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抗体

磷酸化GAB1(Tyr627)单克隆抗体(T.921.2)

MA5-14812

100微升

美国506.00

单克隆

domestic rabbit

未共轭

T.921.2

人类, 小鼠, 大鼠

磷酸化GAB1(Tyr627)单克隆抗体(T.921.2)

MA5-14812

100微升

美国506.00

单克隆

纯化

兔

人类, 小鼠, 大鼠

Western Blot: 1:1,000

人类, 小鼠, 大鼠

T.921.2

IgG

-20°C

Gab1 is a 115 kDa multiple docking protein that plays an essential role in cellular growth, transformation and apoptosis. Gab1 can be phosphorylated by multiple receptor tyrosine kinase (RTKs), including: insulin receptor (IR), platelet-derived growth factor receptor beta] (PDGFRbeta]), hepatocyte growth factor/scatter factor receptor (HGFR/SFR or c-Met), and epidermal growth factor receptor (EGF), as well as in response to cell-cell adhesion. Gab1 is tyrosine phosphorylated on at least 16 sites, some of which serve as binding sites for phosphoatidylinositol 3-kinase (PI3K), Grb2, PLC gamma 1, Nck, and SHP2. Phosphorylation of Gab1 on tyrosines 627 and 659 is critical for its binding to SHP2, and for activation of the ERK/MAPK pathway in response to EGF.

Synthetic phosphopeptide corresponding to residues surrounding Tyr627 of human Gab1.

液体

Western Blot: 1:1,000

AA408973; AW107238; EGK_16125; GAB1; GRB2 associated binding protein 1; GRB2-associated binder 1; GRB2-associated binding protein 1; GRB2-associated binding protein 1 long isoform; GRB2-associated-binding protein 1; Growth factor receptor bound protein 2-associated protein 1; OTTHUMP00000220263