产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
Toll样受体4单克隆抗体(HTA125)
目录 :
MA5-16719
规格 :
200微克
价格 :
美国456.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
HTA125
反应物种 :
豚鼠, 人类, , pigs , 猕猴
应用 :
免疫沉淀, 流式细胞仪, 抑制或激活实验
更多信息或购买 :
文章摘录数: 22
出版应用/物种/样本/稀释参考文献
  • 流式细胞仪; 人类; 图 2
Gren S, Janciauskiene S, Sandeep S, Jonigk D, Kvist P, Gerwien J, et al. The protease inhibitor cystatin C down-regulates the release of IL-? and TNF-? in lipopolysaccharide activated monocytes. J Leukoc Biol. 2016;100:811-822 pubmed
  • 流式细胞仪; 人类; 图 4c
Steiner M, Hawranek T, Schneider M, Ferreira F, Horejs Hoeck J, Harrer A, et al. Elevated Toll-Like Receptor-Induced CXCL8 Secretion in Human Blood Basophils from Allergic Donors Is Independent of Toll-Like Receptor Expression Levels. PLoS ONE. 2016;11:e0149275 pubmed 出版商
  • 流式细胞仪; 人类
Bayram M, Soylu A, Ates H, Kizildag S, Kavukcu S. TLR-4 polymorphisms and leukocyte TLR-4 expression in febrile UTI and renal scarring. Pediatr Nephrol. 2013;28:1827-35 pubmed 出版商
  • 抑制或激活实验; 人类; 图 3
Ahmad U, Ali R, Lebastchi A, Qin L, Lo S, Yakimov A, et al. IFN-gamma primes intact human coronary arteries and cultured coronary smooth muscle cells to double-stranded RNA- and self-RNA-induced inflammatory responses by upregulating TLR3 and melanoma differentiation-associated gene 5. J Immunol. 2010;185:1283-94 pubmed 出版商
  • 流式细胞仪; 人类; 图 1
Tunheim G, Schjetne K, Fredriksen A, Sandlie I, Bogen B. Human CD14 is an efficient target for recombinant immunoglobulin vaccine constructs that deliver T cell epitopes. J Leukoc Biol. 2005;77:303-10 pubmed
Machcińska M, Kotur M, Jankowska A, Maruszewska Cheruiyot M, Łaski A, Kotkowska Z, et al. Cyclosporine A, in Contrast to Rapamycin, Affects the Ability of Dendritic Cells to Induce Immune Tolerance Mechanisms. Arch Immunol Ther Exp (Warsz). 2021;69:27 pubmed 出版商
Martínez García M, Ojeda Ojeda M, Rodríguez Martín E, Insenser M, Moncayo S, Alvarez Blasco F, et al. TLR2 and TLR4 Surface and Gene Expression in White Blood Cells after Fasting and Oral Glucose, Lipid and Protein Challenges: Influence of Obesity and Sex Hormones. Biomolecules. 2020;10: pubmed 出版商
Curtale G, Renzi T, Mirolo M, Drufuca L, Albanese M, De Luca M, et al. Multi-Step Regulation of the TLR4 Pathway by the miR-125a~99b~let-7e Cluster. Front Immunol. 2018;9:2037 pubmed 出版商
Domon H, Nagai K, Maekawa T, Oda M, Yonezawa D, Takeda W, et al. Neutrophil Elastase Subverts the Immune Response by Cleaving Toll-Like Receptors and Cytokines in Pneumococcal Pneumonia. Front Immunol. 2018;9:732 pubmed 出版商
Bartlett D, Willis L, Slentz C, Hoselton A, KELLY L, Huebner J, et al. Ten weeks of high-intensity interval walk training is associated with reduced disease activity and improved innate immune function in older adults with rheumatoid arthritis: a pilot study. Arthritis Res Ther. 2018;20:127 pubmed 出版商
Wisgrill L, Wessely I, Spittler A, Forster Waldl E, Berger A, Sadeghi K. Human lactoferrin attenuates the proinflammatory response of neonatal monocyte-derived macrophages. Clin Exp Immunol. 2018;192:315-324 pubmed 出版商
Hoffman D, Amorim J, DeClue A. Immune Function in Critically Ill Dogs. J Vet Intern Med. 2017;: pubmed 出版商
Bzowska M, Nogieć A, Bania K, Zygmunt M, Zarebski M, Dobrucki J, et al. Involvement of cell surface 90 kDa heat shock protein (HSP90) in pattern recognition by human monocyte-derived macrophages. J Leukoc Biol. 2017;102:763-774 pubmed 出版商
Di Candia L, Gomez E, Venereau E, Chachi L, Kaur D, Bianchi M, et al. HMGB1 is upregulated in the airways in asthma and potentiates airway smooth muscle contraction via TLR4. J Allergy Clin Immunol. 2017;140:584-587.e8 pubmed 出版商
Bazzi S, Modjtahedi H, Mudan S, Akle C, Bahr G. Analysis of the immunomodulatory properties of two heat-killed mycobacterial preparations in a human whole blood model. Immunobiology. 2015;220:1293-304 pubmed 出版商
Avlas O, Bragg A, Fuks A, Nicholson J, Farkash A, Porat E, et al. TLR4 Expression Is Associated with Left Ventricular Dysfunction in Patients Undergoing Coronary Artery Bypass Surgery. PLoS ONE. 2015;10:e0120175 pubmed 出版商
Nazli A, Kafka J, Ferreira V, Anipindi V, Mueller K, Osborne B, et al. HIV-1 gp120 induces TLR2- and TLR4-mediated innate immune activation in human female genital epithelium. J Immunol. 2013;191:4246-58 pubmed 出版商
Jonker M, Wubben J, Haanstra K, Vierboom M, t Hart B. Comparative analysis of inflammatory infiltrates in collagen-induced arthritis, kidney graft rejection and delayed-type hypersensitivity in non-human primates. Inflamm Res. 2013;62:181-94 pubmed 出版商
Li W, Katz B, Spinola S. Haemophilus ducreyi lipooligosaccharides induce expression of the immunosuppressive enzyme indoleamine 2,3-dioxygenase via type I interferons and tumor necrosis factor alpha in human dendritic cells. Infect Immun. 2011;79:3338-47 pubmed 出版商
Martín Martín L, Almeida J, Hernández Campo P, Sanchez M, Lecrevisse Q, Orfao A. Immunophenotypical, morphologic, and functional characterization of maturation-associated plasmacytoid dendritic cell subsets in normal adult human bone marrow. Transfusion. 2009;49:1692-1708 pubmed 出版商
Balachandran P, Pugh N, Ma G, Pasco D. Toll-like receptor 2-dependent activation of monocytes by Spirulina polysaccharide and its immune enhancing action in mice. Int Immunopharmacol. 2006;6:1808-14 pubmed
Wang R, Stephens J, Lacy M. Characterization of monoclonal antibody HTA125 with specificity for human TLR4. Hybrid Hybridomics. 2003;22:357-65 pubmed
产品信息
产品类型 :
抗体
产品名称 :
Toll样受体4单克隆抗体(HTA125)
目录# :
MA5-16719
规格 :
200微克
价格 :
美国456.00
克隆性 :
单克隆
纯度 :
蛋白质G
宿主 :
小鼠
反应物种 :
狗, 豚鼠, 人类, 猪, 猕猴
应用 :
Flow Cytometry: 1:10-1:25, Immunoprecipitation: Assay-dependent
物种 :
狗, 豚鼠, 人类, 猪, 猕猴
克隆 :
HTA125
抗体亚型 :
IgG2a
储存 :
短期存放在4°C。 为长期储存, 存放在-20°C, 避免反复冷冻/解冻
描述 :
TLR4 is member of the Toll like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. Mammalian cells respond to LPS by activating TLR4. TLR4 belongs to the multi-protein complex of lipopolysaccharide (LPS) receptor, containing CD14, LY96 and TLR4, and is involved in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. TLR4 aids in the recognition of pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. Mutations in the TLR4 gene have been associated with differences in LPS responsiveness. Also, several transcript variants of the TLR4 gene have been found, but the protein coding potential of most of them is uncertain. TLR4 is expressed by peripheral blood monocytes and a small population of B-cells and is also expressed in human placenta. Studies with TLR4-deficient mice indicate that the main ligand for TLR is lipopolysaccharide. Consequently, these mice also showed increased susceptibility to Gram-negative sepsis.
免疫原 :
Ba/F3 cell line expressing TLR4 (CD284)
格式 :
液体
应用w/稀释 :
Flow Cytometry: 1:10-1:25, Immunoprecipitation: Assay-dependent
别名 :
ARMD10; CD284; EGK_07381; homolog of Drosophila toll; hToll; lipopolysaccharide response; Lps; Ly87; Ran/M1; Rasl2-8; Tlr4; TLR-4; TOLL; toll like receptor 4; toll/interleukin-l receptor (TIR) domain; toll4; toll-like receptor 4; toll-like receptor 4 immunity-related protein; Toll-like receptor 4-like protein; Toll-like receptor4 protein
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国