产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
Estrogen Receptor alpha Antibody Cocktail
目录 :
MA5-14104
规格 :
500微升
价格 :
美国572.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
1D5, 6F11
反应物种 :
African green monkey, 人类, 小鼠, 大鼠, 鸡, 猫, domestic rabbit, 猕猴
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, EMSA, 免疫组化-石蜡切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 60
出版应用/物种/样本/稀释参考文献
  • 免疫组化; 人类; 1:200
Khandakar B, Mathur S, Kumar L, Kumar S, Datta Gupta S, Iyer V, et al. Tissue biomarkers in prognostication of serous ovarian cancer following neoadjuvant chemotherapy. Biomed Res Int. 2014;2014:401245 pubmed 出版商
  • 免疫印迹; 人类
Lee J, Tiwari A, Shum V, Mills G, Mancini M, Igoshin O, et al. Unraveling the regulatory connections between two controllers of breast cancer cell fate. Nucleic Acids Res. 2014;42:6839-49 pubmed 出版商
  • 免疫组化; 人类; 1:100
Bredow L, Stützel L, Böhringer D, Gundlach E, Reinhard T, Auw Haedrich C. Progesterone and estrogen receptors in conjunctival melanoma and nevi. Graefes Arch Clin Exp Ophthalmol. 2014;252:359-65 pubmed 出版商
  • EMSA; 人类
Kruer T, Cummins T, Powell D, Wittliff J. Characterization of estrogen response element binding proteins as biomarkers of breast cancer behavior. Clin Biochem. 2013;46:1739-46 pubmed 出版商
  • 免疫组化; 人类; 1:50
Grosso S, Katayama M, Roela R, Nonogaki S, Soares F, Brentani H, et al. Breast cancer tissue slices as a model for evaluation of response to rapamycin. Cell Tissue Res. 2013;352:671-84 pubmed 出版商
  • 免疫印迹; 人类
Endoh T, Kawasaki Y, Sugimoto N. Stability of RNA quadruplex in open reading frame determines proteolysis of human estrogen receptor ?. Nucleic Acids Res. 2013;41:6222-31 pubmed 出版商
  • 免疫组化; 人类
  • 免疫印迹; 人类
Li Y, Meeran S, Patel S, Chen H, Hardy T, Tollefsbol T. Epigenetic reactivation of estrogen receptor-α (ERα) by genistein enhances hormonal therapy sensitivity in ERα-negative breast cancer. Mol Cancer. 2013;12:9 pubmed 出版商
  • 免疫组化; 人类; 1:500
Laliotis A, Vrekoussis T, Kafousi M, Sanidas E, Askoxilakis J, Melissas J, et al. Immunohistochemical study of pElk-1 expression in human breast cancer: association with breast cancer biologic profile and clinicopathologic features. Breast. 2013;22:89-95 pubmed 出版商
  • 免疫细胞化学; 人类; 1:35
Marinšek Z, Nolde N, Kardum Skelin I, Nizzoli R, Onal B, Rezanko T, et al. Multinational study of oestrogen and progesterone receptor immunocytochemistry on breast carcinoma fine needle aspirates. Cytopathology. 2013;24:7-20 pubmed 出版商
  • 免疫组化; 人类; 1:100
Marian C, Boilă A, Soanca D, Malau M, Podeanu D, Resetkova E, et al. Malignant transformation of adenomyoepithelioma of the breast by a monophasic population: a report of two cases and review of literature. APMIS. 2013;121:272-9 pubmed 出版商
  • 免疫组化; 人类
Gill M, Paish E, Ronan J, Green A, Ellis I, Lee A. Comparison of the PharmDx immunohistochemical system with standard methods for assessing estrogen and progesterone receptors in invasive carcinoma of the breast. Appl Immunohistochem Mol Morphol. 2013;21:90-3 pubmed 出版商
  • 免疫组化; 鸡; 1:200
Machado S, Bahr J, Hales D, Braundmeier A, Quade B, Nowak R. Validation of the aging hen (Gallus gallus domesticus) as an animal model for uterine leiomyomas. Biol Reprod. 2012;87:86 pubmed 出版商
  • 免疫组化; 人类; 1:50
Martins F, De S, Almendro V, Gonen M, Park S, Blum J, et al. Evolutionary pathways in BRCA1-associated breast tumors. Cancer Discov. 2012;2:503-11 pubmed 出版商
  • 免疫组化; 猕猴
Almeida Francia C, Keator C, Mah K, Holden L, Hergert C, Slayden O. Localization and hormonal regulation of endometrial matrix metalloproteinase-26 in the rhesus macaque. Hum Reprod. 2012;27:1723-34 pubmed 出版商
  • 免疫组化; 人类; 1:100
Hovanessian Larsen L, Taylor D, Hawes D, Spicer D, Press M, Wu A, et al. Lowering oral contraceptive norethindrone dose increases estrogen and progesterone receptor levels with no reduction in proliferation of breast epithelium: a randomized trial. Contraception. 2012;86:238-43 pubmed 出版商
  • 免疫组化; 人类
Maae E, Olsen D, Steffensen K, Jakobsen E, Brandslund I, Sørensen F, et al. Prognostic impact of placenta growth factor and vascular endothelial growth factor A in patients with breast cancer. Breast Cancer Res Treat. 2012;133:257-65 pubmed 出版商
  • 免疫组化; 人类; 1:100
Chung K, Hovanessian Larsen L, Hawes D, Taylor D, Downey S, Spicer D, et al. Breast epithelial cell proliferation is markedly increased with short-term high levels of endogenous estrogen secondary to controlled ovarian hyperstimulation. Breast Cancer Res Treat. 2012;132:653-60 pubmed 出版商
  • 免疫组化; 人类; 1:50
Rijlaarsdam M, van Herk H, Gillis A, Stoop H, Jenster G, Martens J, et al. Specific detection of OCT3/4 isoform A/B/B1 expression in solid (germ cell) tumours and cell lines: confirmation of OCT3/4 specificity for germ cell tumours. Br J Cancer. 2011;105:854-63 pubmed 出版商
  • 免疫组化; 人类; 1:50
Logullo A, Stiepcich M, Osório C, Nonogaki S, Pasini F, Rocha R, et al. Role of Fos-related antigen 1 in the progression and prognosis of ductal breast carcinoma. Histopathology. 2011;58:617-25 pubmed 出版商
  • 免疫组化; 人类; 1:100
Gschwantler Kaulich D, Fink Retter A, Czerwenka K, Hudelist G, Kaulich A, Kubista E, et al. Differential expression pattern of estrogen receptors, aromatase, and sulfotransferase in breast cancer tissue and corresponding lymph node metastases. Tumour Biol. 2011;32:501-8 pubmed 出版商
  • 免疫组化; 人类; 1:50
Joosse S, Brandwijk K, Mulder L, Wesseling J, Hannemann J, Nederlof P. Genomic signature of BRCA1 deficiency in sporadic basal-like breast tumors. Genes Chromosomes Cancer. 2011;50:71-81 pubmed 出版商
  • 免疫组化; 人类; 1:50
Holstege H, van Beers E, Velds A, Liu X, Joosse S, Klarenbeek S, et al. Cross-species comparison of aCGH data from mouse and human BRCA1- and BRCA2-mutated breast cancers. BMC Cancer. 2010;10:455 pubmed 出版商
  • 免疫组化; 人类; 1:50
Joosse S, Brandwijk K, Devilee P, Wesseling J, Hogervorst F, Verhoef S, et al. Prediction of BRCA2-association in hereditary breast carcinomas using array-CGH. Breast Cancer Res Treat. 2012;132:379-89 pubmed 出版商
  • 免疫组化; 人类; 1:100
Horlings H, Lai C, Nuyten D, Halfwerk H, Kristel P, van Beers E, et al. Integration of DNA copy number alterations and prognostic gene expression signatures in breast cancer patients. Clin Cancer Res. 2010;16:651-63 pubmed 出版商
  • 免疫组化; 人类; 1:200
Bueno de Mesquita J, Nuyten D, Wesseling J, VAN Tinteren H, Linn S, van de Vijver M. The impact of inter-observer variation in pathological assessment of node-negative breast cancer on clinical risk assessment and patient selection for adjuvant systemic treatment. Ann Oncol. 2010;21:40-7 pubmed 出版商
  • 免疫组化; 猫
Misirlioglu D, Nak D, Ozyigit M, Nak Y, Akkoc A. HER-2/neu (c-erbB-2) oncoprotein in hyperplastic endometrial polyps detected in two cats. J Feline Med Surg. 2009;11:885-8 pubmed 出版商
  • 免疫组化; 人类; 1:50
Pietersen A, Horlings H, Hauptmann M, Langerød A, Ajouaou A, Cornelissen Steijger P, et al. EZH2 and BMI1 inversely correlate with prognosis and TP53 mutation in breast cancer. Breast Cancer Res. 2008;10:R109 pubmed 出版商
  • 免疫组化; 人类; 1:100
Ceausu M, Terzea D, Georgescu A, Dobrea C, Mihai M, Iosif C, et al. Transitional cell tumors of the ovary: a compact group with a heterogeneous histological and immunophenotypical pattern. Rom J Morphol Embryol. 2008;49:513-6 pubmed
  • 免疫组化; 人类; 1:100
Chakravarty D, Srinivasan R, Ghosh S, Rajwanshi A, Gopalan S. Estrogen receptor beta (ERbeta) in endometrial simple hyperplasia and endometrioid carcinoma. Appl Immunohistochem Mol Morphol. 2008;16:535-42 pubmed 出版商
  • 免疫组化; 人类; 1:50
Joosse S, van Beers E, Tielen I, Horlings H, Peterse J, Hoogerbrugge N, et al. Prediction of BRCA1-association in hereditary non-BRCA1/2 breast carcinomas with array-CGH. Breast Cancer Res Treat. 2009;116:479-89 pubmed 出版商
  • 免疫组化; 人类; 1:100
Bao H, Yu D, Wang J, Qiu T, Yang J, Wang L. Predictive value of serum anti-p53 antibodies, carcino-embryonic antigen, carbohydrate antigen 15-3, estrogen receptor, progesterone receptor and human epidermal growth factor receptor-2 in taxane-based and anthracycline-based neoadjuvant chemotherap. Anticancer Drugs. 2008;19:317-23 pubmed
  • 免疫组化; 人类
Barbareschi M, Buttitta F, Felicioni L, Cotrupi S, Barassi F, Del Grammastro M, et al. Different prognostic roles of mutations in the helical and kinase domains of the PIK3CA gene in breast carcinomas. Clin Cancer Res. 2007;13:6064-9 pubmed
  • 免疫组化; 人类; 1:50
Berns K, Horlings H, Hennessy B, Madiredjo M, Hijmans E, Beelen K, et al. A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer. Cancer Cell. 2007;12:395-402 pubmed
  • 免疫组化; domestic rabbit; 1:50
Onal B, Levin R, Kogan B, Whitbeck C, Chichester P, Walebowa O, et al. The effect of maturation and age on oestrogen-induced functional hypertrophy of the female rabbit bladder. BJU Int. 2007;99:674-9 pubmed
  • 免疫组化; 人类; 1:100
Singer C, Fink Retter A, Gschwantler Kaulich D, Thalhammer T, Hudelist G, Mueller R, et al. Selective spatial upregulation of intratumoral stromal aromatase in breast cancer patients: evidence for imbalance of local estrogen metabolism. Endocr Relat Cancer. 2006;13:1101-7 pubmed
  • 免疫组化; 人类
Schmidt M, Tollenaar R, de Kemp S, Broeks A, Cornelisse C, Smit V, et al. Breast cancer survival and tumor characteristics in premenopausal women carrying the CHEK2*1100delC germline mutation. J Clin Oncol. 2007;25:64-9 pubmed
  • 免疫组化; 人类; 1:50
Hannemann J, Kristel P, VAN Tinteren H, Bontenbal M, van Hoesel Q, Smit W, et al. Molecular subtypes of breast cancer and amplification of topoisomerase II alpha: predictive role in dose intensive adjuvant chemotherapy. Br J Cancer. 2006;95:1334-41 pubmed
  • 免疫组化; 人类
Wang M, Pan J, Song G, Chen H, An L, Qu S. Altered expression of estrogen receptor alpha and beta in advanced gastric adenocarcinoma: correlation with prothymosin alpha and clinicopathological parameters. Eur J Surg Oncol. 2007;33:195-201 pubmed
  • 免疫组化; 人类; 4 ug/ml
  • 免疫组化; 鸡
Berry W, Doernte A, Conner M, Barnes M, Oates S. Spontaneously occurring fibroid tumors of the laying hen oviduct. Poult Sci. 2006;85:1969-74 pubmed
  • 免疫组化; domestic rabbit
Lin A, Levin R, Kogan B, Whitbeck C, Chichester P, Sokol R, et al. Estrogen induced functional hypertrophy and increased force generation of the female rabbit bladder. Neurourol Urodyn. 2006;25:473-9 pubmed
  • 免疫印迹; 人类; 1:100
Turbyville T, Wijeratne E, Liu M, Burns A, Seliga C, Luevano L, et al. Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert. J Nat Prod. 2006;69:178-84 pubmed
  • 免疫组化; 小鼠; 1:50
Wang R, Zhang H, Balasenthil S, Medina D, Kumar R. PAK1 hyperactivation is sufficient for mammary gland tumor formation. Oncogene. 2006;25:2931-6 pubmed
  • 免疫组化; 大鼠
  • 免疫印迹; 大鼠
Weroha S, Li S, Tawfik O, Li J. Overexpression of cyclins D1 and D3 during estrogen-induced breast oncogenesis in female ACI rats. Carcinogenesis. 2006;27:491-8 pubmed
  • 免疫印迹; 人类; 1:750
  • 免疫细胞化学; African green monkey; 1:200
Lipfert L, Fisher J, Wei N, Scafonas A, Su Q, Yudkovitz J, et al. Antagonist-induced, activation function-2-independent estrogen receptor alpha phosphorylation. Mol Endocrinol. 2006;20:516-33 pubmed
  • 免疫组化; 人类; 1:100
Gao R, Bao H, Yang Q, Cong Q, Song J, Wang L. The presence of serum anti-p53 antibodies from patients with invasive ductal carcinoma of breast: correlation to other clinical and biological parameters. Breast Cancer Res Treat. 2005;93:111-5 pubmed
  • 免疫组化; 人类
Inceboz U, Nese N, Uyar Y, Ozcakir H, Kurtul O, Baytur Y, et al. Hormone receptor expressions and proliferation markers in postmenopausal endometrial polyps. Gynecol Obstet Invest. 2006;61:24-8 pubmed
  • 免疫组化; 人类; 1:100
Akhan S, Yavuz E, Tecer A, Iyibozkurt C, Topuz S, Tuzlali S, et al. The expression of Ki-67, p53, estrogen and progesterone receptors affecting survival in uterine leiomyosarcomas. A clinicopathologic study. Gynecol Oncol. 2005;99:36-42 pubmed
  • 免疫组化; 大鼠
Qiu C, Shan L, Yu M, Snyderwine E. Steroid hormone receptor expression and proliferation in rat mammary gland carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Carcinogenesis. 2005;26:763-9 pubmed
He W, Demas D, Conde I, Shajahan Haq A, Baumann W. Mathematical modelling of breast cancer cells in response to endocrine therapy and Cdk4/6 inhibition. J R Soc Interface. 2020;17:20200339 pubmed 出版商
Flötotto T, Niederacher D, Hohmann D, Heimerzheim T, Dall P, Djahansouzi S, et al. Molecular mechanism of estrogen receptor (ER)alpha-specific, estradiol-dependent expression of the progesterone receptor (PR) B-isoform. J Steroid Biochem Mol Biol. 2004;88:131-42 pubmed
Guler G, Uner A, Guler N, Han S, Iliopoulos D, Hauck W, et al. The fragile genes FHIT and WWOX are inactivated coordinately in invasive breast carcinoma. Cancer. 2004;100:1605-14 pubmed
Kapucuoglu N, Coban T, Raunio H, Pelkonen O, Edwards R, Boobis A, et al. Expression of CYP3A4 in human breast tumour and non-tumour tissues. Cancer Lett. 2003;202:17-23 pubmed
Beliakoff J, Bagatell R, Paine Murrieta G, Taylor C, Lykkesfeldt A, Whitesell L. Hormone-refractory breast cancer remains sensitive to the antitumor activity of heat shock protein 90 inhibitors. Clin Cancer Res. 2003;9:4961-71 pubmed
Bethea C, Lu N, Reddy A, Shlaes T, Streicher J, Whittemore S. Characterization of reproductive steroid receptors and response to estrogen in a rat serotonergic cell line. J Neurosci Methods. 2003;127:31-41 pubmed
Hudelist G, Czerwenka K, Kubista E, Marton E, Pischinger K, Singer C. Expression of sex steroid receptors and their co-factors in normal and malignant breast tissue: AIB1 is a carcinoma-specific co-activator. Breast Cancer Res Treat. 2003;78:193-204 pubmed
Zinser G, McEleney K, Welsh J. Characterization of mammary tumor cell lines from wild type and vitamin D3 receptor knockout mice. Mol Cell Endocrinol. 2003;200:67-80 pubmed
Seth P, Porter D, Lahti Domenici J, Geng Y, Richardson A, Polyak K. Cellular and molecular targets of estrogen in normal human breast tissue. Cancer Res. 2002;62:4540-4 pubmed
Querzoli P, Albonico G, di Iasio M, Ferretti S, Rinaldi R, Cariello A, et al. Biophenotypes and survival of BRCA1 and TP53 deleted breast cancer in young women. Breast Cancer Res Treat. 2001;66:135-42 pubmed
Suzuki T, Darnel A, Akahira J, Ariga N, Ogawa S, Kaneko C, et al. 5alpha-reductases in human breast carcinoma: possible modulator of in situ androgenic actions. J Clin Endocrinol Metab. 2001;86:2250-7 pubmed
El Khissiin A, Journe F, Laios I, Seo H, Leclercq G. Evidence of an estrogen receptor form devoid of estrogen binding ability in MCF-7 cells. Steroids. 2000;65:903-13 pubmed
图像
图像 1 :
赛默飞世尔 MA5-14104 图像 1
Formalin-fixed, paraffin-embedded human breast carcinoma stained with Estrogen Receptor antibody4 using peroxidase-conjugate and DAB chromogen. Note nuclear staining of tumor cells.
图像 2 :
赛默飞世尔 MA5-14104 图像 2
产品信息
产品类型 :
抗体
产品名称 :
Estrogen Receptor alpha Antibody Cocktail
目录# :
MA5-14104
规格 :
500微升
价格 :
美国572.00
克隆性 :
Cocktail
宿主 :
小鼠
反应物种 :
人类
应用 :
Immunocytochemistry: 1:50-1:200, Immunohistochemistry (Paraffin): 1:50-1:100, Western Blot: 1:50-1:100
物种 :
人类
克隆 :
1D5, 6F11
抗体亚型 :
IgG1
储存 :
4° C
描述 :
Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins. There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively). Due to alternative RNA splicing, at least 4 estrogen receptor-alpha isoforms are known to exist (Isoform 1 (66 kDa), Isoform 2 (53 kDa), Isoform 3 (47 kDa), Isoform 4 (35 kDa)). Estrogen receptors are widely expressed in different tissue types and are essential for sexual development and reproductive function. They also play a role in other tissues such as bone. Estrogen receptors are involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis.
免疫原 :
重组人类雌激素受体蛋白
格式 :
液体
应用w/稀释 :
Immunocytochemistry: 1:50-1:200, Immunohistochemistry (Paraffin): 1:50-1:100, Western Blot: 1:50-1:100
别名 :
DKFZp686N23123; ER; Er alpha; ER36; ERa; ERalpha; ER-alpha; ERalpha protein; ESR; esr 1; Esr1; esr-1; ESRA; Estr; Estra; Estradiol receptor; estrogen nuclear receptor alpha; Estrogen receptor; estrogen receptor 1; estrogen receptor 1 (alpha); estrogen receptor alpha; estrogen receptor alpha c-terminus splice variant 1-2; estrogen receptor alpha E1-E2-1-2; estrogen receptor alpha E1-N2-E2-1-2; estrogen receptor alpha splice variant, CTERP-1; estrogen receptor alpha splice variant, ERalphaDup5; estrogen receptor alpha splice variant, ERalphai45a; estrogen receptor alpha splice variant, ERalphai45bL; estrogen receptor alpha splice variant, ERalphai45bS; estrogen receptor alpha splice variant, ERalphai45c; estrogen receptor alpha splice variant, ERalphai56; estrogen receptor alpha splice variant, ERalphai67; estrogen receptor alpha variant delta 4; estrogen receptor protein; estrogen receptor, alpha; ESTRR; hER-alpha36; I79_001166; Nr3a1; nuclear receptor; nuclear receptor subfamily 3 group A member 1; RNESTROR; RP1-130E4.1; unnamed protein product
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国