产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
磷酸化IRF3(Ser396)单克隆抗体(E.875.8)
目录 :
MA5-14947
规格 :
100微升
价格 :
美国436.00
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
抗原修饰 :
磷酸化
克隆名称 :
E.875.8
反应物种 :
人类, 小鼠
应用 :
免疫印迹
更多信息或购买 :
文章摘录数: 5
| 出版应用/物种/样本/稀释 | 参考文献 |
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产品信息
产品类型 :
抗体
产品名称 :
磷酸化IRF3(Ser396)单克隆抗体(E.875.8)
目录# :
MA5-14947
规格 :
100微升
价格 :
美国436.00
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
兔
反应物种 :
人类, 小鼠
应用 :
Western Blot: 1:1,000
物种 :
人类, 小鼠
克隆 :
E.875.8
抗体亚型 :
IgG
储存 :
-20°C
描述 :
IFR3 (interferon regulatory factor 3) is a key transcriptional regulator of type I interferon (IFN)-dependent immune responses. It plays a critical role in the innate immune response against DNA and RNA viruses. IFR3 regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. It acts as a more potent activator of the IFN-beta gene than the IFN-alpha gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. IFR3 is found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA, or toll-like receptor signaling. It is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Mutations in the gene can result in encephalopathy, acute, infection-induced, herpes-specific 7.
免疫原 :
Synthetic phosphopeptide corresponding to residues surrounding pSer396 of human IRF-3
格式 :
液体
应用w/稀释 :
Western Blot: 1:1,000
别名 :
C920001K05Rik;IIAE7;干扰素调节因子3;IRF3;IRF-3;IRF3(磷酸化S386);IRF3(pS386);IRF3(pSer386);IRF3磷酸化;IRF3磷酸化S386;IRF3磷酸化Ser386;磷酸化IRF3
更多信息或购买 :
公司信息
赛默飞世尔