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抗体

动力蛋白激活蛋白1单克隆抗体(6B11)

MA5-18308

100微升

美国460.00

单克隆

小鼠

未共轭

6B11

免疫印迹, 免疫沉淀

动力蛋白激活蛋白1单克隆抗体(6B11)

MA5-18308

100微升

美国460.00

单克隆

抗原亲和色谱

小鼠

人类

Immunoprecipitation: 1:50-1:200, Western Blot: 1:1,000-1:1,750

人类

6B11

IgG2b

短期存放在4°C。 为长期储存, 存放在-20°C, 避免反复冷冻/解冻

This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA).

合成多肽对应于N末端人的动力蛋白激活蛋白1

液体

Immunoprecipitation: 1:50-1:200, Western Blot: 1:1,000-1:1,750

150 kDa dynein-associated polypeptide; AL022633; DAP 150; DAP150; DAP-150; DCTN 1; DCTN1; DP 150; DP150; DP-150; dynactin 1; dynactin 1 (p150, glued homolog, Drosophila); dynactin 1, retrograde axonal transport; dynactin subunit 1; Dynactin1; Glued; HMN7B; OTTHUMP00000202491; p135; p150; p150 glued; p150 glued homolog; p150 ; p150glued; p150-glued