产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
Tau Monoclonal Antibody (S.125.0)
目录 :
MA5-15108
规格 :
100µL
价格 :
美国329.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
nonconjugated
克隆名称 :
S.125.0
反应物种 :
人类, 小鼠, 大鼠,
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
文章摘录数: 3
出版应用/物种/样品/稀释参考文献
  • 免疫细胞化学; 人类; 1:300; 图 5b
Begum A, Aguilar J, Elias L, Hong Y. Silver nanoparticles exhibit coating and dose-dependent neurotoxicity in glutamatergic neurons derived from human embryonic stem cells. Neurotoxicology. 2016;57:45-53 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:2000; 图 2d
Fujita K, Motoki K, Tagawa K, Chen X, Hama H, Nakajima K, et al. HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer's disease. Sci Rep. 2016;6:31895 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000
Fu Z, Yang Y, Song J, Jiang Q, Lin Z, Wang Q, et al. LiCl attenuates thapsigargin-induced tau hyperphosphorylation by inhibiting GSK-3? in vivo and in vitro. J Alzheimers Dis. 2010;21:1107-17 pubmed
产品信息
产品类型 :
抗体
产品名称 :
Tau Monoclonal Antibody (S.125.0)
目录# :
MA5-15108
规格 :
100µL
价格 :
美国329.00
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
小鼠
反应物种 :
牛, 人类, 小鼠, 大鼠
应用 :
Immunofluorescence: 1:800, Immunohistochemistry (Frozen): 1:800, Immunohistochemistry (Paraffin): 1:800, Western Blot: 1:1000
物种 :
牛, 人类, 小鼠, 大鼠
克隆 :
S.125.0
抗体亚型 :
IgG1
储存 :
-20°C
描述 :
Tau is a neuronal microtubule-associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerization and stabilize microtubules. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton while the longer isoforms may preferentially play a role in its stabilization. In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimer's diseases (AD) brain. Hyper-phosphorylation impairs the microtubule binding function of Tau, resulting in the destabilization of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Numerous serine/threonine kinases phosphorylate Tau, including GSK-3beta, protein kinase A (PKA), cyclindependent kinase 5 (cdk5) and casein kinase II. Hyper-phosphorylated Tau is found in neurofibrillary lesions in a range and other central nervous system disorders such as Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
免疫原 :
Native bovine tau and the epitope maps to the carboxy-terminus of the protein
格式 :
Liquid
应用w/稀释 :
Immunofluorescence: 1:800, Immunohistochemistry (Frozen): 1:800, Immunohistochemistry (Paraffin): 1:800, Western Blot: 1:1000
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
www.thermo.com.cn
1084193588
公司总部: 美国