产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
p53单克隆抗体(多克隆抗体240)
目录 :
MA5-15244
规格 :
500微升
价格 :
美国447.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
多克隆抗体240
反应物种 :
人类, 小鼠, 猕猴
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 58
参考文献
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Lu W, Bird T, Boulter L, Tsuchiya A, Cole A, Hay T, et al. Hepatic progenitor cells of biliary origin with liver repopulation capacity. Nat Cell Biol. 2015;17:971-983 pubmed 出版商
Rousseau B, Jacquot C, Le Palabe J, Malleter M, Tomasoni C, Boutard T, et al. TP53 transcription factor for the NEDD9/HEF1/Cas-L gene: potential targets in Non-Small Cell Lung Cancer treatment. Sci Rep. 2015;5:10356 pubmed 出版商
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Wu X, Jia S, Zhang X, Si X, Tang W, Luo Y. Two mechanisms underlying the loss of p16(Ink4a) function are associated with distinct tumorigenic consequences for WS MEFs escaping from senescence. Mech Ageing Dev. 2012;133:549-55 pubmed 出版商
Stanga S, Lanni C, Sinforiani E, Mazzini G, Racchi M. Searching for predictive blood biomarkers: misfolded p53 in mild cognitive impairment. Curr Alzheimer Res. 2012;9:1191-7 pubmed
Jia S, Zhao L, Tang W, Luo Y. The gain of function of p53 mutant p53S in promoting tumorigenesis by cross-talking with H-RasV12. Int J Biol Sci. 2012;8:596-605 pubmed 出版商
Rebel H, Bodmann C, van de Glind G, de Gruijl F. UV-induced ablation of the epidermal basal layer including p53-mutant clones resets UV carcinogenesis showing squamous cell carcinomas to originate from interfollicular epidermis. Carcinogenesis. 2012;33:714-20 pubmed 出版商
Hewedi I, Radwan N, Shash L. Diagnostic value of progesterone receptor and p53 expression in uterine smooth muscle tumors. Diagn Pathol. 2012;7:1 pubmed 出版商
Arvai K, Nagy K, Barti Juhasz H, Petak I, Krenacs T, Micsik T, et al. Molecular profiling of parathyroid hyperplasia, adenoma and carcinoma. Pathol Oncol Res. 2012;18:607-14 pubmed 出版商
Zhao L, Jia S, Tang W, Sheng J, Luo Y. Pu-erh tea inhibits tumor cell growth by down-regulating mutant p53. Int J Mol Sci. 2011;12:7581-93 pubmed 出版商
Yuan X, Liu W, Hao J, Gu W, Zhao Y. Topical grape seed proanthocyandin extract reduces sunburn cells and mutant p53 positive epidermal cell formation, and prevents depletion of Langerhans cells in an acute sunburn model. Photomed Laser Surg. 2012;30:20-5 pubmed 出版商
Halperin R, Stafford P, Johnston S. Exploring antibody recognition of sequence space through random-sequence peptide microarrays. Mol Cell Proteomics. 2011;10:M110.000786 pubmed 出版商
Mir S, De Witt Hamer P, Krawczyk P, Balaj L, Claes A, Niers J, et al. In silico analysis of kinase expression identifies WEE1 as a gatekeeper against mitotic catastrophe in glioblastoma. Cancer Cell. 2010;18:244-57 pubmed 出版商
Graziano S, Gu L, Wang X, Tatum A, Vollmer R, Strauss G, et al. Prognostic significance of mucin and p53 expression in stage IB non-small cell lung cancer: a laboratory companion study to CALGB 9633. J Thorac Oncol. 2010;5:810-7 pubmed
Lanni C, Racchi M, Stanga S, Mazzini G, Ranzenigo A, Polotti R, et al. Unfolded p53 in blood as a predictive signature signature of the transition from mild cognitive impairment to Alzheimer's disease. J Alzheimers Dis. 2010;20:97-104 pubmed 出版商
Cenini G, Maccarinelli G, Lanni C, Bonini S, Ferrari Toninelli G, Govoni S, et al. Wild type but not mutant APP is involved in protective adaptive responses against oxidants. Amino Acids. 2010;39:271-83 pubmed 出版商
Palmeira C, Lameiras C, Amaro T, Lima L, Koch A, Lopes C, et al. CIS is a surrogate marker of genetic instability and field carcinogenesis in the urothelial mucosa. Urol Oncol. 2011;29:205-11 pubmed 出版商
Herbst A, Bommer G, Kriegl L, Jung A, Behrens A, Csanadi E, et al. ITF-2 is disrupted via allelic loss of chromosome 18q21, and ITF-2B expression is lost at the adenoma-carcinoma transition. Gastroenterology. 2009;137:639-48, 648.e1-9 pubmed 出版商
Wang Z, Qi Y, Chen Q, Yang D, Tang S, Jin X, et al. Cyclin A is essential for the p53-modulated inhibition from benzo(a)pyrene toxicity in A549 cells. Toxicology. 2009;256:1-6 pubmed 出版商
Holcomb V, Rodier F, Choi Y, Busuttil R, Vogel H, Vijg J, et al. Ku80 deletion suppresses spontaneous tumors and induces a p53-mediated DNA damage response. Cancer Res. 2008;68:9497-502 pubmed 出版商
Agrawal A, Sharma M, Rai S, Singh B, Tiwari M, Chandra R. The effect of the aqueous extract of the roots of Asparagus racemosus on hepatocarcinogenesis initiated by diethylnitrosamine. Phytother Res. 2008;22:1175-82 pubmed 出版商
Reed K, Meniel V, Marsh V, Cole A, Sansom O, Clarke A. A limited role for p53 in modulating the immediate phenotype of Apc loss in the intestine. BMC Cancer. 2008;8:162 pubmed 出版商
Wu Z, Zhang R, Chao C, Zhang J, Zhang Y. Histone deacetylase inhibitor trichostatin A induced caspase-independent apoptosis in human gastric cancer cell. Chin Med J (Engl). 2007;120:2112-8 pubmed
Terzi C, Canda A, Sagol O, Atila K, Sonmez D, Fuzun M, et al. Survivin, p53, and Ki-67 as predictors of histopathologic response in locally advanced rectal cancer treated with preoperative chemoradiotherapy. Int J Colorectal Dis. 2008;23:37-45 pubmed
Tosun M, Tosun E, Kalkan S, Avunduk M. P53 expression between 13-27 weeks old human male fetus gonads. J Mol Histol. 2007;38:271-4 pubmed
Nijhof J, Mulder A, Speksnijder E, Hoogervorst E, Mullenders L, de Gruijl F. Growth stimulation of UV-induced DNA damage retaining epidermal basal cells gives rise to clusters of p53 overexpressing cells. DNA Repair (Amst). 2007;6:1642-50 pubmed
Ramalingam S, Honkanen P, Young L, Shimura T, Austin J, Steeg P, et al. Quantitative assessment of the p53-Mdm2 feedback loop using protein lysate microarrays. Cancer Res. 2007;67:6247-52 pubmed
Vairaktaris E, Kalokerinos G, Goutzanis L, Spyridonidou S, Vassiliou S, Derka S, et al. Diabetes alters expression of p53 and c-myc in different stages of oral oncogenesis. Anticancer Res. 2007;27:1465-73 pubmed
Clarke A, Jones N, Pryde F, Adachi Y, Sansom O. 53BP1 deficiency in intestinal enterocytes does not alter the immediate response to ionizing radiation, but leads to increased nuclear area consistent with polyploidy. Oncogene. 2007;26:6349-55 pubmed
Preyer M, Shu C, Wang J. Delayed activation of Bax by DNA damage in embryonic stem cells with knock-in mutations of the Abl nuclear localization signals. Cell Death Differ. 2007;14:1139-48 pubmed
Zhu Q, Wani G, Yao J, Patnaik S, Wang Q, El Mahdy M, et al. The ubiquitin-proteasome system regulates p53-mediated transcription at p21waf1 promoter. Oncogene. 2007;26:4199-208 pubmed
Bifsha P, Landry K, Ashmarina L, Durand S, Seyrantepe V, Trudel S, et al. Altered gene expression in cells from patients with lysosomal storage disorders suggests impairment of the ubiquitin pathway. Cell Death Differ. 2007;14:511-23 pubmed
Bertozzi C, Chang C, Jairaj S, Shan X, Huang J, Weber B, et al. Multiple initial culture conditions enhance the establishment of cell lines from primary ovarian cancer specimens. In Vitro Cell Dev Biol Anim. 2006;42:58-62 pubmed
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Meniel V, Hay T, Douglas Jones A, Sansom O, Clarke A. Mutations in Apc and p53 synergize to promote mammary neoplasia. Cancer Res. 2005;65:410-6 pubmed
Gruber A, Schmidt P, Url A. Immunohistochemical studies concerning the neuronal cell cycle of the cat using PCNA, Ki-67 and p53 markers. J Vet Med A Physiol Pathol Clin Med. 2004;51:416-9 pubmed
Rosas Acosta G, Russell W, Deyrieux A, Russell D, Wilson V. A universal strategy for proteomic studies of SUMO and other ubiquitin-like modifiers. Mol Cell Proteomics. 2005;4:56-72 pubmed
Mathur S, Kaur P, Sharma M, Katyal A, Singh B, Tiwari M, et al. The treatment of skin carcinoma, induced by UV B radiation, using 1-oxo-5beta, 6beta-epoxy-witha-2-enolide, isolated from the roots of Withania somnifera, in a rat model. Phytomedicine. 2004;11:452-60 pubmed
Hoogervorst E, Van Oostrom C, Beems R, van Benthem J, Gielis S, Vermeulen J, et al. p53 heterozygosity results in an increased 2-acetylaminofluorene-induced urinary bladder but not liver tumor response in DNA repair-deficient Xpa mice. Cancer Res. 2004;64:5118-26 pubmed
Poulin D, Kung A, DeCaprio J. p53 targets simian virus 40 large T antigen for acetylation by CBP. J Virol. 2004;78:8245-53 pubmed
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Facchetti M, Uberti D, Memo M, Missale C. Nerve growth factor restores p53 function in pituitary tumor cell lines via trkA-mediated activation of phosphatidylinositol 3-kinase. Mol Endocrinol. 2004;18:162-72 pubmed
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产品信息
产品类型 :
抗体
产品名称 :
p53单克隆抗体(多克隆抗体240)
目录# :
MA5-15244
规格 :
500微升
价格 :
美国447.00
克隆性 :
单克隆
纯度 :
蛋白质G
宿主 :
小鼠
反应物种 :
人类, 小鼠, 猕猴
应用 :
ChIP assay: 1-3 µg x 10^6 cells, Flow Cytometry: Assay-dependent, Immunocytochemistry: 2 µg/mL, Immunohistochemistry (Paraffin): 2-4 µg/mL, Immunoprecipitation: 2 µg/mL, Western Blot: 1-2 µg/mL
物种 :
人类, 小鼠, 猕猴
克隆 :
多克隆抗体240
抗体亚型 :
IgG1
储存 :
4° C
描述 :
The tumor suppressor protein, p53, is a sequence specific transcription factor that is activated by cellular stress. p53 mediates cell cycle arrest or apoptosis in response to DNA damage or starvation for pyrimidine nucleotides. p53 is up-regulated in response to stress signals and stimulated to activate transcription of specific genes, resulting in expression of p21waf1 and other proteins involved in G1 or G2/M arrest. The structure of p53 comprises an N-terminal transactivation domain, a central DNA-binding domain, an oligomerisation domain, and a C-terminal regulatory domain. There are various phosphorylation sites on p53, of which the phosphorylation at Ser15 is important for p53 activation and stabilization. p53 has been characterized to play a role in blocking the proliferative action of damaged cells and act as an anticancer agent. Phosphorylation of Ser392 in p53 has been shown to associate with the formation of human tumors. In addition, p53 has also been linked to the effects of aging and oxidative stress and an increase in p53 has been linked to deficits in LTP (Long Term Potentiation) in learning and memory. p53 is found in very low levels in normal cells, however, in a variety of transformed cell lines, it is expressed in high amounts, and believed to contribute to transformation and malignancy. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and cause the loss of tumor suppressor activity. Alterations of the TP53 gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families such as Li-Fraumeni syndrome.
免疫原 :
Murine p53 protein corresponding to aa14-289
格式 :
液体
应用w/稀释 :
ChIP assay: 1-3 µg x 10^6 cells, Flow Cytometry: Assay-dependent, Immunocytochemistry: 2 µg/mL, Immunohistochemistry (Paraffin): 2-4 µg/mL, Immunoprecipitation: 2 µg/mL, Western Blot: 1-2 µg/mL
别名 :
Antigen NY-CO-13; bbl; BCC7; bfy; bhy; cellular tumor antigen p53; Cys 51 Stop; EGK_08142; FLJ92943; HGNC11998; I79_002739; LFS1; Li-Fraumeni syndrome; mutant p53; mutant tumor protein 53; OTTMUSP00000006194; p44; p53; p53 cellular tumor antigen; p53 protein; p53 tumor suppressor; p53 tumor suppressor phosphoprotein; phosphoprotein p53; Tp53; tp53.L; transformation related protein 53; transformation-related protein 53; Trp248; Trp53; tumor protein 53; tumor protein p53; tumor protein p53 (Li-Fraumeni syndrome); tumor protein p53 L homeolog; tumor suppressor p53; tumor suppressor p53 phosphoprotein; tumor suppressor protein p53; tumor supressor p53; Tumour Protein p53; XELAEV_180196761mg; Xp53; Xrel3
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国