产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
磷酸化SMAD家族成员2(Ser465, Ser467)单克隆抗体(H.205.4)
目录 :
MA5-15122
规格 :
100微升
价格 :
美国425.00
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
抗原修饰 :
磷酸化
克隆名称 :
H.205.4
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫细胞化学
更多信息或购买 :
文章摘录数: 2
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产品信息
产品类型 :
抗体
产品名称 :
磷酸化SMAD家族成员2(Ser465, Ser467)单克隆抗体(H.205.4)
目录# :
MA5-15122
规格 :
100微升
价格 :
美国425.00
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
兔
反应物种 :
人类, 水貂, 小鼠, 大鼠
应用 :
Immunocytochemistry: 1:100, Western Blot: 1:1,000
物种 :
人类, 水貂, 小鼠, 大鼠
克隆 :
H.205.4
抗体亚型 :
IgG
储存 :
-20°C
描述 :
SMAD2 (MADH2, MAD2) regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. SMAD2 interacts with the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation into the nucleus is a central event in TGF beta signaling. Phosphorylation of threonine 8 in the calmodulin-binding region of the MH1 domain by extracellular signal regulated kinase 1 (ERK1) enhances SMAD2 transcriptional activity, which is negatively regulated by calmodulin. In response to the TGF-beta signal, SMAD2 is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. SMAD2 can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants encoding the SMAD2 protein have been observed.
免疫原 :
Synthetic phosphopeptide corresponding to residues surrounding pSer465/467 of human Smad2
格式 :
液体
应用w/稀释 :
Immunocytochemistry: 1:100, Western Blot: 1:1,000
别名 :
7120426M23Rik; EGK_09664; hMAD-2; hSMAD2; JV18; JV18-1; MAD; MAD homolog 2; Mad protein homolog; Madh2; Madr2; Mad-related protein 2; MGC22139; MGC34440; mMad2; mother against DPP homolog 2; mothers against decapentaplegic homolog 2; Mothers against decapentaplegic-like protein 2; mothers against DPP homolog 2; pSMAD2; Sma- and Mad-related protein 2; SMAD; SMAD 2; SMAD family member 2; SMAD, mothers against DPP homolog 2; Smad2; Smad-2; Smad2Deltaexon3
更多信息或购买 :
公司信息
赛默飞世尔