产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
ALK重组兔单克隆抗体(RM361)
目录 :
MA5-33093
规格 :
100微升
价格 :
美国446.00
克隆性 :
重组
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
RM361
反应物种 :
人类
应用 :
免疫印迹, 免疫组化
更多信息或购买 :
产品信息
产品类型 :
抗体
产品名称 :
ALK重组兔单克隆抗体(RM361)
目录# :
MA5-33093
规格 :
100微升
价格 :
美国446.00
克隆性 :
重组单克隆
纯度 :
蛋白质A
宿主 :
兔
反应物种 :
人类
应用 :
Immunohistochemistry: 1:500-1:1,000, Western Blot: 1:1,000-1:2,000
物种 :
人类
克隆 :
RM361
抗体亚型 :
IgG
储存 :
-20°C
描述 :
Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily. It is vital for brain development. Mutations, rearrangements, and amplifications in the ALK gene have been found in tumors, including anaplastic large cell lymphoma, neurblastoma, and non-small cell lung cancer. Chromosomal rearrangement is the most common genetic alteration. The translocation creates a fusion gene consisting of the ALK gene and the nucleophosmin gene: the 3' half of ALK, derived from chromosome 2, is fused to the 5' portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. These sequences are absent in the product of the transforming NPM-ALK gene. ALK shows the greatest sequence similarity to LTK. ALK plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system.
免疫原 :
A peptide corresponding to the C-terminus of human ALK (Anaplastic lymphoma kinase).
格式 :
液体
应用w/稀释 :
Immunohistochemistry: 1:500-1:1,000, Western Blot: 1:1,000-1:2,000
别名 :
Alk; ALK tyrosine kinase receptor; ALK/NPM1 fusion gene; anaplastic lymphoma kinase; Anaplastic lymphoma kinase Ki1; Anaplastic Lymphoma Kinase p80; anaplastic lymphoma receptor tyrosine kinase; CD246; CD246 antigen; EC 2.7.10.1; kinase ALK; mutant anaplastic lymphoma kinase; NBLST3; npm-alk; p80; Tcrz; TFG/ALK
更多信息或购买 :
公司信息
赛默飞世尔