产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
ALK单克隆抗体(SP8)
目录 :
MA5-14528
规格 :
500微升
价格 :
美国476.00
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
SP8
反应物种 :
人类, 小鼠
应用 :
酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 5
出版应用/物种/样本/稀释参考文献
  • 酶联免疫吸附测定; 人类; 图 s3
Kourentzi K, Crum M, Patil U, Prebisch A, Chavan D, Vu B, et al. Recombinant expression, characterization, and quantification in human cancer cell lines of the Anaplastic Large-Cell Lymphoma-characteristic NPM-ALK fusion protein. Sci Rep. 2020;10:5078 pubmed 出版商
  • 免疫组化; 人类; 1:50
Duijkers F, Gaal J, Meijerink J, Admiraal P, Pieters R, de Krijger R, et al. High anaplastic lymphoma kinase immunohistochemical staining in neuroblastoma and ganglioneuroblastoma is an independent predictor of poor outcome. Am J Pathol. 2012;180:1223-31 pubmed 出版商
  • 免疫组化; 人类; 1:100
Giuriato S, Foisseau M, Dejean E, Felsher D, Al Saati T, Demur C, et al. Conditional TPM3-ALK and NPM-ALK transgenic mice develop reversible ALK-positive early B-cell lymphoma/leukemia. Blood. 2010;115:4061-70 pubmed 出版商
  • 免疫组化; 人类
Horváth E, Mezei T, Pávai Z, Turcu M, Demian S, Toth E, et al. Diagnostic and differential diagnostic criteria of lymphoid neoplasms in bone marrow trephine biopsies: a study of 87 cases. Rom J Morphol Embryol. 2009;50:399-406 pubmed
  • 免疫组化; 人类; 1:100
Giuriato S, Faumont N, Bousquet E, Foisseau M, Bibonne A, Moreau M, et al. Development of a conditional bioluminescent transplant model for TPM3-ALK-induced tumorigenesis as a tool to validate ALK-dependent cancer targeted therapy. Cancer Biol Ther. 2007;6:1318-23 pubmed
图像
图像 1 :
赛默飞世尔 MA5-14528 图像 1
Formalin-fixed, paraffin-embedded Anaplastic lymphoma stained with LK/p80 antibody using AEC chromogen. Note nuclear and cytoplasmic staining of tumor cells.
产品信息
产品类型 :
抗体
产品名称 :
ALK单克隆抗体(SP8)
目录# :
MA5-14528
规格 :
500微升
价格 :
美国476.00
克隆性 :
单克隆
宿主 :
兔
反应物种 :
人类, 小鼠
应用 :
Immunocytochemistry: 1:10-1:100, Immunohistochemistry (Paraffin): 1:100
物种 :
人类, 小鼠
克隆 :
SP8
抗体亚型 :
IgG
储存 :
短期存放在4°C。 为长期储存, 存放在-20°C, 避免反复冷冻/解冻
描述 :
The 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas. The translocation creates a fusion gene consisting of the ALK gene and the nucleophosmin gene: the 3' half of ALK, derived from chromosome 2, is fused to the 5' portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. These sequences are absent in the product of the transforming NPM-ALK gene. ALK shows the greatest sequence similarity to LTK. ALK plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system.
免疫原 :
Recombinant protein corresponding to a region, which spans the tyrosine kinase catalytic domain and part of the C-terminus of the NPM-ALK transcript
格式 :
液体
应用w/稀释 :
Immunocytochemistry: 1:10-1:100, Immunohistochemistry (Paraffin): 1:100
别名 :
Alk; ALK tyrosine kinase receptor; ALK/NPM1 fusion gene; anaplastic lymphoma kinase; Anaplastic lymphoma kinase Ki1; Anaplastic Lymphoma Kinase p80; anaplastic lymphoma receptor tyrosine kinase; CD246; CD246 antigen; EC 2.7.10.1; kinase ALK; mutant anaplastic lymphoma kinase; NBLST3; npm-alk; p80; Tcrz; TFG/ALK
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国