产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
细胞周期蛋白D1重组兔单克隆抗体(SP4)
目录 :
MA5-14512
规格 :
500微升
价格 :
美国446.00
克隆性 :
重组
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
SP4
反应物种 :
baboons, African green monkey, 人类, 小鼠, 大鼠,
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
文章摘录数: 320
出版应用/物种/样本/稀释参考文献
  • 免疫组化; 小鼠; 1:400; 图 2c
Li H, Kurtzeborn K, Kupari J, Gui Y, Siefker E, Lu B, et al. Postnatal prolongation of mammalian nephrogenesis by excess fetal GDNF. Development. 2021;148: pubmed 出版商
  • 免疫组化; 小鼠; 1:100; 图 ev2d
Di Matteo F, Pipicelli F, Kyrousi C, Tovecci I, Penna E, Crispino M, et al. Cystatin B is essential for proliferation and interneuron migration in individuals with EPM1 epilepsy. EMBO Mol Med. 2020;12:e11419 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:100; 图 s17b
Ruess D, Heynen G, Ciecielski K, Ai J, Berninger A, Kabacaoglu D, et al. Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase. Nat Med. 2018;24:954-960 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 3d
Lazaro S, Perez Crespo M, Enguita A, Hernandez P, Martínez Palacio J, Oteo M, et al. Ablating all three retinoblastoma family members in mouse lung leads to neuroendocrine tumor formation. Oncotarget. 2017;8:4373-4386 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 图 4
Walline H, Carey T, Goudsmit C, Bellile E, D Souza G, Peterson L, et al. High-Risk HPV, Biomarkers, and Outcome in Matched Cohorts of Head and Neck Cancer Patients Positive and Negative for HIV. Mol Cancer Res. 2017;15:179-188 pubmed 出版商
  • 免疫印迹; 小鼠; 1:250; 图 9a
Fujimura K, Mitsuhashi T, Shibata S, Shimozato S, Takahashi T. In Utero Exposure to Valproic Acid Induces Neocortical Dysgenesis via Dysregulation of Neural Progenitor Cell Proliferation/Differentiation. J Neurosci. 2016;36:10908-10919 pubmed
  • 免疫组化-石蜡切片; 人类; 表 2
Soon G, Ow G, Chan H, Ng S, Wang S. Primary cardiac diffuse large B-cell lymphoma in immunocompetent patients: clinical, histologic, immunophenotypic, and genotypic features of 3 cases. Ann Diagn Pathol. 2016;24:40-6 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:100; 图 9
Zak M, van Oort T, Hendriksen F, Garcia M, Vassart G, Grolman W. LGR4 and LGR5 Regulate Hair Cell Differentiation in the Sensory Epithelium of the Developing Mouse Cochlea. Front Cell Neurosci. 2016;10:186 pubmed 出版商
  • 免疫组化; 大鼠; 1:250; 图 3
Doobin D, Kemal S, Dantas T, Vallee R. Severe NDE1-mediated microcephaly results from neural progenitor cell cycle arrests at multiple specific stages. Nat Commun. 2016;7:12551 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 图 1a
Kim Y, Jin D, Lee B, Cho E, Han J, Shim Y, et al. Overexpression of β-Catenin and Cyclin D1 is Associated with Poor Overall Survival in Patients with Stage IA-IIA Squamous Cell Lung Cancer Irrespective of Adjuvant Chemotherapy. J Thorac Oncol. 2016;11:2193-2201 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:20; 图 2e
Song J, Song L, Herrera A, Venkataraman G, Murata Collins J, Bedell V, et al. Cyclin D1 expression in peripheral T-cell lymphomas. Mod Pathol. 2016;29:1306-1312 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:100; 图 1g
Kurita D, Takeuchi K, Kobayashi S, Hojo A, Uchino Y, Sakagami M, et al. A cyclin D1-negative mantle cell lymphoma with an IGL-CCND2 translocation that relapsed with blastoid morphology and aggressive clinical behavior. Virchows Arch. 2016;469:471-6 pubmed 出版商
  • 免疫组化; 小鼠; 1:400; 图 4a
Urbán N, van den Berg D, Forget A, Andersen J, Demmers J, Hunt C, et al. Return to quiescence of mouse neural stem cells by degradation of a proactivation protein. Science. 2016;353:292-5 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 表 1
Troxell M, Higgins J. Renal cell carcinoma in kidney allografts: histologic types, including biphasic papillary carcinoma. Hum Pathol. 2016;57:28-36 pubmed 出版商
  • 免疫细胞化学; 人类; 1:10; 图 5
Tomei P, Masola V, Granata S, Bellin G, Carratu P, Ficial M, et al. Everolimus-induced epithelial to mesenchymal transition (EMT) in bronchial/pulmonary cells: when the dosage does matter in transplantation. J Nephrol. 2016;29:881-891 pubmed
  • 免疫组化; 人类; 1:25; 图 1
Lamba Saini M, Bouzin C, Weynand B, Marbaix E. An Appraisal of Proliferation and Apoptotic Markers in Papillary Thyroid Carcinoma: An Automated Analysis. PLoS ONE. 2016;11:e0148656 pubmed 出版商
  • 免疫细胞化学; 人类; 图 2b
Kanter M, Turan G, Usta C, Usta A, Esen H, Tavlı L, et al. Survivin and cycline D1 expressions are associated with malignant potential in mucinous ovarian neoplasms. J Mol Histol. 2016;47:145-52 pubmed 出版商
  • 免疫组化; 大鼠; 图 1
Carabalona A, Hu D, Vallee R. KIF1A inhibition immortalizes brain stem cells but blocks BDNF-mediated neuronal migration. Nat Neurosci. 2016;19:253-62 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:500; 图 3e
Mayr C, Wagner A, Loeffelberger M, Brückner D, Jakab M, Berr F, et al. The BMI1 inhibitor PTC-209 is a potential compound to halt cellular growth in biliary tract cancer cells. Oncotarget. 2016;7:745-58 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 4C
Fujino K, Motooka Y, Hassan W, Ali Abdalla M, Sato Y, Kudoh S, et al. Insulinoma-Associated Protein 1 Is a Crucial Regulator of Neuroendocrine Differentiation in Lung Cancer. Am J Pathol. 2015;185:3164-77 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:100; 图 9
  • 免疫印迹; 小鼠; 图 3
Chaudhary S, Tang X, Arumugam A, Li C, Srivastava R, Weng Z, et al. Shh and p50/Bcl3 signaling crosstalk drives pathogenesis of BCCs in Gorlin syndrome. Oncotarget. 2015;6:36789-814 pubmed 出版商
  • 免疫组化; 人类; 图 s4
Shain A, Garrido M, Botton T, Talevich E, Yeh I, Sanborn J, et al. Exome sequencing of desmoplastic melanoma identifies recurrent NFKBIE promoter mutations and diverse activating mutations in the MAPK pathway. Nat Genet. 2015;47:1194-9 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:50; 图 2
Binder Gallimidi A, Fischman S, Revach B, Bulvik R, Maliutina A, Rubinstein A, et al. Periodontal pathogens Porphyromonas gingivalis and Fusobacterium nucleatum promote tumor progression in an oral-specific chemical carcinogenesis model. Oncotarget. 2015;6:22613-23 pubmed
  • 免疫组化-石蜡切片; 人类; 1:100; 图 1
Jäger W, Xue H, Hayashi T, Janssen C, Awrey S, Wyatt A, et al. Patient-derived bladder cancer xenografts in the preclinical development of novel targeted therapies. Oncotarget. 2015;6:21522-32 pubmed
  • 免疫组化-石蜡切片; 人类
Yin C, Tang G, Lu G, Feng X, Keating M, Medeiros L, et al. Del(20q) in patients with chronic lymphocytic leukemia: a therapy-related abnormality involving lymphoid or myeloid cells. Mod Pathol. 2015;28:1130-7 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:25; 图 6
Brunner S, Weber F, Werner J, Agha A, Farkas S, Schlitt H, et al. Neuroendocrine tumors of the pancreas: a retrospective single-center analysis using the ENETS TNM-classification and immunohistochemical markers for risk stratification. BMC Surg. 2015;15:49 pubmed 出版商
  • 免疫组化; 人类; 1:50; 图 2
Beca F, Pereira M, Cameselle Teijeiro J, Martins D, Schmitt F. Altered PPP2R2A and Cyclin D1 expression defines a subgroup of aggressive luminal-like breast cancer. BMC Cancer. 2015;15:285 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:50
Kim Y, Jin D, Lee B, Cho E, Han J, Shim Y, et al. RARβ2 hypermethylation is associated with poor recurrence-free survival in never-smokers with adenocarcinoma of the lung. Clin Epigenetics. 2015;7:32 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
Li Y, Hu S, Zuo Z, Hong M, Lin P, Li S, et al. CD5-positive follicular lymphoma: clinicopathologic correlations and outcome in 88 cases. Mod Pathol. 2015;28:787-98 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:10
Meykler S, Baloch Z, Barroeta J. A case of marginal zone lymphoma with extensive emperipolesis diagnosed on pleural effusion cytology with immunocytochemistry and flow cytometry. Cytopathology. 2016;27:70-2 pubmed 出版商
  • 免疫组化; 小鼠; 1:50
Dabydeen S, Kang K, Díaz Cruz E, Alamri A, Axelrod M, Bouker K, et al. Comparison of tamoxifen and letrozole response in mammary preneoplasia of ER and aromatase overexpressing mice defines an immune-associated gene signature linked to tamoxifen resistance. Carcinogenesis. 2015;36:122-32 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:10
Zhang Q, Chabot Richards D, Evans M, Spengel K, Andrews J, Kang H, et al. A retrospective study to assess the relative value of peripheral blood, bone marrow aspirate and biopsy morphology, immunohistochemical stains, and flow cytometric analysis in the diagnosis of chronic B cell lymphoproliferative neoplasms. Int J Lab Hematol. 2015;37:390-402 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:100
Contreras Jurado C, García Serrano L, Martínez Fernández M, Ruiz Llorente L, Paramio J, Aranda A. Impaired hair growth and wound healing in mice lacking thyroid hormone receptors. PLoS ONE. 2014;9:e108137 pubmed 出版商
  • 免疫组化; African green monkey; 1:80
Dumitrescu A, Aberdeen G, Pepe G, Albrecht E. Placental estrogen suppresses cyclin D1 expression in the nonhuman primate fetal adrenal cortex. Endocrinology. 2014;155:4774-84 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:50
Inada A, Inada O, Fujii N, Fujishima K, Inai T, Fujii H, et al. ?-cell induction in vivo in severely diabetic male mice by changing the circulating levels and pattern of the ratios of estradiol to androgens. Endocrinology. 2014;155:3829-42 pubmed 出版商
  • 免疫印迹; 小鼠
Yu W, Bonnet M, Farso M, Ma K, Chabot J, Martin E, et al. The expression of apoptosis inducing factor (AIF) is associated with aging-related cell death in the cortex but not in the hippocampus in the TgCRND8 mouse model of Alzheimer's disease. BMC Neurosci. 2014;15:73 pubmed 出版商
  • 免疫组化; 小鼠; 1:500; 图 7b
Alanis D, Chang D, Akiyama H, Krasnow M, Chen J. Two nested developmental waves demarcate a compartment boundary in the mouse lung. Nat Commun. 2014;5:3923 pubmed 出版商
  • 免疫组化; 小鼠
  • 免疫印迹; 小鼠
Tane S, Kubota M, Okayama H, Ikenishi A, Yoshitome S, Iwamoto N, et al. Repression of cyclin D1 expression is necessary for the maintenance of cell cycle exit in adult mammalian cardiomyocytes. J Biol Chem. 2014;289:18033-44 pubmed 出版商
  • 免疫组化; 人类
Bongiovanni M, Mazzucchelli L, Giovanella L, Frattini M, Pusztaszeri M. Well-differentiated follicular patterned tumors of the thyroid with high-grade features can metastasize in the absence of capsular or vascular invasion: report of a case. Int J Surg Pathol. 2014;22:749-56 pubmed 出版商
  • 免疫组化; 人类; 1:40
van den Brand M, Hoevenaars B, Sigmans J, Meijer J, van Cleef P, Groenen P, et al. Sequential immunohistochemistry: a promising new tool for the pathology laboratory. Histopathology. 2014;65:651-7 pubmed 出版商
  • 免疫组化; 人类; 1:50
Chung J, Noh H, Park K, Choi E, Han A. Longer survival in patients with breast cancer with cyclin d1 over-expression after tumor recurrence: longer, but occupied with disease. J Breast Cancer. 2014;17:47-53 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:200
Kiszner G, Wichmann B, Nemeth I, Varga E, Meggyeshazi N, Teleki I, et al. Cell cycle analysis can differentiate thin melanomas from dysplastic nevi and reveals accelerated replication in thick melanomas. Virchows Arch. 2014;464:603-12 pubmed 出版商
  • 免疫组化; 人类; 1:50
Min H, Kim J, Ryoo I, Jung S, Jung C. The role of core needle biopsy in the preoperative diagnosis of follicular neoplasm of the thyroid. APMIS. 2014;122:993-1000 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Scharfmann R, Pechberty S, Hazhouz Y, von Bülow M, Bricout Neveu E, Grenier Godard M, et al. Development of a conditionally immortalized human pancreatic ? cell line. J Clin Invest. 2014;124:2087-98 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:100
Li J, Bai X, Zou Y, Hao Y, Xu X. Aberration of the Wnt signaling pathway in pulmonary fatal adenocarcinoma: a case report. Chin J Cancer Res. 2014;26:E13-6 pubmed 出版商
  • 免疫组化; 人类
Bergshoeff V, Van der Heijden S, Haesevoets A, Litjens S, Bot F, Voogd A, et al. Chromosome instability predicts progression of premalignant lesions of the larynx. Pathology. 2014;46:216-24 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
Neumeister V, Parisi F, England A, Siddiqui S, Anagnostou V, Zarrella E, et al. A tissue quality index: an intrinsic control for measurement of effects of preanalytical variables on FFPE tissue. Lab Invest. 2014;94:467-74 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 2a
  • 免疫印迹; 小鼠
  • 免疫组化-石蜡切片; 人类; 图 3e
Berkenkamp B, Susnik N, Baisantry A, Kuznetsova I, Jacobi C, Sörensen Zender I, et al. In vivo and in vitro analysis of age-associated changes and somatic cellular senescence in renal epithelial cells. PLoS ONE. 2014;9:e88071 pubmed 出版商
  • 免疫印迹; 小鼠
Marttinen M, Pajari A, Paivarinta E, Storvik M, Marttinen P, Nurmi T, et al. Plant sterol feeding induces tumor formation and alters sterol metabolism in the intestine of Apc(Min) mice. Nutr Cancer. 2014;66:259-69 pubmed 出版商
  • 免疫组化; 人类; 1:100
Elesawy B, Abd El Hafez A, Shawky A, Arafa M. Immunohistochemistry-based subtyping of breast carcinoma in Egyptian women: a clinicopathologic study on 125 patients. Ann Diagn Pathol. 2014;18:21-6 pubmed 出版商
  • 免疫细胞化学; 小鼠
Bizen N, Inoue T, Shimizu T, Tabu K, Kagawa T, Taga T. A growth-promoting signaling component cyclin D1 in neural stem cells has antiastrogliogenic function to execute self-renewal. Stem Cells. 2014;32:1602-15 pubmed 出版商
  • 免疫细胞化学; 人类
Spencer S, Cappell S, Tsai F, Overton K, Wang C, Meyer T. The proliferation-quiescence decision is controlled by a bifurcation in CDK2 activity at mitotic exit. Cell. 2013;155:369-83 pubmed 出版商
  • 免疫组化; 人类
Wang S, Tzankov A, Xu Monette Z, Hoeller S, Wang S, Richards K, et al. Clonally related composite follicular lymphoma and mantle cell lymphoma with clinicopathologic features and biological implications. Hum Pathol. 2013;44:2658-67 pubmed 出版商
  • 免疫组化; 人类
Rasmussen P. Diffuse large B-cell lymphoma and mantle cell lymphoma of the ocular adnexal region, and lymphoma of the lacrimal gland: an investigation of clinical and histopathological features. Acta Ophthalmol. 2013;91 Thesis 5:1-27 pubmed 出版商
  • 免疫印迹; 犬; 1:200; 图 7
  • 免疫印迹; 人类; 1:200; 图 7
Mudaliar M, Haggart R, Miele G, Sellar G, Tan K, Goodlad J, et al. Comparative gene expression profiling identifies common molecular signatures of NF-?B activation in canine and human diffuse large B cell lymphoma (DLBCL). PLoS ONE. 2013;8:e72591 pubmed 出版商
  • 免疫组化; 人类; 1:25
Gröbe A, Eichhorn W, Fraederich M, Kluwe L, Vashist Y, Wikner J, et al. Immunohistochemical and FISH analysis of EGFR and its prognostic value in patients with oral squamous cell carcinoma. J Oral Pathol Med. 2014;43:205-10 pubmed 出版商
  • 免疫组化; 小鼠
Zhu S, Mott R, Fry E, Taneja P, Kulik G, Sui G, et al. Cooperation between Dmp1 loss and cyclin D1 overexpression in breast cancer. Am J Pathol. 2013;183:1339-1350 pubmed 出版商
  • 免疫组化; 小鼠; 1:500
Pribluda A, Elyada E, Wiener Z, Hamza H, Goldstein R, Biton M, et al. A senescence-inflammatory switch from cancer-inhibitory to cancer-promoting mechanism. Cancer Cell. 2013;24:242-56 pubmed 出版商
  • 免疫组化; 小鼠; 1:300
Nobs L, Nestel S, Kulik A, Nitsch C, Atanasoski S. Cyclin D1 is required for proliferation of Olig2-expressing progenitor cells in the injured cerebral cortex. Glia. 2013;61:1443-55 pubmed 出版商
  • 免疫印迹; 小鼠
Pitzonka L, Wang X, Ullas S, Wolff D, Wang Y, Goodrich D. The THO ribonucleoprotein complex is required for stem cell homeostasis in the adult mouse small intestine. Mol Cell Biol. 2013;33:3505-14 pubmed 出版商
  • 免疫组化; 人类; 1:80
Shin S, Lal A, De Vries S, Suzuki J, Roy R, Hwang E, et al. Florid lobular carcinoma in situ: molecular profiling and comparison to classic lobular carcinoma in situ and pleomorphic lobular carcinoma in situ. Hum Pathol. 2013;44:1998-2009 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:100
Bradford C, Kumar B, Bellile E, Lee J, Taylor J, D SILVA N, et al. Biomarkers in advanced larynx cancer. Laryngoscope. 2014;124:179-87 pubmed 出版商
  • 免疫组化; 人类
Ferrara G, Misciali C, Brenn T, Cerroni L, Kazakov D, Perasole A, et al. The impact of molecular morphology techniques on the expert diagnosis in melanocytic skin neoplasms. Int J Surg Pathol. 2013;21:483-92 pubmed 出版商
  • 免疫组化; 人类; 1:75
West D, Dogan A, Quint P, Tricker Klar M, Porcher J, Ketterling R, et al. Clonally related follicular lymphomas and Langerhans cell neoplasms: expanding the spectrum of transdifferentiation. Am J Surg Pathol. 2013;37:978-86 pubmed 出版商
  • 免疫组化; 人类; 1:25
Hudolin T, Kastelan Z, Ilic I, Levarda Hudolin K, Basic Jukic N, Rieken M, et al. Immunohistochemical analysis of the expression of MAGE-A and NY-ESO-1 cancer/testis antigens in diffuse large B-cell testicular lymphoma. J Transl Med. 2013;11:123 pubmed 出版商
  • 免疫组化; 小鼠; 1:50
Nakles R, Kallakury B, Furth P. The PPAR? agonist efatutazone increases the spectrum of well-differentiated mammary cancer subtypes initiated by loss of full-length BRCA1 in association with TP53 haploinsufficiency. Am J Pathol. 2013;182:1976-85 pubmed 出版商
  • 免疫组化; 人类; 1:100
El Hafez A, El Aaty Shawky A, Hasan B. Cyclin D1 overexpression associates with favourable prognostic factors in invasive breast carcinoma. Cancer Biomark. 2012;12:149-54 pubmed 出版商
  • 免疫组化; 小鼠; 1:50
Watson A, Rahrmann E, Moriarity B, Choi K, Conboy C, Greeley A, et al. Canonical Wnt/?-catenin signaling drives human schwann cell transformation, progression, and tumor maintenance. Cancer Discov. 2013;3:674-89 pubmed 出版商
  • 免疫细胞化学; 人类; 1:100
  • 免疫组化; 小鼠; 1:500
Noah T, Lo Y, Price A, Chen G, King E, Washington M, et al. SPDEF functions as a colorectal tumor suppressor by inhibiting β-catenin activity. Gastroenterology. 2013;144:1012-1023.e6 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:10; 表 2
Nichele I, Zamo A, Bertolaso A, Bifari F, Tinelli M, Franchini M, et al. VR09 cell line: an EBV-positive lymphoblastoid cell line with in vivo characteristics of diffuse large B cell lymphoma of activated B-cell type. PLoS ONE. 2012;7:e52811 pubmed 出版商
  • 免疫组化; 小鼠
Anttonen T, Kirjavainen A, Belevich I, Laos M, Richardson W, Jokitalo E, et al. Cdc42-dependent structural development of auditory supporting cells is required for wound healing at adulthood. Sci Rep. 2012;2:978 pubmed 出版商
  • 免疫组化; 人类; 1:25
Butte J, Torres J, Veras E, Matsuo K, Gonen M, D Angelica M, et al. Regional differences in gallbladder cancer pathogenesis: insights from a comparison of cell cycle-regulatory, PI3K, and pro-angiogenic protein expression. Ann Surg Oncol. 2013;20:1470-81 pubmed 出版商
  • 免疫组化; 人类
Hong A, Jones D, Chatfield M, Lee C, Zhang M, Clark J, et al. HPV status of oropharyngeal cancer by combination HPV DNA/p16 testing: biological relevance of discordant results. Ann Surg Oncol. 2013;20 Suppl 3:S450-8 pubmed 出版商
  • 免疫组化; 小鼠; 1:200
Kopecky B, Jahan I, Fritzsch B. Correct timing of proliferation and differentiation is necessary for normal inner ear development and auditory hair cell viability. Dev Dyn. 2013;242:132-47 pubmed 出版商
  • 免疫组化; 人类; 1:50
Koay M, Crook M, Stewart C. Cyclin D1, E-cadherin and beta-catenin expression in FIGO Stage IA cervical squamous carcinoma: diagnostic value and evidence for epithelial-mesenchymal transition. Histopathology. 2012;61:1125-33 pubmed 出版商
  • 免疫组化; 人类; 1:200
Erovic B, Kim D, Cassol C, Goldstein D, Irish J, Asa S, et al. Prognostic and predictive markers in medullary thyroid carcinoma. Endocr Pathol. 2012;23:232-42 pubmed 出版商
  • 免疫组化; 人类
Myklebust M, Li Z, Tran T, Rui H, Knudsen E, Elsaleh H, et al. Expression of cyclin D1a and D1b as predictive factors for treatment response in colorectal cancer. Br J Cancer. 2012;107:1684-91 pubmed 出版商
  • 免疫组化; 人类; 1:100
Alvelos M, Vinagre J, Fonseca E, Barbosa E, Teixeira Gomes J, Sobrinho Simoes M, et al. MEN1 intragenic deletions may represent the most prevalent somatic event in sporadic primary hyperparathyroidism. Eur J Endocrinol. 2013;168:119-28 pubmed 出版商
  • 免疫组化; 人类
  • 免疫印迹; 人类
Neumeister V, Anagnostou V, Siddiqui S, England A, Zarrella E, Vassilakopoulou M, et al. Quantitative assessment of effect of preanalytic cold ischemic time on protein expression in breast cancer tissues. J Natl Cancer Inst. 2012;104:1815-24 pubmed 出版商
  • 免疫组化; 人类; 1:50
Jang K, Kim Y, Bae J, Chung M, Moon W, Kang M, et al. Expression of Cyclin D1 Is Associated with β-Catenin Expression and Correlates with Good Prognosis in Colorectal Adenocarcinoma. Transl Oncol. 2012;5:370-8 pubmed
  • 免疫组化; 人类; 1:10
Munari E, Rinaldi M, Ambrosetti A, Bonifacio M, Bonalumi A, Chilosi M, et al. Absence of TCL1A expression is a useful diagnostic feature in splenic marginal zone lymphoma. Virchows Arch. 2012;461:677-85 pubmed 出版商
  • 免疫组化; 人类; 1:200
Erovic B, Harris L, Jamali M, Goldstein D, Irish J, Asa S, et al. Biomarkers of parathyroid carcinoma. Endocr Pathol. 2012;23:221-31 pubmed 出版商
  • 免疫组化; 人类; 1:200
Hsieh R, Nico M, Coutinho Camillo C, Buim M, Sangueza M, Lourenço S. The CDKN2A and MAP kinase pathways: molecular roads to primary oral mucosal melanoma. Am J Dermatopathol. 2013;35:167-75 pubmed 出版商
  • 免疫组化; 小鼠; 1:400
Virolainen S, Achim K, Peltopuro P, Salminen M, Partanen J. Transcriptional regulatory mechanisms underlying the GABAergic neuron fate in different diencephalic prosomeres. Development. 2012;139:3795-805 pubmed
  • 免疫组化; 人类; 1:250
Gruver A, Huba M, Dogan A, Hsi E. Fibrin-associated large B-cell lymphoma: part of the spectrum of cardiac lymphomas. Am J Surg Pathol. 2012;36:1527-37 pubmed 出版商
  • 免疫印迹; 小鼠
Marttinen M, Paivarinta E, Storvik M, Huikko L, Luoma Halkola H, Piironen V, et al. Plant stanols induce intestinal tumor formation by up-regulating Wnt and EGFR signaling in Apc Min mice. J Nutr Biochem. 2013;24:343-52 pubmed 出版商
  • 免疫组化; 人类; 1:40
Kornegoor R, Verschuur Maes A, Buerger H, Hogenes M, de Bruin P, Oudejans J, et al. Immunophenotyping of male breast cancer. Histopathology. 2012;61:1145-55 pubmed 出版商
  • 免疫印迹; 小鼠
Ikenishi A, Okayama H, Iwamoto N, Yoshitome S, Tane S, Nakamura K, et al. Cell cycle regulation in mouse heart during embryonic and postnatal stages. Dev Growth Differ. 2012;54:731-8 pubmed 出版商
  • 免疫组化; 人类
Hoeller S, Zhou Y, Kanagal Shamanna R, Xu Monette Z, Hoehn D, Bihl M, et al. Composite mantle cell lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma: a clinicopathologic and molecular study. Hum Pathol. 2013;44:110-21 pubmed 出版商
  • 免疫组化; 人类
Nilsson C, Koliadi A, Johansson I, Ahlin C, Thorstenson S, Bergkvist L, et al. High proliferation is associated with inferior outcome in male breast cancer patients. Mod Pathol. 2013;26:87-94 pubmed 出版商
  • 免疫组化; 人类; 1:25
Zhang Y, Xu Z, Wang J, Wei D, Pan X. G1/S-specific cyclin-D1 might be a prognostic biomarker for patients with laryngeal squamous cell carcinoma. Asian Pac J Cancer Prev. 2012;13:2133-7 pubmed
  • 免疫组化; 人类; 1:25
Therkildsen C, Isinger Ekstrand A, Ladelund S, Nissen A, Rambech E, Bernstein I, et al. Cancer risks and immunohistochemical profiles linked to the Danish MLH1 Lynch syndrome founder mutation. Fam Cancer. 2012;11:579-85 pubmed 出版商
  • 免疫组化; 人类
Toru S, Bilezikci B. Early changes in carcinogenesis of colorectal adenomas. West Indian Med J. 2012;61:10-6 pubmed
  • 免疫组化; 人类; 1:40
Adam P, Schiefer A, Prill S, Henopp T, Quintanilla Martinez L, Bösmüller H, et al. Incidence of preclinical manifestations of mantle cell lymphoma and mantle cell lymphoma in situ in reactive lymphoid tissues. Mod Pathol. 2012;25:1629-36 pubmed 出版商
  • 免疫组化; 人类
Tang L, Contractor T, Clausen R, Klimstra D, Du Y, Allen P, et al. Attenuation of the retinoblastoma pathway in pancreatic neuroendocrine tumors due to increased cdk4/cdk6. Clin Cancer Res. 2012;18:4612-20 pubmed 出版商
  • 免疫组化; 人类; 1:100
Assmann G, Kappler R, Zeindl Eberhart E, Schmid I, Häberle B, Graeb C, et al. ?-Catenin mutations in 2 nested stromal epithelial tumors of the liver--a neoplasia with defective mesenchymal-epithelial transition. Hum Pathol. 2012;43:1815-27 pubmed 出版商
  • 免疫组化; 人类; 1:200
Erovic B, Al Habeeb A, Harris L, Goldstein D, Kim D, Ghazarian D, et al. Identification of novel target proteins in sebaceous gland carcinoma. Head Neck. 2013;35:642-8 pubmed 出版商
  • 免疫组化; 人类; 1:25
Calderaro J, Moroch J, Pierron G, Pedeutour F, Grison C, Maille P, et al. SMARCB1/INI1 inactivation in renal medullary carcinoma. Histopathology. 2012;61:428-35 pubmed 出版商
  • 免疫组化; 人类; 1:800
Meijer D, de Jong D, Pansuriya T, van den Akker B, Picci P, Szuhai K, et al. Genetic characterization of mesenchymal, clear cell, and dedifferentiated chondrosarcoma. Genes Chromosomes Cancer. 2012;51:899-909 pubmed 出版商
  • 免疫组化; 人类
Hsiao S, Cortada I, Colomo L, Ye H, Liu H, Kuo S, et al. SOX11 is useful in differentiating cyclin D1-positive diffuse large B-cell lymphoma from mantle cell lymphoma. Histopathology. 2012;61:685-93 pubmed 出版商
  • 免疫组化; 人类
Rasmussen P, Ralfkiaer E, Prause J, Sjö L, Toft P, Siersma V, et al. Diffuse large B-cell lymphoma of the ocular adnexal region: a nation-based study. Acta Ophthalmol. 2013;91:163-9 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
  • 免疫组化; 小鼠
Joshi A, Wang H, Jiang G, Douglas W, Chan J, Korach K, et al. Endometrial tumorigenesis in Pten(+/-) mice is independent of coexistence of estrogen and estrogen receptor ?. Am J Pathol. 2012;180:2536-47 pubmed 出版商
  • 免疫组化; 人类
Speisky D, Ducès A, Bieche I, Rebours V, Hammel P, Sauvanet A, et al. Molecular profiling of pancreatic neuroendocrine tumors in sporadic and Von Hippel-Lindau patients. Clin Cancer Res. 2012;18:2838-49 pubmed 出版商
  • 免疫组化; 人类
Liu W, Medeiros L, Lin P, Romaguera J, Wang S, Jorgensen J. Usefulness of flow cytometric immunophenotyping for bone marrow staging in patients with mantle cell lymphoma after therapy. Am J Clin Pathol. 2012;137:634-40 pubmed 出版商
  • 免疫组化; 人类
Jaso J, Chen L, Li S, Lin P, Chen W, Miranda R, et al. CD5-positive mucosa-associated lymphoid tissue (MALT) lymphoma: a clinicopathologic study of 14 cases. Hum Pathol. 2012;43:1436-43 pubmed 出版商
  • 免疫组化; 大鼠; 1:500
  • 免疫印迹; 大鼠; 1:500
Efthimiadi L, Farso M, Quirion R, Krantic S. Cyclin D1 induction preceding neuronal death via the excitotoxic NMDA pathway involves selective stimulation of extrasynaptic NMDA receptors and JNK pathway. Neurodegener Dis. 2012;10:80-91 pubmed 出版商
  • 免疫组化; 人类; 1:200
Huang S, Cheng S, Chuang W, Chen I, Liao C, Wang H, et al. Cyclin D1 overexpression and poor clinical outcomes in Taiwanese oral cavity squamous cell carcinoma. World J Surg Oncol. 2012;10:40 pubmed 出版商
  • 免疫组化; 人类; 1:35
Formosa R, Gruppetta M, Falzon S, Santillo G, Degaetano J, Xuereb Anastasi A, et al. Expression and clinical significance of Wnt players and survivin in pituitary tumours. Endocr Pathol. 2012;23:123-31 pubmed 出版商
  • 免疫组化; 人类
Svec A, Rangaiah M, Giles M, Jaksa R, McAulay K. EBV+ diffuse large B-cell lymphoma arising within atrial myxoma. An example of a distinct primary cardiac EBV+ DLBCL of immunocompetent patients. Pathol Res Pract. 2012;208:172-6 pubmed 出版商
  • 免疫组化; 人类; 1:50
Rasamny J, Allak A, Krook K, Jo V, Policarpio Nicolas M, Sumner H, et al. Cyclin D1 and FADD as biomarkers in head and neck squamous cell carcinoma. Otolaryngol Head Neck Surg. 2012;146:923-31 pubmed 出版商
  • 免疫组化; 人类; 1:40
Kornegoor R, Verschuur Maes A, Buerger H, van Diest P. The 3-layered ductal epithelium in gynecomastia. Am J Surg Pathol. 2012;36:762-8 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000
Boutant M, Ramos O, Tourrel Cuzin C, Movassat J, Ilias A, Vallois D, et al. COUP-TFII controls mouse pancreatic β-cell mass through GLP-1-β-catenin signaling pathways. PLoS ONE. 2012;7:e30847 pubmed 出版商
  • 免疫组化; 小鼠; 1:200
Le T, Conley K, Mead T, Rowan S, Yutzey K, Brown N. Requirements for Jag1-Rbpj mediated Notch signaling during early mouse lens development. Dev Dyn. 2012;241:493-504 pubmed 出版商
  • 免疫组化; 人类; 1:30
Tan L, Tan S, Tang T, Lim S, Tan D, Lim L, et al. Angioimmunoblastic T-cell lymphoma with hyperplastic germinal centres (pattern 1) shows superior survival to patterns 2 and 3: a meta-analysis of 56 cases. Histopathology. 2012;60:570-85 pubmed 出版商
  • 免疫组化; 人类
Schrijvers M, Pattje W, Slagter Menkema L, Mastik M, Gibcus J, Langendijk J, et al. FADD expression as a prognosticator in early-stage glottic squamous cell carcinoma of the larynx treated primarily with radiotherapy. Int J Radiat Oncol Biol Phys. 2012;83:1220-6 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
Zuo Z, Tang Y, Bi C, Zhang W, Zhao S, Wang X, et al. Extraosseous (extramedullary) plasmacytomas: a clinicopathologic and immunophenotypic study of 32 Chinese cases. Diagn Pathol. 2011;6:123 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:50
Jung Y, Joo K, Seong D, Choi Y, Kong D, Kim Y, et al. Identification of prognostic biomarkers for glioblastomas using protein expression profiling. Int J Oncol. 2012;40:1122-32 pubmed 出版商
  • 免疫组化; 小鼠
Yan Q, Feng Q, Beier F. Reduced chondrocyte proliferation, earlier cell cycle exit and increased apoptosis in neuronal nitric oxide synthase-deficient mice. Osteoarthritis Cartilage. 2012;20:144-51 pubmed 出版商
  • 免疫组化; 人类
Tang A, Hauff S, Owen J, Graham M, Czerwinski M, Park J, et al. UM-SCC-104: a new human papillomavirus-16-positive cancer stem cell-containing head and neck squamous cell carcinoma cell line. Head Neck. 2012;34:1480-91 pubmed 出版商
  • 免疫组化; 人类
Karlsson C, Karlsson M. Effects of long-term storage on the detection of proteins, DNA, and mRNA in tissue microarray slides. J Histochem Cytochem. 2011;59:1113-21 pubmed 出版商
  • 免疫组化; 人类; 1:40
Gerhardt J, Montani M, Wild P, Beer M, Huber F, Hermanns T, et al. FOXA1 promotes tumor progression in prostate cancer and represents a novel hallmark of castration-resistant prostate cancer. Am J Pathol. 2012;180:848-61 pubmed 出版商
  • 免疫组化; 人类
Woelber L, Hess S, Bohlken H, Tennstedt P, Eulenburg C, Simon R, et al. EGFR gene copy number increase in vulvar carcinomas is linked with poor clinical outcome. J Clin Pathol. 2012;65:133-9 pubmed 出版商
  • 免疫组化; 人类
Guarnieri V, Baorda F, Battista C, Bisceglia M, Balsamo T, Gruppioni E, et al. A rare S33C mutation of CTNNB1 encoding ?-catenin in a parathyroid adenoma found in an Italian primary hyperparathyroid cohort. Endocrine. 2012;41:152-5 pubmed 出版商
  • 免疫组化; 人类
Clement C, Potluri V, Gonzales J, Qian Y. Translocation (5; 11) in a conjunctival MALT lymphoma. Int J Clin Exp Pathol. 2011;4:722-6 pubmed
  • 免疫组化; 小鼠; 1:250; 图 2
Loponen H, Ylikoski J, Albrecht J, Pirvola U. Restrictions in cell cycle progression of adult vestibular supporting cells in response to ectopic cyclin D1 expression. PLoS ONE. 2011;6:e27360 pubmed 出版商
  • 免疫组化; 人类; 1:100
Makarewicz R, Zyromska A, Andrusewicz H. Comparative analysis of biological profiles of benign prostate hyperplasia and prostate cancer as potential diagnostic, prognostic and predictive indicators. Folia Histochem Cytobiol. 2011;49:452-7 pubmed
  • 免疫组化-石蜡切片; 小鼠; 1:100
  • 免疫印迹; 小鼠; 1:1000
Na B, Huang Z, Wang Q, Qi Z, Tian Y, Lu C, et al. Transgenic expression of entire hepatitis B virus in mice induces hepatocarcinogenesis independent of chronic liver injury. PLoS ONE. 2011;6:e26240 pubmed 出版商
  • 免疫组化; 人类; 1:25
Gauchotte G, Vigouroux C, Rech F, Battaglia Hsu S, Soudant M, Pinelli C, et al. Expression of minichromosome maintenance MCM6 protein in meningiomas is strongly correlated with histologic grade and clinical outcome. Am J Surg Pathol. 2012;36:283-91 pubmed 出版商
  • 免疫印迹; 小鼠
Moustafa T, Fickert P, Magnes C, Guelly C, Thueringer A, Frank S, et al. Alterations in lipid metabolism mediate inflammation, fibrosis, and proliferation in a mouse model of chronic cholestatic liver injury. Gastroenterology. 2012;142:140-151.e12 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:50; 图 5
Wang G, Yan Q, Woods A, Aubrey L, Feng Q, Beier F. Inducible nitric oxide synthase-nitric oxide signaling mediates the mitogenic activity of Rac1 during endochondral bone growth. J Cell Sci. 2011;124:3405-13 pubmed 出版商
  • 免疫组化; 人类; 1:250
Hill B, Weil A, Kalaycio M, Cook J. Pulmonary involvement by chronic lymphocytic leukemia/small lymphocytic lymphoma is a specific pathologic finding independent of inflammatory infiltration. Leuk Lymphoma. 2012;53:589-95 pubmed 出版商
  • 免疫组化; 人类; 1:100
Perisanidis C, Perisanidis B, Wrba F, Brandstetter A, El Gazzar S, Papadogeorgakis N, et al. Evaluation of immunohistochemical expression of p53, p21, p27, cyclin D1, and Ki67 in oral and oropharyngeal squamous cell carcinoma. J Oral Pathol Med. 2012;41:40-6 pubmed 出版商
  • 免疫印迹; 人类
Xu W, Du M, Zhao Y, Wang Q, Sun W, Chen B. ?-Tocotrienol inhibits cell viability through suppression of ?-catenin/Tcf signaling in human colon carcinoma HT-29 cells. J Nutr Biochem. 2012;23:800-7 pubmed 出版商
  • 免疫组化; 人类
Sherman M, Hanson C, Hoyer J. An assessment of the usefulness of immunohistochemical stains in the diagnosis of hairy cell leukemia. Am J Clin Pathol. 2011;136:390-9 pubmed 出版商
  • 免疫组化; 人类; 1:100
Vlachostergios P, Karasavvidou F, Patrikidou A, Voutsadakis I, Kakkas G, Moutzouris G, et al. p53 and cyclooxygenase-2 expression are directly associated with cyclin D1 expression in radical prostatectomy specimens of patients with hormone-naïve prostate cancer. Pathol Oncol Res. 2012;18:245-52 pubmed 出版商
  • 免疫组化; 人类; 1:50
Lax S, Schauer G, Prein K, Kapitan M, Silbert D, Berghold A, et al. Expression of the nuclear bile acid receptor/farnesoid X receptor is reduced in human colon carcinoma compared to nonneoplastic mucosa independent from site and may be associated with adverse prognosis. Int J Cancer. 2012;130:2232-9 pubmed 出版商
  • 免疫组化; 人类
Bagazgoitia L, Cuevas Santos J, Juarranz A, Jaen P. Photodynamic therapy reduces the histological features of actinic damage and the expression of early oncogenic markers. Br J Dermatol. 2011;165:144-51 pubmed 出版商
  • 免疫组化; 人类
Kimura Y, Sato K, Imamura Y, Arakawa F, Kiyasu J, Takeuchi M, et al. Small cell variant of mantle cell lymphoma is an indolent lymphoma characterized by bone marrow involvement, splenomegaly, and a low Ki-67 index. Cancer Sci. 2011;102:1734-41 pubmed 出版商
  • 免疫组化; 人类; 1:100
de Vreeze R, van Coevorden F, Boerrigter L, Nederlof P, Haas R, Bras J, et al. Delineation of chondroid lipoma: an immunohistochemical and molecular biological analysis. Sarcoma. 2011;2011:638403 pubmed 出版商
  • 免疫组化; 人类; 1:30
Acikalin M, Etiz D, Gürbüz M, Ozudogru E, Canaz F, Colak E. Prognostic significance of galectin-3 and cyclin D1 expression in undifferentiated nasopharyngeal carcinoma. Med Oncol. 2012;29:742-9 pubmed 出版商
  • 免疫组化; 人类; 1:40
Huh Y, Schweighofer C, Ketterling R, Knudson R, Vega F, Kim J, et al. Chronic lymphocytic leukemia with t(14;19)(q32;q13) is characterized by atypical morphologic and immunophenotypic features and distinctive genetic features. Am J Clin Pathol. 2011;135:686-96 pubmed 出版商
  • 免疫组化; 小鼠; 1:100
Hao F, Pysz M, Curry K, Haas K, Seedhouse S, Black A, et al. Protein kinase C? signaling regulates inhibitor of DNA binding 1 in the intestinal epithelium. J Biol Chem. 2011;286:18104-17 pubmed 出版商
  • 免疫组化; 人类; 1:25
Fleischmann A, Rocha C, Saxer Sekulic N, Zlobec I, Sauter G, Thalmann G. High-level cytoplasmic cyclin D1 expression in lymph node metastases from prostate cancer independently predicts early biochemical failure and death in surgically treated patients. Histopathology. 2011;58:781-9 pubmed 出版商
  • 免疫组化; 人类
Canzonieri V, Barzan L, Franchin G, Vaccher E, Talamini R, Sulfaro S, et al. Alteration of G1/S transition regulators influences recurrences in head and neck squamous carcinomas. J Cell Physiol. 2012;227:233-8 pubmed 出版商
  • 免疫组化; 人类; 1:100
Yu S, Chen S, Lu W, Liu T, Lin C. Expression of CD19 and lack of miR-223 distinguish extramedullary plasmacytoma from multiple myeloma. Histopathology. 2011;58:896-905 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Pighi C, Gu T, Dalai I, Barbi S, Parolini C, Bertolaso A, et al. Phospho-proteomic analysis of mantle cell lymphoma cells suggests a pro-survival role of B-cell receptor signaling. Cell Oncol (Dordr). 2011;34:141-53 pubmed 出版商
  • 免疫组化; 人类
Schmatz A, Streubel B, Kretschmer Chott E, Puspok A, Jager U, Mannhalter C, et al. Primary follicular lymphoma of the duodenum is a distinct mucosal/submucosal variant of follicular lymphoma: a retrospective study of 63 cases. J Clin Oncol. 2011;29:1445-51 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 图 2
van der Weyden L, Alcolea M, Jones P, Rust A, Arends M, Adams D. Acute sensitivity of the oral mucosa to oncogenic K-ras. J Pathol. 2011;224:22-32 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Ng C, Ng P, Lui V, Li J, Chan J, Fung K, et al. FHL2 exhibits anti-proliferative and anti-apoptotic activities in liver cancer cells. Cancer Lett. 2011;304:97-106 pubmed 出版商
  • 免疫组化; 人类; 1:100
Allison K, Kandalaft P, Sitlani C, Dintzis S, Gown A. Routine pathologic parameters can predict Oncotype DX recurrence scores in subsets of ER positive patients: who does not always need testing?. Breast Cancer Res Treat. 2012;131:413-24 pubmed 出版商
  • 免疫组化; 人类; 1:100
Gualco G, Klumb C, Barber G, Weiss L, Bacchi C. Pediatric lymphomas in Brazil. Clinics (Sao Paulo). 2010;65:1267-77 pubmed
  • 免疫组化; 人类; 1:100
Xu X, Sun P, Li J, Jheon S, Lee C, Chung J. Aberrant Wnt1/?-catenin expression is an independent poor prognostic marker of non-small cell lung cancer after surgery. J Thorac Oncol. 2011;6:716-24 pubmed 出版商
  • 免疫组化; 人类
Lucioni M, Novara F, Riboni R, Fiandrino G, Nicola M, Kindl S, et al. CD5(-) diffuse large B-cell lymphoma with peculiar cyclin D1+ phenotype. Pathologic and molecular characterization of a single case. Hum Pathol. 2011;42:1204-8 pubmed 出版商
  • 免疫组化; 小鼠; 1:125
  • 免疫印迹; 小鼠; 1:500
Elyada E, Pribluda A, Goldstein R, Morgenstern Y, Brachya G, Cojocaru G, et al. CKI? ablation highlights a critical role for p53 in invasiveness control. Nature. 2011;470:409-13 pubmed 出版商
  • 免疫组化; 人类
Vela Chavez T, Adam P, Kremer M, Bink K, Bacon C, Menon G, et al. Cyclin D1 positive diffuse large B-cell lymphoma is a post-germinal center-type lymphoma without alterations in the CCND1 gene locus. Leuk Lymphoma. 2011;52:458-66 pubmed 出版商
  • 免疫印迹; 小鼠
Bruggeman L, Drawz P, Kahoud N, Lin K, Barisoni L, Nelson P. TNFR2 interposes the proliferative and NF-?B-mediated inflammatory response by podocytes to TNF-?. Lab Invest. 2011;91:413-25 pubmed 出版商
  • 免疫组化; 小鼠; 1:50
Torre C, Benhamouche S, Mitchell C, Godard C, Veber P, Letourneur F, et al. The transforming growth factor-? and cyclin D1 genes are direct targets of ?-catenin signaling in hepatocyte proliferation. J Hepatol. 2011;55:86-95 pubmed 出版商
  • 免疫组化; 人类
Jansen C, Feuth T, Raemaekers J, Rijntjes J, Meijer J, Westenend P, et al. Protein profiling in pathology: analysis and evaluation of 239 frozen tissue biopsies for diagnosis of B-cell lymphomas. Proteomics Clin Appl. 2010;4:519-27 pubmed 出版商
  • 免疫组化; 人类; 1:100
Li X, Liu M, Zhang Y, Wang J, Zheng Y, Li J, et al. CK5/6, EGFR, Ki-67, cyclin D1, and nm23-H1 protein expressions as predictors of pathological complete response to neoadjuvant chemotherapy in triple-negative breast cancer patients. Med Oncol. 2011;28 Suppl 1:S129-34 pubmed 出版商
  • 免疫组化; 人类; 1:50
Nishimura I, Ohishi Y, Oda Y, Kishimoto J, Yasunaga M, Okuma E, et al. Expression and localization of E-cadherin and ?-catenin in uterine carcinosarcoma. Virchows Arch. 2011;458:85-94 pubmed 出版商
  • 免疫组化; 人类; 1:25
  • 免疫组化; 大鼠; 1:25
Schwensen K, Burgess J, Graf N, Alexander S, Harris D, Phillips J, et al. Early cyst growth is associated with the increased nuclear expression of cyclin D1/Rb protein in an autosomal-recessive polycystic kidney disease rat model. Nephron Exp Nephrol. 2011;117:e93-103 pubmed 出版商
  • 免疫组化; 人类
Ianotto J, Tempescul A, Eveillard J, André N, Morel F, Quintin Roue I, et al. Acute dyspnoea and single tracheal localisation of mantle cell lymphoma. J Hematol Oncol. 2010;3:34 pubmed 出版商
  • 免疫组化; 小鼠
Gonzalez Suarez E, Jacob A, Jones J, Miller R, Roudier Meyer M, Erwert R, et al. RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis. Nature. 2010;468:103-7 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:100; 图 1, 2, 3
  • 免疫组化; 人类; 1:100
Cheuk W, Tam F, Chan A, Luk I, Yuen A, Chan W, et al. Idiopathic cervical fibrosis--a new member of IgG4-related sclerosing diseases: report of 4 cases, 1 complicated by composite lymphoma. Am J Surg Pathol. 2010;34:1678-85 pubmed 出版商
  • 免疫组化; 人类; 1:100
Koo J, Shin E, Hong S. Immunohistochemical characteristics of diffuse sclerosing variant of papillary carcinoma: comparison with conventional papillary carcinoma. APMIS. 2010;118:744-52 pubmed 出版商
  • 免疫组化; 人类; 1:100
Haller F, Cortis J, Helfrich J, Cameron S, Schüler P, Schwager S, et al. Epithelioid/mixed phenotype in gastrointestinal stromal tumors with KIT mutation from the stomach is associated with accelerated passage of late phases of the cell cycle and shorter disease-free survival. Mod Pathol. 2011;24:248-55 pubmed 出版商
  • 免疫组化; 人类; 1:40
Schmid S, Tinguely M, Cione P, Moch H, Bode B. Flow cytometry as an accurate tool to complement fine needle aspiration cytology in the diagnosis of low grade malignant lymphomas. Cytopathology. 2011;22:397-406 pubmed 出版商
  • 免疫组化; 人类
Christian B, Zhao W, Hamadani M, Sotomayor E, Navarro W, Devine S, et al. Mantle cell lymphoma 12 years after allogeneic bone marrow transplantation occurring simultaneously in recipient and donor. J Clin Oncol. 2010;28:e629-32 pubmed 出版商
  • 免疫组化; 人类
Gladkikh A, Potashnikova D, Korneva E, Khudoleeva O, Vorobjev I. Cyclin D1 expression in B-cell lymphomas. Exp Hematol. 2010;38:1047-57 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Feuerborn A, Srivastava P, Küffer S, Grandy W, Sijmonsma T, Gretz N, et al. The Forkhead factor FoxQ1 influences epithelial differentiation. J Cell Physiol. 2011;226:710-9 pubmed 出版商
  • 免疫组化; 人类; 1:50
Quinn J, Glassford J, Percy L, Munson P, Marafioti T, Rodriguez Justo M, et al. APRIL promotes cell-cycle progression in primary multiple myeloma cells: influence of D-type cyclin group and translocation status. Blood. 2011;117:890-901 pubmed 出版商
  • 免疫印迹; 人类; 1:2500
Nelson A, Holt J. Impact of RING and BRCT domain mutations on BRCA1 protein stability, localization and recruitment to DNA damage. Radiat Res. 2010;174:1-13 pubmed 出版商
  • 免疫组化; 小鼠
Lee G, Goretsky T, Managlia E, Dirisina R, Singh A, Brown J, et al. Phosphoinositide 3-kinase signaling mediates beta-catenin activation in intestinal epithelial stem and progenitor cells in colitis. Gastroenterology. 2010;139:869-81, 881.e1-9 pubmed 出版商
  • 免疫印迹; 人类
Lui V, Lau C, Ho K, Ng M, Cheng S, Tsao S, et al. Anti-invasion, anti-proliferation and anoikis-sensitization activities of lapatinib in nasopharyngeal carcinoma cells. Invest New Drugs. 2011;29:1241-52 pubmed 出版商
  • 免疫组化; 人类; 1:100
Jung C, Kang Y, Bae J, Lim D, Choi Y, Lee K. Unique patterns of tumor growth related with the risk of lymph node metastasis in papillary thyroid carcinoma. Mod Pathol. 2010;23:1201-8 pubmed 出版商
  • 免疫细胞化学; 人类; 1:50
Hitomi M, Stacey D. The checkpoint kinase ATM protects against stress-induced elevation of cyclin D1 and potential cell death in neurons. Cytometry A. 2010;77:524-33 pubmed 出版商
  • 免疫组化; 人类; 1:100
Hong A, Dobbins T, Lee C, Jones D, Fei J, Clark J, et al. Use of cyclin D1 in conjunction with human papillomavirus status to predict outcome in oropharyngeal cancer. Int J Cancer. 2011;128:1532-45 pubmed 出版商
  • 免疫组化; 人类; 1:50
Karim R, Gerega S, Yang Y, Spillane A, Carmalt H, Scolyer R, et al. p16 and pRb immunohistochemical expression increases with increasing tumour grade in mammary phyllodes tumours. Histopathology. 2010;56:868-75 pubmed 出版商
  • 免疫组化; 人类; 1:100
Schor A, Moraes M, Bisson F, Bisson M, Luiz O, Bacchi C. Primary plasmacytoma of the cervix in a 21-year-old female patient. Int J Gynecol Pathol. 2010;29:290-3 pubmed 出版商
  • 免疫组化; 人类; 1:50
de Vicente J, Torre Iturraspe A, Gutiérrez A, Lequerica Fernandez P. Immunohistochemical comparative study of the odontogenic keratocysts and other odontogenic lesions. Med Oral Patol Oral Cir Bucal. 2010;15:e709-15 pubmed
  • 免疫组化; 人类; 1:50
Hakim S, Kosmehl H, Sieg P, Trenkle T, Jacobsen H, Attila Benedek G, et al. Altered expression of cell-cell adhesion molecules ?-catenin/E-cadherin and related Wnt-signaling pathway in sporadic and syndromal keratocystic odontogenic tumors. Clin Oral Investig. 2011;15:321-8 pubmed 出版商
  • 免疫组化; 人类; 1:20
Levidou G, Saetta A, Karlou M, Thymara I, Pratsinis H, Pavlopoulos P, et al. D-type cyclins in superficial and muscle-invasive bladder urothelial carcinoma: correlation with clinicopathological data and prognostic significance. J Cancer Res Clin Oncol. 2010;136:1563-71 pubmed 出版商
  • 免疫组化; 人类
Brezillon S, Zeltz C, Schneider L, Terryn C, Vuillermoz B, Ramont L, et al. Lumican inhibits B16F1 melanoma cell lung metastasis. J Physiol Pharmacol. 2009;60 Suppl 4:15-22 pubmed
  • 免疫组化; 人类; 1:100
Metcalf R, Zhao S, Anderson M, Lu Z, Galperin I, Marinelli R, et al. Characterization of D-cyclin proteins in hematolymphoid neoplasms: lack of specificity of cyclin-D2 and D3 expression in lymphoma subtypes. Mod Pathol. 2010;23:420-33 pubmed 出版商
  • 免疫组化; 人类; 1:50
Perrotto J, Abbott J, Ceilley R, Ahmed I. The role of immunohistochemistry in discriminating primary from secondary extramammary Paget disease. Am J Dermatopathol. 2010;32:137-43 pubmed 出版商
  • 免疫组化; 人类; 1:50
Aamodt R, Jonsdottir K, Andersen S, Bondi J, Bukholm G, Bukholm I. Differences in protein expression and gene amplification of cyclins between colon and rectal adenocarcinomas. Gastroenterol Res Pract. 2009;2009:285830 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 表 1
Leong A, Haffajee Z. Citraconic anhydride: a new antigen retrieval solution. Pathology. 2010;42:77-81 pubmed 出版商
  • 免疫组化; 人类; 1:100
Alberghini M, Kliskey K, Krenacs T, Picci P, Kindblom L, Forsyth R, et al. Morphological and immunophenotypic features of primary and metastatic giant cell tumour of bone. Virchows Arch. 2010;456:97-103 pubmed 出版商
  • 免疫组化; 人类; 1:50
Quinn J, Percy L, Glassford J, Somana K, Rodriguez Justo M, Yong K. CD20-positive multiple myeloma - differential expression of cyclins D1 and D2 suggests a heterogeneous disease. Br J Haematol. 2010;149:156-9 pubmed 出版商
  • 免疫组化; 人类
Huang Y, de Reynies A, de Leval L, Ghazi B, Martin Garcia N, Travert M, et al. Gene expression profiling identifies emerging oncogenic pathways operating in extranodal NK/T-cell lymphoma, nasal type. Blood. 2010;115:1226-37 pubmed 出版商
  • 免疫组化; 小鼠
Laine H, Sulg M, Kirjavainen A, Pirvola U. Cell cycle regulation in the inner ear sensory epithelia: role of cyclin D1 and cyclin-dependent kinase inhibitors. Dev Biol. 2010;337:134-46 pubmed 出版商
  • 免疫组化; 人类; 1:50
Garcia C, Hunt K, Kang H, Babb A, Gale J, Vasef M, et al. Most morphologic features in chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) do not reliably predict underlying FISH genetics or immunoglobulin heavy chain variable region somatic mutational status. Appl Immunohistochem Mol Morphol. 2010;18:119-27 pubmed 出版商
  • 免疫组化; 人类; 1:2000
Stefancikova L, Moulis M, Fabian P, Falkova I, Vasova I, Kren L, et al. Complex analysis of cyclin D1 expression in mantle cell lymphoma: two cyclin D1-negative cases detected. J Clin Pathol. 2009;62:948-50 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Huesca M, Lock L, Khine A, Viau S, Peralta R, Cukier I, et al. A novel small molecule with potent anticancer activity inhibits cell growth by modulating intracellular labile zinc homeostasis. Mol Cancer Ther. 2009;8:2586-96 pubmed 出版商
  • 免疫组化; 人类; 图 3
Italiano A, Bianchini L, Gjernes E, Keslair F, Ranchere Vince D, Dumollard J, et al. Clinical and biological significance of CDK4 amplification in well-differentiated and dedifferentiated liposarcomas. Clin Cancer Res. 2009;15:5696-703 pubmed 出版商
  • 免疫组化; 人类
Mangseth K, Helgeland L, Klos J, Molven A, Vintermyr O. Improved diagnostic segregation of mantle cell lymphoma by determination of cyclin D1/D3 expression ratio in formalin-fixed tissue. Diagn Mol Pathol. 2009;18:150-5 pubmed 出版商
  • 免疫组化; 人类; 1:100
Cheuk W, Lee K, Chong L, Yuen S, Chan J. IgG4-related Sclerosing disease: a potential new etiology of cutaneous pseudolymphoma. Am J Surg Pathol. 2009;33:1713-9 pubmed 出版商
  • 免疫组化; 人类
Horváth E, Mezei T, Pávai Z, Turcu M, Demian S, Toth E, et al. Diagnostic and differential diagnostic criteria of lymphoid neoplasms in bone marrow trephine biopsies: a study of 87 cases. Rom J Morphol Embryol. 2009;50:399-406 pubmed
  • 免疫组化; 人类
Myong N. Cyclin D1 overexpression, p16 loss, and pRb inactivation play a key role in pulmonary carcinogenesis and have a prognostic implication for the long-term survival in non-small cell lung carcinoma patients. Cancer Res Treat. 2008;40:45-52 pubmed 出版商
  • 免疫组化; 人类; 1:100
Karim R, Li W, Sanki A, Colman M, Yang Y, Thompson J, et al. Reduced p16 and increased cyclin D1 and pRb expression are correlated with progression in cutaneous melanocytic tumors. Int J Surg Pathol. 2009;17:361-7 pubmed 出版商
  • 免疫组化; 人类
Chiu A, Frizzera G, Mathew S, Hyjek E, Chadburn A, Tam W, et al. Diffuse blastoid B-cell lymphoma: a histologically aggressive variant of t(14;18)-negative follicular lymphoma. Mod Pathol. 2009;22:1507-17 pubmed 出版商
  • 免疫组化; 人类
Quintanilla Martinez L, Slotta Huspenina J, Koch I, Klier M, Hsi E, de Leval L, et al. Differential diagnosis of cyclin D2+ mantle cell lymphoma based on fluorescence in situ hybridization and quantitative real-time-PCR. Haematologica. 2009;94:1595-8 pubmed 出版商
  • 免疫组化; 人类; 1:50
D Angelo E, Spagnoli L, Prat J. Comparative clinicopathologic and immunohistochemical analysis of uterine sarcomas diagnosed using the World Health Organization classification system. Hum Pathol. 2009;40:1571-85 pubmed 出版商
  • 免疫组化; 人类; 1:100
Park Y, Kim Y, Lee Y, Kim S, Park S, Kim K, et al. Papillary microcarcinoma in comparison with larger papillary thyroid carcinoma in BRAF(V600E) mutation, clinicopathological features, and immunohistochemical findings. Head Neck. 2010;32:38-45 pubmed 出版商
  • 免疫组化; 人类; 1:25
Mitrovic Z, Ilic I, Nola M, Aurer I, Sonicki Z, Basic Kinda S, et al. CD43 expression is an adverse prognostic factor in diffuse large B-Cell lymphoma. Clin Lymphoma Myeloma. 2009;9:133-7 pubmed 出版商
  • 免疫印迹; 人类
Mamaghani S, Patel S, Hedley D. Glycogen synthase kinase-3 inhibition disrupts nuclear factor-kappaB activity in pancreatic cancer, but fails to sensitize to gemcitabine chemotherapy. BMC Cancer. 2009;9:132 pubmed 出版商
  • 免疫组化; 人类
Jacquemier J, Charafe Jauffret E, Monville F, Esterni B, Extra J, Houvenaeghel G, et al. Association of GATA3, P53, Ki67 status and vascular peritumoral invasion are strongly prognostic in luminal breast cancer. Breast Cancer Res. 2009;11:R23 pubmed 出版商
  • 免疫组化; 人类; 1:100
Polotsky A, Zhu L, Santoro N, Pollard J. Lithium chloride treatment induces epithelial cell proliferation in xenografted human endometrium. Hum Reprod. 2009;24:1960-7 pubmed 出版商
  • 免疫组化; 人类; 1:40
Luu V, Boysen G, Struckmann K, Casagrande S, von Teichman A, Wild P, et al. Loss of VHL and hypoxia provokes PAX2 up-regulation in clear cell renal cell carcinoma. Clin Cancer Res. 2009;15:3297-304 pubmed 出版商
  • 免疫组化; 小鼠; 1:100
Le T, Conley K, Brown N. Jagged 1 is necessary for normal mouse lens formation. Dev Biol. 2009;328:118-26 pubmed 出版商
  • 免疫组化; 人类
Sukov W, Ketterling R, Lager D, Carlson A, Sinnwell J, Chow G, et al. CCND1 rearrangements and cyclin D1 overexpression in renal oncocytomas: frequency, clinicopathologic features, and utility in differentiation from chromophobe renal cell carcinoma. Hum Pathol. 2009;40:1296-303 pubmed 出版商
  • 免疫组化; 人类; 1:100
Cheuk W, Chan A, Lam W, Chow S, Crowley P, Lloydd R, et al. IgG4-related sclerosing mastitis: description of a new member of the IgG4-related sclerosing diseases. Am J Surg Pathol. 2009;33:1058-64 pubmed 出版商
  • 免疫组化; 小鼠; 1:100
Volate S, Muga S, Issa A, Nitcheva D, Smith T, Wargovich M. Epigenetic modulation of the retinoid X receptor alpha by green tea in the azoxymethane-Apc Min/+ mouse model of intestinal cancer. Mol Carcinog. 2009;48:920-33 pubmed 出版商
  • 免疫组化; 人类; 1:80
Boone J, van Hillegersberg R, Offerhaus G, van Diest P, Borel Rinkes I, ten Kate F. Targets for molecular therapy in esophageal squamous cell carcinoma: an immunohistochemical analysis. Dis Esophagus. 2009;22:496-504 pubmed 出版商
  • 免疫组化; 小鼠; 1:100
  • 免疫印迹; 人类; 1:2000
Pysz M, Leontieva O, Bateman N, Uronis J, Curry K, Threadgill D, et al. PKCalpha tumor suppression in the intestine is associated with transcriptional and translational inhibition of cyclin D1. Exp Cell Res. 2009;315:1415-28 pubmed 出版商
  • 免疫印迹; 人类; 图 s4
Rogers S, Box C, Chambers P, Barbachano Y, Nutting C, Rhys Evans P, et al. Determinants of response to epidermal growth factor receptor tyrosine kinase inhibition in squamous cell carcinoma of the head and neck. J Pathol. 2009;218:122-30 pubmed 出版商
  • 免疫组化; 人类
Wildeman M, Gibcus J, Hauptmann M, Begg A, van Velthuysen M, Hoebers F, et al. Radiotherapy in laryngeal carcinoma: can a panel of 13 markers predict response?. Laryngoscope. 2009;119:316-22 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 图 1
  • 免疫组化; 人类
Dawson M, Opat S, Taouk Y, Donovan M, Zammit M, Monaghan K, et al. Clinical and immunohistochemical features associated with a response to bortezomib in patients with multiple myeloma. Clin Cancer Res. 2009;15:714-22 pubmed 出版商
  • 免疫组化; 人类; 1:250
Gibson S, Hsi E. Epstein-Barr virus-positive B-cell lymphoma of the elderly at a United States tertiary medical center: an uncommon aggressive lymphoma with a nongerminal center B-cell phenotype. Hum Pathol. 2009;40:653-61 pubmed 出版商
  • 免疫组化; 小鼠; 1:75
Patil M, Lee S, Macias E, Lam E, Xu C, Jones K, et al. Role of cyclin D1 as a mediator of c-Met- and beta-catenin-induced hepatocarcinogenesis. Cancer Res. 2009;69:253-61 pubmed 出版商
  • 免疫组化; 人类
Kelley T, Baz R, Hussein M, Karafa M, Cook J. Clinical significance of cyclin D1, fibroblast growth factor receptor 3, and p53 immunohistochemistry in plasma cell myeloma treated with a thalidomide-based regimen. Hum Pathol. 2009;40:405-12 pubmed 出版商
  • 免疫组化; 人类
Naushad H, Choi W, Page C, Sanger W, Weisenburger D, Aoun P. Mantle cell lymphoma with flow cytometric evidence of clonal plasmacytic differentiation: a case report. Cytometry B Clin Cytom. 2009;76:218-24 pubmed 出版商
  • 免疫组化; 人类; 1:50
Da Silva L, Buck L, Simpson P, Reid L, McCallum N, Madigan B, et al. Molecular and morphological analysis of adenoid cystic carcinoma of the breast with synchronous tubular adenosis. Virchows Arch. 2009;454:107-14 pubmed 出版商
  • 免疫组化; 人类; 1:50
Mudhar H, Saunders E, Rundle P, Rennie I, Sisley K. The in vivo modulatory effects of an anterior-chamber microenvironment on uveal melanoma. Br J Ophthalmol. 2009;93:535-40 pubmed 出版商
  • 免疫组化; 小鼠
Jin L, Burniat A, Dumont J, Miot F, Corvilain B, Franc B. Human thyroid tumours, the puzzling lessons from E7 and RET/PTC3 transgenic mice. Br J Cancer. 2008;99:1874-83 pubmed 出版商
  • 免疫组化; 人类; 1:50
van Dekken H, Hop W, Tilanus H, Haringsma J, van der Valk H, Wink J, et al. Immunohistochemical evaluation of a panel of tumor cell markers during malignant progression in Barrett esophagus. Am J Clin Pathol. 2008;130:745-53 pubmed 出版商
  • 免疫组化; 人类
Cinti C, Vindigni C, Zamparelli A, La Sala D, Epistolato M, Marrelli D, et al. Activated Akt as an indicator of prognosis in gastric cancer. Virchows Arch. 2008;453:449-55 pubmed 出版商
  • 免疫组化; 人类; 1:100
Huang H, West R, Tzeng C, van de Rijn M, Wang J, Chou S, et al. Immunohistochemical and biogenetic features of diffuse-type tenosynovial giant cell tumors: the potential roles of cyclin A, P53, and deletion of 15q in sarcomatous transformation. Clin Cancer Res. 2008;14:6023-32 pubmed 出版商
  • 免疫组化; 人类; 1:50
Gaumann A, Bode Lesniewska B, Zimmermann D, Fanburg Smith J, Kirkpatrick C, Hofstadter F, et al. Exploration of the APC/beta-catenin (WNT) pathway and a histologic classification system for pulmonary artery intimal sarcoma. A study of 18 cases. Virchows Arch. 2008;453:473-84 pubmed 出版商
  • 免疫组化; 人类; 1:50
Lagoo A, Haggerty C, Kim Y, Hammons M, Neufeld K, Redher C, et al. Morphologic features of 115 lymphomas of the orbit and ocular adnexa categorized according to the World Health Organization classification: are marginal zone lymphomas in the orbit mucosa-associated lymphoid tissue-type lymphomas?. Arch Pathol Lab Med. 2008;132:1405-16 pubmed 出版商
  • 免疫组化; 小鼠; 1:200
Svärd J, Rozell B, Toftgard R, Teglund S. Tumor suppressor gene co-operativity in compound Patched1 and suppressor of fused heterozygous mutant mice. Mol Carcinog. 2009;48:408-19 pubmed 出版商
  • 免疫组化; 人类
Wang X, Asplund A, Porwit A, Flygare J, Smith C, Christensson B, et al. The subcellular Sox11 distribution pattern identifies subsets of mantle cell lymphoma: correlation to overall survival. Br J Haematol. 2008;143:248-52 pubmed 出版商
  • 免疫组化; 人类; 1:50
Bertolo C, Guerrero D, Vicente F, Cordoba A, Esteller M, Ropero S, et al. Differences and molecular immunohistochemical parameters in the subtypes of infiltrating ductal breast cancer. Am J Clin Pathol. 2008;130:414-24 pubmed 出版商
  • 免疫组化; 小鼠; 1:25
Brellier F, Bergoglio V, Valin A, Barnay S, Chevallier Lagente O, Vielh P, et al. Heterozygous mutations in the tumor suppressor gene PATCHED provoke basal cell carcinoma-like features in human organotypic skin cultures. Oncogene. 2008;27:6601-6 pubmed 出版商
  • 免疫组化; 人类; 1:50
Carney J, Stratakis C. Stromal, fibrous, and fatty gastrointestinal tumors in a patient with a PDGFRA gene mutation. Am J Surg Pathol. 2008;32:1412-20 pubmed 出版商
  • 免疫印迹; 人类
Neuwirt H, Arias M, Puhr M, Hobisch A, Culig Z. Oligomeric proanthocyanidin complexes (OPC) exert anti-proliferative and pro-apoptotic effects on prostate cancer cells. Prostate. 2008;68:1647-54 pubmed 出版商
  • 免疫组化; 人类; 1:100
Bozzi F, Ferrari A, Negri T, Conca E, Luca D, Losa M, et al. Molecular characterization of synovial sarcoma in children and adolescents: evidence of akt activation. Transl Oncol. 2008;1:95-101 pubmed
  • 免疫组化-冰冻切片; 小鼠; 1:100; 图 6
Rowan S, Conley K, Le T, Donner A, Maas R, Brown N. Notch signaling regulates growth and differentiation in the mammalian lens. Dev Biol. 2008;321:111-22 pubmed 出版商
  • 免疫组化; 人类; 1:50
Hunt K, Reichard K, Wilson C. Mantle cell lymphoma lacking the t(11;14) translocation: a case report and brief review of the literature. J Clin Pathol. 2008;61:869-70 pubmed 出版商
  • 免疫组化; 小鼠; 1:500
  • 免疫印迹; 小鼠; 1:500
Koeller H, Ross M, Glickstein S. Cyclin D1 in excitatory neurons of the adult brain enhances kainate-induced neurotoxicity. Neurobiol Dis. 2008;31:230-41 pubmed 出版商
  • 免疫组化; 人类
Ioannou M, Stathakis E, Lazaris A, Papathomas T, Tsiambas E, Koukoulis G. Immunohistochemical evaluation of 95 bone marrow reactive plasmacytoses. Pathol Oncol Res. 2009;15:25-9 pubmed 出版商
  • 免疫组化; 人类
Alatas N, Baba F. Proliferating active cells, lymphocyte subsets, and dendritic cells in recurrent tonsillitis: their effect on hypertrophy. Arch Otolaryngol Head Neck Surg. 2008;134:477-83 pubmed 出版商
  • 免疫组化; 人类; 1:50
Marchio C, Iravani M, Natrajan R, Lambros M, Savage K, Tamber N, et al. Genomic and immunophenotypical characterization of pure micropapillary carcinomas of the breast. J Pathol. 2008;215:398-410 pubmed 出版商
  • 免疫组化; 人类; 1:40
Huh Y, Lin K, Vega F, Schlette E, Yin C, Keating M, et al. MYC translocation in chronic lymphocytic leukaemia is associated with increased prolymphocytes and a poor prognosis. Br J Haematol. 2008;142:36-44 pubmed 出版商
  • 免疫组化; 人类; 1:100
Haller F, Löbke C, Ruschhaupt M, Cameron S, Schulten H, Schwager S, et al. Loss of 9p leads to p16INK4A down-regulation and enables RB/E2F1-dependent cell cycle promotion in gastrointestinal stromal tumours (GISTs). J Pathol. 2008;215:253-62 pubmed 出版商
  • 免疫组化; 人类; 1:100
Yi Y, Nowak N, Pacchia A, Morrison C. Chromosome 11 genomic changes in parathyroid adenoma and hyperplasia: array CGH, FISH, and tissue microarrays. Genes Chromosomes Cancer. 2008;47:639-48 pubmed 出版商
  • 免疫组化; 人类; 1:75
Yang C, Hung W, Wang S, Kang W, Chen W, Huang Y, et al. Immunoexpression and prognostic role of hTERT and cyclin D1 in urothelial carcinoma. APMIS. 2008;116:309-16 pubmed 出版商
  • 免疫组化; 人类; 1:100
Min H, Choe G, Kim S, Park Y, Park D, Youn Y, et al. S100A4 expression is associated with lymph node metastasis in papillary microcarcinoma of the thyroid. Mod Pathol. 2008;21:748-55 pubmed 出版商
  • 免疫组化; 人类
Bink K, Haralambieva E, Kremer M, Ott G, Beham Schmid C, de Leval L, et al. Primary extramedullary plasmacytoma: similarities with and differences from multiple myeloma revealed by interphase cytogenetics. Haematologica. 2008;93:623-6 pubmed 出版商
  • 免疫组化; 人类; 1:50
Eigeliene N, Härkönen P, Erkkola R. Effects of estradiol and medroxyprogesterone acetate on expression of the cell cycle proteins cyclin D1, p21 and p27 in cultured human breast tissues. Cell Cycle. 2008;7:71-80 pubmed
  • 免疫组化; 人类; 1:100
Audard V, Cavard C, Richa H, Infante M, Couvelard A, Sauvanet A, et al. Impaired E-cadherin expression and glutamine synthetase overexpression in solid pseudopapillary neoplasm of the pancreas. Pancreas. 2008;36:80-3 pubmed 出版商
  • 免疫组化; 人类; 1:100
Aronica E, Boer K, Becker A, Redeker S, Spliet W, van Rijen P, et al. Gene expression profile analysis of epilepsy-associated gangliogliomas. Neuroscience. 2008;151:272-92 pubmed
  • 免疫组化; 小鼠
Kubota Y, Takubo K, Suda T. Bone marrow long label-retaining cells reside in the sinusoidal hypoxic niche. Biochem Biophys Res Commun. 2008;366:335-9 pubmed
  • 免疫印迹; 大鼠
Xie T, Niu Y, Ge K, Lu S. Regulation of keratinocyte proliferation in rats with deep, partial-thickness scald: modulation of cyclin D1-cyclin-dependent kinase 4 and histone H1 kinase activity of M-phase promoting factor. J Surg Res. 2008;147:9-14 pubmed
  • 免疫组化; 小鼠; 1:5000
Glickstein S, Moore H, Slowinska B, Racchumi J, Suh M, Chuhma N, et al. Selective cortical interneuron and GABA deficits in cyclin D2-null mice. Development. 2007;134:4083-93 pubmed
  • 免疫组化; 人类; 1:50
Tan D, Marchio C, Jones R, Savage K, Smith I, Dowsett M, et al. Triple negative breast cancer: molecular profiling and prognostic impact in adjuvant anthracycline-treated patients. Breast Cancer Res Treat. 2008;111:27-44 pubmed
  • 免疫组化; 人类
He H, Cheng L, Weiss L, Chu P. Clinical outcome of incidental pelvic node malignant B-cell lymphomas discovered at the time of radical prostatectomy. Leuk Lymphoma. 2007;48:1976-80 pubmed
  • 免疫组化; 大鼠; 1:200
Vogetseder A, Picard N, Gaspert A, Walch M, Kaissling B, Le Hir M. Proliferation capacity of the renal proximal tubule involves the bulk of differentiated epithelial cells. Am J Physiol Cell Physiol. 2008;294:C22-8 pubmed
  • 免疫组化; 人类; 1:100
Melck A, Masoudi H, Griffith O, Rajput A, Wilkins G, Bugis S, et al. Cell cycle regulators show diagnostic and prognostic utility for differentiated thyroid cancer. Ann Surg Oncol. 2007;14:3403-11 pubmed
  • 免疫组化; 人类; 1:100
Demirkan N, Kesen Z, Akdag B, Larue L, Delmas V. The effect of the sun on expression of beta-catenin, p16 and cyclin d1 proteins in melanocytic lesions. Clin Exp Dermatol. 2007;32:733-9 pubmed
  • 免疫组化; 人类; 1:75
El Demellawy D, Ross C, Sur M, Alowami S. Synchronously diagnosed lymph nodal collision tumor of malignant melanoma and chronic lymphocytic leukemia/small lymphocytic lymphoma: case report. Diagn Pathol. 2007;2:34 pubmed
  • 免疫组化; 人类; 1:100
Park Y, Kwak S, Kim D, Kim H, Choe G, Park D, et al. Diagnostic value of galectin-3, HBME-1, cytokeratin 19, high molecular weight cytokeratin, cyclin D1 and p27(kip1) in the differential diagnosis of thyroid nodules. J Korean Med Sci. 2007;22:621-8 pubmed
  • 免疫组化; 人类; 1:100
Farmer P, Bailey D, Burns B, Day A, LeBrun D. The reliability of lymphoma diagnosis in small tissue samples is heavily influenced by lymphoma subtype. Am J Clin Pathol. 2007;128:474-80 pubmed
  • 免疫组化; 人类; 1:30
Papadopoulos O, Betsi E, Tsakistou G, Frangoulis M, Fangoulis M, Kouvatseas G, et al. Expression of cyclin D1 and Ki-67 in squamous cell carcinoma of the penis. Anticancer Res. 2007;27:2167-74 pubmed
  • 免疫组化; 人类; 1:50
de Roos M, van der Vegt B, Peterse J, Patriarca C, De Vries J, de Bock G, et al. The expression pattern of MUC1 (EMA) is related to tumour characteristics and clinical outcome in 'pure' ductal carcinoma in situ of the breast. Histopathology. 2007;51:227-38 pubmed
  • 免疫组化; 人类; 1:50
van der Vegt B, de Roos M, Peterse J, Patriarca C, Hilkens J, de Bock G, et al. The expression pattern of MUC1 (EMA) is related to tumour characteristics and clinical outcome of invasive ductal breast carcinoma. Histopathology. 2007;51:322-35 pubmed
  • 免疫组化; 人类; 1:50
Wong S, Chan J, Lo E, Chan A, Wong M, Chan C, et al. The contribution of bifunctional SkipDewax pretreatment solution, rabbit monoclonal antibodies, and polymer detection systems in immunohistochemistry. Arch Pathol Lab Med. 2007;131:1047-55 pubmed
  • 免疫组化; 人类; 1:50
Filipits M, Pirker R, Dunant A, Lantuejoul S, Schmid K, Huynh A, et al. Cell cycle regulators and outcome of adjuvant cisplatin-based chemotherapy in completely resected non-small-cell lung cancer: the International Adjuvant Lung Cancer Trial Biologic Program. J Clin Oncol. 2007;25:2735-40 pubmed
  • 免疫组化; 人类; 1:100
Papay J, Krenacs T, Moldvay J, Stelkovics E, Furak J, Molnar B, et al. Immunophenotypic profiling of nonsmall cell lung cancer progression using the tissue microarray approach. Appl Immunohistochem Mol Morphol. 2007;15:19-30 pubmed
  • 免疫组化; 人类; 1:100
Demirkan N, Bir F, Erdem O, Duzcan E. Immunohistochemical expression of beta-catenin, E-cadherin, cyclin D1 and c-myc in benign trichogenic tumors. J Cutan Pathol. 2007;34:467-73 pubmed
  • 免疫组化; 人类; 1:100
Aronica E, Boer K, Baybis M, Yu J, Crino P. Co-expression of cyclin D1 and phosphorylated ribosomal S6 proteins in hemimegalencephaly. Acta Neuropathol. 2007;114:287-93 pubmed
  • 免疫组化; 人类; 1:50
Phuoc N, Ehara H, Gotoh T, Nakano M, Yokoi S, Deguchi T, et al. Immunohistochemical analysis with multiple antibodies in search of prognostic markers for clear cell renal cell carcinoma. Urology. 2007;69:843-8 pubmed
  • 免疫组化; 人类; 1:50
Li W, Tran N, Lee S, O Brien C, Tse G, Scolyer R, et al. New evidence for geographic variation in the role of human papillomavirus in tonsillar carcinogenesis. Pathology. 2007;39:217-22 pubmed
  • 免疫组化; 人类; 1:200
van Dekken H, Wink J, Vissers K, Franken P, Ruud Schouten W, J Hop W, et al. Wnt pathway-related gene expression during malignant progression in ulcerative colitis. Acta Histochem. 2007;109:266-72 pubmed
  • 免疫印迹; 小鼠; 1:1000
Okano J, Suzuki S, Shiota K. Involvement of apoptotic cell death and cell cycle perturbation in retinoic acid-induced cleft palate in mice. Toxicol Appl Pharmacol. 2007;221:42-56 pubmed
  • 免疫组化; 人类; 1:100
Mansoor A, Akbari M, Auer I, Lai R. Cyclin D1 and t(11;14)-positive B-cell neoplasms resembling marginal zone B-cell lymphoma: a morphological variant of mantle cell lymphoma. Hum Pathol. 2007;38:797-802 pubmed
  • 免疫组化; 人类
Guglielmelli T, Giugliano E, Cappia S, Papotti M, Saglio G. Frequency and distribution of trisomy 11 in multiple myeloma patients: relation with overexpression of CCND1 and t(11;14). Cancer Genet Cytogenet. 2007;173:51-6 pubmed
  • 免疫组化; 人类; 1:75
Wang S, Chen W, Li S, Li S, Yang S, Chai C. Expression of human telomerase reverse transcriptase and cyclin-D1 in olfactory neuroblastoma. APMIS. 2007;115:17-21 pubmed
  • 免疫组化; baboons; 1:80
Dumitrescu A, Aberdeen G, Pepe G, Albrecht E. Developmental expression of cell cycle regulators in the baboon fetal adrenal gland. J Endocrinol. 2007;192:237-47 pubmed
  • 免疫组化; 人类; 1:40
Huh Y, Abruzzo L, Rassidakis G, Parry Jones N, Schlette E, Brito Bapabulle V, et al. The t(14;19)(q32;q13)-positive small B-cell leukaemia: a clinicopathologic and cytogenetic study of seven cases. Br J Haematol. 2007;136:220-8 pubmed
  • 免疫组化; 人类; 1:50; 图 2
Reis Filho J, Simpson P, Turner N, Lambros M, Jones C, Mackay A, et al. FGFR1 emerges as a potential therapeutic target for lobular breast carcinomas. Clin Cancer Res. 2006;12:6652-62 pubmed
  • 免疫组化; 人类; 1:100
Perrone F, Suardi S, Pastore E, Casieri P, Orsenigo M, Caramuta S, et al. Molecular and cytogenetic subgroups of oropharyngeal squamous cell carcinoma. Clin Cancer Res. 2006;12:6643-51 pubmed
  • 免疫组化; 人类; 1:40
Vega F, Padula A, Valbuena J, Stancu M, Jones D, Medeiros L. Lymphomas involving the pleura: a clinicopathologic study of 34 cases diagnosed by pleural biopsy. Arch Pathol Lab Med. 2006;130:1497-502 pubmed
  • 免疫组化; 人类; 1:50
Subramaniam M, Navarro S, Pellin A, Lopez Guerrero J, Carda C, Heredia Alvaro J, et al. Tissue microarray profiling of primary and xenotransplanted synovial sarcomas demonstrates the immunophenotypic similarities existing between SYT-SSX fusion gene confirmed, biphasic, and monophasic fibrous variants. Virchows Arch. 2006;449:435-47 pubmed
  • 免疫组化; 人类
Chuang S, Huang W, Hsieh P, Tseng H, Campo E, Colomer D, et al. Mantle cell lymphoma in Taiwan: clinicopathological and molecular study of 21 cases including one cyclin D1-negative tumor expressing cyclin D2. Pathol Int. 2006;56:440-8 pubmed
  • 免疫组化; 人类; 1:100
Kostopoulos I, Cocco M, Ginanneschi C, D Amuri A, Lazzi S, Fabbri A, et al. Overlapping morphologic and immunophenotypic profiles in small B-cell lymphoma. A report of two cases. Virchows Arch. 2006;449:320-7 pubmed
  • 免疫组化; 人类; 1:100
Handra Luca A, Ruhin B, Lesty C, Fouret P. P27, SKP2, and extra-cellular signal-related kinase signalling in human salivary gland mucoepidermoid carcinoma. Oral Oncol. 2006;42:1005-10 pubmed
  • 免疫印迹; 人类; 1:400
Juhlin C, Larsson C, Yakoleva T, Leibiger I, Leibiger B, Alimov A, et al. Loss of parafibromin expression in a subset of parathyroid adenomas. Endocr Relat Cancer. 2006;13:509-23 pubmed
  • 免疫组化; 人类; 1:250
Cook J, Hsi E, Worley S, Tubbs R, Hussein M. Immunohistochemical analysis identifies two cyclin D1+ subsets of plasma cell myeloma, each associated with favorable survival. Am J Clin Pathol. 2006;125:615-24 pubmed
  • 免疫组化; 人类
Zamo A, Zanotti R, Lestani M, Ott G, Katzenberger T, Scarpa A, et al. Molecular characterization of composite mantle cell and follicular lymphoma. Virchows Arch. 2006;448:639-43 pubmed
  • 免疫组化; 人类; 1:50
Charlotte F, Doghmi K, Cassoux N, Ye H, Du M, Kujas M, et al. Ocular adnexal marginal zone B cell lymphoma: a clinical and pathologic study of 23 cases. Virchows Arch. 2006;448:506-16 pubmed
  • 免疫组化; 大鼠
  • 免疫印迹; 大鼠
Weroha S, Li S, Tawfik O, Li J. Overexpression of cyclins D1 and D3 during estrogen-induced breast oncogenesis in female ACI rats. Carcinogenesis. 2006;27:491-8 pubmed
  • 免疫组化; 小鼠
Bauer S, Patterson P. The cell cycle-apoptosis connection revisited in the adult brain. J Cell Biol. 2005;171:641-50 pubmed
  • 免疫组化; 人类; 1:100
Torlakovic E, Nielsen S, Vyberg M. Antibody selection in immunohistochemical detection of cyclin D1 in mantle cell lymphoma. Am J Clin Pathol. 2005;124:782-9 pubmed
  • 免疫组化; 人类
Medeiros L, Estrov Z, Rassidakis G. Z-138 cell line was derived from a patient with blastoid variant mantle cell lymphoma. Leuk Res. 2006;30:497-501 pubmed
  • 免疫组化-石蜡切片; 人类; 1:40
  • 免疫组化; 人类; 1:15
Konoplev S, Medeiros L, Bueso Ramos C, Jorgensen J, Lin P. Immunophenotypic profile of lymphoplasmacytic lymphoma/Waldenström macroglobulinemia. Am J Clin Pathol. 2005;124:414-20 pubmed
  • 免疫组化; 大鼠; 1:150
Siegenthaler J, Miller M. Ethanol disrupts cell cycle regulation in developing rat cortex interaction with transforming growth factor beta1. J Neurochem. 2005;95:902-12 pubmed
  • 免疫细胞化学; 大鼠
  • 免疫组化; 大鼠; 1:100
Siegenthaler J, Miller M. Transforming growth factor beta 1 promotes cell cycle exit through the cyclin-dependent kinase inhibitor p21 in the developing cerebral cortex. J Neurosci. 2005;25:8627-36 pubmed
  • 免疫组化; 人类; 1:100
Fu K, Weisenburger D, Greiner T, Dave S, Wright G, Rosenwald A, et al. Cyclin D1-negative mantle cell lymphoma: a clinicopathologic study based on gene expression profiling. Blood. 2005;106:4315-21 pubmed
  • 免疫组化; 小鼠
Barisoni L, Madaio M, Eraso M, Gasser D, Nelson P. The kd/kd mouse is a model of collapsing glomerulopathy. J Am Soc Nephrol. 2005;16:2847-51 pubmed
  • 免疫印迹; 人类
Siitonen T, Koistinen P, Savolainen E. Increase in Ara-C cytotoxicity in the presence of valproate, a histone deacetylase inhibitor, is associated with the concurrent expression of cyclin D1 and p27(Kip 1) in acute myeloblastic leukemia cells. Leuk Res. 2005;29:1335-42 pubmed
  • 免疫组化; 人类
  • 免疫印迹; 人类
Kveiborg M, Fröhlich C, Albrechtsen R, Tischler V, Dietrich N, Holck P, et al. A role for ADAM12 in breast tumor progression and stromal cell apoptosis. Cancer Res. 2005;65:4754-61 pubmed
  • 免疫组化; 人类
Sander B, Flygare J, Porwit MacDonald A, Smith C, Emanuelsson E, Kimby E, et al. Mantle cell lymphomas with low levels of cyclin D1 long mRNA transcripts are highly proliferative and can be discriminated by elevated cyclin A2 and cyclin B1. Int J Cancer. 2005;117:418-30 pubmed
  • 免疫组化; 小鼠
Burns J, Abdallah B, Guldberg P, Rygaard J, Schrøder H, Kassem M. Tumorigenic heterogeneity in cancer stem cells evolved from long-term cultures of telomerase-immortalized human mesenchymal stem cells. Cancer Res. 2005;65:3126-35 pubmed
  • 免疫组化; 人类; 1:100
Kovacs G, Stelkovics E, Krenacs L, Gonda G, Goth M, Kovacs L, et al. Low level of cyclin D1 protein expression in thyroid microcarcinomas from an autopsy series. Endocrine. 2005;26:41-4 pubmed
  • 免疫印迹; 人类
Yau T, Chan C, Chan K, Lee M, Wong C, Fan S, et al. HDPR1, a novel inhibitor of the WNT/beta-catenin signaling, is frequently downregulated in hepatocellular carcinoma: involvement of methylation-mediated gene silencing. Oncogene. 2005;24:1607-14 pubmed
Zhang M, Lu Q, Hou H, Sun D, Chen M, Ning F, et al. Garcinol inhibits the proliferation of endometrial cancer cells by inducing cell cycle arrest. Oncol Rep. 2021;45:630-640 pubmed 出版商
Girardi B, Pricci M, Giorgio F, Piazzolla M, Iannone A, Losurdo G, et al. Silymarin, boswellic acid and curcumin enriched dietetic formulation reduces the growth of inherited intestinal polyps in an animal model. World J Gastroenterol. 2020;26:1601-1612 pubmed 出版商
Chen F, Jimenez R, Sharma K, Luu H, Hsu B, Ravindranathan A, et al. Broad Distribution of Hepatocyte Proliferation in Liver Homeostasis and Regeneration. Cell Stem Cell. 2020;26:27-33.e4 pubmed 出版商
Matsui T, Chiyo T, Kobara H, Fujihara S, Fujita K, Namima D, et al. Telmisartan Inhibits Cell Proliferation and Tumor Growth of Esophageal Squamous Cell Carcinoma by Inducing S-Phase Arrest In Vitro and In Vivo. Int J Mol Sci. 2019;20: pubmed 出版商
Samarajeewa A, Lenz D, Xie L, Chiang H, Kirchner R, Mulvaney J, et al. Transcriptional response to Wnt activation regulates the regenerative capacity of the mammalian cochlea. Development. 2018;145: pubmed 出版商
Yeh I, Lang U, Durieux E, Tee M, Jorapur A, Shain A, et al. Combined activation of MAP kinase pathway and β-catenin signaling cause deep penetrating nevi. Nat Commun. 2017;8:644 pubmed 出版商
Wen J, Lee J, Malhotra A, Nahta R, Arnold A, Buss M, et al. WIP1 modulates responsiveness to Sonic Hedgehog signaling in neuronal precursor cells and medulloblastoma. Oncogene. 2016;35:5552-5564 pubmed 出版商
Hsieh W, Huang Y, Wang T, Ming Y, Tsai C, Pang J. IFI27, a novel epidermal growth factor-stabilized protein, is functionally involved in proliferation and cell cycling of human epidermal keratinocytes. Cell Prolif. 2015;48:187-97 pubmed 出版商
Valkenburg K, Yu X, De Marzo A, Spiering T, Matusik R, Williams B. Activation of Wnt/β-catenin signaling in a subpopulation of murine prostate luminal epithelial cells induces high grade prostate intraepithelial neoplasia. Prostate. 2014;74:1506-20 pubmed 出版商
Nobs L, Baranek C, Nestel S, Kulik A, Kapfhammer J, Nitsch C, et al. Stage-specific requirement for cyclin D1 in glial progenitor cells of the cerebral cortex. Glia. 2014;62:829-39 pubmed 出版商
Kucherlapati M, Esfahani S, Habibollahi P, Wang J, Still E, Bronson R, et al. Genotype directed therapy in murine mismatch repair deficient tumors. PLoS ONE. 2013;8:e68817 pubmed 出版商
Al Moustafa A, Foulkes W, Wong A, Jallal H, Batist G, Yu Q, et al. Cyclin D1 is essential for neoplastic transformation induced by both E6/E7 and E6/E7/ErbB-2 cooperation in normal cells. Oncogene. 2004;23:5252-6 pubmed
Cheuk W, Wong K, Wong C, Chan J. Consistent immunostaining for cyclin D1 can be achieved on a routine basis using a newly available rabbit monoclonal antibody. Am J Surg Pathol. 2004;28:801-7 pubmed
Vuillermoz B, Khoruzhenko A, D Onofrio M, Ramont L, Venteo L, Perreau C, et al. The small leucine-rich proteoglycan lumican inhibits melanoma progression. Exp Cell Res. 2004;296:294-306 pubmed
图像
图像 1 :
赛默飞世尔 MA5-14512 图像 1
Formalin-fixed, paraffin-embedded human mantle cell lymphoma stained with Cyclin D1 using peroxidase-conjugate and DAB. Note nuclear staining of tumor cells.
图像 2 :
赛默飞世尔 MA5-14512 图像 2
产品信息
产品类型 :
抗体
产品名称 :
细胞周期蛋白D1重组兔单克隆抗体(SP4)
目录# :
MA5-14512
规格 :
500微升
价格 :
美国446.00
克隆性 :
重组单克隆
纯度 :
亲和色谱
宿主 :
反应物种 :
人类, 小鼠, 大鼠
应用 :
Flow Cytometry: 1:30, Immunocytochemistry: 1:50-1:250, Immunohistochemistry (Frozen): Assay-dependent, Immunohistochemistry (Paraffin): 1:100, Western Blot: 1:1,000
物种 :
人类, 小鼠, 大鼠
克隆 :
SP4
抗体亚型 :
IgG
储存 :
-20° C, 避免反复冷冻/解冻
描述 :
Cyclin D1 (PRAD-1, bcl-1) is one of the key cell cycle regulators, and functions in association with cdk4 and/or cdk6 by phosphorylating the Rb protein. Cyclin D1 is a putative proto-oncogene overexpressed in a wide variety of human neoplasms including mantle cell lymphomas (MCL). In addition, cyclin D1 positively regulates protein phosphorylation, mammary gland epithelial cell proliferation, and fat cell differentiation. In humans, the CCND1 gene encoding cyclin D1 is present on chromosome 11. Cyclin D1 is a cytoplasmic and nuclear protein that is synthesized during G1 phase and assembles with either cyclin-dependent kinase 4 (CDK4) or CDK6 in response to growth factor stimulation. D-type cyclin-CDK complexes act to inactivate the growth-suppressive function of the Rb protein through its phosphorylation, and titrate CDK inhibitors such as p21Cip1 and p27Kip1. Without growth factor-mediated stimulation, Cyclin D1 is unstable, and undergoes ubiquitin-mediated degradation, which is triggered by its phosphorylation. Cyclin D1 destabilization participates in G1/S phase arrest. The Cyclin D1 protein belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclin D1 forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. The Cyclin D1 protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. Cyclin D1 has been successfully employed and is a promising tool for further studies in both cell cycle biology and cancer associated abnormalities.
免疫原 :
A合成肽来自C末端人的细胞周期蛋白D1
格式 :
液体
应用w/稀释 :
Flow Cytometry: 1:30, Immunocytochemistry: 1:50-1:250, Immunohistochemistry (Frozen): Assay-dependent, Immunohistochemistry (Paraffin): 1:100, Western Blot: 1:1,000
别名 :
AI327039; B-cell CLL/lymphoma 1; B-cell lymphoma 1 protein; BCL1; BCL-1; BCL-1 oncogene; CCND1; CCND1 protein; cD1; cDNA; CycD1; cyclin D1; Cyl-1; D11S287E; FLJ93625; G1/S-specific cyclin-D1; mRNA; PRAD1; PRAD-1; PRAD1 oncogene; U21B31
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国