产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
直流-SIGN单克隆抗体(5D7)
目录 :
MA5-15745
规格 :
100微克
价格 :
美国402.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
5D7
反应物种 :
人类
应用 :
免疫印迹, 免疫组化
更多信息或购买 :
图像
图像 1 :
赛默飞世尔 MA5-15745 图像 1
Western blot detection of DC-SIGN fusion protein in human placenta at (A) 1 and (B) 2 ug/mL.
图像 2 :
赛默飞世尔 MA5-15745 图像 2
Immunohistochemistry staining of lymph node tissue using MA5-15745 anti-DC-SIGN antibody at a concentration of 10 µg/ml.
产品信息
产品类型 :
抗体
产品名称 :
直流-SIGN单克隆抗体(5D7)
目录# :
MA5-15745
规格 :
100微克
价格 :
美国402.00
克隆性 :
单克隆
纯度 :
抗原亲和色谱
宿主 :
小鼠
反应物种 :
人类
应用 :
Immunohistochemistry: 10 µg/mL, Western Blot: 1-2 µg/mL
物种 :
人类
克隆 :
5D7
抗体亚型 :
IgG1
储存 :
-20°C
描述 :
This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.
免疫原 :
A recombinant His-tagged protein fragment corresponding to the extracellular region of human DC-SIGN.
格式 :
液体
应用w/稀释 :
Immunohistochemistry: 10 µg/mL, Western Blot: 1-2 µg/mL
别名 :
CD209; CD209 antigen; CD209 antigen-like protein A; CD209 molecule; Cd209a; CD209a antigen; CD209a molecule; Cd209d; CD209d antigen; CDSIGN; Cire; CLEC4L; Clec4m; C-type lectin domain family 4 member L; C-type lectin domain family 4, member L; C-type lectin domain family 4, member M; Dcsign; DC-SIGN; DC-SIGN1; Dc-signr; DC-SIGN-related protein; Dendritic cell-specific ICAM-3-grabbing non-integrin; dendritic cell-specific ICAM-3-grabbing non-integrin 1; dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin; dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin; HIV gpl20-binding protein; MGC129965; MGC130443; RGD1561104; SIGN-R1; SIGNR5
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国