NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

抗体

NUP98单克隆抗体(J.750.3)

MA5-14907

100微升

美国446

单克隆

domestic rabbit

未共轭

J.750.3

人类, 小鼠, 大鼠

免疫印迹, 免疫细胞化学, 免疫沉淀

NUP98单克隆抗体(J.750.3)

MA5-14907

100微升

美国446

单克隆

亲和色谱

兔

Human, Mouse, Non-human primate, Rat

Immunocytochemistry: 1:50, Immunofluorescence: 1:50, Immunoprecipitation: 1:50, Western Blot: 1:1000

Human, Mouse, Non-human primate, Rat

J.750.3

IgG

-20°C

Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kDa nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kDa precursor protein. This cleavage results in the 98 kDa nucleoporin as well as a 96 kDa nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kDa nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromosome translocations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15. 5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.

Synthetic peptide corresponding to residues surrounding Pro671 of human NUP98

液体

Immunocytochemistry: 1:50, Immunofluorescence: 1:50, Immunoprecipitation: 1:50, Western Blot: 1:1000

4732457F17; 96 kDa nucleoporin; 98 kDa nucleoporin; ADAR2; ADIR2; AI849286; GLFG-repeat containing nucleoporin; Nuclear pore complex protein Nup96; Nuclear pore complex protein Nup98; nuclear pore complex protein Nup98; nuclear pore complex protein Nup98-Nup96; nuclear pore complex protein Nup98-Nup96; nucleoporin 98; nucleoporin 98 and 96 precursor; nucleoporin 98 L homeolog; nucleoporin 98kD; nucleoporin 98kDa; Nucleoporin Nup96; Nucleoporin Nup98; NUP196; nup96; NUP98; nup98.L; NUP98/PHF23 fusion 2 protein; Nup98-Nup96; OTTHUMP00000013954