产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
胸苷酸合成酶单克隆抗体(TS 106)
目录 :
MA5-13512
规格 :
500微升
价格 :
美国436.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
TS 106
反应物种 :
人类
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫细胞化学, 免疫沉淀, 流式细胞仪
更多信息或购买 :
文章摘录数: 27
参考文献
Cardona A, Rojas L, Wills B, Arrieta O, Carranza H, Vargas C, et al. Pemetrexed/Carboplatin/Bevacizumab followed by Maintenance Pemetrexed/Bevacizumab in Hispanic Patients with Non-Squamous Non-Small Cell Lung Cancer: Outcomes according to Thymidylate Synthase Expression. PLoS ONE. 2016;11:e0154293 pubmed 出版商
Kim J, Shin E, Kim J, Lee H, Lee D, Kim S, et al. Impact of intratumoral expression levels of fluoropyrimidine-metabolizing enzymes on treatment outcomes of adjuvant S-1 therapy in gastric cancer. PLoS ONE. 2015;10:e0120324 pubmed 出版商
Miura J, Johnston F, Thomas J, George B, Eastwood D, Tsai S, et al. Molecular profiling in gastric cancer: examining potential targets for chemotherapy. J Surg Oncol. 2014;110:302-6 pubmed 出版商
Lustgarten D, Deshpande C, Aggarwal C, Wang L, Saloura V, Vachani A, et al. Thymidylate synthase and folyl-polyglutamate synthase are not clinically useful markers of response to pemetrexed in patients with malignant pleural mesothelioma. J Thorac Oncol. 2013;8:469-77 pubmed 出版商
Garg D, Beribisky A, Ponterini G, Ligabue A, Marverti G, Martello A, et al. Translational repression of thymidylate synthase by targeting its mRNA. Nucleic Acids Res. 2013;41:4159-70 pubmed 出版商
Kao S, Lee K, Klebe S, Henderson D, McCaughan B, Vardy J, et al. Excision repair cross complementation group 1 and thymidylate synthase expression in patients with mesothelioma. Clin Lung Cancer. 2013;14:164-71 pubmed 出版商
Giudice S, Benassi L, Bertazzoni G, Veratti E, Morini D, Azzoni P, et al. Biological evaluation of MR36, a novel non-polyglutamatable thymidylate synthase inhibitor that blocks cell cycle progression in melanoma cell lines. Invest New Drugs. 2012;30:1484-92 pubmed 出版商
Lee S, Choi Y, Park Y, Kim S, Cho E, Ahn J, et al. Thymidylate synthase and thymidine phosphorylase as predictive markers of capecitabine monotherapy in patients with anthracycline- and taxane-pretreated metastatic breast cancer. Cancer Chemother Pharmacol. 2011;68:743-51 pubmed 出版商
Lee S, Park Y, Kim K, Cho E, Ahn Y, Kim K, et al. Thymidine synthase, thymidine phosphorylase, and excision repair cross-complementation group 1 expression as predictive markers of capecitabine plus cisplatin chemotherapy as first-line treatment for patients with advanced oesophageal squamous cell c. Br J Cancer. 2010;103:845-51 pubmed 出版商
Jeong S, Han J, Kim J, Ahn M, Hwang Y, Lee H, et al. Bax predicts outcome in gastric cancer patients treated with 5-fluorouracil, leucovorin, and oxaliplatin palliative chemotherapy. Dig Dis Sci. 2011;56:131-8 pubmed 出版商
Righi L, Papotti M, Ceppi P, Billè A, Bacillo E, Molinaro L, et al. Thymidylate synthase but not excision repair cross-complementation group 1 tumor expression predicts outcome in patients with malignant pleural mesothelioma treated with pemetrexed-based chemotherapy. J Clin Oncol. 2010;28:1534-9 pubmed 出版商
Kostopoulos I, Karavasilis V, Karina M, Bobos M, Xiros N, Pentheroudakis G, et al. Topoisomerase I but not thymidylate synthase is associated with improved outcome in patients with resected colorectal cancer treated with irinotecan containing adjuvant chemotherapy. BMC Cancer. 2009;9:339 pubmed 出版商
Han S, Oh D, Im S, Park S, Lee K, Song H, et al. Phase II study and biomarker analysis of cetuximab combined with modified FOLFOX6 in advanced gastric cancer. Br J Cancer. 2009;100:298-304 pubmed 出版商
Keam B, Im S, Han S, Ham H, Kim M, Oh D, et al. Modified FOLFOX-6 chemotherapy in advanced gastric cancer: Results of phase II study and comprehensive analysis of polymorphisms as a predictive and prognostic marker. BMC Cancer. 2008;8:148 pubmed 出版商
Correale P, Del Vecchio M, La Placa M, Montagnani F, Di Genova G, Savellini G, et al. Chemotherapeutic drugs may be used to enhance the killing efficacy of human tumor antigen peptide-specific CTLs. J Immunother. 2008;31:132-47 pubmed 出版商
Zheng Z, Li X, Schell M, Chen T, Boulware D, Robinson L, et al. Thymidylate synthase in situ protein expression and survival in stage I nonsmall-cell lung cancer. Cancer. 2008;112:2765-73 pubmed 出版商
Di Costanzo F, Gasperoni S, Manzione L, Bisagni G, Labianca R, Bravi S, et al. Adjuvant chemotherapy in completely resected gastric cancer: a randomized phase III trial conducted by GOIRC. J Natl Cancer Inst. 2008;100:388-98 pubmed 出版商
Kim M, Cho K, Kwon G, Park S, Kim Y, Kim J, et al. ERCC1 predicting chemoradiation resistance and poor outcome in oesophageal cancer. Eur J Cancer. 2008;44:54-60 pubmed
Bendardaf R, Lamlum H, Ristamaki R, Korkeila E, Syrjanen K, Pyrhonen S. Thymidylate synthase and microsatellite instability in colorectal cancer: implications for disease free survival, treatment response and survival with metastases. Acta Oncol. 2008;47:1046-53 pubmed
Bodmer N, Walters D, Fuchs B. Pemetrexed, a multitargeted antifolate drug, demonstrates lower efficacy in comparison to methotrexate against osteosarcoma cell lines. Pediatr Blood Cancer. 2008;50:905-8 pubmed
Grunda J, Nabors L, Palmer C, Chhieng D, Steg A, Mikkelsen T, et al. Increased expression of thymidylate synthetase (TS), ubiquitin specific protease 10 (USP10) and survivin is associated with poor survival in glioblastoma multiforme (GBM). J Neurooncol. 2006;80:261-74 pubmed
Correale P, Del Vecchio M, Di Genova G, Savellini G, La Placa M, Terrosi C, et al. 5-fluorouracil-based chemotherapy enhances the antitumor activity of a thymidylate synthase-directed polyepitopic peptide vaccine. J Natl Cancer Inst. 2005;97:1437-45 pubmed
Shebzukhov Y, Koroleva E, Khlgatian S, Lagarkova M, Meshcheryakov A, Lichinitser M, et al. Humoral immune response to thymidylate synthase in colon cancer patients after 5-FU chemotherapy. Immunol Lett. 2005;100:88-93 pubmed
Ricciardiello L, Ceccarelli C, Angiolini G, Pariali M, Chieco P, Paterini P, et al. High thymidylate synthase expression in colorectal cancer with microsatellite instability: implications for chemotherapeutic strategies. Clin Cancer Res. 2005;11:4234-40 pubmed
Jin J, Huang M, Wei H, Liu G. Mechanism of 5-fluorouracil required resistance in human hepatocellular carcinoma cell line Bel(7402). World J Gastroenterol. 2002;8:1029-34 pubmed
Nanni O, Volpi A, Frassineti G, De Paola F, Granato A, Dubini A, et al. Role of biological markers in the clinical outcome of colon cancer. Br J Cancer. 2002;87:868-75 pubmed
Gribaudo G, Riera L, Lembo D, De Andrea M, Johnson L, Landolfo S. The anticytomegaloviral activity of raltitrexed is abrogated in quiescent mouse fibroblasts that overexpress thymidylate synthase. Virus Res. 2001;73:57-65 pubmed
产品信息
产品类型 :
抗体
产品名称 :
胸苷酸合成酶单克隆抗体(TS 106)
目录# :
MA5-13512
规格 :
500微升
价格 :
美国436.00
克隆性 :
单克隆
纯度 :
蛋白质G
宿主 :
小鼠
反应物种 :
人类
应用 :
ELISA: Assay-dependent, Flow Cytometry: Assay-dependent, Immunocytochemistry: Assay-dependent, Immunoprecipitation: 2 µg/mL, Western Blot: 1-2 µg/mL
物种 :
人类
克隆 :
TS 106
抗体亚型 :
IgG1, kappa
储存 :
4° C
描述 :
Thymidylate Synthase (TS) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
免疫原 :
重组人类TS酶
格式 :
液体
应用w/稀释 :
ELISA: Assay-dependent, Flow Cytometry: Assay-dependent, Immunocytochemistry: Assay-dependent, Immunoprecipitation: 2 µg/mL, Western Blot: 1-2 µg/mL
别名 :
HST422; MGC88736; OK/SW-cl.29; Thymidylate synthase; thymidylate synthetase; TMS; TS; Tsase; Tyms; tysy
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国