NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

抗体

SOX1重组兔单克隆抗体(JJ20-40)

MA5-32447

100微升

美国496.00

重组

domestic rabbit

未共轭

JJ20-40

人类, 小鼠

免疫印迹, 免疫组化, 免疫细胞化学

SOX1重组兔单克隆抗体(JJ20-40)

MA5-32447

100微升

美国496.00

重组单克隆

蛋白质A

兔

人类, 小鼠

Immunocytochemistry: 1:50-1:100, Immunohistochemistry: 1:50-1:100, Western Blot: 1:500-1:2,000

人类, 小鼠

JJ20-40

IgG

短期存放在4°C。 为长期储存, 存放在-20°C, 避免反复冷冻/解冻

SOX1, also known as SRY (sex determining region Y)-box 1, is a transcription factor belonging to the SRY-related HMG box family of transcription factors with a HMG box DNA-binding domain. SOX1 works through multiple independent pathways to promote neuronal cell fate determination and differentiation. This nuclear protein acts as a modulator of LINE retroposons promoter activity and is also involved in the development of the central nervous system, mainly neural and lens development. Transcriptional activator SOX1 binds directly to the HES1 promoter and suppresses HES1 transcription, thus attenuating Notch signaling. It also binds to beta-catenin and suppresses beta-catenin-mediated TCF/LEF signaling, thus potentially attenuating the WNT signaling pathway. Expression of SOX1 is seen mostly in embryonic tissues and moderately in brain.

Synthetic peptide within Human SOX1 aa 1-50

液体

Immunocytochemistry: 1:50-1:100, Immunohistochemistry: 1:50-1:100, Western Blot: 1:500-1:2,000

BB176347; LOC100912302; sex determining region Y-box 1; Sox1; Sox-1; sox1.S; SRY (sex determining region Y)-box 1; SRY box 1; SRY-box 1; SRY-box 1 S homeolog; SRY-box containing gene 1; SRY-box containing protein; SRY-box transcription factor 1; SRY-related HMG-box gene 1; transcription factor SOX-1; transcription factor SOX-1-like; XELAEV_18015596mg; XlSox1; xSox1