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抗体

毛细血管扩张性共济失调症突变蛋白单克隆抗体(2C1)

MA5-31599

1毫升

美国436.00

单克隆

小鼠

未共轭

2C1

人类, 小鼠, 大鼠

免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片

毛细血管扩张性共济失调症突变蛋白单克隆抗体(2C1)

MA5-31599

1毫升

美国436.00

单克隆

小鼠

Human, Mouse, Non-human primate, Rat

Immunocytochemistry: 1:250-1:500, Immunohistochemistry (Paraffin): 1:50, Immunoprecipitation: Assay-dependent, Western Blot: 1:100

Human, Mouse, Non-human primate, Rat

2C1

IgG1

短期存放在4°C。 为长期储存, 存放在-20°C, 避免反复冷冻/解冻

Ataxia-telangiectasia Mutated (ATM) is a protein that belongs to the PI3/PI4 kinase family. Ataxia-telangiectasia is a rare autosomal recessive disorder characterized by progressive neurologic degeneration, immunologic deficiency, and an increased risk of lymphoid cancer. The ATM gene codes for a protein belonging to the phosphoinositide 3-kinase (PI3K) superfamily. ATM phosphorylates proteins instead of lipid and has many downstream targets that act as cell-cycle regulators including: P53, Mdm2, BRCA1, and SMC1. The ATM protein is responsible for repairing double-stranded DNA breaks that occur because of ionizing radiation and other mutagens. The ATM’s C-terminal region has extensive homology to the catalytic domains of phosphatidylinositol 3-kinases (PI3 kinases). Studies have shown that ATM becomes autophosphorylated and upregulated by exposure to ionizing radiation. AT cells are hypersensitive to ionizing radiation, impaired in mediating the inhibition of DNA synthesis and display delays in p53 induction. Further, DNA damage caused by ionizing irradiation activates ATM-kinase, leading to a cascade of kinase reactions that regulate cell cycle, apoptosis, and DNA damage repair. Studies have linked ATM to apoptosis along with Nbs1 and Chk2 in the E2F1 pathway.

Recombinant protein expressed in E. coli corresponding to amino acids 2577-3056.

液体

Immunocytochemistry: 1:250-1:500, Immunohistochemistry (Paraffin): 1:50, Immunoprecipitation: Assay-dependent, Western Blot: 1:100

AI256621; AT mutated; A-T mutated; A-T mutated homolog; AT mutated protein; AT1; ATA; Ataxia t; Ataxia telangiectasia gene mutated in human beings; ataxia telangiectasia mutated; Ataxia telangiectasia mutated homolog; ATC; ATD; ATDC; ATE; Atm; ATM (phospho S1981); ATM (pS1981); ATM (pSer1981); ATM phospho S1981; ATM phospho Ser1981; ATM serine/threonine kinase; C030026E19Rik; DKFZp781A0353; EC 2.7.1.37; MGC74674; phospho ATM; phospho S1981 ATM; serine-protein kinase ATM; TEL1; TEL1, telomere maintenance 1, homolog; TELO1