产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
胸苷酸合成酶单克隆抗体(TS 106)
目录 :
MA5-13512
规格 :
500微升
价格 :
美国395.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
TS 106
反应物种 :
人类
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫细胞化学, 免疫沉淀, 流式细胞仪
更多信息或购买 :
文章摘录数: 27
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Cardona A, Rojas L, Wills B, Arrieta O, Carranza H, Vargas C, et al. Pemetrexed/Carboplatin/Bevacizumab followed by Maintenance Pemetrexed/Bevacizumab in Hispanic Patients with Non-Squamous Non-Small Cell Lung Cancer: Outcomes according to Thymidylate Synthase Expression. PLoS ONE. 2016;11:e0154293 pubmed 出版商
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Lee S, Park Y, Kim K, Cho E, Ahn Y, Kim K, et al. Thymidine synthase, thymidine phosphorylase, and excision repair cross-complementation group 1 expression as predictive markers of capecitabine plus cisplatin chemotherapy as first-line treatment for patients with advanced oesophageal squamous cell c. Br J Cancer. 2010;103:845-51 pubmed 出版商
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Righi L, Papotti M, Ceppi P, Billè A, Bacillo E, Molinaro L, et al. Thymidylate synthase but not excision repair cross-complementation group 1 tumor expression predicts outcome in patients with malignant pleural mesothelioma treated with pemetrexed-based chemotherapy. J Clin Oncol. 2010;28:1534-9 pubmed 出版商
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Kim M, Cho K, Kwon G, Park S, Kim Y, Kim J, et al. ERCC1 predicting chemoradiation resistance and poor outcome in oesophageal cancer. Eur J Cancer. 2008;44:54-60 pubmed
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Bendardaf R, Lamlum H, Ristamaki R, Korkeila E, Syrjanen K, Pyrhonen S. Thymidylate synthase and microsatellite instability in colorectal cancer: implications for disease free survival, treatment response and survival with metastases. Acta Oncol. 2008;47:1046-53 pubmed
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Bodmer N, Walters D, Fuchs B. Pemetrexed, a multitargeted antifolate drug, demonstrates lower efficacy in comparison to methotrexate against osteosarcoma cell lines. Pediatr Blood Cancer. 2008;50:905-8 pubmed
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Grunda J, Nabors L, Palmer C, Chhieng D, Steg A, Mikkelsen T, et al. Increased expression of thymidylate synthetase (TS), ubiquitin specific protease 10 (USP10) and survivin is associated with poor survival in glioblastoma multiforme (GBM). J Neurooncol. 2006;80:261-74 pubmed
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Correale P, Del Vecchio M, Di Genova G, Savellini G, La Placa M, Terrosi C, et al. 5-fluorouracil-based chemotherapy enhances the antitumor activity of a thymidylate synthase-directed polyepitopic peptide vaccine. J Natl Cancer Inst. 2005;97:1437-45 pubmed
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Shebzukhov Y, Koroleva E, Khlgatian S, Lagarkova M, Meshcheryakov A, Lichinitser M, et al. Humoral immune response to thymidylate synthase in colon cancer patients after 5-FU chemotherapy. Immunol Lett. 2005;100:88-93 pubmed
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Ricciardiello L, Ceccarelli C, Angiolini G, Pariali M, Chieco P, Paterini P, et al. High thymidylate synthase expression in colorectal cancer with microsatellite instability: implications for chemotherapeutic strategies. Clin Cancer Res. 2005;11:4234-40 pubmed
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Jin J, Huang M, Wei H, Liu G. Mechanism of 5-fluorouracil required resistance in human hepatocellular carcinoma cell line Bel(7402). World J Gastroenterol. 2002;8:1029-34 pubmed
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Nanni O, Volpi A, Frassineti G, De Paola F, Granato A, Dubini A, et al. Role of biological markers in the clinical outcome of colon cancer. Br J Cancer. 2002;87:868-75 pubmed
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Gribaudo G, Riera L, Lembo D, De Andrea M, Johnson L, Landolfo S. The anticytomegaloviral activity of raltitrexed is abrogated in quiescent mouse fibroblasts that overexpress thymidylate synthase. Virus Res. 2001;73:57-65 pubmed
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产品信息
产品类型 :
抗体
产品名称 :
胸苷酸合成酶单克隆抗体(TS 106)
目录# :
MA5-13512
规格 :
500微升
价格 :
美国395.00
克隆性 :
单克隆
纯度 :
蛋白质G
宿主 :
小鼠
反应物种 :
人类
应用 :
ELISA: Assay-dependent, Flow Cytometry: Assay-dependent, Immunocytochemistry: Assay-dependent, Immunoprecipitation: 2 µg/mL, Western Blot: 1-2 µg/mL
物种 :
人类
克隆 :
TS 106
抗体亚型 :
IgG1, kappa
储存 :
4° C
描述 :
Thymidylate Synthase (TS) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
免疫原 :
重组人类TS酶
格式 :
液体
应用w/稀释 :
ELISA: Assay-dependent, Flow Cytometry: Assay-dependent, Immunocytochemistry: Assay-dependent, Immunoprecipitation: 2 µg/mL, Western Blot: 1-2 µg/mL
别名 :
HST422; MGC88736; OK/SW-cl.29; Thymidylate synthase; thymidylate synthetase; TMS; TS; Tsase; Tyms; tysy
更多信息或购买 :
公司信息
赛默飞世尔