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抗体

WIBG单克隆抗体(OTI9C7)

MA5-26797

100微升

美国486.00

单克隆

小鼠

未共轭

OTI9C7

免疫组化, 免疫组化-石蜡切片

WIBG单克隆抗体(OTI9C7)

MA5-26797

100微升

美国486.00

单克隆

亲和色谱

小鼠

人类

免疫组化(石蜡): 1:150

人类

OTI9C7

IgG1

-20° C, 避免反复冷冻/解冻

Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC. [UniProt]

Full length human recombinant protein of WIBG produced in HEK293T cell

液体

免疫组化(石蜡): 1:150

A030010B05Rik; Partner of Y14 and mago; protein wibg homolog; PYM; PYM homolog 1 exon junction complex-associated factor; PYM homolog 1, exon junction complex associated factor; Pym1; RGD1306096; WIBG; within bgcn homolog; within bgcn homolog (Drosophila)