产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
AXIN2单克隆抗体(J.415.10)
目录 :
MA5-15015
规格 :
100微升
价格 :
美国391
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
J.415.10
反应物种 :
人类
应用 :
免疫印迹, 免疫沉淀
更多信息或购买 :
文章摘录数: 1
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图像 1 :
产品信息
产品类型 :
抗体
产品名称 :
AXIN2单克隆抗体(J.415.10)
目录# :
MA5-15015
规格 :
100微升
定价 :
美国391
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
兔
反应物种 :
人类
应用 :
Immunoprecipitation: 1:50, Western Blot: 1:1,000
物种 :
人类
克隆 :
J.415.10
抗体亚型 :
IgG
储存 :
-20°C
描述 :
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
免疫原 :
Synthetic peptide corresponding to residues surrounding Pro566 of human Axin2
格式 :
液体
应用w/稀释 :
Immunoprecipitation: 1:50, Western Blot: 1:1,000
别名 :
Axi1; axil; axin 2; Axin like protein; axin2; axin-2; Axin-like protein; Axis inhibition protein 2; conductin; DKFZp781B0869; MGC10366; MGC126582; ODCRCS
更多信息或购买 :
公司信息
赛默飞世尔