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抗体

AKT1(E17K突变体)重组兔单克隆抗体(RM336)

MA5-33069

50微克

美国460.00

重组

domestic rabbit

未共轭

RM336

免疫印迹, 酶联免疫吸附测定, 免疫组化

AKT1(E17K突变体)重组兔单克隆抗体(RM336)

MA5-33069

50微克

美国460.00

重组单克隆

蛋白质A

兔

人类

ELISA: 0.05-0.5 µg/mL, Immunohistochemistry: 0.2-1 µg/mL, Western Blot: 0.1-0.5 µg/mL

人类

RM336

IgG

-20°C

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene.

A peptide corresponding to Akt E17K mutant.

液体

ELISA: 0.05-0.5 µg/mL, Immunohistochemistry: 0.2-1 µg/mL, Western Blot: 0.1-0.5 µg/mL

AKT; AKT serine/threonine kinase 1; AKT1; AKT1m; CWS6; PKB; PKB alpha; PKB-ALPHA; PRKBA; Protein kinase B; Protein kinase B alpha; proto-oncogene c-Akt; RAC; rac protein kinase alpha; RAC-ALPHA; RAC-alpha serine/threonine-protein kinase; RAC-PK-alpha; serine-threonine protein kinase; v-akt murine thymoma viral oncogene homolog 1; v-akt murine thymoma viral oncogene-like protein 1