产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
GITRL单克隆抗体(109114)
目录 :
MA5-23852
规格 :
100微克
价格 :
美国422.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
109114
反应物种 :
人类
应用 :
酶联免疫吸附测定, 中和反应, 流式细胞仪
更多信息或购买 :
文章摘录数: 1
产品信息
产品类型 :
抗体
产品名称 :
GITRL单克隆抗体(109114)
目录# :
MA5-23852
规格 :
100微克
价格 :
美国422.00
克隆性 :
单克隆
纯度 :
蛋白质A/G
宿主 :
小鼠
反应物种 :
人类
应用 :
ELISA: 0.5-2 µg/mL (Detection), 2-8 µg/mL (Capture), Flow Cytometry: 2.5 µg per million cells, Neutralization: Assay-Dependent
物种 :
人类
克隆 :
109114
抗体亚型 :
IgG1
储存 :
-20° C, 避免反复冷冻/解冻
描述 :
The tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate numerous biological functions including cell proliferation, differentiation, and survival through regulating the activation of the transcription factor NF-kappa-B and various mitogen-activated protein kinases. The glucocorticoid-induced tumor necrosis factor receptor (GITR) is an emerging member of this family that is expressed on CD4+ CD25+ regulatory T cells and appears to have crucial immune regulation functions. Its ligand GITRL is expressed in endothelial and antigen-presenting cells and can activate NF-kappa-B, induce both pro- and anti-apoptotic effects, inhibit the suppressive activity of regulatory T cells, and co-stimulate responder T cells through GITR. Dominant negative forms of NIK and TRAF2 expressed in transfected 293 cells substantially inhibited NF-kappa-B activation, suggesting that the GITRL-GITR pathway involves both NIK and TRAF2.
免疫原 :
Sf 21-derived recombinant human GITR Ligand/TNFSF18Glu52-Ser177
格式 :
冻干
应用w/稀释 :
ELISA: 0.5-2 µg/mL (Detection), 2-8 µg/mL (Capture), Flow Cytometry: 2.5 µg per million cells, Neutralization: Assay-Dependent
别名 :
Activation-inducible TNF-related ligand; AITR ligand; AITRL; GITR ligand; Gitrl; GITRLigand; Glucocorticoid-induced TNF-related ligand; glucocorticoid-induced TNFR-related protein ligand; glucocorticoid-induced-tumor necrosis factor receptor ligand; hGITRL; RP1-15D23.1; TL6; TNF superfamily member 18; Tnfsf18; TNLG2A; tumor necrosis factor (ligand) superfamily member 18; tumor necrosis factor (ligand) superfamily, member 18; tumor necrosis factor ligand 2A; tumor necrosis factor ligand superfamily member 18; tumor necrosis factor superfamily member 18; UNQ149/PRO175
更多信息或购买 :
公司信息
赛默飞世尔