产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
B细胞淋巴瘤2相关的X蛋白单克隆抗体(6A7)
目录 :
MA5-14003
规格 :
500微升
价格 :
美国405.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
6A7
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 42
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 1:1000; 图 4d
Cho J, Lee J, Kim H, Lee H, Fang Z, Kwon H, et al. Ethyl Acetate Fraction of Amomum villosum var. xanthioides Attenuates Hepatic Endoplasmic Reticulum Stress-Induced Non-Alcoholic Steatohepatitis via Improvement of Antioxidant Capacities. Antioxidants (Basel). 2021;10: pubmed 出版商
  • 免疫组化; 人类; 1:500; 图 8e
  • 免疫印迹; 人类; 图 2d
Loureiro J, Raimundo L, Calheiros J, Carvalho C, Barcherini V, Lima N, et al. Targeting p53 for Melanoma Treatment: Counteracting Tumour Proliferation, Dissemination and Therapeutic Resistance. Cancers (Basel). 2021;13: pubmed 出版商
  • 流式细胞仪; 人类
Wang Y, Lv J, Cheng Y, DU J, Chen D, Li C, et al. Apoptosis induced by Ginkgo biloba (EGb761) in melanoma cells is Mcl-1-dependent. PLoS ONE. 2015;10:e0124812 pubmed 出版商
  • 免疫组化-石蜡切片; 大鼠; 1:50
Mohamed H, el Swefy S, Hasan R, HASAN A. Neuroprotective effect of resveratrol in diabetic cerebral ischemic-reperfused rats through regulation of inflammatory and apoptotic events. Diabetol Metab Syndr. 2014;6:88 pubmed 出版商
  • 免疫印迹; 大鼠
Xu H, Zhu G, Tian Y. Protective effects of trimetazidine on bone marrow mesenchymal stem cells viability in an ex vivo model of hypoxia and in vivo model of locally myocardial ischemia. J Huazhong Univ Sci Technolog Med Sci. 2012;32:36-41 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1500
Xinxing W, Hong F, Rui Z, Yun Z, Jingbo G, Lingjia Q. Phosphorylated nerve growth factor-induced clone B (NGFI-B) translocates from the nucleus to mitochondria of stressed rat cardiomyocytes and induces apoptosis. Stress. 2012;15:545-53 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000
Baquedano E, García Cáceres C, Diz Chaves Y, Lagunas N, Calmarza Font I, Azcoitia I, et al. Prenatal stress induces long-term effects in cell turnover in the hippocampus-hypothalamus-pituitary axis in adult male rats. PLoS ONE. 2011;6:e27549 pubmed 出版商
  • 免疫细胞化学; 人类; 1.6 ug/ml
Kim B, Hong S. Sequential caspase-2 and caspase-8 activation is essential for saikosaponin a-induced apoptosis of human colon carcinoma cell lines. Apoptosis. 2011;16:184-97 pubmed 出版商
  • 免疫印迹; 人类; 1.33 ug/ml
Kim B, Maeng K, Lee K, Hong S. Combined treatment with the Cox-2 inhibitor niflumic acid and PPAR? ligand ciglitazone induces ER stress/caspase-8-mediated apoptosis in human lung cancer cells. Cancer Lett. 2011;300:134-44 pubmed 出版商
  • 免疫印迹; 人类
Choi B, Lee C. Cell cycle arrest and cytochrome c-mediated apoptotic induction by MCS-5A is associated with up-regulation of p16(INK4a) in HL-60 cells. Bioorg Med Chem Lett. 2010;20:3880-4 pubmed 出版商
  • 免疫组化; 小鼠
Perumalsamy L, Nagala M, Sarin A. Notch-activated signaling cascade interacts with mitochondrial remodeling proteins to regulate cell survival. Proc Natl Acad Sci U S A. 2010;107:6882-7 pubmed 出版商
  • 免疫组化; 大鼠; 1:100
Giris M, Erbil Y, Depboylu B, Mete O, Turkoglu U, Abbasoglu S, et al. Heme oxygenase-1 prevents hyperthyroidism induced hepatic damage via an antioxidant and antiapoptotic pathway. J Surg Res. 2010;164:266-75 pubmed 出版商
  • 免疫细胞化学; 大鼠; 1:500
  • 免疫印迹; 大鼠; 1:1000
Delgado Rubín A, Chowen J, Argente J, Frago L. Growth hormone-releasing peptide 6 protection of hypothalamic neurons from glutamate excitotoxicity is caspase independent and not mediated by insulin-like growth factor I. Eur J Neurosci. 2009;29:2115-24 pubmed 出版商
  • 免疫沉淀; 人类
Kim B, Choi Y, Han Y, Yun Y, Hong S. N,N-dimethyl phytosphingosine induces caspase-8-dependent cytochrome c release and apoptosis through ROS generation in human leukemia cells. Toxicol Appl Pharmacol. 2009;239:87-97 pubmed 出版商
  • 免疫组化; 大鼠; 1:500
  • 免疫印迹; 大鼠; 1:5000
García Cáceres C, Lechuga Sancho A, Argente J, Frago L, Chowen J. Death of hypothalamic astrocytes in poorly controlled diabetic rats is associated with nuclear translocation of apoptosis inducing factor. J Neuroendocrinol. 2008;20:1348-60 pubmed 出版商
  • 免疫印迹; 人类; 1.6 ug/ml
Kim B, Chung H. Desferrioxamine (DFX) induces apoptosis through the p38-caspase8-Bid-Bax pathway in PHA-stimulated human lymphocytes. Toxicol Appl Pharmacol. 2008;228:24-31 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:50; 图 2A
Takei H, Buckleair L, Powell S. Immunohistochemical expression of apoptosis regulating proteins and sex hormone receptors in meningiomas. Neuropathology. 2008;28:62-8 pubmed
  • 免疫组化; 大鼠
  • 免疫印迹; 大鼠
Chen X, Chen Y, Bi Y, Fu N, Shan C, Wang S, et al. Preventive cardioprotection of erythropoietin against doxorubicin-induced cardiomyopathy. Cardiovasc Drugs Ther. 2007;21:367-74 pubmed
  • 免疫印迹; 人类
Kim B, Chung H. Hypoxia/reoxygenation induces apoptosis through a ROS-mediated caspase-8/Bid/Bax pathway in human lymphocytes. Biochem Biophys Res Commun. 2007;363:745-50 pubmed
  • 免疫细胞化学; 人类
Parikh N, Koshy C, Dhayabaran V, Perumalsamy L, Sowdhamini R, Sarin A. The N-terminus and alpha-5, alpha-6 helices of the pro-apoptotic protein Bax, modulate functional interactions with the anti-apoptotic protein Bcl-xL. BMC Cell Biol. 2007;8:16 pubmed
  • 免疫印迹; 小鼠; 1:1000
Ray S, Chatterjee A. Influence of glutathione on the induction of chromosome aberrations, delay in cell cycle kinetics and cell cycle regulator proteins in irradiated mouse bone marrow cells. Int J Radiat Biol. 2007;83:347-54 pubmed
  • 免疫细胞化学; 大鼠; 1:100
Chai Y, Niu L, Sun X, Ding J, Hu G. Iptakalim protects PC12 cell against H2O2-induced oxidative injury via opening mitochondrial ATP-sensitive potassium channel. Biochem Biophys Res Commun. 2006;350:307-14 pubmed
Chen J, Xu Q, Zhang W, Zhen Y, Cheng F, Hua G, et al. MiR-203-3p inhibits the oxidative stress, inflammatory responses and apoptosis of mice podocytes induced by high glucose through regulating Sema3A expression. Open Life Sci. 2020;15:939-950 pubmed 出版商
Chong S, Iskandar K, Lai J, Qu J, Raman D, Valentin R, et al. Serine-70 phosphorylated Bcl-2 prevents oxidative stress-induced DNA damage by modulating the mitochondrial redox metabolism. Nucleic Acids Res. 2020;48:12727-12745 pubmed 出版商
Jabeen A, Sharma A, Gupta I, Kheraldine H, Vranic S, Al Moustafa A, et al. Elaeagnus angustifolia Plant Extract Inhibits Epithelial-Mesenchymal Transition and Induces Apoptosis via HER2 Inactivation and JNK Pathway in HER2-Positive Breast Cancer Cells. Molecules. 2020;25: pubmed 出版商
Ullah M, Liu D, Rai S, Razavi M, Concepcion W, Thakor A. Pulsed focused ultrasound enhances the therapeutic effect of mesenchymal stromal cell-derived extracellular vesicles in acute kidney injury. Stem Cell Res Ther. 2020;11:398 pubmed 出版商
Mai N, Yamaguchi Y, Choijookhuu N, Matsumoto J, Nanashima A, Takagi H, et al. Photodynamic Therapy Using a Novel Phosphorus Tetraphenylporphyrin Induces an Anticancer Effect via Bax/Bcl-xL-related Mitochondrial Apoptosis in Biliary Cancer Cells. Acta Histochem Cytochem. 2020;53:61-72 pubmed 出版商
Lin V, Hu J, Zolekar A, Yan L, Wang Y. Urine Sample-Derived Cerebral Organoids Suitable for Studying Neurodevelopment and Pharmacological Responses. Front Cell Dev Biol. 2020;8:304 pubmed 出版商
Huang H, Tian X, Peng X, Huang L, Mei L, Zhan Y, et al. Antifungal itraconazole ameliorates experimental autoimmune encephalomyelitis through a novel mechanism of action. Adv Clin Exp Med. 2020;29:535-545 pubmed 出版商
Kurppa K, Liu Y, To C, Zhang T, Fan M, Vajdi A, et al. Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway. Cancer Cell. 2020;37:104-122.e12 pubmed 出版商
Du J, Gao R, Wang Y, Nguyen T, Yang F, Shi Y, et al. MicroRNA-26a/b have protective roles in oral lichen planus. Cell Death Dis. 2020;11:15 pubmed 出版商
Langley M, Yoon H, Kim H, Choi C, Simon W, Kleppe L, et al. High fat diet consumption results in mitochondrial dysfunction, oxidative stress, and oligodendrocyte loss in the central nervous system. Biochim Biophys Acta Mol Basis Dis. 2020;1866:165630 pubmed 出版商
ElKhoely A. Diallyl sulfide ameliorates carbon tetrachloride-induced hepatotoxicity in rats via suppressing stress-activated MAPK signaling pathways. J Biochem Mol Toxicol. 2019;33:e22307 pubmed 出版商
Li Z, Jiang X, Chen P, Wu X, Duan A, Qin Y. Combined effects of octreotide and cisplatin on the proliferation of side population cells from anaplastic thyroid cancer cell lines. Oncol Lett. 2018;16:4033-4042 pubmed 出版商
Shen P, Chen J, Pan M. The protective effects of total paeony glycoside on ischemia/reperfusion injury in H9C2 cells via inhibition of the PI3K/Akt signaling pathway. Mol Med Rep. 2018;18:3332-3340 pubmed 出版商
Qian Y, Song J, Sun P, Yi R, Liu H, Feng X, et al. Lactobacillus casei Strain Shirota Enhances the In Vitro Antiproliferative Effect of Geniposide in Human Oral Squamous Carcinoma HSC-3 Cells. Molecules. 2018;23: pubmed 出版商
Lei X, Lei L, Zhang Z, Cheng Y. Diazoxide inhibits of ER stress‑mediated apoptosis during oxygen‑glucose deprivation in vitro and cerebral ischemia‑reperfusion in vivo. Mol Med Rep. 2018;17:8039-8046 pubmed 出版商
Karch J, Schips T, Maliken B, Brody M, Sargent M, Kanisicak O, et al. Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak. elife. 2017;6: pubmed 出版商
Maejima Y, Kyoi S, Zhai P, Liu T, Li H, Ivessa A, et al. Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2. Nat Med. 2013;19:1478-88 pubmed 出版商
Calore F, Genisset C, Casellato A, Rossato M, Codolo G, Esposti M, et al. Endosome-mitochondria juxtaposition during apoptosis induced by H. pylori VacA. Cell Death Differ. 2010;17:1707-16 pubmed 出版商
Jordà E, Verdaguer E, Jimenez A, Canudas A, Rimbau V, Camps P, et al. (+/-)-huprine Y, (-)-huperzine A and tacrine do not show neuroprotective properties in an apoptotic model of neuronal cytoskeletal alteration. J Alzheimers Dis. 2004;6:577-83; discussion 673-81 pubmed
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产品信息
产品类型 :
抗体
产品名称 :
B细胞淋巴瘤2相关的X蛋白单克隆抗体(6A7)
目录# :
MA5-14003
规格 :
500微升
价格 :
美国405.00
克隆性 :
单克隆
纯度 :
蛋白质G
宿主 :
小鼠
反应物种 :
人类, 小鼠, 大鼠
应用 :
Flow Cytometry: 0.5 µg/test, Immunocytochemistry: 1:10-1:100, Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:10-1:100
物种 :
人类, 小鼠, 大鼠
克隆 :
6A7
抗体亚型 :
IgG1
储存 :
4° C
描述 :
BAX is a members of the Bcl-2 Family and plays an important role in regulation of apoptosis. Whereas Bcl-2 is commonly regarded as an anti-apoptotic protein, BAX is considered to have a pro-apoptotic function. Regulation of apoptosis is supposed to involve both homo- and heterodimerization of different isoforms of BAX and Bcl-2. The Bax gene encodes different isoforms including Bax alpha (21 kDa) and Bax beta (24 kDa), whereas both isoforms contain the BH1, BH2 and BH3 domains, Bax beta has a unique carboxyl terminus and does not contain a hydrophobic transmembrane domain. Bcl-2 is also expressed in different Isoforms. Bcl-2 beta differs in the 3' UTR and coding region compared to variant alpha. Bcl-2 beta is shorter (22 kDa) and has a distinct C-terminus compared to Bcl-2 alpha (26 kDa). BAX is a member of the BCL-2 family of proteins, which function as regulators of apoptosis. Overexpression of BAX functions to promote cell death. BAX can form homodimers and is also able to heterodimerize with other BCL-2 related proteins.
免疫原 :
A Synthetic peptide, aa 12-24 (Cys-GPTSSEQIMKTGA), of human Bax protein. This amino acid sequence is shared by human, mouse and rat Bax protein.
格式 :
液体
应用w/稀释 :
Flow Cytometry: 0.5 µg/test, Immunocytochemistry: 1:10-1:100, Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:10-1:100
别名 :
apoptosis regulator BAX; Apoptosis regulator Bcl-X; Bax; Bax zeta; BAX-ALPHA; Bax-alpha protein; Baxdelta2G9; Baxdelta2G9omega; Baxdelta2omega; BCL2 associated X protein; BCL2 associated X, apoptosis regulator; BCL2 like 1; BCL2-associated protein; Bcl-2-associated protein Bax; Bcl2-associated protein Bax; Bcl-2-associated X protein; BCL2-associated X protein; BCL2-associated X protein omega; BCL2L; BCL2L1; Bcl2-L-1; BCL2L4; Bcl2-L-4; BCL2-like 1; bcl-2-like protein 1; Bcl-2-like protein 4; BCLX; Bcl-X; BCL-XL/S; PPP1R52; protein phosphatase 1, regulatory subunit 52
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国