产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
Toll样受体5单克隆抗体(19D759.2)
目录 :
MA5-16237
规格 :
100微克
价格 :
美国452
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
19D759.2
反应物种 :
人类, 小鼠,
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片, dot blot
更多信息或购买 :
产品信息
产品类型 :
抗体
产品名称 :
Toll样受体5单克隆抗体(19D759.2)
目录# :
MA5-16237
规格 :
100微克
价格 :
美国452
克隆性 :
单克隆
纯度 :
蛋白质G
宿主 :
小鼠
反应物种 :
狗, 人类, 小鼠
应用 :
Dot Blot: Assay-Dependent, Flow Cytometry: 0.5-1 µg per million cells, Immunocytochemistry: 5 µg/mL, Immunohistochemistry (Frozen): 10 µg/mL, Immunohistochemistry (Paraffin): 5 µg/mL, Immunoprecipitation: Assay-Dependent, Western Blot: 1-3 µg/mL
物种 :
狗, 人类, 小鼠
克隆 :
19D759.2
抗体亚型 :
IgG2a, kappa
储存 :
-20° C, 避免反复冷冻/解冻
描述 :
TLR5 is a Type I membrane protein belonging to the Toll-like receptor family, participates in the innate immune response to microbial agents. TLR5 also plays a role in mediating detection of bacterial flagellins. TLR5 acts via MyD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. TLR5 protein binds to TIRAP and MyD88 via their respective TIR domains TLR5 is highly expressed in liver, and is detected in lung and at very low levels in most other tissues. The TLR5 gene lies in a locus that is associated with susceptibility to Salmonella. Inbred strains of mice can be classified into 3 categories according to their resistance to infection with S.typhimurium: susceptible (BALB/c, C57BL/6, C3H/He), intermediate (DBA/2, C75L) and resistant (A, CBA). The strain MOLF/Ei is highly susceptible to the infection, has a unique TLR5 haplotype and a lower expression of TRL5. A common TLR5 stop codon polymorphism that disrupts TLR5 signaling is associated with susceptibility to Legionnaires’ disease and demonstrates the importance of TLR5 in the innate immune response.
免疫原 :
Synthetic peptide (aa 708-724) of TLR5 protein.
格式 :
液体
应用w/稀释 :
Dot Blot: Assay-Dependent, Flow Cytometry: 0.5-1 µg per million cells, Immunocytochemistry: 5 µg/mL, Immunohistochemistry (Frozen): 10 µg/mL, Immunohistochemistry (Paraffin): 5 µg/mL, Immunoprecipitation: Assay-Dependent, Western Blot: 1-3 µg/mL
别名 :
FLJ10052; MELIOS; MGC126430; MGC126431; RP11-239E10.1; SLE1; SLEB1; systemic lupus erythematosus susceptibility 1; TIL3; Tlr5; toll like receptor 5; Toll/interleukin-1 receptor-like protein 3; toll-like receptor 5
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国