产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
胰岛素样生长因子1受体甲单克隆抗体(24-57)
目录 :
MA5-13812
规格 :
500微升
价格 :
美国530
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
24-57
反应物种 :
人类, domestic rabbit
应用 :
免疫沉淀
更多信息或购买 :
文章摘录数: 2
参考文献
Beauvais D, Jung O, Yang Y, Sanderson R, Rapraeger A. Syndecan-1 (CD138) Suppresses Apoptosis in Multiple Myeloma by Activating IGF1 Receptor: Prevention by SynstatinIGF1R Inhibits Tumor Growth. Cancer Res. 2016;76:4981-93 pubmed 出版商
Calzone F, Cajulis E, Chung Y, Tsai M, Mitchell P, Lu J, et al. Epitope-specific mechanisms of IGF1R inhibition by ganitumab. PLoS ONE. 2013;8:e55135 pubmed 出版商
产品信息
产品类型 :
抗体
产品名称 :
胰岛素样生长因子1受体甲单克隆抗体(24-57)
目录# :
MA5-13812
规格 :
500微升
定价 :
美国530
克隆性 :
单克隆
纯度 :
蛋白质G
宿主 :
小鼠
反应物种 :
人类, 兔
应用 :
Immunoprecipitation: Assay-dependent, Inhibition Assays: 1.5 µg/mL
物种 :
人类, 兔
克隆 :
24-57
抗体亚型 :
IgG1, kappa
储存 :
4° C
描述 :
IGF1R (Insulin-like Growth Factor1 Receptor) is a receptor tyrosine kinase that mediates actions of insulin-like growth factor 1 (IFG1). It binds IGF1 with high affinity and IGF2/insulin with lower affinity. Activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survial of malignant cells. Ligand binding activates the receptor kinase and leads to receptor autophosphorylation and tyrosines phosphorylation of multiple substrates that function as signaling adapter proteins.
免疫原 :
IGF-1R/3T3 mouse fibroblasts transfected with human type I IGF-receptor cDNA
格式 :
液体
应用w/稀释 :
Immunoprecipitation: Assay-dependent, Inhibition Assays: 1.5 µg/mL
别名 :
A330103N21Rik; CD221; D930020L01; hyft; IGF-1 receptor; Igf1r; IGF-1R; IGF-I receptor; IGFIR; IGFIRC; IGFR; Igfr1; insulin like growth factor 1 receptor; insulin-like growth factor 1 receptor; Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain; insulin-like growth factor 1 receptor beta subunit; insulin-like growth factor I receptor; insulin-like growth factor receptor 1; insulin-like growth factor-I receptor; insulin-like growth factor-I receptor precursor; JTK13; line 186; soluble IGF1R variant 1; soluble IGF1R variant 2
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国