版商
Perez Boza J, Boeckx A, Lion M, Dequiedt F, Struman I. hnRNPA2B1 inhibits the exosomal export of miR-503 in endothelial cells. Cell Mol Life Sci. 2020;77:4413-4428 pubmed 出版商
Esteban S, Clemente C, Koziol A, Gonzalo P, Rius C, Martinez F, et al. Endothelial MT1-MMP targeting limits intussusceptive angiogenesis and colitis via TSP1/nitric oxide axis. EMBO Mol Med. 2020;12:e10862 pubmed 出版商
Waddingham M, Sonobe T, Tsuchimochi H, Edgley A, Sukumaran V, Chen Y, et al. Diastolic dysfunction is initiated by cardiomyocyte impairment ahead of endothelial dysfunction due to increased oxidative stress and inflammation in an experimental prediabetes model. J Mol Cell Cardiol. 2019;137:119-131 pubmed 出版商
Seif K, Alidzanovic L, Tischler B, Ibrahim N, Zagrapan B, Rauscher S, et al. Neutrophil-Mediated Proteolysis of Thrombospondin-1 Promotes Platelet Adhesion and String Formation. Thromb Haemost. 2018;118:2074-2085 pubmed 出版商
Aiken J, Mandel E, Riddell M, Birot O. Hyperglycaemia correlates with skeletal muscle capillary regression and is associated with alterations in the murine double minute-2/forkhead box O1/thrombospondin-1 pathway in type 1 diabetic BioBreeding rats. Diab Vasc Dis Res. 2019;16:28-37 pubmed 出版商
de Back D, Nezjad S, Beuger B, Veldhuis M, Clifford E, Ait Ichou F, et al. Apheresis causes complement deposition on red blood cells (RBCs) and RBC antigen alterations, possibly inducing enhanced clearance. Transfusion. 2018;58:2627-2634 pubmed 出版商
Farnoodian M, Sorenson C, Sheibani N. PEDF expression affects the oxidative and inflammatory state of choroidal endothelial cells. Am J Physiol Cell Physiol. 2018;314:C456-C472 pubmed 出版商
Martín Granado V, Ortiz Rivero S, Carmona R, Gutiérrez Herrero S, Barrera M, San Segundo L, et al. C3G promotes a selective release of angiogenic factors from activated mouse platelets to regulate angiogenesis and tumor metastasis. Oncotarget. 2017;8:110994-111011 pubmed 出版商
Diaz A, Merino P, Manrique L, Ospina J, Cheng L, Wu F, et al. A Cross Talk between Neuronal Urokinase-type Plasminogen Activator (uPA) and Astrocytic uPA Receptor (uPAR) Promotes Astrocytic Activation and Synaptic Recovery in the Ischemic Brain. J Neurosci. 2017;37:10310-10322 pubmed 出版商
Talme T, Bergdahl E, Sundqvist K. Methotrexate and its therapeutic antagonists caffeine and theophylline, target a motogenic T-cell mechanism driven by thrombospondin-1 (TSP-1). Eur J Immunol. 2016;46:1279-90 pubmed 出版商
Krencik R, Hokanson K, Narayan A, Dvornik J, Rooney G, Rauen K, et al. Dysregulation of astrocyte extracellular signaling in Costello syndrome. Sci Transl Med. 2015;7:286ra66 pubmed 出版商
Farnoodian M, Kinter J, Yadranji Aghdam S, Zaitoun I, Sorenson C, Sheibani N. Expression of pigment epithelium-derived factor and thrombospondin-1 regulate proliferation and migration of retinal pigment epithelial cells. Physiol Rep. 2015;3: pubmed 出版商
Audet G, Fulks D, Stricker J, Olfert I. Chronic delivery of a thrombospondin-1 mimetic decreases skeletal muscle capillarity in mice. PLoS ONE. 2013;8:e55953 pubmed 出版商
Chandler R, Brennan J, Schisler J, Serber D, Patterson C, Magnuson T. ARID1a-DNA interactions are required for promoter occupancy by SWI/SNF. Mol Cell Biol. 2013;33:265-80 pubmed 出版商
Ito T, Sato F, Kan T, Cheng Y, David S, Agarwal R, et al. Polo-like kinase 1 regulates cell proliferation and is targeted by miR-593* in esophageal cancer. Int J Cancer. 2011;129:2134-46 pubmed 出版商
Ali N, Gaughan A, Orosz C, Baran C, McMaken S, Wang Y, et al. Latency associated peptide has in vitro and in vivo immune effects independent of TGF-beta1. PLoS ONE. 2008;3:e1914 pubmed 出版商
Li S, Forslöw A, Sundqvist K. Autocrine regulation of T cell motility by calreticulin-thrombospondin-1 interaction. J Immunol. 2005;174:654-61 pubmed
Flügel Koch C, Ohlmann A, Fuchshofer R, Welge Lussen U, Tamm E. Thrombospondin-1 in the trabecular meshwork: localization in normal and glaucomatous eyes, and induction by TGF-beta1 and dexamethasone in vitro. Exp Eye Res. 2004;79:649-63 pubmed
Ziehr J, Sheibani N, Sorenson C. Alterations in cell-adhesive and migratory properties of proximal tubule and collecting duct cells from bcl-2 -/- mice. Am J Physiol Renal Physiol. 2004;287:F1154-63 pubmed
Sengupta K, Banerjee S, Saxena N, Banerjee S. Thombospondin-1 disrupts estrogen-induced endothelial cell proliferation and migration and its expression is suppressed by estradiol. Mol Cancer Res. 2004;2:150-8 pubmed
Hochegger K, Knight S, Hugo C, Mayer G, Lawler J, Mayadas T, et al. Role of thrombospondin-1 in the autologous phase of an accelerated model of anti-glomerular basement membrane glomerulonephritis. Nephron Exp Nephrol. 2004;96:e31-8 pubmed
Uno K, Hayashi H, Kuroki M, Uchida H, Yamauchi Y, Kuroki M, et al. Thrombospondin-1 accelerates wound healing of corneal epithelia. Biochem Biophys Res Commun. 2004;315:928-34 pubmed
Qin H, Shao Q, Thomas T, Kalra J, Alaoui Jamali M, Laird D. Connexin26 regulates the expression of angiogenesis-related genes in human breast tumor cells by both GJIC-dependent and -independent mechanisms. Cell Commun Adhes. 2003;10:387-93 pubmed
Salvesen H, Gulluoglu M, Stefansson I, Akslen L. Significance of CD 105 expression for tumour angiogenesis and prognosis in endometrial carcinomas. APMIS. 2003;111:1011-8 pubmed
Liu X, Wu Z, Sheibani N, Brandt C, Polansky J, Kaufman P. Low dose latrunculin-A inhibits dexamethasone-induced changes in the actin cytoskeleton and alters extracellular matrix protein expression in cultured human trabecular meshwork cells. Exp Eye Res. 2003;77:181-8 pubmed
Lopes N, Gregg D, Vasudevan S, Hassanain H, Goldschmidt Clermont P, Kovacic H. Thrombospondin 2 regulates cell proliferation induced by Rac1 redox-dependent signaling. Mol Cell Biol. 2003;23:5401-8 pubmed
Alaoui Jamali M, Song D, Benlimame N, Yen L, Deng X, Hernandez Perez M, et al. Regulation of multiple tumor microenvironment markers by overexpression of single or paired combinations of ErbB receptors. Cancer Res. 2003;63:3764-74 pubmed
Stenina O, Krukovets I, Wang K, Zhou Z, Forudi F, Penn M, et al. Increased expression of thrombospondin-1 in vessel wall of diabetic Zucker rat. Circulation. 2003;107:3209-15 pubmed
Su X, Sorenson C, Sheibani N. Isolation and characterization of murine retinal endothelial cells. Mol Vis. 2003;9:171-8 pubmed
Rice A, Steward M, Quinn C. Thrombospondin 1 protein expression relates to good prognostic indices in ductal carcinoma in situ of the breast. J Clin Pathol. 2002;55:921-5 pubmed
Burnett T, Tash J, Hunt J. Investigation of the role of nitric oxide synthase 2 in pregnancy using mutant mice. Reproduction. 2002;124:49-57 pubmed
Mattern J, Koomägi R, Volm M. Characteristics of long-term survivors of untreated lung cancer. Lung Cancer. 2002;36:277-82 pubmed
Li S, Ivanoff A, Bergström S, Sandström A, Christensson B, van Nerven J, et al. T lymphocyte expression of thrombospondin-1 and adhesion to extracellular matrix components. Eur J Immunol. 2002;32:1069-79 pubmed
Kragh M, Quistorff B, Tenan M, Van Meir E, Kristjansen P. Overexpression of thrombospondin-1 reduces growth and vascular index but not perfusion in glioblastoma. Cancer Res. 2002;62:1191-5 pubmed
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Zhao X, Hu Y, Miller G, Mitchell R, Libby P. Association of thrombospondin-1 and cardiac allograft vasculopathy in human cardiac allografts. Circulation. 2001;103:525-31 pubmed
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图像
图像 1 :
赛默飞世尔 MA5-13398 图像 1
图像 2 :
赛默飞世尔 MA5-13398 图像 2
图像 3 :
赛默飞世尔 MA5-13398 图像 3
产品信息
产品类型 :
抗体
产品名称 :
凝血酶敏感素1单克隆抗体(A6.1)
目录# :
MA5-13398
规格 :
200微升
价格 :
美国425.00
克隆性 :
单克隆
纯度 :
蛋白质G
宿主 :
小鼠
反应物种 :
Bovine, Canine, Equine, Human, Mouse, Ovine, Porcine, Rat
应用 :
Flow Cytometry: Assay-dependent, Immunocytochemistry: 1:20-1:200, Immunohistochemistry (Paraffin): 1:25-1:50, Immunomicroscopy: Assay-dependent, Immunoprecipitation: 2 µg/mL, Western Blot: 1-2 µg/mL
物种 :
Bovine, Canine, Equine, Human, Mouse, Ovine, Porcine, Rat
克隆 :
A6.1
抗体亚型 :
IgG1
储存 :
4° C
描述 :
Thrombospondin is a protein from platelet a-granules. It is made up of three identical subunits bound by interchain disulfides. It is secreted at sites of platelet activation and aggregation and is involved in the processes of chemotaxis, adhesion, proliferation and differentiation of leukocytes, fibroblasts, smooth muscle and endothelial cells.
免疫原 :
Reduced and alkylated purified human TSP (fully denatured) from the supernatant of thrombin-activated platelets
格式 :
液体
应用w/稀释 :
Flow Cytometry: Assay-dependent, Immunocytochemistry: 1:20-1:200, Immunohistochemistry (Paraffin): 1:25-1:50, Immunomicroscopy: Assay-dependent, Immunoprecipitation: 2 µg/mL, Western Blot: 1-2 µg/mL
别名 :
glycoprotein G; tbsp1; THBS; Thbs1; Thbs-1; thrombospondin; thrombospondin 1; thrombospondin-1; thrombospondin-1p180; thrombospondin-p50; ThrombospondinTHBS1; TSP; TSP1; TSP-1
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国