产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
CDK9单克隆抗体(K.513.1)
目录 :
MA5-14912
规格 :
100微升
价格 :
美国395.00
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
K.513.1
反应物种 :
中国人仓鼠, 人类, 小鼠, 大鼠, ,
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
文章摘录数: 2
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 图 6b
Niu Q, Liu Z, Alamer E, Fan X, Chen H, Endsley J, et al. Structure-guided drug design identifies a BRD4-selective small molecule that suppresses HIV. J Clin Invest. 2019;129:3361-3373 pubmed 出版商
Alamer E, Zhong C, Liu Z, Niu Q, Long F, Guo L, et al. Epigenetic Suppression of HIV in Myeloid Cells by the BRD4-Selective Small Molecule Modulator ZL0580. J Virol. 2020;94: pubmed 出版商
图像
图像 1 :
赛默飞世尔 MA5-14912 图像 1
图像 2 :
赛默飞世尔 MA5-14912 图像 2
产品信息
产品类型 :
抗体
产品名称 :
CDK9单克隆抗体(K.513.1)
目录# :
MA5-14912
规格 :
100微升
价格 :
美国395.00
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
反应物种 :
Bovine, Canine, Hamster, Human, Mouse, Non-human primate, Rat
应用 :
Flow Cytometry: 1:200, Immunocytochemistry: 1:100, Immunohistochemistry (Frozen): 1:200, Immunohistochemistry (Paraffin): 1:200, Immunoprecipitation: 1:100, Western Blot: 1:1,000
物种 :
Bovine, Canine, Hamster, Human, Mouse, Non-human primate, Rat
克隆 :
K.513.1
抗体亚型 :
IgG
储存 :
-20°C
描述 :
CDK9 (cyclin-dependent kinase 9) is a member of the cyclin-dependent protein kinase family. It is involved in the regulation of transcription. CDK9 is a member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex. This complex facilitates the transition from abortive to productive elongation by phosphorylating the CTD of the large subunit of RNA polymerase II, POLR2A, SUPT5H, and RDBP. The complex is inactive when in the 7SK snRNP complex form. CDK9 phosphorylates EP300, MYOD1, RPB1/POLR2A, AR, DSIF, and NELF. It regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors. CDK9 promotes RNA synthesis in genetic programs for cell growth, differentiation, and viral pathogenesis. The CDK9/cyclin-K complex also has kinase activity towards CTD of RNAPII and can substitute for CDK9/cyclin-T P-TEFb in vitro. Chronic activation of CDK9 causes cardiac myocyte enlargement leading to cardiac hypertrophy and confers a predisposition to heart failure.
免疫原 :
Synthetic peptide corresponding to residues near the carboxy terminus of human CDK9
格式 :
液体
应用w/稀释 :
Flow Cytometry: 1:200, Immunocytochemistry: 1:100, Immunohistochemistry (Frozen): 1:200, Immunohistochemistry (Paraffin): 1:200, Immunoprecipitation: 1:100, Western Blot: 1:1,000
别名 :
C-2k; CDC2L4; CDC2-related kinase; Cdk9; Cell division cycle 2-like protein kinase 4; Cell division protein kinase 9; CTK1; cyclin dependent kinase 9; cyclin-dependent kinase 9; cyclin-dependent kinase 9 (CDC2-related kinase); PITALRE; RP11-228B15.5; serine/threonine protein kinase PITALRE; Serine/threonine-protein kinase PITALRE; TAK; Tat-associated kinase complex catalytic subunit
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国