产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
细胞周期蛋白B1单克隆抗体(GNS1)
目录 :
MA5-14319
规格 :
500微升
价格 :
美国454.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
GNS1
反应物种 :
中国人仓鼠, 人类, 小鼠, 牛
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 24
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 图 2
Liu Y, Liu C, Chang Z, Wadas B, Brower C, Song Z, et al. Degradation of the Separase-cleaved Rec8, a Meiotic Cohesin Subunit, by the N-end Rule Pathway. J Biol Chem. 2016;291:7426-38 pubmed 出版商
  • 免疫细胞化学; 人类; 1:200
  • 免疫印迹; 人类; 1:10000
Szeto S, Williams E, Rudner A, Lee J. Phosphorylation of filamin A by Cdk1 regulates filamin A localization and daughter cell separation. Exp Cell Res. 2015;330:248-66 pubmed 出版商
  • 免疫沉淀; 小鼠
Tane S, Kubota M, Okayama H, Ikenishi A, Yoshitome S, Iwamoto N, et al. Repression of cyclin D1 expression is necessary for the maintenance of cell cycle exit in adult mammalian cardiomyocytes. J Biol Chem. 2014;289:18033-44 pubmed 出版商
  • 免疫印迹; 人类
Caffarelli N, Fehr A, Yu D. Cyclin A degradation by primate cytomegalovirus protein pUL21a counters its innate restriction of virus replication. PLoS Pathog. 2013;9:e1003825 pubmed 出版商
  • 免疫印迹; 人类
Kollar P, Bárta T, Hosek J, Soucek K, Závalová V, Artinian S, et al. Prenylated Flavonoids from Morus alba L. Cause Inhibition of G1/S Transition in THP-1 Human Leukemia Cells and Prevent the Lipopolysaccharide-Induced Inflammatory Response. Evid Based Complement Alternat Med. 2013;2013:350519 pubmed 出版商
  • 免疫沉淀; 小鼠
Ikenishi A, Okayama H, Iwamoto N, Yoshitome S, Tane S, Nakamura K, et al. Cell cycle regulation in mouse heart during embryonic and postnatal stages. Dev Growth Differ. 2012;54:731-8 pubmed 出版商
  • 免疫印迹; 人类
Fehr A, Gualberto N, Savaryn J, Terhune S, Yu D. Proteasome-dependent disruption of the E3 ubiquitin ligase anaphase-promoting complex by HCMV protein pUL21a. PLoS Pathog. 2012;8:e1002789 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1
Chen S, Fu S, Hsu S, Huang Y, Hsu B. Synergistic Effect of Hyperglycemia and p27(kip1) Suppression on Adult Mouse Islet Beta Cell Replication. Int J Endocrinol. 2012;2012:417390 pubmed 出版商
  • 免疫印迹; 人类
Horiuchi D, Huskey N, Kusdra L, Wohlbold L, Merrick K, Zhang C, et al. Chemical-genetic analysis of cyclin dependent kinase 2 function reveals an important role in cellular transformation by multiple oncogenic pathways. Proc Natl Acad Sci U S A. 2012;109:E1019-27 pubmed 出版商
  • 免疫印迹; 人类; 1:50
Gilley R, Lochhead P, Balmanno K, Oxley D, Clark J, Cook S. CDK1, not ERK1/2 or ERK5, is required for mitotic phosphorylation of BIMEL. Cell Signal. 2012;24:170-80 pubmed 出版商
  • 免疫沉淀; 人类
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
Coulonval K, Kooken H, Roger P. Coupling of T161 and T14 phosphorylations protects cyclin B-CDK1 from premature activation. Mol Biol Cell. 2011;22:3971-85 pubmed 出版商
  • 免疫细胞化学; 人类
Knight G, Pugh A, Yates E, Bell I, Wilson R, Moody C, et al. A cyclin-binding motif in human papillomavirus type 18 (HPV18) E1^E4 is necessary for association with CDK-cyclin complexes and G2/M cell cycle arrest of keratinocytes, but is not required for differentiation-dependent viral genome amplification or L. Virology. 2011;412:196-210 pubmed 出版商
  • 免疫组化; 牛
  • 免疫印迹; 牛; 1:200
Uzbekova S, Arlot Bonnemains Y, Dupont J, Dalbies Tran R, Papillier P, Pennetier S, et al. Spatio-temporal expression patterns of aurora kinases a, B, and C and cytoplasmic polyadenylation-element-binding protein in bovine oocytes during meiotic maturation. Biol Reprod. 2008;78:218-33 pubmed
  • 免疫印迹; 牛; 1:1000
Tosca L, Uzbekova S, Chabrolle C, Dupont J. Possible role of 5'AMP-activated protein kinase in the metformin-mediated arrest of bovine oocytes at the germinal vesicle stage during in vitro maturation. Biol Reprod. 2007;77:452-65 pubmed
  • 免疫印迹; 人类; 1:500
Wiseman D, Werner S, Crowell P. Cell cycle arrest by the isoprenoids perillyl alcohol, geraniol, and farnesol is mediated by p21(Cip1) and p27(Kip1) in human pancreatic adenocarcinoma cells. J Pharmacol Exp Ther. 2007;320:1163-70 pubmed
  • 免疫细胞化学; 人类; 1:100
Brito D, Rieder C. Mitotic checkpoint slippage in humans occurs via cyclin B destruction in the presence of an active checkpoint. Curr Biol. 2006;16:1194-200 pubmed
  • 免疫印迹; 人类; 1 ug/ml
Lokeshwar V, Cerwinka W, Lokeshwar B. HYAL1 hyaluronidase: a molecular determinant of bladder tumor growth and invasion. Cancer Res. 2005;65:2243-50 pubmed
  • 免疫印迹; 人类
Davy C, Jackson D, Raj K, Peh W, Southern S, Das P, et al. Human papillomavirus type 16 E1 E4-induced G2 arrest is associated with cytoplasmic retention of active Cdk1/cyclin B1 complexes. J Virol. 2005;79:3998-4011 pubmed 出版商
Qiao R, Weissmann F, Yamaguchi M, Brown N, VanderLinden R, Imre R, et al. Mechanism of APC/CCDC20 activation by mitotic phosphorylation. Proc Natl Acad Sci U S A. 2016;113:E2570-8 pubmed 出版商
Tumurbaatar I, Cizmecioglu O, Hoffmann I, Grummt I, Voit R. Human Cdc14B promotes progression through mitosis by dephosphorylating Cdc25 and regulating Cdk1/cyclin B activity. PLoS ONE. 2011;6:e14711 pubmed 出版商
Davy C, Ayub M, Jackson D, Das P, McIntosh P, Doorbar J. HPV16 E1--E4 protein is phosphorylated by Cdk2/cyclin A and relocalizes this complex to the cytoplasm. Virology. 2006;349:230-44 pubmed 出版商
Sanchez V, McElroy A, Spector D. Mechanisms governing maintenance of Cdk1/cyclin B1 kinase activity in cells infected with human cytomegalovirus. J Virol. 2003;77:13214-24 pubmed
Sheen J, Woo J, Dickson R. c-Myc alters the DNA damage-induced G2/M arrest in human mammary epithelial cells. Br J Cancer. 2003;89:1479-85 pubmed
Dellinger R, Karjian P, Neuteboom S. NB1011 induces Ser15 phosphorylation of p53 and activates the G2/M checkpoint. Anticancer Drugs. 2003;14:449-55 pubmed
图像
图像 1 :
赛默飞世尔 MA5-14319 图像 1
图像 2 :
赛默飞世尔 MA5-14319 图像 2
产品信息
产品类型 :
抗体
产品名称 :
细胞周期蛋白B1单克隆抗体(GNS1)
目录# :
MA5-14319
规格 :
500微升
价格 :
美国454.00
克隆性 :
单克隆
纯度 :
蛋白质G
宿主 :
小鼠
反应物种 :
仓鼠, 人类, 小鼠
应用 :
Flow Cytometry: Assay-dependent, Immunocytochemistry: Assay-dependent, Immunoprecipitation: 2 µg/mL, Western Blot: 1-2 µg/mL
物种 :
仓鼠, 人类, 小鼠
克隆 :
GNS1
抗体亚型 :
IgG1
储存 :
4° C
描述 :
Cyclins bind to and regulate the activity of the Cyclin dependent protein kinases (CDKs). Cyclin B1 or CCNB1 is a regulatory protein involved in mitosis. It is essential for the control of the cell cycle at the G2/M transition. Cyclin B1 complexes with p34 (cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. Cyclin B1 is not ubiquitinated during G2/M phase, resulting in its steady accumulation during G2 phase, followed by  abrupt APC dependent destruction at the end of mitosis. Destruction of Cyclin B1 is required for cell cycle progression. Cyclin B1 is overexpressed in various cancers, including breast, prostate, and non-small cell lung cancer.
免疫原 :
人类细胞周期蛋白B1蛋白
格式 :
液体
应用w/稀释 :
Flow Cytometry: Assay-dependent, Immunocytochemistry: Assay-dependent, Immunoprecipitation: 2 µg/mL, Western Blot: 1-2 µg/mL
别名 :
Ccn-2; CCNB; Ccnb1; Ccnb1-rs1; Ccnb1-rs13; Cycb; Cycb1; Cycb1-rs1; Cycb-4; Cycb-5; cyclin B; cyclin B1; cyclin B1, related sequence 1; cyclin B1, related sequence 13; G2/mitotic-specific cyclin B1; G2/mitotic-specific cyclin-B1; I79_013589; OTTHUMP00000221981; OTTHUMP00000223023
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国