产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
MMP2单克隆抗体(CA-4001(CA719E3C))
目录 :
MA5-13590
规格 :
500微升
价格 :
美国450.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
CA-4001(CA719E3C)
反应物种 :
人类, 小鼠, 大鼠, 鸡
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片, 抑制或激活实验
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 37
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 图 4b
Yi R, Zhang J, Sun P, Qian Y, Zhao X. Protective Effects of Kuding Tea (Ilex kudingcha C. J. Tseng) Polyphenols on UVB-Induced Skin Aging in SKH1 Hairless Mice. Molecules. 2019;24: pubmed 出版商
  • 免疫组化; 人类; 1:50
Guan H, Tan J, Zhang F, Gao L, Bai L, Qi D, et al. Myofibroblasts from salivary gland adenoid cystic carcinomas promote cancer invasion by expressing MMP2 and CXCL12. Histopathology. 2015;66:781-90 pubmed 出版商
  • 免疫组化; 人类; 0.3:250
Costescu M, Coman O, Tampa M, Tudose I, Coman L, Georgescu S. Axillary basal cell carcinoma--a rare form of a frequent kind of carcinoma. Rom J Morphol Embryol. 2013;54:851-6 pubmed
  • 免疫组化; 鸡
Sevimli A, Yagci A, Bulbul A. Matrix metalloproteinase, vitamin A and methylprednisolone effects on experimentally induced amyloid arthropathy. Biotech Histochem. 2013;88:336-44 pubmed 出版商
  • 免疫组化; 人类
Puff C, Risha E, Baumgartner W. Regression of canine cutaneous histiocytoma is associated with an orchestrated expression of matrix metalloproteinases. J Comp Pathol. 2013;149:208-15 pubmed 出版商
  • 免疫组化; 人类; 1:250
Beltran E, Matiasek K, De Risio L, De Stefani A, Feliu Pascual A, Matiasek L. Expression of MMP-2 and MMP-9 in benign canine rostrotentorial meningiomas is not correlated to the extent of peritumoral edema. Vet Pathol. 2013;50:1091-8 pubmed 出版商
  • 免疫印迹; 小鼠
Guo L, Chen C, Shi M, Wang F, Chen X, Diao D, et al. Stat3-coordinated Lin-28-let-7-HMGA2 and miR-200-ZEB1 circuits initiate and maintain oncostatin M-driven epithelial-mesenchymal transition. Oncogene. 2013;32:5272-82 pubmed 出版商
  • 免疫印迹; 小鼠; 5 ug/ml
Barczyk M, Lu N, Popova S, Bolstad A, Gullberg D. ?11?1 integrin-mediated MMP-13-dependent collagen lattice contraction by fibroblasts: evidence for integrin-coordinated collagen proteolysis. J Cell Physiol. 2013;228:1108-19 pubmed 出版商
  • 免疫组化; 人类
Kim J, Kim H, Koo B, Rha K, Yoon Y. Expression of matrix metalloproteinase-12 is correlated with extracapsular spread of tumor from nodes with metastasis in head and neck squamous cell carcinoma. Eur Arch Otorhinolaryngol. 2013;270:1137-42 pubmed 出版商
  • 抑制或激活实验; 人类; 4 ug/ml
Yamamoto N, Bryce N, Metzler Nolte N, Hambley T. Effects of enzymatic activation on the distribution of fluorescently tagged MMP-2 cleavable peptides in cancer cells and spheroids. Bioconjug Chem. 2012;23:1110-8 pubmed 出版商
  • 免疫组化; 大鼠; 1:100
Ma J, Mercer R, Barger M, Schwegler Berry D, Scabilloni J, MA J, et al. Induction of pulmonary fibrosis by cerium oxide nanoparticles. Toxicol Appl Pharmacol. 2012;262:255-64 pubmed 出版商
  • 免疫组化; 人类; 1:25
Omran O, Thabet M. Gelatinases A and B expression in human colorectal cancer in upper Egypt: a clinicopathological study. Ultrastruct Pathol. 2012;36:108-16 pubmed 出版商
  • 免疫印迹; 大鼠
Sun M, Chen K, Tsao Y, Kao L, Han W, Lin K, et al. Down-regulation of matrix metalloproteinase-9 by pyrrolidine dithiocarbamate prevented retinal ganglion cell death after transection of optic nerve in rats. Curr Eye Res. 2011;36:1053-63 pubmed 出版商
  • 免疫组化; 人类; 1:100
Mallis A, Teymoortash A, Mastronikolis N, Werner J, Papadas T. MMP-2 expression in 102 patients with glottic laryngeal cancer. Eur Arch Otorhinolaryngol. 2012;269:639-42 pubmed 出版商
  • 免疫组化; 大鼠; 1:100
Ucar E, Borazan A, Semerci E, Binici D, Yaldiz M, Aysal A, et al. The effects of interferon alpha2b on chemically-induced peritoneal fibrosis and on peritoneal tissue MMP-2 and TIMP-2 levels in rats. J Int Med Res. 2010;38:187-94 pubmed
  • 免疫印迹; 小鼠; 图 3a
Seo J, Kim T, Leem Y, Lee K, Park S, Baek I, et al. SK-PC-B70M confers anti-oxidant activity and reduces Abeta levels in the brain of Tg2576 mice. Brain Res. 2009;1261:100-8 pubmed 出版商
  • 免疫印迹; 人类; 1:400
He Q, Pang R, Song X, Chen J, Chen H, Chen B, et al. Rosiglitazone Suppresses the Growth and Invasiveness of SGC-7901 Gastric Cancer Cells and Angiogenesis In Vitro via PPARgamma Dependent and Independent Mechanisms. PPAR Res. 2008;2008:649808 pubmed 出版商
  • 免疫细胞化学; 人类; 1:50
Ullmann U, Gilles C, De Rycke M, Van de Velde H, Sermon K, Liebaers I. GSK-3-specific inhibitor-supplemented hESC medium prevents the epithelial-mesenchymal transition process and the up-regulation of matrix metalloproteinases in hESCs cultured in feeder-free conditions. Mol Hum Reprod. 2008;14:169-79 pubmed 出版商
  • 免疫印迹; 人类; 1:500
Ou D, Tao Y, Tang F, Yang L. The hepatitis B virus X protein promotes hepatocellular carcinoma metastasis by upregulation of matrix metalloproteinases. Int J Cancer. 2007;120:1208-14 pubmed
  • 抑制或激活实验; 鸡
Linask K, Han M, Cai D, Brauer P, Maisastry S. Cardiac morphogenesis: matrix metalloproteinase coordination of cellular mechanisms underlying heart tube formation and directionality of looping. Dev Dyn. 2005;233:739-53 pubmed
  • 免疫组化; 大鼠; 1:100
Scabilloni J, Wang L, Antonini J, Roberts J, Castranova V, Mercer R. Matrix metalloproteinase induction in fibrosis and fibrotic nodule formation due to silica inhalation. Am J Physiol Lung Cell Mol Physiol. 2005;288:L709-17 pubmed
Abdelkader N, Elbaset M, Moustafa P, Ibrahim S. Empagliflozin mitigates type 2 diabetes-associated peripheral neuropathy: a glucose-independent effect through AMPK signaling. Arch Pharm Res. 2022;45:475-493 pubmed 出版商
Karagülle O, Yurttas A. Ozone combined with doxorubicin exerts cytotoxic and anticancer effects on Luminal-A subtype human breast cancer cell line. Rev Assoc Med Bras (1992). 2022;68:507-513 pubmed 出版商
Wang L, Zhang Z, Wang L, Wei H, Zhang T, Zhang L, et al. TGF-β1/SH2B3 axis regulates anoikis resistance and EMT of lung cancer cells by modulating JAK2/STAT3 and SHP2/Grb2 signaling pathways. Cell Death Dis. 2022;13:472 pubmed 出版商
Gajda Morszewski P, Gurgul I, Janczy Cempa E, Mazuryk O, x141 omzik M, Brindell M. Inhibition of Matrix Metalloproteinases and Cancer Cell Detachment by Ru(II) Polypyridyl Complexes Containing 4,7-Diphenyl-1,10-phenanthroline Ligands-New Candidates for Antimetastatic Agents. Pharmaceuticals (Basel). 2021;14: pubmed 出版商
Huang S, Sulistyowati E, Chao Y, Wu B, Dai Z, Hsu J, et al. In Vitro Evaluation of the Anti-Inflammatory Effect of KMUP-1 and In Vivo Analysis of Its Therapeutic Potential in Osteoarthritis. Biomedicines. 2021;9: pubmed 出版商
Custers L, Khabirova E, Coorens T, Oliver T, Calandrini C, Young M, et al. Somatic mutations and single-cell transcriptomes reveal the root of malignant rhabdoid tumours. Nat Commun. 2021;12:1407 pubmed 出版商
Celentano A, Yap T, Paolini R, Yiannis C, Mirams M, Koo K, et al. Inhibition of matrix metalloproteinase-2 modulates malignant behaviour of oral squamous cell carcinoma cells. J Oral Pathol Med. 2021;50:323-332 pubmed 出版商
Rhee H, Han M, Kim S, Kim I, Lee H, Bae S, et al. The expression of two isoforms of matrix metalloproteinase-2 in aged mouse models of diabetes mellitus and chronic kidney disease. Kidney Res Clin Pract. 2018;37:222-229 pubmed 出版商
Pellikainen J, Ropponen K, Kataja V, Kellokoski J, Eskelinen M, Kosma V. Expression of matrix metalloproteinase (MMP)-2 and MMP-9 in breast cancer with a special reference to activator protein-2, HER2, and prognosis. Clin Cancer Res. 2004;10:7621-8 pubmed
Andersen T, del Carmen Ovejero M, Kirkegaard T, Lenhard T, Foged N, Delaisse J. A scrutiny of matrix metalloproteinases in osteoclasts: evidence for heterogeneity and for the presence of MMPs synthesized by other cells. Bone. 2004;35:1107-19 pubmed
Gaiotto M, Focchi J, Ribalta J, Stavale J, Baracat E, Lima G, et al. Comparative study of MMP-2 (matrix metalloproteinase 2) immune expression in normal uterine cervix, intraepithelial neoplasias, and squamous cells cervical carcinoma. Am J Obstet Gynecol. 2004;190:1278-82 pubmed
Bovo A, da Silva I, Takita L, Fochi J, Stavale J, Marks G, et al. A comparative study of MMP-2 in vulvar neoplasms. Gynecol Oncol. 2004;93:454-7 pubmed
Kirkegaard T, Hansen A, Bruun E, Brynskov J. Expression and localisation of matrix metalloproteinases and their natural inhibitors in fistulae of patients with Crohn's disease. Gut. 2004;53:701-9 pubmed
Alami J, Williams B, Yeger H. Derivation and characterization of a Wilms' tumour cell line, WiT 49. Int J Cancer. 2003;107:365-74 pubmed
Miao Q, Baumgartner W, Failing K, Alldinger S. Phase-dependent expression of matrix metalloproteinases and their inhibitors in demyelinating canine distemper encephalitis. Acta Neuropathol. 2003;106:486-94 pubmed
Ratzinger G, Stoitzner P, Ebner S, Lutz M, Layton G, Rainer C, et al. Matrix metalloproteinases 9 and 2 are necessary for the migration of Langerhans cells and dermal dendritic cells from human and murine skin. J Immunol. 2002;168:4361-71 pubmed
图像
图像 1 :
赛默飞世尔 MA5-13590 图像 1
产品信息
产品类型 :
抗体
产品名称 :
MMP2单克隆抗体(CA-4001(CA719E3C))
目录# :
MA5-13590
规格 :
500微升
价格 :
美国450.00
克隆性 :
单克隆
纯度 :
蛋白质G
宿主 :
小鼠
反应物种 :
人类, 小鼠, 大鼠
应用 :
Immunohistochemistry (Paraffin): Assay-dependent, Inhibition Assays: 2-4 µg/mL, Western Blot: 0.5-1.0 µg/mL
物种 :
人类, 小鼠, 大鼠
克隆 :
CA-4001(CA719E3C)
抗体亚型 :
IgG1
储存 :
4° C
描述 :
MMP (matrix metalloproteinase) are proteolytic enzymes capable of degrading connective tissue components. MMP have a common mode of activation, a conserved amino acid sequence in the putative metal binding-active site region, and are inhibited by specific tissue inhibitors of metalloproteinases (TIMPs). MMPa and TIMPs play a significant role in regulating angiogenesis. MMP2 is synthesized as a 631 amino acid proenzyme which is activated by cleavage of the first 80 amino acids, and contains the basic structure of propeptide, catalytic, and hemopexin domains. The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane-bound zincendopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non-fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. In general, a signal peptide, a propeptide, and a catalytic domain containing the highly conserved zinc-binding site characterizes the structure of the MMPs. Functionally, MMP2 is involved in tissue remodeling. Mutations in MMP-2 gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms of MMP-2 have been found.
免疫原 :
N-terminal peptide APSPIIKFPGD-VAPKTDK of procollagenase IV
格式 :
液体
应用w/稀释 :
Immunohistochemistry (Paraffin): Assay-dependent, Inhibition Assays: 2-4 µg/mL, Western Blot: 0.5-1.0 µg/mL
别名 :
72 kDa gelatinase; 72 kDa type IV collagenase; 72 kDa type IV collagenase isoform a preproprotein; 72kD gelatinase; 72kD type IV collagenase; 72kDa gelatinase; 72kDa type IV collagenase; CLG 4A; CLG4; CLG4A; Collagenase; collagenase type IV-A; endopeptidase; GelA; gelatinase A; Gelatinase alpha; Mat; matrix metallo protease; matrix metallopeptidase 2; matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); matrix metalloprotease 2; matrix metalloproteinase; matrix metalloproteinase 2; matrix metalloproteinase 2 (72 KDa type IV collagenase); matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); matrix metalloproteinase-2; matrix metalloproteinase-II; MMP; MMP2; MMP-2; MMP-2 protein; MMP-II; MMPs; MONA; neutrophil gelatinase; PEX; prepro-72kDa matrix metalloproteinase; Progelatinase A; TBE1; TBE-1; wu:fa99h12; wu:fk89d01
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国