产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
CD40单克隆抗体(9G10)
目录 :
MA5-15535
规格 :
100微升
价格 :
美国457
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
9G10
反应物种 :
人类, 小鼠
应用 :
酶联免疫吸附测定, 免疫细胞化学
更多信息或购买 :
文章摘录数: 1
图像
图像 1 :
Confocal immunofluorescence analysis of human peripheral blood lymphocyles (left) and mouse L1210 cells (right) using CD40 antibody (green). Blue: DRAQ5 fluorescent DNA dye.
产品信息
产品类型 :
抗体
产品名称 :
CD40单克隆抗体(9G10)
目录# :
MA5-15535
规格 :
100微升
定价 :
美国457
克隆性 :
单克隆
宿主 :
小鼠
反应物种 :
人类, 小鼠
应用 :
ELISA: 1:10,000, Immunocytochemistry: 1:200-1:1,000
物种 :
人类, 小鼠
克隆 :
9G10
抗体亚型 :
IgG1
储存 :
短期存放在4°C。 为长期储存, 存放在-20°C, 避免反复冷冻/解冻
描述 :
The CD40 antigen is a single chain glycoprotein that is known to be a member of the tumor necrosis factor/nerve growth factor superfamily and shows a significant homology to the Hodgkin's disease associated antigen, CD30. CD40 is present on all B cells except plasma cells and is also found on some epithelial cells, carcinomas and lymphoid dendritic cells. CD40 has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of CD40, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with CD40 and serves as a mediator of the signal transduction. The interaction of CD40 and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of CD40 encoding distinct isoforms have been reported. Diseases associated with CD40 dysfunction include Type 3 Hyper-Igm immunodeficiency and CD40 ligand deficiency.
免疫原 :
Purified recombinant fragment of CD40 expressed in E. Coli.
格式 :
液体
应用w/稀释 :
ELISA: 1:10,000, Immunocytochemistry: 1:200-1:1,000
别名 :
AI326936; B cell surface antigen CD40; B cell-associated molecule; B-cell surface antigen CD40; Bp50; CD antigen CD40; Cd40; CD40 antigen; CD40 antigen (TNF receptor superfamily member 5); CD40 antigen, TNF receptor superfamily member 5; CD40 molecule; CD40 molecule, TNF receptor superfamily member 5; CD40L receptor; CDw40; GP39; HIGM1; I79_006806; IGM; IMD3; Immunoglobulin M; ImmunoglobulinM; membrane protein CD40; MGC9013; p50; receptor for ligand CD154; sCD40; soluble CD40; T-BAM; T-cell differentiation antigen; Tnfrsf5; TRAP; tumor necrosis factor receptor superfamily member 5; tumor necrosis factor receptor superfamily, member 5
更多信息或购买 :
公司信息
赛默飞世尔