产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
EGF单克隆抗体(9D7F11)
目录 :
MA5-15571
规格 :
100微升
价格 :
美国439
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
9D7F11
反应物种 :
人类
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化
更多信息或购买 :
图像
图像 1 :
Immunohistochemical analysis of paraffin-embedded human breast cancer,Lung breast tissues using EGF antibody
图像 2 :
Immunohistochemical analysis of paraffin-embedded human Uterus tissues using anFtEG antibody
产品信息
产品类型 :
抗体
产品名称 :
EGF单克隆抗体(9D7F11)
目录# :
MA5-15571
规格 :
100微升
定价 :
美国439
克隆性 :
单克隆
宿主 :
小鼠
反应物种 :
人类
应用 :
ELISA: 1:10,000, Immunohistochemistry: 1:200-1:1,000, Western Blot: 1:500-1:2,000
物种 :
人类
克隆 :
9D7F11
抗体亚型 :
IgG1
储存 :
短期存放在4°C。 为长期储存, 存放在-20°C, 避免反复冷冻/解冻
描述 :
EGF (Epidermal growth factor) exerts its actions by binding to the EGF Receptor, a 170 kDa protein kinase. Activation of EGFR initiates diverse cellular pathways in response to toxic environmental stimuli, or to EGF binding to the receptor, the EGFR forms homo- or heterodimers with other family members. Each dimeric receptor complex initiates a distinct signaling pathway by recruiting different Src homology 2 (SH2) containing effector proteins. EGF is far and wide expressed in kidney, cerebrum, prostrate and salivary glands. EGF acts as a potent mitogenic factor and the phosphorylated receptor recruits adapter proteins like GRB2 that activates complex downstream signaling cascades. EGF activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STAT modules. Research studies suggest the protein may also play important role in activating the NF-kappa-B signaling cascade. Defects in the EGGF gene are the cause of hypomagnesemia type 4 and dysregulation has been associated with the growth and progression of certain cancers.
免疫原 :
纯化重组片段对应于人EGF在大肠杆菌中表达
格式 :
液体
应用w/稀释 :
ELISA: 1:10,000, Immunohistochemistry: 1:200-1:1,000, Western Blot: 1:500-1:2,000
别名 :
AI790464; beta-urogastrone; EGF; Epidermal growth factor; epidermal growth factor (beta-urogastrone); epidermal growth factor precursor; H-EGF; HOMG4; Pro-epidermal growth factor; Pro-epidermal growth factor precursor (EGF); sb:eu639; URG; Urogastrone
更多信息或购买 :
公司信息
赛默飞世尔