产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
角蛋白8单克隆抗体(TS1)
目录 :
MA5-14428
规格 :
500微升
价格 :
美国400.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
TS1
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片, 免疫印迹基因敲除验证
更多信息或购买 :
文章摘录数: 24
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 图 2e
Kuga T, Kume H, Adachi J, Kawasaki N, Shimizu M, Hoshino I, et al. Casein kinase 1 is recruited to nuclear speckles by FAM83H and SON. Sci Rep. 2016;6:34472 pubmed 出版商
  • 免疫细胞化学; 人类; 图 2c
  • 免疫印迹; 人类; 图 3h
Kuga T, Sasaki M, Mikami T, Miake Y, Adachi J, Shimizu M, et al. FAM83H and casein kinase I regulate the organization of the keratin cytoskeleton and formation of desmosomes. Sci Rep. 2016;6:26557 pubmed 出版商
  • 免疫组化; 人类; 1:300
BaÅŸak K, KiroÄŸlu K. Multiple oncocytic cystadenoma with intraluminal crystalloids in parotid gland: case report. Medicine (Baltimore). 2014;93:e246 pubmed 出版商
  • 免疫沉淀; 人类
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
Snider N, Park H, Omary M. A conserved rod domain phosphotyrosine that is targeted by the phosphatase PTP1B promotes keratin 8 protein insolubility and filament organization. J Biol Chem. 2013;288:31329-37 pubmed 出版商
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
Kuga T, Kume H, Kawasaki N, Sato M, Adachi J, Shiromizu T, et al. A novel mechanism of keratin cytoskeleton organization through casein kinase I? and FAM83H in colorectal cancer. J Cell Sci. 2013;126:4721-31 pubmed 出版商
  • 免疫沉淀; 人类
Snider N, Leonard J, Kwan R, Griggs N, Rui L, Omary M. Glucose and SIRT2 reciprocally mediate the regulation of keratin 8 by lysine acetylation. J Cell Biol. 2013;200:241-7 pubmed 出版商
  • 免疫印迹; 人类
Duan Y, Sun Y, Zhang F, Zhang W, Wang D, Wang Y, et al. Keratin K18 increases cystic fibrosis transmembrane conductance regulator (CFTR) surface expression by binding to its C-terminal hydrophobic patch. J Biol Chem. 2012;287:40547-59 pubmed 出版商
  • 免疫组化; 人类
  • 免疫印迹; 人类
Létourneau I, Quinn M, Wang L, Portelance L, Caceres K, Cyr L, et al. Derivation and characterization of matched cell lines from primary and recurrent serous ovarian cancer. BMC Cancer. 2012;12:379 pubmed 出版商
  • 免疫组化; 人类; 1:100
Barak S, Wang Z, Miettinen M. Immunoreactivity for calretinin and keratins in desmoid fibromatosis and other myofibroblastic tumors: a diagnostic pitfall. Am J Surg Pathol. 2012;36:1404-9 pubmed 出版商
  • 免疫印迹; 小鼠
Hanada S, Harada M, Abe M, Akiba J, Sakata M, Kwan R, et al. Aging modulates susceptibility to mouse liver Mallory-Denk body formation. J Histochem Cytochem. 2012;60:475-83 pubmed 出版商
  • 免疫印迹; 小鼠
Singla A, Moons D, Snider N, Wagenmaker E, Jayasundera V, Omary M. Oxidative stress, Nrf2 and keratin up-regulation associate with Mallory-Denk body formation in mouse erythropoietic protoporphyria. Hepatology. 2012;56:322-31 pubmed 出版商
  • 免疫组化; 小鼠
  • 免疫印迹; 小鼠
Chang H, Chen B, Wu C, Tsao Z, Chen Y, Chang C, et al. Hedgehog overexpression leads to the formation of prostate cancer stem cells with metastatic property irrespective of androgen receptor expression in the mouse model. J Biomed Sci. 2011;18:6 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:200
Snider N, Weerasinghe S, INIGUEZ LLUHI J, Herrmann H, Omary M. Keratin hypersumoylation alters filament dynamics and is a marker for human liver disease and keratin mutation. J Biol Chem. 2011;286:2273-84 pubmed 出版商
  • 免疫组化; 人类
Carvalho L, Pereira E, Frappart L, Boniol M, Bernardo W, Tarricone V, et al. Molecular characterization of breast cancer in young Brazilian women. Rev Assoc Med Bras (1992). 2010;56:278-87 pubmed
  • 免疫细胞化学; 小鼠
  • 免疫印迹; 小鼠
Gilbert S, Ruel A, Loranger A, Marceau N. Switch in Fas-activated death signaling pathway as result of keratin 8/18-intermediate filament loss. Apoptosis. 2008;13:1479-93 pubmed 出版商
  • 免疫组化; 人类
  • 免疫印迹; 人类
Ouellet V, Zietarska M, Portelance L, Lafontaine J, Madore J, Puiffe M, et al. Characterization of three new serous epithelial ovarian cancer cell lines. BMC Cancer. 2008;8:152 pubmed 出版商
  • 免疫印迹; 人类; 1:200; 图 6
Page J, Johnson M, Olsavsky K, Strom S, Zarbl H, Omiecinski C. Gene expression profiling of extracellular matrix as an effector of human hepatocyte phenotype in primary cell culture. Toxicol Sci. 2007;97:384-97 pubmed
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
Tao G, Nakamichi I, Ku N, Wang J, Frolkis M, Gong X, et al. Bispecific and human disease-related anti-keratin rabbit monoclonal antibodies. Exp Cell Res. 2006;312:411-22 pubmed
  • 免疫细胞化学; 人类; 1:300
  • 免疫印迹; 人类
Scott G, Atsriku C, Kaminker P, Held J, Gibson B, Baldwin M, et al. Vitamin K3 (menadione)-induced oncosis associated with keratin 8 phosphorylation and histone H3 arylation. Mol Pharmacol. 2005;68:606-15 pubmed
  • 免疫印迹基因敲除验证; 小鼠; 图 3
Gilbert S, Loranger A, Marceau N. Keratins modulate c-Flip/extracellular signal-regulated kinase 1 and 2 antiapoptotic signaling in simple epithelial cells. Mol Cell Biol. 2004;24:7072-81 pubmed
Peculis R, Mandrika I, Petrovska R, Dortane R, Megnis K, Nazarovs J, et al. Pituispheres Contain Genetic Variants Characteristic to Pituitary Adenoma Tumor Tissue. Front Endocrinol (Lausanne). 2020;11:313 pubmed 出版商
Pu T, Xiong L, Liu Q, Zhang M, Cai Q, Liu H, et al. Delineation of retroperitoneal metastatic lymph nodes in ovarian cancer with near-infrared fluorescence imaging. Oncol Lett. 2017;14:2869-2877 pubmed 出版商
Maitra D, Elenbaas J, Whitesall S, Basrur V, D Alecy L, Omary M. Ambient Light Promotes Selective Subcellular Proteotoxicity after Endogenous and Exogenous Porphyrinogenic Stress. J Biol Chem. 2015;290:23711-24 pubmed 出版商
Sørensen C, Andresen B, Jensen U, Jensen T, Jensen P, Gregersen N, et al. Functional testing of keratin 14 mutant proteins associated with the three major subtypes of epidermolysis bullosa simplex. Exp Dermatol. 2003;12:472-9 pubmed
图像
图像 1 :
赛默飞世尔 MA5-14428 图像 1
产品信息
产品类型 :
抗体
产品名称 :
角蛋白8单克隆抗体(TS1)
目录# :
MA5-14428
规格 :
500微升
价格 :
美国400.00
克隆性 :
单克隆
纯度 :
蛋白质G
宿主 :
小鼠
反应物种 :
人类
应用 :
Immunocytochemistry: 2 µg/mL, Immunohistochemistry (Paraffin): 1:200-1:400, Immunoprecipitation: 1:50, Western Blot: 1:25-1:50
物种 :
人类
克隆 :
TS1
抗体亚型 :
IgG1, kappa
储存 :
4° C
描述 :
Cytokeratin 8 is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. Cutokeratin 8 typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis.
免疫原 :
Keratin preparation from a human carcinoma
格式 :
液体
应用w/稀释 :
Immunocytochemistry: 2 µg/mL, Immunohistochemistry (Paraffin): 1:200-1:400, Immunoprecipitation: 1:50, Western Blot: 1:25-1:50
别名 :
AA960620; AL022697; AU019895; C CY K2C8; CARD2; cb186; CK 8; CK8; CK-8; CYK8; CYKER; cytokeratin 8; cytokeratin 8 (370 AA); cytokeratin endo A; Cytokeratin-8; cytokeratin-A; DreK8; EndoA; etID33550.23; etID43142.23; etID43142.8; hard keratin; K2C8; K8; K-8; KERA; keratin 8; keratin 8, type II; keratin complex 2, basic, gene 8; keratin, type 2, gene 8; Keratin, type II cytoskeletal 8; keratin, type II cytoskeletal 8-like protein; keratin-8; KO; Krt-2.8; Krt2-8; krt8; LOW QUALITY PROTEIN: keratin, type II cytoskeletal 8; sb:cb186; type II cytokeratin A (no.8); type-II keratin Kb8; wu:fa20h05; wu:fa95h10; wu:fb96c06; zfk8; zf-K8
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国