产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
VDR单克隆抗体(9A7gamma.E10.E4)
目录 :
MA5-14617
规格 :
500微升
价格 :
美国405.00
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
未共轭
克隆名称 :
9A7gamma.E10.E4
反应物种 :
中国人仓鼠, 人类, 小鼠, 大鼠, 鸡, pigs
应用 :
免疫印迹, 免疫细胞化学
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 8
参考文献
Thakkar A, Wang B, Picon Ruiz M, Buchwald P, Ince T. Vitamin D and androgen receptor-targeted therapy for triple-negative breast cancer. Breast Cancer Res Treat. 2016;157:77-90 pubmed 出版商
Silvagno F, Consiglio M, Foglizzo V, Destefanis M, Pescarmona G. Mitochondrial translocation of vitamin D receptor is mediated by the permeability transition pore in human keratinocyte cell line. PLoS ONE. 2013;8:e54716 pubmed 出版商
Alimirah F, Peng X, Yuan L, Mehta R, von Knethen A, Choubey D, et al. Crosstalk between the peroxisome proliferator-activated receptor ? (PPAR?) and the vitamin D receptor (VDR) in human breast cancer cells: PPAR? binds to VDR and inhibits 1?,25-dihydroxyvitamin D3 mediated transactivation. Exp Cell Res. 2012;318:2490-7 pubmed 出版商
Sidler Lauff K, Boos A, Kraenzlin M, Liesegang A. Influence of different calcium supplies and a single vitamin D injection on vitamin D receptor and calbindin D9k immunoreactivities in the gastrointestinal tract of goat kids. J Anim Sci. 2010;88:3598-610 pubmed 出版商
Lange T, Zou Y, Singh R, Kim K, Kristjansdottir K, Sholler G, et al. Chemotherapeutic effect of calcidiol derivative B3CD in a neuroblastoma xenograft model. Chem Biol Drug Des. 2010;76:164-73 pubmed 出版商
Sahin M, Canda A, Yorukoglu K, Mungan M, Sade M, Kirkali Z. 1,25 Dihydroxyvitamin D(3) receptor expression in superficial transitional cell carcinoma of the bladder: a possible prognostic factor?. Eur Urol. 2005;47:52-7 pubmed
Narvaez C, Byrne B, Romu S, Valrance M, Welsh J. Induction of apoptosis by 1,25-dihydroxyvitamin D3 in MCF-7 Vitamin D3-resistant variant can be sensitized by TPA. J Steroid Biochem Mol Biol. 2003;84:199-209 pubmed
Zinser G, McEleney K, Welsh J. Characterization of mammary tumor cell lines from wild type and vitamin D3 receptor knockout mice. Mol Cell Endocrinol. 2003;200:67-80 pubmed
产品信息
产品类型 :
抗体
产品名称 :
VDR单克隆抗体(9A7gamma.E10.E4)
目录# :
MA5-14617
规格 :
500微升
价格 :
美国405.00
克隆性 :
单克隆
纯度 :
蛋白质G
宿主 :
大鼠
反应物种 :
两栖动物, 鸡, 鱼类, 仓鼠, 人类, 小鼠, 猪, 大鼠
应用 :
Gel Shift: 1mg/mL, Immunocytochemistry: 2 µg/mL, Western Blot: 1-2 µg/mL
物种 :
两栖动物, 鸡, 鱼类, 仓鼠, 人类, 小鼠, 猪, 大鼠
克隆 :
9A7gamma.E10.E4
抗体亚型 :
IgG2b
储存 :
4° C
描述 :
Steroid receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. The 1,25-dihydroxy-vitamin D3 receptor (VDR) belongs to the superfamily of steroid hormone receptors which includes estrogen, progesterone, glucocorticoid, androgen, and thyroid hormone receptors. Vitamin D modulates calcium and phosphorus homeostasis, bone remodeling, cell growth regulation, and differentiation. Studies have found VDR in the intestine, bone, kidney, epidermis, and cells of the endocrine immune system. Repression of T-cell proliferation and interleukin-2 (IL-2) gene expression, for example, occurs when VDR binds within the IL-2 enhancer. Formation of VDR/retinoic X receptor (RXR) heterodimers in the presence of intracellular 1,25(OH)2D3 has been shown to interfere with assembly of nuclear factor of activated T-cells (NFATp)/Fos/Jun/DNA complex and subsequent IL-2 gene transcription. The corresponding gene for the vitamin D receptor is NR1I1.
免疫原 :
维生素D受体蛋白来自鸡肠
格式 :
液体
应用w/稀释 :
Gel Shift: 1mg/mL, Immunocytochemistry: 2 µg/mL, Western Blot: 1-2 µg/mL
别名 :
1,25-dihydroxyvitamin D3 receptor; HGNC:12679; I79_025795; Nr1i1; Nuclear receptor subfamily 1 group I member 1; PPP1R163; protein phosphatase 1, regulatory subunit 163; vdr; vdr.S; vdr-A; vitamin D (1,25- dihydroxyvitamin D3) receptor; vitamin D (1,25- dihydroxyvitamin D3) receptor S homeolog; vitamin D (1,25-dihydroxyvitamin D3) receptor; vitamin D nuclear receptor variant 1; vitamin D receptor; vitamin D receptor protein; vitamin D receptor S homeolog; Vitamin D3 receptor; XELAEV_18015993mg; xVDR
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国