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抗体

CDKL2单克隆抗体(6H8)

MA5-20569

100微克

美国446

单克隆

小鼠

未共轭

6H8

免疫印迹, 酶联免疫吸附测定, 免疫细胞化学

CDKL2单克隆抗体(6H8)

MA5-20569

100微克

美国446

单克隆

亲和色谱

小鼠

人类

ELISA: Assay-Dependent, Immunocytochemistry: 10 µg/mL, Immunofluorescence: 10 µg/mL, Western Blot: 1-5 µg/mL

人类

6H8

IgG1, kappa

-20° C, 避免反复冷冻/解冻

The activation of signal transduction pathways by growth factors, hormones and neurotransmitters is mediated by the MAP kinases ERK 1 and ERK 2. ERK proteins are regulated by dual phosphorylation at specific tyrosine and threonine sites mapping within a characteristic Thr-Glu-Tyr motif. The protein kinase p56 KKIAMRE is distantly related to the MAP kinase group of proteins and is closely related to p42 KKIALRE. KKIAMRE is predominantly expressed in testis, kidney, brain and lung. KKIAMRE contains the conserved MAP kinase dual phosphorylation motif in the sequence Thr-Asp-Tyr and is activated by treatment of cells by EGF. However, unlike other MAP kinases, the EGF-stimulated kinase activity does not require phosphorylation of KKIAMRE and KKIALRE in the Thr-Asp-Tyr motif.

CDKL2 (NP_003939, 394 a.a. ~ 493 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

液体

ELISA: Assay-Dependent, Immunocytochemistry: 10 µg/mL, Immunofluorescence: 10 µg/mL, Western Blot: 1-5 µg/mL

5330436L21Rik; AI505225; CDC2-related kinase; CDKL2; cyclin dependent kinase like 2; cyclin-dependent kinase-like 2; cyclin-dependent kinase-like 2 (CDC2-related kinase); KKIAMRE; Kkm; P56; p56 KKIAMRE protein kinase; protein kinase p56 KKIAMRE; serine/threonine protein kinase KKIAMRE; serine/threonine-protein kinase KKIAMRE; testicular tissue protein Li 35