产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
Toll样受体4单克隆抗体(76B357.1)
目录 :
MA5-16216
规格 :
100微克
价格 :
美国429
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
76B357.1
反应物种 :
人类, 小鼠, 大鼠, 牛, pigs
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 中和反应, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片, dot blot
更多信息或购买 :
文章摘录数: 7
| 出版应用/物种/样本/稀释 | 参考文献 |
|---|---|
| van Haren S, Dowling D, Foppen W, Christensen D, Andersen P, Reed S, et al. Age-Specific Adjuvant Synergy: Dual TLR7/8 and Mincle Activation of Human Newborn Dendritic Cells Enables Th1 Polarization. J Immunol. 2016;197:4413-4424 pubmed
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产品信息
产品类型 :
抗体
产品名称 :
Toll样受体4单克隆抗体(76B357.1)
目录# :
MA5-16216
规格 :
100微克
价格 :
美国429
克隆性 :
单克隆
纯度 :
蛋白质G
宿主 :
小鼠
反应物种 :
Bovine, Human, Mammalia, Mouse, Porcine, Rat
应用 :
ChIP Assay: 1:10-1:500, Dot Blot: Assay-Dependent, ELISA: 0.5 µg, Flow Cytometry: 1:10-1:500, Immunocytochemistry: 1:10-1:500, Immunohistochemistry (Frozen): 1:500, Immunohistochemistry (Paraffin): 5 µg/mL, In vitro Assay: Assay-Dependent, Neutralization: Assay-Dependent, Western Blot: 1-3 µg/mL
物种 :
Bovine, Human, Mammalia, Mouse, Porcine, Rat
克隆 :
76B357.1
抗体亚型 :
IgG2b, kappa
储存 :
短期存放在4°C。 为长期储存, 存放在-20°C, 避免反复冷冻/解冻
描述 :
TLR4 is member of the Toll like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. Mammalian cells respond to LPS by activating TLR4. TLR4 belongs to the multi-protein complex of lipopolysaccharide (LPS) receptor, containing CD14, LY96 and TLR4, and is involved in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. TLR4 aids in the recognition of pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. Mutations in the TLR4 gene have been associated with differences in LPS responsiveness. Also, several transcript variants of the TLR4 gene have been found, but the protein coding potential of most of them is uncertain. TLR4 is expressed by peripheral blood monocytes and a small population of B-cells and is also expressed in human placenta. Studies with TLR4-deficient mice indicate that the main ligand for TLR is lipopolysaccharide. Consequently, these mice also showed increased susceptibility to Gram-negative sepsis.
免疫原 :
Synthetic peptide (aa 100-200 of human TLR4, isoform C, LPEYFSNLTNLEHL) of TLR4/CD284 protein.
格式 :
液体
应用w/稀释 :
ChIP Assay: 1:10-1:500, Dot Blot: Assay-Dependent, ELISA: 0.5 µg, Flow Cytometry: 1:10-1:500, Immunocytochemistry: 1:10-1:500, Immunohistochemistry (Frozen): 1:500, Immunohistochemistry (Paraffin): 5 µg/mL, In vitro Assay: Assay-Dependent, Neutralization: Assay-Dependent, Western Blot: 1-3 µg/mL
别名 :
ARMD10; CD284; EGK_07381; homolog of Drosophila toll; hToll; lipopolysaccharide response; Lps; Ly87; Ran/M1; Rasl2-8; Tlr4; TLR-4; TOLL; toll like receptor 4; toll/interleukin-l receptor (TIR) domain; toll4; toll-like receptor 4; toll-like receptor 4 immunity-related protein; Toll-like receptor 4-like protein; Toll-like receptor4 protein
更多信息或购买 :
公司信息
赛默飞世尔