产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
PIEZO1单克隆抗体(2-10)
目录 :
MA5-32876
规格 :
100微升
价格 :
美国420
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
2-10
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学
更多信息或购买 :
文章摘录数: 3
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产品信息
产品类型 :
抗体
产品名称 :
PIEZO1单克隆抗体(2-10)
目录# :
MA5-32876
规格 :
100微升
价格 :
美国420
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
小鼠
反应物种 :
人类, 小鼠
应用 :
Immunocytochemistry: 1:50-1:200, Immunohistochemistry: 1:200-1:600, Western Blot: 1:500-1:2,000
物种 :
人类, 小鼠
克隆 :
2-10
抗体亚型 :
IgG2a
储存 :
短期存放在4°C。 为长期储存, 存放在-20°C, 避免反复冷冻/解冻
描述 :
Piezo1 is a pore-forming subunit of a mechanosensitive non-specific cation channel, and generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Structurally, Piezo1 contains 36 transmembrane domains and functions as a homotetramer. Piezo1 plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling. In the kidney, Piezo1 may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Piezo1 acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation and plays a key role in blood vessel formation and vascular structure in both development and adult physiology. The protein encoded by the Piezo1 gene is a mechanically-activated ion channel that links mechanical forces to biological signals. Defects in this gene have been associated with dehydrated hereditary stomatocytosis. Diseases associated with PIEZO1 include Dehydrated Hereditary Stomatocytosis with/without Pseudohyperkalemia And/Or Perinatal Edema and Lymphedema.
免疫原 :
Recombinant protein within Human Protein FAM38A aa 1275-1540
格式 :
液体
应用w/稀释 :
Immunocytochemistry: 1:50-1:200, Immunohistochemistry: 1:200-1:600, Western Blot: 1:500-1:2,000
别名 :
9630020g22; DHS; Fam38a; family with sequence similarity 38, member A; KIAA0233; LMPH3; Membrane protein induced by beta-amyloid treatment; Mib; mKIAA0233; piezo type mechanosensitive ion channel component 1; Piezo1; piezo-type mechanosensitive ion channel component 1; Protein FAM38A; protein PIEZO1
更多信息或购买 :
公司信息
赛默飞世尔