Phospho-Syk (Tyr525, Tyr526) Monoclonal Antibody (F.724.5) | 赛默飞世尔 MA5-14918 产品信息

产品简要

公司名称 :

赛默飞世尔

其他品牌 :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

产品类型 :

抗体

产品名称 :

Phospho-Syk (Tyr525, Tyr526) Monoclonal Antibody (F.724.5)

MA5-14918

规格 :

100微升

价格 :

美国446

克隆性 :

单克隆

宿主 :

domestic rabbit

共轭标签 :

未共轭

抗原修饰 :

磷酸化

克隆名称 :

F.724.5

反应物种 :

人类, 小鼠, 大鼠

应用 :

免疫印迹, 免疫细胞化学, 免疫沉淀, 流式细胞仪

更多信息或购买 :

赛默飞世尔产品网页

文章摘录数: 7

出版应用/物种/样本/稀释	参考文献
免疫印迹; 人类; 1:1000; 图 4i	Zhao P, Xu Y, Jiang L, Fan X, Ku Z, Li L, et al. LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions. Mol Neurodegener. 2022;17:44 pubmed 出版商
免疫印迹; 人类; 1:200; 图 1g	Hall Roberts H, Agarwal D, Obst J, Smith T, Monzón Sandoval J, Di Daniel E, et al. TREM2 Alzheimer's variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages. Alzheimers Res Ther. 2020;12:151 pubmed 出版商
免疫印迹; 小鼠; 1:1000; 图 2h	Lopes A, Silva R, Fonseca M, Gomes F, Maganin A, Ribeiro L, et al. Molecular basis of carrageenan-induced cytokines production in macrophages. Cell Commun Signal. 2020;18:141 pubmed 出版商
免疫印迹; 小鼠; 图 6b	Bergsma A, Ganguly S, Wiegand M, Dick D, Williams B, Miranti C. Regulation of cytoskeleton and adhesion signaling in osteoclasts by tetraspanin CD82. Bone Rep. 2019;10:100196 pubmed 出版商
免疫印迹; 小鼠; 图 3f	Zhao Y, Wu X, Li X, Jiang L, Gui X, Liu Y, et al. TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function. Neuron. 2018;97:1023-1031.e7 pubmed 出版商
	Obst J, Hall Roberts H, Smith T, Kreuzer M, Magno L, Di Daniel E, et al. PLCγ2 regulates TREM2 signalling and integrin-mediated adhesion and migration of human iPSC-derived macrophages. Sci Rep. 2021;11:19842 pubmed 出版商
	Natunen T, Martiskainen H, Marttinen M, Gabbouj S, Koivisto H, Kemppainen S, et al. Diabetic phenotype in mouse and humans reduces the number of microglia around β-amyloid plaques. Mol Neurodegener. 2020;15:66 pubmed 出版商

图像

图像 1 :

产品信息

产品类型 :

抗体

产品名称 :

Phospho-Syk (Tyr525, Tyr526) Monoclonal Antibody (F.724.5)

目录# :

MA5-14918

规格 :

100微升

价格 :

美国446

克隆性 :

单克隆

纯度 :

亲和色谱

宿主 :

兔

反应物种 :

人类, 小鼠, 大鼠

应用 :

Flow Cytometry: 1:400, Immunocytochemistry: 1:200, Immunofluorescence: 1:200, Immunoprecipitation: 1:50, Western Blot: 1:1000

物种 :

人类, 小鼠, 大鼠

克隆 :

F.724.5

抗体亚型 :

IgG

储存 :

-20°C

描述 :

Syk is a cytoplasmic protein tyrosine kinase that translocates to the plasma membrane upon B cell antigen receptor (BCR) or the high-affinity IgE receptor (FcepsilonRI) triggering, and phosphorylates downstream adaptor proteins, thereby providing docking sites for initiation of subsequent signaling pathways, such as calcium mobilization, cytoskeleton remodeling, or transcription of specific genes. Syk binds to the receptor assemblies through interactions of its pair of SH2 domains with ITAM motives of the receptor, which have been phosphorylated by Src-family kinases. These kinases also help to activate Syk by phosphorylation of its activation loop.

免疫原 :

Synthetic phosphopeptide corresponding to residues surrounding pTyr525/526 of human Syk

格式 :

液体

应用w/稀释 :

Flow Cytometry: 1:400, Immunocytochemistry: 1:200, Immunofluorescence: 1:200, Immunoprecipitation: 1:50, Western Blot: 1:1000

别名 :

DKFZp313N1010; EC 2.7.10.2; FLJ25043; FLJ37489; HGNC:11205; kinase Syk; KSYK; p72Syk; p72-Syk; ptk72; SP1; spleen associated tyrosine kinase; spleen tyrosine kinase; Syk; syk signaling; Sykb; tyrosine-kinase syk; Tyrosine-protein kinase SYK

更多信息或购买 :

赛默飞世尔产品网页

公司信息

赛默飞世尔

上海浦东新金桥路27号7号楼

analyze.cn@thermofisher.com

http://www.thermo.com.cn

1084193588

公司总部: 美国