产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
TSC2单克隆抗体(T.309.0)
目录 :
MA5-15004
规格 :
100微升
价格 :
美国399
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
T.309.0
反应物种 :
人类
应用 :
免疫印迹, 免疫沉淀
更多信息或购买 :
文章摘录数: 2
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图像
图像 1 :
产品信息
产品类型 :
抗体
产品名称 :
TSC2单克隆抗体(T.309.0)
目录# :
MA5-15004
规格 :
100微升
定价 :
美国399
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
兔
反应物种 :
人类
应用 :
Immunoprecipitation: 1:50, Western Blot: 1:1,000
物种 :
人类
克隆 :
T.309.0
抗体亚型 :
IgG
储存 :
-20°C
描述 :
TSC2 (Tuberin, Tuberous sclerosis complex, TSC Complex Subunit 2), is implicated as a tumor suppressor and may function in vesicular transport, play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. TSC2 associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Phosphorylation of tuberin on Ser 939 and Thr 1462 regulates its interaction with hamartin, and is stimulated by various growth factors through the phosphoinositide 3-kinase/Akt pathway. TSC2 may have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking. TSC2 specifically stimulates the intrinsic GTPase activity of the Ras related protein RAP1A and RAB5, suggesting a possible mechanism for its role in regulating cellular growth. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors and are involved in diseases such as lymphangioleiomyomatosis and TSC2 angiomyolipoma. Alternative splicing results in transcript variants of three different isoforms of TSC2.
免疫原 :
Synthetic peptide from the amino terminus of human tuberin.
格式 :
液体
应用w/稀释 :
Immunoprecipitation: 1:50, Western Blot: 1:1,000
别名 :
LAM; Nafld; OTTHUMP00000198394; PPP1R160; protein phosphatase 1, regulatory subunit 160; Rc; renal carcinoma; Tcs2; Tsc2; TSC4; Tuberin; tuberous sclerosis 2; tuberous sclerosis 2 homolog protein; tuberous sclerosis 2 protein; Tuberous sclerosis 2 protein homolog
更多信息或购买 :
公司信息
赛默飞世尔