产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
周期蛋白E单克隆抗体(HE12)
目录 :
MA5-14336
规格 :
500微升
价格 :
美国446.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
HE12
反应物种 :
African green monkey, 人类, 小鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 流式细胞仪, 免疫组化-石蜡切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 33
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 图 4b
Pozner A, Terooatea T, Buck Koehntop B. Cell-specific Kaiso (ZBTB33) Regulation of Cell Cycle through Cyclin D1 and Cyclin E1. J Biol Chem. 2016;291:24538-24550 pubmed
  • 免疫组化-石蜡切片; 人类; 1:50; 图 2
Duchnowska R, Wysocki P, Korski K, Czartoryska ArÅ‚ukowicz B, NiwiÅ„ska A, Orlikowska M, et al. Immunohistochemical prediction of lapatinib efficacy in advanced HER2-positive breast cancer patients. Oncotarget. 2016;7:550-64 pubmed 出版商
  • 免疫印迹; 人类
Bisteau X, Paternot S, Colleoni B, Ecker K, Coulonval K, De Groote P, et al. CDK4 T172 phosphorylation is central in a CDK7-dependent bidirectional CDK4/CDK2 interplay mediated by p21 phosphorylation at the restriction point. PLoS Genet. 2013;9:e1003546 pubmed 出版商
  • 免疫细胞化学; 人类
Suzuki M, Yamauchi M, Oka Y, Suzuki K, Yamashita S. Live-cell imaging visualizes frequent mitotic skipping during senescence-like growth arrest in mammary carcinoma cells exposed to ionizing radiation. Int J Radiat Oncol Biol Phys. 2012;83:e241-50 pubmed 出版商
  • 免疫印迹; 人类; 0.5 ug/ml; 图 s2
Lofmark S, de Klerk N, Aro H. Neisseria gonorrhoeae infection induces altered amphiregulin processing and release. PLoS ONE. 2011;6:e16369 pubmed 出版商
  • 免疫印迹; 人类; 1:200; 图 6e
Rico Bautista E, Yang C, Lu L, Roth G, Wolf D. Chemical genetics approach to restoring p27Kip1 reveals novel compounds with antiproliferative activity in prostate cancer cells. BMC Biol. 2010;8:153 pubmed 出版商
  • 免疫印迹; 小鼠
Cimica V, Smith M, Zhang Z, Mathur D, Mani S, Kalpana G. Potent inhibition of rhabdoid tumor cells by combination of flavopiridol and 4OH-tamoxifen. BMC Cancer. 2010;10:634 pubmed 出版商
  • 免疫印迹; 人类
Holubcová Z, Matula P, Sedláčková M, Vinarsky V, Dolezalova D, Bárta T, et al. Human embryonic stem cells suffer from centrosomal amplification. Stem Cells. 2011;29:46-56 pubmed 出版商
  • 免疫印迹; 人类
Bárta T, Vinarsky V, Holubcová Z, Dolezalova D, Verner J, Pospisilova S, et al. Human embryonic stem cells are capable of executing G1/S checkpoint activation. Stem Cells. 2010;28:1143-52 pubmed 出版商
  • 免疫印迹; 人类; 1 ug/ml; 图 2
Chimploy K, Díaz G, Li Q, Carter O, Dashwood W, Mathews C, et al. E2F4 and ribonucleotide reductase mediate S-phase arrest in colon cancer cells treated with chlorophyllin. Int J Cancer. 2009;125:2086-94 pubmed 出版商
  • 免疫组化; 人类
Martin D, Boersma B, Yi M, Reimers M, Howe T, Yfantis H, et al. Differences in the tumor microenvironment between African-American and European-American breast cancer patients. PLoS ONE. 2009;4:e4531 pubmed 出版商
  • 免疫印迹; 人类
Cheng T, Teng C, Tsai W, Yeh C, Wu M, Hsu H, et al. Multitarget therapy of malignant cancers by the head-to-tail tandem array multiple shRNAs expression system. Cancer Gene Ther. 2009;16:516-31 pubmed 出版商
  • 免疫印迹; 人类
Hudson T, Hartle D, Hursting S, Nunez N, Wang T, Young H, et al. Inhibition of prostate cancer growth by muscadine grape skin extract and resveratrol through distinct mechanisms. Cancer Res. 2007;67:8396-405 pubmed
  • 免疫印迹; 人类
Al Ayyoubi S, Gali Muhtasib H. Differential apoptosis by gallotannin in human colon cancer cells with distinct p53 status. Mol Carcinog. 2007;46:176-86 pubmed
  • 免疫印迹; 人类; 2.6 ug/ml; 图 4
Jones A, Jonsson A, Aro H. Neisseria gonorrhoeae infection causes a G1 arrest in human epithelial cells. FASEB J. 2007;21:345-55 pubmed
  • 免疫印迹; 人类; 1:500
Wiseman D, Werner S, Crowell P. Cell cycle arrest by the isoprenoids perillyl alcohol, geraniol, and farnesol is mediated by p21(Cip1) and p27(Kip1) in human pancreatic adenocarcinoma cells. J Pharmacol Exp Ther. 2007;320:1163-70 pubmed
  • 免疫组化; 人类; 1:100
Kliman H, Honig S, Walls D, Luna M, McSweet J, Copperman A. Optimization of endometrial preparation results in a normal endometrial function test (EFT) and good reproductive outcome in donor ovum recipients. J Assist Reprod Genet. 2006;23:299-303 pubmed
  • 免疫组化; 人类
Boersma B, Howe T, Goodman J, Yfantis H, Lee D, Chanock S, et al. Association of breast cancer outcome with status of p53 and MDM2 SNP309. J Natl Cancer Inst. 2006;98:911-9 pubmed
  • 免疫印迹; African green monkey
  • 免疫印迹; 人类
Yang X, Liu J, Ye L, Liao Q, Wu J, Gao J, et al. HCV NS2 protein inhibits cell proliferation and induces cell cycle arrest in the S-phase in mammalian cells through down-regulation of cyclin A expression. Virus Res. 2006;121:134-43 pubmed
  • 免疫印迹; 人类
Siitonen T, Koistinen P, Savolainen E. Increase in Ara-C cytotoxicity in the presence of valproate, a histone deacetylase inhibitor, is associated with the concurrent expression of cyclin D1 and p27(Kip 1) in acute myeloblastic leukemia cells. Leuk Res. 2005;29:1335-42 pubmed
  • 免疫印迹; 人类; 1:200
Lu L, Schulz H, Wolf D. The F-box protein SKP2 mediates androgen control of p27 stability in LNCaP human prostate cancer cells. BMC Cell Biol. 2002;3:22 pubmed
Bajzikova M, Kovarova J, Coelho A, Boukalova S, Oh S, Rohlenova K, et al. Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells. Cell Metab. 2019;29:399-416.e10 pubmed 出版商
Jurisevic M, Arsenijević A, Pantic J, Gajovic N, Milovanovic J, Milovanovic M, et al. The organic ester O,O'-diethyl-(S,S)-ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoate dihydrochloride attenuates murine breast cancer growth and metastasis. Oncotarget. 2018;9:28195-28212 pubmed 出版商
Wang L, Tu Z, Liu C, Liu H, Kaldis P, Chen Z, et al. Dual roles of TRF1 in tethering telomeres to the nuclear envelope and protecting them from fusion during meiosis. Cell Death Differ. 2018;25:1174-1188 pubmed 出版商
Tadokoro T, Fujihara S, Chiyo T, Oura K, Samukawa E, Yamana Y, et al. Induction of apoptosis by Galectin-9 in liver metastatic cancer cells: In vitro study. Int J Oncol. 2017;51:607-614 pubmed 出版商
Yang C, Fazli L, Loguercio S, Zharkikh I, Aza Blanc P, Gleave M, et al. Downregulation of c-SRC kinase CSK promotes castration resistant prostate cancer and pinpoints a novel disease subclass. Oncotarget. 2015;6:22060-71 pubmed
Drayton S, Rowe J, Jones R, Vatcheva R, Cuthbert Heavens D, Marshall J, et al. Tumor suppressor p16INK4a determines sensitivity of human cells to transformation by cooperating cellular oncogenes. Cancer Cell. 2003;4:301-10 pubmed
Joaquin M, Watson R. The cell cycle-regulated B-Myb transcription factor overcomes cyclin-dependent kinase inhibitory activity of p57(KIP2) by interacting with its cyclin-binding domain. J Biol Chem. 2003;278:44255-64 pubmed
Dubowy R, Feinberg R, Keefe D, Doncel G, Williams S, McSweet J, et al. Improved endometrial assessment using cyclin E and p27. Fertil Steril. 2003;80:146-56 pubmed
Murillo G, Salti G, Kosmeder J, Pezzuto J, Mehta R. Deguelin inhibits the growth of colon cancer cells through the induction of apoptosis and cell cycle arrest. Eur J Cancer. 2002;38:2446-54 pubmed
Lewis J, Thomas T, Klinge C, Gallo M, Thomas T. Regulation of cell cycle and cyclins by 16alpha-hydroxyestrone in MCF-7 breast cancer cells. J Mol Endocrinol. 2001;27:293-307 pubmed
Hennigan R, Stambrook P. Dominant negative c-jun inhibits activation of the cyclin D1 and cyclin E kinase complexes. Mol Biol Cell. 2001;12:2352-63 pubmed
Richter J, Wagner U, Kononen J, Fijan A, Bruderer J, Schmid U, et al. High-throughput tissue microarray analysis of cyclin E gene amplification and overexpression in urinary bladder cancer. Am J Pathol. 2000;157:787-94 pubmed
图像
图像 1 :
赛默飞世尔 MA5-14336 图像 1
图像 2 :
赛默飞世尔 MA5-14336 图像 2
图像 3 :
赛默飞世尔 MA5-14336 图像 3
产品信息
产品类型 :
抗体
产品名称 :
周期蛋白E单克隆抗体(HE12)
目录# :
MA5-14336
规格 :
500微升
价格 :
美国446.00
克隆性 :
单克隆
纯度 :
蛋白质G
宿主 :
小鼠
反应物种 :
人类, 小鼠
应用 :
Flow Cytometry: 1-2 µg/test, Immunohistochemistry (Paraffin): 2-4 µg/mL, Western Blot: 1-2 µg/mL
物种 :
人类, 小鼠
克隆 :
HE12
抗体亚型 :
IgG1
储存 :
4° C
描述 :
Cyclin E belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclin E forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available.
免疫原 :
重组人类周期蛋白E蛋白
格式 :
液体
应用w/稀释 :
Flow Cytometry: 1-2 µg/test, Immunohistochemistry (Paraffin): 2-4 µg/mL, Western Blot: 1-2 µg/mL
别名 :
AW538188; Ccne; Ccne1; CycE1; CYCLE; cyclin E; cyclin E1; cyclin Es; cyclin Et; E-S; G1/S-specific cyclin-E1; pCCNE1
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国