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抗体

CTCF单克隆抗体(1D11)

MA5-15792

100微升

美国405.00

单克隆

小鼠

未共轭

1D11

人类, 小鼠

免疫印迹, 酶联免疫吸附测定

CTCF单克隆抗体(1D11)

MA5-15792

100微升

美国405.00

单克隆

小鼠

Human, Mouse, Non-human primate

ELISA: 1:10,000, Western Blot: 1:500-1:2,000

Human, Mouse, Non-human primate

1D11

IgG1

短期存放在4°C。 为长期储存, 存放在-20°C, 避免反复冷冻/解冻

Transcriptional factor CTCF is a ubiquitously expressed 11-zinc finger domain containing, DNA-binding nuclear phosphoprotein that is involved in multiple aspects of normal gene regulation including transcriptional repression and activation, gene silencing, chromatin insulation and regulation of imprinted sites. CTCF uses different combinations of ZF domains and interacts with the CCCTC motif on the DNA. It can bind to HAT- and HDAC-containing complexes thereby influencing transcriptional activation or repression respectively. It is a multifunctional protein involved in the transactivation of APPB gene, silencing of c-myc gene, and insulation of human beta-globin and DMI myotonic dystrophy locus and imprinting control of IGF2 and H19 regions. CTCF has also been shown to regulate the transcription of Pax6 and IRAK2 promoter thereby opening a therapeutic avenue. Mutations in this gene have been associated with invasive breast cancers, prostate cancers and Wilms' tumors.

纯化重组片段对应于人CTCF在大肠杆菌中表达

液体

ELISA: 1:10,000, Western Blot: 1:500-1:2,000

11 zinc finger transcriptional repressor; 11-zinc finger protein; AW108038; CCCTC-binding factor; CCCTC-binding factor (zinc finger protein); Ctcf; ctcf protein; CTCFL paralog; im:7152666; MRD21; OTTHUMP00000197610; Transcriptional repressor CTCF; Unknown (protein for IMAGE:8125283)