产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
IRE1甲单克隆抗体(J.607.10)
目录 :
MA5-14991
规格 :
100微升
价格 :
美国473
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
J.607.10
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫沉淀, 核糖核酸免疫沉淀
更多信息或购买 :
文章摘录数: 1
产品信息
产品类型 :
抗体
产品名称 :
IRE1甲单克隆抗体(J.607.10)
目录# :
MA5-14991
规格 :
100微升
定价 :
美国473
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
兔
反应物种 :
人类, 小鼠
应用 :
Immunoprecipitation: 1:50, RNA Immunoprecipitation: Assay-dependent, Western Blot: 1:500
物种 :
人类, 小鼠
克隆 :
J.607.10
抗体亚型 :
IgG
储存 :
-20°C
描述 :
IRE1 alpha is the endoplasmic reticulum to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. IRE1 alpha protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals. Specifically, IRE1 acts as the sensor of unfolded proteins in the ER that initiates transmittance of the unfolded protein signal from the ER to the nucleus by splicing XBP1 mRNA converting it into a potent unfolded-protein response transcriptional activator. Null mutants are viable, but IRE1 is essential for viability under stress conditions that cause unfolded proteins to accumulate in the ER. Depletion of IRE1p through the expression of a dominant negative form of IRE1p has no effect on transfected cells, but cell death via apoptosis occurs under stress conditions that cause unfolded proteins to accumulate in the ER.
免疫原 :
Synthetic peptide corresponding to residues surrounding His963 of human IRE1a
格式 :
液体
应用w/稀释 :
Immunoprecipitation: 1:50, RNA Immunoprecipitation: Assay-dependent, Western Blot: 1:500
别名 :
9030414B18Rik; AI225830; C85377; endoplasmic reticulum (ER) to nucleus signalling 1; endoplasmic reticulum to nucleus signaling 1; endoplasmic reticulum to nucleus signalling 1; endoplasmic reticulum-to-nucleus signaling 1; Endoribonuclease; ER to nucleus signalling 1; ERN1; FLJ30999; hIRE1p; inositol-requiring 1; inositol-requiring 1 alpha; inositol-requiring enzyme 1; inositol-requiring protein 1; IRE1; IRE1a; IRE1a antibody; Ire1alpha; Ire1-alpha; Ire1p; IRE1p antibody; MGC163277; MGC163279; protein kinase/endoribonuclease; RGD1559716; Serine/threonine-protein kinase; Serine/threonine-protein kinase/endoribonuclease IRE1; serine/threonine-protein kinase/endoribonuclease IRE1-like
更多信息或购买 :
公司信息
赛默飞世尔