产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
磷酸化TAK1(Thr184, Thr187)单克隆抗体(K.846.3)
目录 :
MA5-15073
规格 :
100µL
价格 :
美国345
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
抗原修饰 :
磷酸化
克隆名称 :
K.846.3
反应物种 :
人类, 小鼠, 大鼠, 鸡, 牛, 斑马鱼, 非洲爪蛙
应用 :
免疫印迹, 流式细胞仪
更多信息或购买 :
文章摘录数: 1
图像
图像 1 :
产品信息
产品类型 :
抗体
产品名称 :
磷酸化TAK1(Thr184, Thr187)单克隆抗体(K.846.3)
目录# :
MA5-15073
规格 :
100µL
价格 :
美国345
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
兔
反应物种 :
牛, 鸡, 人类, 小鼠, 大鼠, 非洲爪蛙, 斑马鱼
应用 :
Western Blot: 1:1000
物种 :
牛, 鸡, 人类, 小鼠, 大鼠, 非洲爪蛙, 斑马鱼
克隆 :
K.846.3
抗体亚型 :
IgG
储存 :
-20°C
描述 :
TAK1 (also known as MAP3K7), a part of the serine/threonine kinase family, is a versatile protein with many signaling functions. Originally identified as a TGF- beta-activated kinase, TAK1 interacts with TGF- beta-receptor and TRAF6 to modulate TGF- beta activation of JNK and p38. It has additional roles in activation of p38 and JNK through Wnt, BMP, and activin signaling pathways as well in response to thyroid hormone, osmotic stress, endothelin, and ephrine. Through activation of von Hippel-Lindau tumor suppressor expression, TAK1 represses PDGF-B, integrin beta1 and integrin beta5, promoting proper wound healing. TAK1 also plays an essential role in IKK activation in numerous signaling pathways including IL-1, IL-6, IL-18, TNF, CD40, TLR, and RIG-I. Activation of the TAK1-IKK pathway requires TAB2/3 and ubiquitination. In this process, TAB2/3 binds to the C-terminal region of TAK1 and becomes polyubiquitinated, TAK1 is autophosphorylated at Thr178, Thr184, Thr187 and Ser192, and finally TAK1 phosphorylates IKK- beta. Additionally, TAK1 represses human telomerase reverse transcriptase suggesting a role in regulation of cell lifespan.
免疫原 :
Phosphopeptide corresponding to residues surrounding pThr184 and pThr187 of human TAK1
格式 :
液体
应用w/稀释 :
Western Blot: 1:1000
别名 :
B430101B05; BOS_9732; C87327; hypothetical protein LOC553788; I79_000697; M3K7; Map3k7; map3k7.L; MAPKKK; MEKK7; mitogen activated protein kinase kinase kinase 7; Mitogen-activated protein kinase kinase kinase 7; mitogen-activated protein kinase kinase kinase 7 L homeolog; RP1-154G14.1; si:ch211-225h9.1; TAK1; TAK1z; TGF1a; TGF-beta activated kinase 1; TGF-beta-activated kinase 1; TGF-beta-activated kinase TAK1; transforming growth factor beta-activated kinase 1; Transforming growth factor-beta-activated kinase 1; XELAEV_18027270mg; xTAK1; zgc:110612
更多信息或购买 :
公司信息
赛默飞世尔