产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
ErbB2 (HER-2) Antibody Cocktail
目录 :
MA5-14057
规格 :
500微升
价格 :
美国446.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
e2-4001, 3B5
反应物种 :
仓鼠, 人类, 小鼠, 大鼠, 猫
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 135
| 出版应用/物种/样本/稀释 | 参考文献 |
|---|---|
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| Hu S, Sun Y, Meng Y, Wang X, Yang W, Fu W, et al. Molecular architecture of the ErbB2 extracellular domain homodimer. Oncotarget. 2015;6:1695-706 pubmed
|
| |
| |
| |
| |
| |
| |
| |
| |
| Karaca H, Deniz K, Berk V, Inanc M, Ozkan M. Association of human epidermal growth factor receptor-2 expression and clinicopathological findings in patients with colorectal cancer. Asian Pac J Cancer Prev. 2012;13:6221-5 pubmed
|
| |
| |
| |
| Cheol Kim D, Thorat M, Lee M, Cho S, Vasiljevic N, Scibior Bentkowska D, et al. Quantitative DNA methylation and recurrence of breast cancer: a study of 30 candidate genes. Cancer Biomark. 2012;11:75-88 pubmed
|
| |
| |
| Toru S, Bilezikci B. Early changes in carcinogenesis of colorectal adenomas. West Indian Med J. 2012;61:10-6 pubmed
|
| |
| |
| Cortés M, Cariaga Martínez A, Lobo M, Martín Orozco R, Motiño O, Rodríguez Ubreva F, et al. EGF promotes neuroendocrine-like differentiation of prostate cancer cells in the presence of LY294002 through increased ErbB2 expression independent of the phosphatidylinositol 3-kinase-AKT pathway. Carcinogenesis. 2012;33:1169-77 pubmed 出版商
|
| Eren F, Calay Z, Durak H, Eren B, Comunoglu N, Aydin O. C-Erb-b2 oncogene expression in intraductal proliferative lesions of the breast. Bosn J Basic Med Sci. 2012;12:41-50 pubmed
|
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| Gong Y, Sweet W, Duh Y, Greenfield L, Tarco E, Trivedi S, et al. Performance of chromogenic in situ hybridization on testing HER2 Status in breast carcinomas with chromosome 17 polysomy and equivocal (2+) herceptest results: a study of two institutions using the conventional and new ASCO/CAP scoring criteria. Am J Clin Pathol. 2009;132:228-36 pubmed 出版商
|
| |
| |
| Middleton L, Price K, Puig P, Heydon L, Tarco E, Sneige N, et al. Implementation of American Society of Clinical Oncology/College of American Pathologists HER2 Guideline Recommendations in a tertiary care facility increases HER2 immunohistochemistry and fluorescence in situ hybridization concordance and decreases t. Arch Pathol Lab Med. 2009;133:775-80 pubmed 出版商
|
| |
| Shi Y, Huang W, Tan Y, Jin X, Dua R, Penuel E, et al. A novel proximity assay for the detection of proteins and protein complexes: quantitation of HER1 and HER2 total protein expression and homodimerization in formalin-fixed, paraffin-embedded cell lines and breast cancer tissue. Diagn Mol Pathol. 2009;18:11-21 pubmed 出版商
|
| |
| |
| |
| |
| Bao H, Yu D, Wang J, Qiu T, Yang J, Wang L. Predictive value of serum anti-p53 antibodies, carcino-embryonic antigen, carbohydrate antigen 15-3, estrogen receptor, progesterone receptor and human epidermal growth factor receptor-2 in taxane-based and anthracycline-based neoadjuvant chemotherap. Anticancer Drugs. 2008;19:317-23 pubmed
|
| |
| |
| |
| |
| |
| |
| Yaren A, Kelten C, Akbulut M, Teke Z, Duzcan E, Erdem E. Primary neuroendocrine carcinoma of the breast: a case report. Tumori. 2007;93:496-8 pubmed
|
| Kassouf W, Black P, Tuziak T, Bondaruk J, Lee S, Brown G, et al. Distinctive expression pattern of ErbB family receptors signifies an aggressive variant of bladder cancer. J Urol. 2008;179:353-8 pubmed
|
| Kreike B, van Kouwenhove M, Horlings H, Weigelt B, Peterse H, Bartelink H, et al. Gene expression profiling and histopathological characterization of triple-negative/basal-like breast carcinomas. Breast Cancer Res. 2007;9:R65 pubmed
|
| Hu S, Zhu Z, Li L, Chang L, Li W, Cheng L, et al. Epitope mapping and structural analysis of an anti-ErbB2 antibody A21: Molecular basis for tumor inhibitory mechanism. Proteins. 2008;70:938-49 pubmed
|
| Vairaktaris E, Moulavassili P, Loukeri S, Spyridonidou S, Yapijakis C, Vassiliou S, et al. Abundance and localization of skeletal muscle-related erbB2 may stimulate tumour growth during initial stages of oral oncogenesis. J Musculoskelet Neuronal Interact. 2007;7:185-90 pubmed
|
| Kiley S, Chevalier R. Species differences in renal Src activity direct EGF receptor regulation in life or death response to EGF. Am J Physiol Renal Physiol. 2007;293:F895-903 pubmed
|
| Liu W, Zscheppang K, Murray S, Nielsen H, Dammann C. The ErbB4 receptor in fetal rat lung fibroblasts and epithelial type II cells. Biochim Biophys Acta. 2007;1772:737-47 pubmed
|
| Zscheppang K, Liu W, Volpe M, Nielsen H, Dammann C. ErbB4 regulates fetal surfactant phospholipid synthesis in primary fetal rat type II cells. Am J Physiol Lung Cell Mol Physiol. 2007;293:L429-35 pubmed
|
| Ostrander J, Daniel A, Lofgren K, Kleer C, Lange C. Breast tumor kinase (protein tyrosine kinase 6) regulates heregulin-induced activation of ERK5 and p38 MAP kinases in breast cancer cells. Cancer Res. 2007;67:4199-209 pubmed
|
| Andre F, Mazouni C, Liedtke C, Kau S, Frye D, Green M, et al. HER2 expression and efficacy of preoperative paclitaxel/FAC chemotherapy in breast cancer. Breast Cancer Res Treat. 2008;108:183-90 pubmed
|
| Gong Y, Yan K, Lin F, Anderson K, Sotiriou C, Andre F, et al. Determination of oestrogen-receptor status and ERBB2 status of breast carcinoma: a gene-expression profiling study. Lancet Oncol. 2007;8:203-11 pubmed
|
| Schaefer G, Shao L, Totpal K, Akita R. Erlotinib directly inhibits HER2 kinase activation and downstream signaling events in intact cells lacking epidermal growth factor receptor expression. Cancer Res. 2007;67:1228-38 pubmed
|
| Tokatli F, Alas R, Altaner S, Pala F, Uygun K, Uzal C, et al. [An analysis of genetic transmission in a father and son with osteosarcoma]. Acta Orthop Traumatol Turc. 2006;40:407-10 pubmed
|
| Mazouni C, Hall A, Broglio K, Fritsche H, Andre F, Esteva F, et al. Kinetics of serum HER-2/neu changes in patients with HER-2-positive primary breast cancer after initiation of primary chemotherapy. Cancer. 2007;109:496-501 pubmed
|
| Schmidt M, Tollenaar R, de Kemp S, Broeks A, Cornelisse C, Smit V, et al. Breast cancer survival and tumor characteristics in premenopausal women carrying the CHEK2*1100delC germline mutation. J Clin Oncol. 2007;25:64-9 pubmed
|
| Zscheppang K, Korenbaum E, Bueter W, Ramadurai S, Nielsen H, Dammann C. ErbB receptor dimerization, localization, and co-localization in mouse lung type II epithelial cells. Pediatr Pulmonol. 2006;41:1205-12 pubmed
|
| Skalova A, Gnepp D, Simpson R, Lewis J, Janssen D, Sima R, et al. Clonal nature of sclerosing polycystic adenosis of salivary glands demonstrated by using the polymorphism of the human androgen receptor (HUMARA) locus as a marker. Am J Surg Pathol. 2006;30:939-44 pubmed
|
| Karg A, Dinç Z, Basok O, Ucvet A. MUC4 expression and its relation to ErbB2 expression, apoptosis, proliferation, differentiation, and tumor stage in non-small cell lung cancer (NSCLC). Pathol Res Pract. 2006;202:577-83 pubmed
|
| Hansen M, Roehm P, Chatterjee P, Green S. Constitutive neuregulin-1/ErbB signaling contributes to human vestibular schwannoma proliferation. Glia. 2006;53:593-600 pubmed
|
| Lerdrup M, Hommelgaard A, Grandal M, van Deurs B. Geldanamycin stimulates internalization of ErbB2 in a proteasome-dependent way. J Cell Sci. 2006;119:85-95 pubmed
|
| Gao R, Bao H, Yang Q, Cong Q, Song J, Wang L. The presence of serum anti-p53 antibodies from patients with invasive ductal carcinoma of breast: correlation to other clinical and biological parameters. Breast Cancer Res Treat. 2005;93:111-5 pubmed
|
| Cabioglu N, Sahin A, Doucet M, Yavuz E, Igci A, O Yildirim E, et al. Chemokine receptor CXCR4 expression in breast cancer as a potential predictive marker of isolated tumor cells in bone marrow. Clin Exp Metastasis. 2005;22:39-46 pubmed
|
| Khalili P, Arakelian A, Chen G, Singh G, Rabbani S. Effect of Herceptin on the development and progression of skeletal metastases in a xenograft model of human breast cancer. Oncogene. 2005;24:6657-66 pubmed
|
| Stewart L, Lyles B, Lin M, Weigel N. Vitamin D receptor agonists induce prostatic acid phosphatase to reduce cell growth and HER-2 signaling in LNCaP-derived human prostate cancer cells. J Steroid Biochem Mol Biol. 2005;97:37-46 pubmed
|
| Guler G, Uner A, Guler N, Han S, Iliopoulos D, McCue P, et al. Concordant loss of fragile gene expression early in breast cancer development. Pathol Int. 2005;55:471-8 pubmed
|
| Diaz L, Cristofanilli M, Zhou X, Welch K, Smith T, Yang Y, et al. Beta4 integrin subunit gene expression correlates with tumor size and nuclear grade in early breast cancer. Mod Pathol. 2005;18:1165-75 pubmed
|
| Diaz L, Zhou X, Wright E, Cristofanilli M, Smith T, Yang Y, et al. CD44 expression is associated with increased survival in node-negative invasive breast carcinoma. Clin Cancer Res. 2005;11:3309-14 pubmed
|
| Knudsen K, Sauer C, Johnson K, Wheelock M. Effect of N-cadherin misexpression by the mammary epithelium in mice. J Cell Biochem. 2005;95:1093-107 pubmed
|
| Di Palma S, Skalova A, Vanìèek T, Simpson R, Starek I, Leivo I. Non-invasive (intracapsular) carcinoma ex pleomorphic adenoma: recognition of focal carcinoma by HER-2/neu and MIB1 immunohistochemistry. Histopathology. 2005;46:144-52 pubmed
|
| Skalova A, Ryska A, Kajo K, Di Palma S, Kinkor Z, Michal M. Cystic hypersecretory carcinoma: rare and poorly recognized variant of intraductal carcinoma of the breast. Report of five cases. Histopathology. 2005;46:43-9 pubmed
|
| Price Schiavi S, Andrechek E, Idris N, Li P, Rong M, Zhang J, et al. Expression, location, and interactions of ErbB2 and its intramembrane ligand Muc4 (sialomucin complex) in rat mammary gland during pregnancy. J Cell Physiol. 2005;203:44-53 pubmed
|
Xu K, Riggs A, Ding Y, Yu F. Role of ErbB2 in Corneal Epithelial Wound Healing. Invest Ophthalmol Vis Sci. 2004;45:4277-83 pubmed
| |
Tan P, Lui G, Chiang G, Yap W, Poh W, Bay B. Ductal carcinoma in situ with spindle cells: a potential diagnostic pitfall in the evaluation of breast lesions. Histopathology. 2004;45:343-51 pubmed
| |
Zinser G, Welsh J. Vitamin D receptor status alters mammary gland morphology and tumorigenesis in MMTV-neu mice. Carcinogenesis. 2004;25:2361-72 pubmed
| |
Kansra S, Stoll S, Johnson J, Elder J. Autocrine extracellular signal-regulated kinase (ERK) activation in normal human keratinocytes: metalloproteinase-mediated release of amphiregulin triggers signaling from ErbB1 to ERK. Mol Biol Cell. 2004;15:4299-309 pubmed
| |
Gossett D, Alo P, Bristow R, Galati M, Kyshtoobayeva A, Fruehauf J, et al. Inability of immunohistochemistry to predict clinical outcomes of endometrial cancer patients. Int J Gynecol Cancer. 2004;14:145-51 pubmed
| |
Cloven N, Kyshtoobayeva A, Burger R, Yu I, Fruehauf J. In vitro chemoresistance and biomarker profiles are unique for histologic subtypes of epithelial ovarian cancer. Gynecol Oncol. 2004;92:160-6 pubmed
| |
Esteva F, Sahin A, Rassidakis G, Yuan L, Smith T, Yang Y, et al. Jun activation domain binding protein 1 expression is associated with low p27(Kip1)levels in node-negative breast cancer. Clin Cancer Res. 2003;9:5652-9 pubmed
| |
Middleton L, Amin M, Gwyn K, Theriault R, Sahin A. Breast carcinoma in pregnant women: assessment of clinicopathologic and immunohistochemical features. Cancer. 2003;98:1055-60 pubmed
| |
Simpson R, Prasad A, Lewis J, Skalova A, David L. Mucin-rich variant of salivary duct carcinoma: a clinicopathologic and immunohistochemical study of four cases. Am J Surg Pathol. 2003;27:1070-9 pubmed
| |
Vadlamudi R, Sahin A, Adam L, Wang R, Kumar R. Heregulin and HER2 signaling selectively activates c-Src phosphorylation at tyrosine 215. FEBS Lett. 2003;543:76-80 pubmed
| |
Ramsauer V, Carraway C, Salas P, Carraway K. Muc4/sialomucin complex, the intramembrane ErbB2 ligand, translocates ErbB2 to the apical surface in polarized epithelial cells. J Biol Chem. 2003;278:30142-7 pubmed
| |
Kremser R, Obrist P, Spizzo G, Erler H, Kendler D, Kemmler G, et al. Her2/neu overexpression in differentiated thyroid carcinomas predicts metastatic disease. Virchows Arch. 2003;442:322-8 pubmed
| |
Dakappagari N, Pyles J, Parihar R, Carson W, Young D, Kaumaya P. A chimeric multi-human epidermal growth factor receptor-2 B cell epitope peptide vaccine mediates superior antitumor responses. J Immunol. 2003;170:4242-53 pubmed
| |
Davis D, Buchholz T, Hess K, Sahin A, Valero V, McConkey D. Automated quantification of apoptosis after neoadjuvant chemotherapy for breast cancer: early assessment predicts clinical response. Clin Cancer Res. 2003;9:955-60 pubmed
| |
Shimizu H, Seiki T, Asada M, Yoshimatsu K, Koyama N. Alpha6beta1 integrin induces proteasome-mediated cleavage of erbB2 in breast cancer cells. Oncogene. 2003;22:831-9 pubmed
| |
Verschraegen C, Hu W, Du Y, Mendoza J, Early J, Deavers M, et al. Establishment and characterization of cancer cell cultures and xenografts derived from primary or metastatic Mullerian cancers. Clin Cancer Res. 2003;9:845-52 pubmed
| |
Thomas C, Chouinard M, Cox M, Parsons S, Stallings Mann M, Garcia R, et al. Spontaneous activation and signaling by overexpressed epidermal growth factor receptors in glioblastoma cells. Int J Cancer. 2003;104:19-27 pubmed
| |
van Eeden S, Quaedvlieg P, Taal B, Offerhaus G, Lamers C, van Velthuysen M. Classification of low-grade neuroendocrine tumors of midgut and unknown origin. Hum Pathol. 2002;33:1126-32 pubmed
| |
Kansra S, Stoll S, Elder J. Differential cytoskeletal association of ErbB1 and ErbB2 during keratinocyte differentiation. Biochem Biophys Res Commun. 2002;295:1108-17 pubmed
| |
Tsigris C, Karayiannakis A, Zbar A, Syrigos K, Baibas N, Diamantis T, et al. Clinical significance of serum and urinary c-erbB-2 levels in colorectal cancer. Cancer Lett. 2002;184:215-22 pubmed
| |
Esteva F, Valero V, Booser D, Guerra L, Murray J, Pusztai L, et al. Phase II study of weekly docetaxel and trastuzumab for patients with HER-2-overexpressing metastatic breast cancer. J Clin Oncol. 2002;20:1800-8 pubmed
| |
Half E, Tang X, Gwyn K, Sahin A, Wathen K, Sinicrope F. Cyclooxygenase-2 expression in human breast cancers and adjacent ductal carcinoma in situ. Cancer Res. 2002;62:1676-81 pubmed
| |
Murillo H, Schmidt L, Tindall D. Tyrphostin AG825 triggers p38 mitogen-activated protein kinase-dependent apoptosis in androgen-independent prostate cancer cells C4 and C4-2. Cancer Res. 2001;61:7408-12 pubmed
| |
Moasser M, Basso A, Averbuch S, Rosen N. The tyrosine kinase inhibitor ZD1839 ("Iressa") inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells. Cancer Res. 2001;61:7184-8 pubmed
|
产品信息
产品类型 :
抗体
产品名称 :
ErbB2 (HER-2) Antibody Cocktail
目录# :
MA5-14057
规格 :
500微升
价格 :
美国446.00
克隆性 :
Cocktail
纯度 :
蛋白质G
宿主 :
小鼠
反应物种 :
人类
应用 :
Flow Cytometry: 1:10-1:100, Immunohistochemistry (Paraffin): 0.25-0.5 µg/mL, Immunoprecipitation: 2 µg/mL, Western Blot: 1 µg/mL
物种 :
人类
克隆 :
e2-4001, 3B5
抗体亚型 :
IgG1
储存 :
4° C
描述 :
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
免疫原 :
Cytoplasmic domain of recombinant human c-erbB-2/HER-2 oncoprotein (e2-4001) and a synthetic peptide from the C-terminus of human c-erbB-2 protein (3B5)
格式 :
液体
应用w/稀释 :
Flow Cytometry: 1:10-1:100, Immunohistochemistry (Paraffin): 0.25-0.5 µg/mL, Immunoprecipitation: 2 µg/mL, Western Blot: 1 µg/mL
别名 :
avian erythroblastosis oncogene B 2; Avian erythroblastosis viral (v-erb-B2) oncogene homologue 2 (neuro/glioblastoma derived oncogene homolog); CD antigen CD340; CD340; c-erb B2/neu protein; c-erbB2; C-erbB-2; c-neu; epidermal growth factor receptor-related protein; erbb 2; ERBB2; erb-b2; Erbb-2; ErbB2 (pTyr1139); ErbB2 (pY1139); ErbB2 phospho Y1139; erb-b2 receptor tyrosine kinase 2; her 2; HER2; HER-2; HER-2/neu; herstatin; human epidermal growth factor receptor 2; Kiaa3023; metas; Metastatic lymph node gene 19 protein; mKIAA3023; MLN 19; MLN19; NEU; Neu oncogene; NEU proto-oncogene; neuro/glioblastoma derived oncogene homolog; neuroblastoma/glioblastoma derived oncogene homolog; NGL; p185erbB2; p185neu; phospho ErbB2; proto-oncogene c-ErbB-2; Proto-oncogene Neu; receptor tyrosine-protein kinase erbB-2; TKR1; Tyrosine kinase-type cell surface receptor HER2; v-erb-b2 avian erythroblastic leukemia viral oncogene 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
更多信息或购买 :
公司信息
赛默飞世尔