产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
XRCC1单克隆抗体(33-2-5)
目录 :
MA5-13412
规格 :
500微升
价格 :
美国450.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
33-2-5
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 26
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠
Horton J, Gassman N, Dunigan B, Stefanick D, Wilson S. DNA polymerase β-dependent cell survival independent of XRCC1 expression. DNA Repair (Amst). 2015;26:23-9 pubmed 出版商
  • 免疫印迹; 小鼠
Horton J, Stefanick D, Prasad R, Gassman N, Kedar P, Wilson S. Base excision repair defects invoke hypersensitivity to PARP inhibition. Mol Cancer Res. 2014;12:1128-39 pubmed 出版商
  • 免疫印迹; 小鼠
Horton J, Stefanick D, Gassman N, Williams J, Gabel S, Cuneo M, et al. Preventing oxidation of cellular XRCC1 affects PARP-mediated DNA damage responses. DNA Repair (Amst). 2013;12:774-85 pubmed 出版商
  • 免疫印迹; 人类; 图 s2
Masaoka A, Gassman N, Horton J, Kedar P, Witt K, Hobbs C, et al. Interaction between DNA Polymerase ? and BRCA1. PLoS ONE. 2013;8:e66801 pubmed 出版商
  • 免疫组化; 人类; 1:200
  • 免疫印迹; 人类
Sultana R, Abdel Fatah T, Abbotts R, Hawkes C, Albarakati N, Seedhouse C, et al. Targeting XRCC1 deficiency in breast cancer for personalized therapy. Cancer Res. 2013;73:1621-34 pubmed 出版商
  • 免疫组化; 人类; 1:200
Abdel Fatah T, Sultana R, Abbotts R, Hawkes C, Seedhouse C, Chan S, et al. Clinicopathological and functional significance of XRCC1 expression in ovarian cancer. Int J Cancer. 2013;132:2778-86 pubmed 出版商
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
Watt H, Rachid Z, Jean Claude B. The Concept of Divergent Targeting through the Activation and Inhibition of Receptors as a Novel Chemotherapeutic Strategy: Signaling Responses to Strong DNA-Reactive Combinatorial Mimicries. J Signal Transduct. 2012;2012:282050 pubmed 出版商
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类; 1:1000
Jin R, Sun Y, Qi X, Zhang H, Zhang Y, Li N, et al. E2F1 is involved in DNA single-strand break repair through cell-cycle-dependent upregulation of XRCC1 expression. DNA Repair (Amst). 2011;10:926-33 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Todorova M, Larroque A, Dauphin Pierre S, Fang Y, Jean Claude B. Subcellular distribution of a fluorescence-labeled combi-molecule designed to block epidermal growth factor receptor tyrosine kinase and damage DNA with a green fluorescent species. Mol Cancer Ther. 2010;9:869-82 pubmed 出版商
  • 免疫组化; 人类; 1:300
Kang C, Jang B, Kim D, Chung D, Kim Y, Jheon S, et al. The prognostic significance of ERCC1, BRCA1, XRCC1, and betaIII-tubulin expression in patients with non-small cell lung cancer treated by platinum- and taxane-based neoadjuvant chemotherapy and surgical resection. Lung Cancer. 2010;68:478-83 pubmed 出版商
  • 免疫印迹; 人类
Chou W, Wang H, Wong F, Ding S, Wu P, Shieh S, et al. Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair. EMBO J. 2008;27:3140-50 pubmed 出版商
  • 免疫细胞化学; 人类
Kulkarni A, McNeill D, Gleichmann M, Mattson M, Wilson D. XRCC1 protects against the lethality of induced oxidative DNA damage in nondividing neural cells. Nucleic Acids Res. 2008;36:5111-21 pubmed 出版商
  • 免疫印迹; 人类
Kuo C, Liu J, Shiah H, Ma L, Chang J. Tamoxifen accelerates proteasomal degradation of O6-methylguanine DNA methyltransferase in human cancer cells. Int J Cancer. 2007;121:2293-300 pubmed
  • 免疫印迹; 人类
Bekker Jensen S, Fugger K, Danielsen J, Gromova I, Sehested M, Celis J, et al. Human Xip1 (C2orf13) is a novel regulator of cellular responses to DNA strand breaks. J Biol Chem. 2007;282:19638-43 pubmed
  • 免疫细胞化学; 人类
Nakajima S, Lan L, Kanno S, Usami N, Kobayashi K, Mori M, et al. Replication-dependent and -independent responses of RAD18 to DNA damage in human cells. J Biol Chem. 2006;281:34687-95 pubmed
  • 免疫印迹; 人类; 1:150
Bu D, Tomlinson G, Lewis C, Zhang C, Kildebeck E, Euhus D. An intronic polymorphism associated with increased XRCC1 expression, reduced apoptosis and familial breast cancer. Breast Cancer Res Treat. 2006;99:257-65 pubmed
  • 免疫印迹; 人类
Wong H, Wilson D. XRCC1 and DNA polymerase beta interaction contributes to cellular alkylating-agent resistance and single-strand break repair. J Cell Biochem. 2005;95:794-804 pubmed
  • 免疫细胞化学; 人类; 1:500
  • 免疫印迹; 人类; 1:500
Takanami T, Nakamura J, Kubota Y, Horiuchi S. The Arg280His polymorphism in X-ray repair cross-complementing gene 1 impairs DNA repair ability. Mutat Res. 2005;582:135-45 pubmed
Cichocka M, Karlik A, Plewka P, Gawade K, St x119 pie x144 A, x15a wiergiel P, et al. The Novel Role of hnRNP UL1 in Human Cell Nucleoli. Int J Biol Sci. 2022;18:4809-4823 pubmed 出版商
Tsukada K, Matsumoto Y, Shimada M. Linker region is required for efficient nuclear localization of polynucleotide kinase phosphatase. PLoS ONE. 2020;15:e0239404 pubmed 出版商
Sengupta S, Wang H, Yang C, Szczesny B, Hegde M, Mitra S. Ligand-induced gene activation is associated with oxidative genome damage whose repair is required for transcription. Proc Natl Acad Sci U S A. 2020;117:22183-22192 pubmed 出版商
Lee K, Piett C, Andrews J, Mann E, Nagel Z, Gassman N. Defective base excision repair in the response to DNA damaging agents in triple negative breast cancer. PLoS ONE. 2019;14:e0223725 pubmed 出版商
Audebert M, Salles B, Calsou P. Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining. J Biol Chem. 2004;279:55117-26 pubmed
Lan L, Nakajima S, Oohata Y, Takao M, Okano S, Masutani M, et al. In situ analysis of repair processes for oxidative DNA damage in mammalian cells. Proc Natl Acad Sci U S A. 2004;101:13738-43 pubmed
Park S, Lam W, Cheng Y. X-ray repair cross-complementing gene I protein plays an important role in camptothecin resistance. Cancer Res. 2002;62:459-65 pubmed
Martinet W, Knaapen M, De Meyer G, Herman A, Kockx M. Oxidative DNA damage and repair in experimental atherosclerosis are reversed by dietary lipid lowering. Circ Res. 2001;88:733-9 pubmed
产品信息
产品类型 :
抗体
产品名称 :
XRCC1单克隆抗体(33-2-5)
目录# :
MA5-13412
规格 :
500微升
价格 :
美国450.00
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
小鼠
反应物种 :
人类, 大鼠
应用 :
Immunohistochemistry (Paraffin): 1-2 µg/mL, Immunoprecipitation: 2 µg/mL, Western Blot: 1-2 µg/mL
物种 :
人类, 大鼠
克隆 :
33-2-5
抗体亚型 :
IgG2b
储存 :
4° C
描述 :
XRCC1 (X-ray cross complementing factor-1) is involved in DNA base excision repair. XRCC1 is a 70 kDa protein that has been shown to be physically associated with other DNA repair enzymes, including poly (ADP-ribose) polymerase (PARP), DNA Ligase III and DNA polymerase beta. XRCC1 contains a BRCT domain (for BRCA1 carboxyl terminus) which was originally found in the tumor suppressor protein BRCA1. Recently, the BRCT domain has been shown to mediate the protein-protein interaction of XRCC1 and DNA ligase III-alpha.
免疫原 :
重组人类XRCC1蛋白
格式 :
液体
应用w/稀释 :
Immunohistochemistry (Paraffin): 1-2 µg/mL, Immunoprecipitation: 2 µg/mL, Western Blot: 1-2 µg/mL
别名 :
DNA repair protein XRCC1; RCC; X-ray repair complementing defective repair in Chinese hamster cells 1; X-ray repair cross complementing 1; x-ray repair cross-complementing group 1 protein; X-ray repair cross-complementing protein 1; XRCC1; Xrcc-1
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国