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抗体

HP1甲单克隆抗体(F.747.6)

MA5-14989

100微升

美国379

单克隆

domestic rabbit

未共轭

F.747.6

人类, 小鼠, 大鼠

免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片

HP1甲单克隆抗体(F.747.6)

MA5-14989

100微升

美国379

单克隆

亲和色谱

兔

Human, Mouse, Non-human primate, Rat

Immunocytochemistry: 1:100, Immunohistochemistry (Paraffin): 1:200, Immunoprecipitation: 1:25, Western Blot: 1:1,000

Human, Mouse, Non-human primate, Rat

F.747.6

IgG

-20°C

Heterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, where it mediates gene silencing. It has been shown that mammalian methyltransferases that selectively methylate histone H3 on lysine-9 generate a binding site for HP1 proteins, a family of heterochromatic adaptor molecules implicated in both gene silencing and supranucleosomal chromatin structure. High-affinity in vitro recognition of a methylated histone H3 peptide by HP1 requires a functional chromodomain. Thus, the HP1 chromodomain is a specific interaction motif for the methyl epitope on lysine-9 of histone H3. In vivo, heterochromatin association of HP1 proteins is lost in Suv39h double-null primary mouse fibroblasts but is restored after reintroduction of a catalytically active SUV39H1 HMTase.

Synthetic peptide corresponding to the carboxy terminus of human HP1 a

液体

Immunocytochemistry: 1:100, Immunohistochemistry (Paraffin): 1:200, Immunoprecipitation: 1:25, Western Blot: 1:1,000

2610029O15Rik; antigen p25; C75991; Cbx5; Cbx5 antibody; chromobox 5; chromobox homolog 5; chromobox homolog 5 (HP1 alpha homolog, Drosophila); chromobox protein homolog 5; chromobox-like protein 5; epididymis luminal protein 25; HEL25; heterochromatin protein 1 alpha; heterochromatin protein 1 homolog alpha; heterochromatin protein 1-alpha; HGNC:1555; HP1; HP1 alpha; HP-1 alpha antibody; HP1 alpha homolog; Hp1a; Hp1alpha; HP1-ALPHA; HP1Hs alpha; HP1Hs-alpha; mHP1(alpha)