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抗体

蛋白Z单克隆抗体(2B4)

MA5-15533

100微升

美国438

单克隆

小鼠

未共轭

2B4

免疫印迹, 酶联免疫吸附测定

蛋白Z单克隆抗体(2B4)

MA5-15533

100微升

美国438

单克隆

小鼠

人类

ELISA: 1:10,000, Western Blot: 1:500-1:2,000

人类

2B4

IgG1

短期存放在4°C。 为长期储存, 存放在-20°C, 避免反复冷冻/解冻

PROZ protein Z, vitamin K-dependent plasma glycoprotein. It is 62 kDa large and 396 amino acids long. It has four domains: a gla-rich region, two EGF-like domains and a trypsin-like domain. It lacks the serine residue that would make it catalytically active as a serine protease. It is a member of the coagulation cascade, the group of blood proteins that leads to the formation of blood clots. It is vitamin K-dependent, and its functionality is therefore impaired in warfarin therapy. It is a glycoprotein. Although it is not enzymatically active, it is structurally related to several serine proteases of the coagulation cascade: factors VII, IX, X and protein C. The carboxyglutamate residues (which require vitamin K) bind protein Z to phospholipid surfaces. The main role of protein Z appears to be the degradation of factor Xa. This is done by protein Z-related protease inhibitor (ZPI), but the reaction is accelerated 1000-fold by the presence of protein Z. Oddly, ZPI also degrades factor XI, but this reaction does not require the presence of protein Z. In some studies, deficiency states have been associated with a propensity to thrombosis. Others, however, link it to bleeding tendency; there is no clear explanation for this, as it acts physiologically as an inhibitor, and deficiency would logically have led to a predisposition for thrombosis.

Purified recombinant fragment of PROZ expressed in E. Coli.

液体

ELISA: 1:10,000, Western Blot: 1:500-1:2,000

protein Z, vitamin K dependent plasma glycoprotein; protein Z, vitamin K-dependent plasma glycoprotein; PROZ; PZ; vitamin K-dependent protein Z; vitamin K-dependent protein Z precursor variant 1