产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
Podoplanin Monoclonal Antibody (8.1.1)
目录 :
MA5-18054
规格 :
100微升
价格 :
美国506.00
克隆性 :
单克隆
宿主 :
Syrian golden hamster
共轭标签 :
未共轭
克隆名称 :
8.1.1
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片, 抑制或激活实验
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 6
出版应用/物种/样本/稀释参考文献
  • 免疫组化-冰冻切片; 小鼠; 1:100; 图 7b
  • 流式细胞仪; 小鼠; 1:100; 图 s10
Beckmann D, Römer Hillmann A, Krause A, Hansen U, Wehmeyer C, Intemann J, et al. Lasp1 regulates adherens junction dynamics and fibroblast transformation in destructive arthritis. Nat Commun. 2021;12:3624 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 ex1e
Croft A, Campos J, Jansen K, Turner J, Marshall J, Attar M, et al. Distinct fibroblast subsets drive inflammation and damage in arthritis. Nature. 2019;570:246-251 pubmed 出版商
  • 抑制或激活实验; 小鼠; 图 5
  • 免疫组化; 小鼠; 图 3a
  • 免疫印迹; 小鼠; 图 4b
Payne H, Ponomaryov T, Watson S, Brill A. Mice with a deficiency in CLEC-2 are protected against deep vein thrombosis. Blood. 2017;129:2013-2020 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 图 2b
Nazari B, Rice L, Stifano G, Barron A, Wang Y, Korndorf T, et al. Altered Dermal Fibroblasts in Systemic Sclerosis Display Podoplanin and CD90. Am J Pathol. 2016;186:2650-64 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 7a
  • 免疫组化; 小鼠; 图 10a
Peske J, Thompson E, Gemta L, Baylis R, Fu Y, Engelhard V. Effector lymphocyte-induced lymph node-like vasculature enables naive T-cell entry into tumours and enhanced anti-tumour immunity. Nat Commun. 2015;6:7114 pubmed 出版商
  • 流式细胞仪; 小鼠
Baptista A, Roozendaal R, Reijmers R, Koning J, Unger W, Greuter M, et al. Lymph node stromal cells constrain immunity via MHC class II self-antigen presentation. elife. 2014;3: pubmed 出版商
产品信息
产品类型 :
抗体
产品名称 :
Podoplanin Monoclonal Antibody (8.1.1)
目录# :
MA5-18054
规格 :
100微升
价格 :
美国506.00
克隆性 :
单克隆
纯度 :
蛋白质G
宿主 :
Syrian Hamster
反应物种 :
小鼠
应用 :
Immunocytochemistry: Assay-dependent, Immunohistochemistry (Frozen): 0.5-1 µg/mL, Immunoprecipitation: Assay-dependent, Western Blot: Assay-dependent
物种 :
小鼠
克隆 :
8.1.1
抗体亚型 :
IgG
储存 :
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
描述 :
Podoplanin (PDPN, T1A, gp38, Aggrus) is a mucin type-1 glycoprotein with a 40-43 kDa molecular weight. Podoplanin is expressed in many tumors and normal cells, especially lymphatic epithelial cells and follicular DCs. Podoplanin localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes. Podoplanin appears to serve as a ligand for CLEC-2 and expression is positively correlated with tumors expressing greater invasive and metastatic potential. Podoplanin is directly involved in cell migration, aids metastases formation and tumor cell invasion of tissue. Further, it has also been determined that podoplanin expression is induced through Src activation of Cas and, recently, there are indications of podoplanin presence on Th17 cells. Initial studies below indicate the presence of podoplanin on a small but distinct population of CD4+ cells from human PBMC. Dysfunction of the podoplanin protein has been linked to diseases such as lymphangioma and subglottis neoplasm. Podoplanin has also been proposed as a marker for lung injury due to the physiological function of the protein.
免疫原 :
Thymic epithelial mouse cells
格式 :
液体
应用w/稀释 :
Immunocytochemistry: Assay-dependent, Immunohistochemistry (Frozen): 0.5-1 µg/mL, Immunoprecipitation: Assay-dependent, Western Blot: Assay-dependent
别名 :
29kDa cytosolic podoplanin intracellular domain; Aggrus; CTA-520D8.1; E11; E11 antigen epitope; epithelial cell surface transmembrane protein antigen; glycoprotein 36; Glycoprotein 38; glycoprotein, 36-KD; GP36; Gp38; GP40; HT1A-1; hT1alpha-1; hT1alpha-2; lung type I cell membrane associated glycoprotein; lung type-I cell membrane-associated glycoprotein (T1A-2); Ots8; OTS-8; OTTHUMP00000009640; OTTHUMP00000044504; PA2.26; PA2.26 antigen; PDPN; PICD; Podoplanin; PSEC0003; PSEC0025; pulmonary type I alveolar epithelial cell transmembrane differentiation marker; RANDAM-2; RP23-348F1.2; RTI140; RTI40; T1a; T1A2; T1A-2; T1alpha; T1-alpha; TI1A; Transmembrane glycoprotein E11; type I cell 40 kDa protein
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国